A general method for accessing 5-alkyl-5-aryl-γ-lactams has been developed using readily available aryl bromides, nitroalkanes, and methyl acrylate as the starting materials. The palladium-catalyzed arylation of nitroalkanes gave the 1-aryl-substituted nitroalkanes, which underwent the DBU-medi...

The effects of 16-androstene steroids on skatole deposition in backfat and lean pork water activity, pH and microbial flora were determined. An experimental pig population composed of 28 boars, 30 gilts and 29 barrows from commercial Duroc/Hampshire cross Yorkshire breed was used and slaughtered...

The hepatic metabolism of the 16-androstene steroids was investigated using isolated porcine hepatocytes. This study demonstrated that the liver is capable of producing both phase I and phase II steroid metabolites from 16-androstene steroid precursors. 16-Androstene metabolites were recovered b...

This study examined the involvement of sulphoconjugation in the biosynthesis of the 16-androstene steroids in Leydig cells of the mature boar, since the formation of steroid sulphoconjugates can reduce the levels of these steroids that accumulate in fatty tissue. Leydig cells were purified from ...

Increased public interest in the welfare of pigs reared for pork production has led to an enhanced effort in finding alternatives to castration for controlling the unpleasant odour and flavour from heated pork products known as boar taint. The purpose of this study was to investigate the testicu...

Bendamustine is a drug of choice for the treatment of several cancers including non- Hodgkin lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL). The unstable nature of the drug, however, offers a major obstacle in its effective formulation development. The present study was aimed to achieve i...

Chemoimmunotherapy with bendamustine and rituximab is an alternative treatment for elderly patients with CLL. The aim of this observational multicenter study was to prospectively assess efficacy and safety of bendamustine and rituximab in front-line therapy in patients with CLL and significant c...

A selective, sensitive and rapid mice dried blood spot (DBS) method has been developed and validated for the simultaneous quantification of bendamustine (BM) and γ-hydroxy-bendamustine (HBM) as per regulatory guidelines using an LC-MS/MS. Quality control, calibration curve and study sample DBS ...

The enantioselective resolution of (R,S)-2,3-dichloro-1-propanol ((R,S)-DCP) to (S)-DCP by whole cells of a recombinant Escherichia coli expressing halohydrin dehalogenase (HHDH) activity was limited by product inhibition. To solve this problem to improve the productivity of (S)-DCP, an n-heptan...

The mutant form of Citrobacter freundii methionine γ-lyase with the replacement of active site Cys115 for His has been found to be inactive in the γ-elimination reaction of methionine while fully active in the γ-elimination reaction of O-acetyl-l-homoserine and in the β-elimination reaction ...

The glycosyl donor 2,3-di-O-benzoyl-5-O-levulinoyl-6-O-pivaloyl-β-D-Galactofuranosyl chloride and properly-protected L-homoserine covalently bound to polystyrene were employed for the stereoregular formation of a D-galactofuranosyl heptamer containing β-(1→)-interglycosidic bonds and a β-lin...

The vibrational spectra for l-β-Homoserine have been measured (IR absorption: 4000–400 cm− 1/Raman spectra: 4000–200 cm− 1). Characteristic vibrational modes of ammonium (− NH3+), carboxylate (− CO2−) and hydroxyl (− OH) groups across the 3700–1400 cm− 1 are all identified to have originated...

CeO2 electrospun nanofibers were decorated with a NH (CH2)nNH2+ CH2(CH2)8CH3 then followed by embedding of polyoxometalate H5PMo10V2O40 to give [email protected](n)/CeO2 nanofiber hybrids (where n = 2, 4, 6, 8 and 10). Such designation confirmed no leaching of HPMoV from CeO2 support, interactin...

BackgroundAccording to the European Drug Report, the use of novel psychoactive substances (NPS) is constantly growing. NPS are widely abused by human adolescent subjects. 5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is one of the most frequently used hallucinogenic NPS. 5-MeO-DIPT intoxicati...

ABSTRACTThe coupled reaction of methyl acetate and n-hexane was carried out over a HZSM-5 catalyst. In addition to a thermal coupling effect, systematic variations in the product distribution were also observed in the coupled system. The bezene-toluene-xylene (BTX) selectivity was remarkably imp...

Porous carbons with high adsorption capacity of n-hexane were developed by carbonization of MOF-5 with green carbon sources (glucose or sucrose) and activation with KOH. The effects of the additions of carbon sources and KOH activator on the porosity of porous carbon were discussed. The porous c...

H-ZSM-5 and Cu-HZSM-5 composite zeolites with a medium SiO2/AL2O3 ratio was successfully synthesized using a incipient-wetness impregnation method and characterized via physico-chemical analysis, such as X-ray diffraction (XRD), scanning electron microscope (SEM),N2-physisorption, BET, and tempe...

The kinetics of n-butane conversion over HZSM-5 zeolites at low temperature were studied. The results show that n-butane conversion mainly occurs via monomolecular pathway under low n-butane pressure (

Green synthesis of nanosized AlPO-n and SAPO-n (n = 5 and 18) crystals with AFI- and AEI-type structures from non-reacted precursor suspensions with an essential chemical compensation is presented. The crystallization of both materials was accomplished within few minutes (5–18 min) instead of s...

Brain-derived neurotrophic factor (BDNF) is a key modulator during the development of jugular and nodose ganglia neurons, which represent the origin of a large proportion of the sensory innervation of the lung. It belongs to the family of neurotrophins, which have been shown to induce the expres...