We report the catalytic effects of metal oxides on the CO2 absorption rate in an aqueous potassium salt of l-lysine-HCl using the vapor liquid equilibrium method. The best CO2 absorption rate obtained through testing metal oxides in a highly concentrated potassium salt of amino acids (2.0 M) was...

Two N-substituted 2-methyl-4-/5-nitroimidazole derivatives (3 & 4) have been synthesized by K2CO3 catalyzed reaction between 2-methyl-5-nitro-1H-imidazole (1) or metronidazole (2) and acrylonitrile. The derivates were obtained in good yields and characterized by IR spectroscopy, 1H-NMR spectrosc...

The ethyl 2-(4-methyl-(2-benzylidenehydrazinyl))thiazole-4-carboxylate (1) was synthesized via reaction of 4-methyl-(1-benzylidenehydrazinyl)-2-carbothioamide with ethyl bromopyruvate. The compound is characterized by FTIR and NMR before being analyzed by X-ray diffraction method. These properti...

Three series of novel 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones, designed as simplified analogs of curcumin with maleic diamide tether, were synthesized and bioevaluated. These compounds displayed potent cytotoxicity towards human Molt 4/C8 and CEM T-lymphocyte...

Based on N,N′-bis(5-ethyl-1,3,4-thiadiazol-2-yl)-2,6-pyridinedicarboxamide (H2L) and inorganic ZnII and CdII salts, three polynuclear complexes [Zn6(μ4-O)2(L)4] (1), [Zn3(μ3-O)2(L)2(H2L)] (2) and [Cd5(μ3-O)2(L)3(H2L)(CH3OH)(DMF)] (3) have been prepared and their crystal structures have been ...

This paper presents new experimental data on some key physicochemical properties of original bioactive 6-(acetylamino)-N-(5-ethyl-1,3,4-thiadiazol-2-yl) hexanamide (AETH). Thermal analysis of the compound under study has been carried out using differential scanning calorimetry and thermogravimet...

The selective catalytic reduction of NO with C3H6 and CO was investigated over platinum group metal (PGM; Pd, Rh, or Pt) supported on NbOPO4. Rh/NbOPO4 exhibits a lower light-off temperature of NO reduction to N2 compared to Pd- or Pt-loaded NbOPO4 catalysts and Rh/Al2O3 under stoichiometric con...

The synthetic nucleoside tiazofurin(2-β-ribofuranosylthiazole-4-carboxamide) and its selenium analog selenazofurin inhibited the growth of L1210 leukemia cell culture in a dose dependent manner with IC50 value of 2.0 and 0.2 Um respectively. The GTPATP ratio was diminished 4–6 fold as measured...

The nucleosides ribavirin, selenazofurin, tiazofurin and bredinin all exhibit the lowering of guanylate pools in vitro and in vivo by the inhibition of IMP dehydrogenase. However, each of these nucleosides has a separate profile of antiviral and antitumor activity. The IMP dehydrogenase inhibiti...

The inhibitory effects of selenazofurin and ribavirin on influenza A and B virus infections in mice were compared. Both compounds, when administered intraperitoneally (i.p.), reduced lung consolidation and prolonged mean day of death, but ribavirin more effectively increased survivor number and ...

The biochemical and cytotoxic activities of the IMP dehydrogenase (IMPDH) inhibitors benzamide riboside, tiazofurin, and selenazofurin were compared. These three C-nucleosides exert their cytotoxicity by forming an analogue of NAD, wherein nicotinamide is replaced by the C-nucleoside base. The a...

AimsAlthough baicalin could attenuate obesity-induced insulin resistance, the detailed mechanism of baicalin on glucose uptake has not been sufficiently explored as yet. The aim of this study was to survey if baicalin might facilitate glucose uptake and to explore its signal mechanisms in L6 myo...

The combined use of pH-zone-refining counter-current chromatography (CCC) and conventional CCC was successfully employed for the preparative separation and purification of baicalin and wogonoside from the traditional Chinese medicinal herb Scutellaria Baicalensis Georgi. A more environmentally f...

Suppression of xanthine oxidase (XO) may contribute to control hyperuricemia and gout. In this study, baicalein and baicalin, two dietary flavones, were found to inhibit the formation of uric acid and generation of superoxide anion (O2−) catalysed by XO through interaction with primary amino aci...

Sirtuin 1 (SirT1) and signal transducer and activator of transcription 3 (STAT3) oppositely regulate hepatic gluconeogenic genes and the association remains to be elucidated. Baicalin is a natural flavonoid with beneficial effects on glucose and lipid metabolism. This study aims to investigate t...

Heat stress has been documented to reduce reproductive performance of female animals through injury to germ cells, with few studies available in male animals. The objectives of this study were to evaluate protective effects of baicalin on testicular tissue damage of mice subjected to heat stress...

Short-chain fatty acids (SCFAs) are produced by the fermentation of dietary fiber by the gut microbiota and are beneficial to the health of the body. Insufficient SCFAs productions are associated with type 2 diabetes (T2D). We used a long-term high-fat diet to simulate the pathogenesis of T2D an...

ObjectiveThis study was aimed to explore effect of baicalin on IKK/IKB/NF-kB signaling pathway and apoptosis-related proteins in rats with ulcerative colitis (UC).

Bacterial pneumonia is a leading cause of death in the animal husbandry. Acute lung injury (ALI), most often seen as a part of systemic inflammatory process, characterized by progressive hypoxemia, edema, and neutrophil accumulation in the lung. Baicalin has been reported to inhibit inflammatory...

BackgroundDepression is a common disease that endangers people’s physical and mental health. Traditional Chinese medicine has advantages in treating the emotional and cognitive symptoms of depressive disorders.