We report a 2-(4-amino-2-hydroxyphenyl)benzothiazole based Schiff-base, a potential excited state intramolecular proton transfer (ESIPT) chromophore, exhibits aggregation induced emission enhancement (AIEE) in the solvent mixture of DMSO:HB. The presence of Cu2+ ions promote imine hydrolysis res...

The treatment of 4-nitrobenzofurazan with secondary amines resulted in the formation of 4-amino-5,7-bis(dialkylamino)-benzofurazans, as established by X-ray diffraction analyses; this is the first example of SNH reaction with synchronous alteration of three functions.

Malondialdehyde (MDA) is a critical product of polyunsaturated fatty acid peroxidation and represents a common biomarker of oxidative stress. In this study, we have developed a fluorogenic MDA probe, 4-hydrazinyl-7-nitrobenzofurazan (NBDH). The reaction between NBDH and MDA in acidic conditions ...

The standard (p° = 0.1 MPa) molar enthalpies of formation, at T = 298.15 K, in the gaseous phase, for two nitrobenzofurazan derivatives, 4-N,N-dimethylamino-7-nitrobenzofurazan (DMANBF) and 4-N,N-diethylamino-7-nitrobenzofurazan (DEANBF), were derived from their enthalpies of combustion and sub...

3-Hydroxyhexobarbital dehydrogenase (3HBD) catalyzes NAD(P)+-linked oxidation of 3-hydroxyhexobarbital into 3-oxohexobarbital. The enzyme has been thought to act as a dehydrogenase for xenobiotic alcohols and some hydroxysteroids, but its physiological function remains unknown. We have purified ...

This work aims to describe the wine fermentation characteristics of 23 natural S. cerevisiae × S. kudriavzevii hybrid yeasts related to fermentative environments isolated from different regions and their significance for the aroma spectra of the produced wines. Fermentations were performed at 1...

We present the python package reskit, developed to calculate the coefficients of an analytical continuation of the S-matrix of a physical system by means of Padé approximants and, from this fit, determine the complex poles of this S-matrix.The current implementation of the program is restricted...

The N-methyl-d-aspartate receptor (NMDAR) antagonist (R,S)-ketamine produces rapid and sustained antidepressant effects in treatment-resistant patients with depression although intranasal use of (R,S)-ketamine in ketamine abusers is popular. In March 5, 2019, nasal spray of (S)-ketamine for trea...

Cu2ZnSn(S,Se)4 (CZTSSe) absorber layers with various S/(S + Se) ratios at the surface and in the bulk were synthesized to investigate the effect of the S/(S + Se) ratios on the formation of secondary phases in the CZTSSe absorber layer. The higher density ZnS and Cu2SnSe3 (CTSe) secondary phases...

The rings considered in this article are commutative with identity. Modules are assumed to be unitary. Let R be a ring and let S be a multiplicatively closed subset of R. We say that a module M over R satisfiesS- strongaccr∗ if for every submodule N of M and for every sequence of elements of R,...

An effective synthetic route for preparation of oligo(fluorene-co- dibenzothiophene-S,S-dioxide)s (trimer SOF2, pentamer SOF4, heptamer SOF6 and nonamer SOF8) based on meta- or para-linked dibenzothiophene-S,S-dioxide (SO) unit as the core was developed by convergence method, for which the inter...

We treated 36 women with laparoscopically proven endometriosis with danazol 600 mg/d (n = 17) or gestrinone 5.0 mg/wk (n = 19) for 6 months. Endometrial samples were obtained before and at 3 and 6 months of treatment and were studied by light, scanning, and transmission electron microscopy. At 3...

Objectives: To evaluate the effects of triptoreline, gestrinone, and both, on experimental endometriosis in rats. Study design: Experimental endometriosis was surgically induced in 225 Wistar rats. Of these, 202 rats showed at least one grown implant, 22 of which composed the control group, whil...

Clinical and experimental evidence supports the hypothesis that some steroidal drugs with androgenic effects might influence the immune system. The present study investigated whether gestrinone is able to affect macrophage and lymphocyte activity in vitro. Macrophage function was determined by p...

ObjectivesTo evaluate the efficacy of gestrinone versus leuprolide acetate (LA) in improving pelvic pain in women with endometriosis and to compare their effects on bone mineral density and serum lipid profile.

ObjectiveTo compare danazol and gestrinone treatment as preoperative endometrial preparation for operative hysteroscopy.

The study was to investigate the effect of gestrinone on the growth of human uterine leiomyoma cells and on the levels and activity of p38, Src and estrogen receptor alpha (ERα). Human uterine leiomyoma cells were cultured and treated with dimethylsulfoxide (DMSO) or a gestrinone concentration ...

BackgroundA previous investigation showed that among 120 healthy women treated with a single oral dose of gestrinone for emergency contraception (EC), there was only one pregnancy. The effect of a single oral dose of gestrinone given for EC on ovarian function and endometrial development was stu...

Gestrinone is a synthetic steroid hormone with anti-estrogenic and anti-progesterone properties. It is used to treat endometriosis, shrink uterine fibroids and reduce menorrhagia; besides, it has been investigated for use as contraceptive. Also, due to its anabolic effects, it has been included ...

Steroidal 3-alkoxy-3,5-dienes have been converted into 6-aminomethyl- and 6-methyl-derivatives by novel extensions of the Vilsmeier process.