Tetrabutylammonium cyanide has been used as non-metallic catalyst for the diastereoselective cyanosilylation of α-hydroxyketones derived from the chiral pool. This affords α-substituted-α,β-dihydroxynitriles with high levels of asymmetric induction.

A series of thiol-functionalized organic compounds were selected to analyze the scope and efficiency of a new thioacetate deprotection method using catalytic tetrabutylammonium cyanide (TBACN) to effect the transformation of a thioacetate group to a free thiol in the presence of a protic solvent...

Fluoride (5–70 μg) in a final volume of 100 ml was determined. The analysis was based on the colored reaction of Al-HHSNNA and the bleaching effect of fluoride on it. The method is simple and rapid, and the accuracy is satisfactory when applied to different types of water. The procedure compar...

The oxidation of 2-hydroxynaphthaldehyde oxime with lead(IV) acetate (LTA) gave a mixture of naphtho[1,8-de][1,2]oxazine and a spiro dimer. LTA oxidation of 6-bromo (or nitro)-2-hydroxynaphthaldehyde oximes provided only spiro dimers. Similar treatment of (2-hydroxy-1-naphthyl)keto oximes with L...

H-point standard additions method (HPSAM), based on spectrophotometric and spectrofluorimetric measurements, was proposed for simultaneous determination of glafenine (G) and glafenic acid (GA). A study of the absorption spectra of G and GA in various pH media has been carried out. Reasonably res...

We have examined the effects of treatment of the rat with 3,5-dimethyl-3′-isopropyl thyronine (DIMIT) and 3,5-diethyl-3′-isopropyl thyronine (DIET) on serum thyrotropin (TSH) concentration, heart weight, hepatic outer ring (5′-) monodeiodination of T4 to T3, cardiac outer ring monodeiodinatio...

Density functional theory (using Becke's exchange and Lee-Yang-Parr's correlation functionals (BLYP)) and ab initio Hartree-Fock calculations were carried out in order to investigate the molecular structure and vibrational spectra of 9,10-anthraquinone and its perdeuterated analog. The...

An efficient deprotection of N-p-toluenesulfinyl group of β-branched Baylis–Hillman adducts has been developed by using Amberlite IR-120 (plus) ion-exchange resin in methanol solution at room temperature. Good to quantitative yields have been obtained for six examples. No racemization was dete...

DIBAL reduction of enantiopure N-p-toluenesulfinyl ketimines derived from 2-pyridyl ketones bearing an additional substituent on the 6-position of the pyridine ring afforded the related N-p-toluenesulfinyl amines with high yields and diastereoselectivities. The results of a number experiments ex...

A novel set of 1,4-diaryl-1,2,3-triazoles were projected as a tool to study the effect of both the heteroaromatic triazole as a core ring and a variety of chemical groups with different electronic features, size and shape on the catalytic activity of the two COX isoenzymes. The new triazoles wer...

Two sulfamoyl azides, H2NS(O)2N3 and MeN(H)S(O)2N3, have been isolated as neat substances and characterized. The solid-state structure of the parent molecule H2NS(O)2N3 has been established with X-ray crystallography. The thermal decomposition of both azides has been studied by combining flash v...

Metabolism of the proximate carcinogen trans-3,4-dihydroxy-3,4dihydrodibenz[c,h]acridine has been examined with rat liver enzymes. The dihydrodiol is metabolized at a rate of 2.4 nmol/nmol of cytochrome P450 1A1/min with microsomes from 3-methylcholanthrene-treated rats, a rate more than 10-fold...

New molecular receptors with a dibenz[c,h]acridine as spacer and having functionality complementary to urea have been developed.

The high-performance liquid chromatographic (HPLC) separation of enantiomers of oxide and hydroxy derivatives of dibenz[a,j]acridine and 7-methylbenz[c]acridine was investigated on a chiral stationary phase chromatography column using commercially available columns. In most cases either poor or ...

The development of the commercialization of 2,6-naphthalenedicarboxylic acid (2,6-NDA), dimethyl-2,6-naphthalenedicarboxylate (2,6-NDC) and their homopolymer with ethylene glycol, polyethylene naphthalate (PEN), is reviewed. Many of the significant alternative chemical routes to produce 2,6-dime...

4-Iodoanisoles 3a,b, 3d and 4-bromoanisoles 4a–d were readily obtained. An extreme steric hindrance precluded obtaining 3c. Catalytic borylation of 3a,b, 3d followed by hydrolysis of boronic ester 26a,b, 26d easily provided the boronic acids 5a,b, 5d. Compounds 5a and 5d were also synthesised, ...

PurposePrimary fluid secretion in secretory epithelia relies on the unidirectional transport of ions and water across a single cell layer. This mechanism requires the asymmetric apico-basal distribution of ion transporters and intracellular Ca2+ signaling. The primary aim of the present study wa...

SummaryHuman polyomaviruses cause a common childhood infection worldwide and typically elicit a neutralizing antibody and cellular immune response, while establishing a dormant infection in the kidney with minimal clinical manifestations. However, viral reactivation can cause severe pathology in...

The association of stone tools and modified bones at archaeological African Plio-Pleistocene sites is essential to understanding the socio-economics of early hominin behavior. Previous research at BK suggests the site was repeatedly visited by hominins for short time periods. During these occupa...

5,10-Dideazatetrahydrofolate (DDATHF) is an antifolate drug, the cytotoxic effects of which can be fully reversed by hypoxanthine, suggesting that DDATHF exerts its effects by inhibiting de novo purine biosynthesis. ICI198583 is a quinazoline based inhibitor of thymidylate synthase. In this stud...