A post-proline cleaving enzyme isolated from bovine brain and previously shown to act on the neuropeptides thyrotropin releasing hormone (TRH: pGlu-His-Pro-NH2) and luteinizing hormone releasing hormone (LRH: pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) has now been found to cleave the Pro4-Gln...

The 14 C-terminal heptapeptide analogues and one hexapeptide analogue of substance P (SP) were synthesized on the basis of the SP antagonist [D-Pro2, D-Trp7,9]SP-(1−11). They were tested in the guinea-pit ileum preparation for spasmogenic and antagonistic activities. All analogues except two had...

A series of novel derivatives of oxcarbazepine (5), 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide was synthesised and evaluated for their anticonvulsant activity and sodium channel blocking properties. The oxime 8 was found to be the most active compound from this series, displaying g...

In this study the oxidative degradation by hydrogen peroxide of native grape anthocyanin was studied in model solutions and in red wines added with increasing concentration of sulfur dioxide and glutathione (GSH). The presence of hydrogen peroxide and metal ions in traces allowed to investigate ...

Anthocyanins lipophilization recently emerged as an efficient tool to deliver oil-soluble dyes aiming to expand their applications in lipophilic matrices such as cosmetics formulations. Sodium dodecyl sulfate (SDS) micelles were used to solubilize malvidin-3-glucoside derivatives bearing an este...

A moderate red wine consumption and a colored fruit-rich diet protect the cardiovascular system, thanks to the presence of several polyphenols. Malvidin-3-0-glucoside (malvidin), an anthocyanidine belonging to polyphenols, is highly present in red grape skin and red wine. Its biological activity...

Understanding the degradation of anthocyanins (Acys) during microwave treatment is required for the application of this novel technology to fruit and vegetable processing. The pH 3.5 buffer solutions containing 50 mg/l malvidin-3-glucoside (Mv-3-glu) and malvidin-3,5-diglucoside (Mv-3,5-diglu), ...

At red wine pH, malvidin-3-glucoside (mv-3-glc), the major anthocyanin of red wine, is expected to be present mainly in its non-colored hemiketal form. However, due to copigmentation with flavanols (e.g. epicatechin), the stabilization of the colored forms of mv-3-glc occurs. Some flavanols have...

Vascular inflammatory responses are key mediators of endothelial dysfunction that leads to various pathologies in many diseases including atherosclerosis and cancer. The purpose of the study was to investigate the effects and molecular mechanisms of Malvidin, a natural pigment with strong antiox...

UV-A radiations are known to induce cellular oxidative stress, leading to premature skin aging. Consumption of açai fruit (Euterpe oleracea Martius) is known to have many health benefits due to its high level of antioxidants. Herein, we analyzed the ability of phenolic compounds extracted from t...

We recently demonstrated that California table grapes and a methanol-extractable, polyphenol-rich fraction decreased adiposity, insulin resistance, or markers of inflammation in high-fat fed mice. Malvidin and peonidin glycosides were the 2 most abundant anthocyanins in the polyphenol-rich fract...

Blueberries, a rich source of anthocyanins have attracted considerable attention as functional foods that confer immense health benefits including anticancer properties. Herein, we assessed the potential of blueberry and its major constituent malvidin to target STAT-3, a potentially druggable on...

BackgroundAnthocyanidins are plant phytochemicals found at high concentrations in berries, vegetables and flowers. Anthocyanidins have been extensively investigated due to their antioxidative, antidiabetic and anti-inflammatory effects. Few studies show that anthocyanidins decrease obesity and i...

A simple method to fabricate redox-responsive composite hydrogel films via incorporating chitosan (CS) microspheres into carboxymethyl cellulose (CMC) hydrogel using a di-sulphide cross-linker cystamine dihydrochloride (CYS) have done in this paper. Dual drugs, an anticancer, 5-Fluorouracil (5-F...

The present work describes the electrochemical detection of Cd2+ using reduced graphene oxide (rGO), carboxymethyl cellulose (CMC) and glutathione (GSH) modified glassy carbon electrode (GCE) by Square Wave Anodic Stripping Voltammetry (SWASV). The prepared nanocomposite was characterized by X-r...

The synthesis and characterization of two soluble poly(3,4-dimethylpyrrole) substituted with butyl and hexyl on the nitrogen moiety is reported. The poly(1-alkyl-3,4-dimethyl-2,5-pyrrolylene) (alkyl: butyl, hexyl) were synthesized by oxidative coupling polymerization of 1-alkyl-3,4-dimethylpyrro...

4-Nitrophenylacetic acid (NPA) was recorded and analyzed using FT-IR and FT-Raman spectra. The theoretical vibrational frequencies were carried out with the help of quantum chemical calculations. The electron density based local reactivity descriptors such as Fukui functions were calculated to e...

Human saliva contained 4-hydroxyphenylacetic acid (HPA) (2–10 μM) and nitrite (60–300 μM). HPA was nitrated to 4-hydroxy-3-nitrophenylacetic acid (NO2HPA) when HPA and sodium nitrite were mixed at pH 1.0. NO2HPA was also formed when saliva was incubated under acidic conditions. These results...

The Fab fragment of the anti-4-hydroxy-3-nitrophenylacetic acid monoclonal antibody, 88C6/12, has been crystallized in the presence of the eliciting hapten, 4-hydroxy-3-nitrophenacetyl-ε-aminocaproic acid (NP-aminocap) and the heteroclitic iodinated analog, 4-hydroxy-3-iodo-5-nitrophenylacetyl-...

Two C-nucleosides bearing small fluorescent groups as a base were synthesized by Heck-type coupling reaction and incorporated into DNA. They exhibited environment-sensitive fluorescence and opposite solvatochromic properties. The modified DNAs containing 3-aminobenzonitrile or 3-aminobenzoic aci...