Epidemiological studies have shown that high molecular weight phthalates (HMW) such as diethylhexyl phthalate (DEHP), are associated with hypertension in humans, while low molecular weight phthalates (LMW) such as dibutyl phthalate (DBP), have hardly any impact on the elevation of blood pressure...

The link between phthalate exposure and the risk of subclinical atherosclerosis in young population remains unclear. This study investigated the association between phthalate exposure and subclinical atherosclerosis, in terms of carotid intima-media thickness (CIMT), in young population. From a ...

Carbonohydrazide and its thio-analogue undergo di-addition with ethoxycarbonyl isothiocyanate. The reaction terminates at the mono-addition stage when one of the hydrazine moieties of the (thio)carbonohydrazide is blocked. The resulting 6-(substiiuted)amino-1-ethoxycarbonyl-thiobiureas and bithi...

The interaction of amidrazones and isocyanate esters in dimethylformamide produces good yields of 4-substituted -1-imidoylsemicarbazides. They are unaffected by acids, but are cyclised to 3-alkyl (or aryl)-1,2,4-triazol-3-ones or their 4-substituted analogues in alkaline media. Analogous linear ...

1-[(3-methylphenyl)piperazin-1-yl]-3-[thio(4-acetamidophenyl]propane and its analogs have shown good hypotensive activity and the title compound has shown a profile of centrally acting anti-hypertensive agent. It also binds with the 5-HT2 receptors. The conformation of the title compound was det...

A combination of the experimental and theoretical study was carried out on the reaction mechanism associated with the pyrolysis of 2-pyridylacetic acid in the gas phase. Methylpyridine and carbon dioxide were analyzed as the products, using a static system over the pressure range of 18–55 torr ...

High-pressure liquid-chromatography and microcalorimetry have been used to determine equilibrium constants and enthalpies of reaction for the disproportionation reaction of adenosine 5′-diphosphate (ADP) to adenosine 5′-triphosphate (ATP) andadenosine 5′-monophosphate (AMP). Adenylate kinase ...

The self-association of adenosine 5′-triphosphate (ATP) and of adenosine 5′-diphosphate (ADP) was studied in aqueous solution at different pH values, over the concentration range from 5×10−6 to 5×10−2 M, by ultraviolet spectroscopy. Measures of the molar absorptivity of the ultraviolet bands...

Interactions with the human breast cancer resistance protein (hBCRP) significantly influence the pharmacokinetic properties of a drug and can even lead to drug-drug interactions. As efflux pump from the ABC superfamily, hBCRP utilized energy gained by adenosine 5′-triphosphate (ATP) hydrolysis ...

cis-1,2-Divinylcyclobutanes are transformed with dibenzonitrilepalladium(II) chloride into the corresponding cis,cis-cycloocta-1,5-diene-PdCl2 complexes. When e.g. the 3-methyl-cis,cis-cycloocta-1,5-diene-PdCl2 complex is prepared using trans- or cis-3-methyl-cis-1,2-divinylcyclobutane or the co...

Transition structures and energetics for the Cope rearrangements of cis-1,2-divinylcyclobutane, obtained by RHF/6-31G* and MP2(full)/6-31G*//RHF/6-31G* calculations, are reported. Three transition structures (endo-boatlike, chairlike and exo-boatlike) have been located, giving rise to formation ...

Aromaticity of transition structures for Cope rearrangements of cis-1,2-divinylcyclopropane and cis-1,2-divinylcyclobutane is evaluated on the basis of GIAO-HF/6-31+G*//B3LYP/6-31G* calculated NICS values.

Mutual diffusion coefficient values for binary aqueous solutions of both L-glutamic acid (H2Glu) and sodium L-glutamate (NaHGlu) were measured with the Taylor dispersion technique, at T = 298.15 K, and concentrations ranging from (0.001 to 0.100) mol · dm−3. The results were discussed on the ba...

The enantioselective synthesis of 1-benzyl-4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-1H-indol-7-yl acetate (4) and 1-benzyl-6,7-dihydro-7-hydroxy-6,6-dimethyl-1H-indol-4(5H)-one (5), which are important intermediates in pharmaceutical industry, was carried out for the first time, both by enzyme-medi...

Candida albicans biofilm represents a major clinical problem due to its intrinsic tolerance to anti-fungal compounds and it has been highly related to infections in catheterized patients. Few compounds are described as able to inhibit biofilm formation or to interfere with preformed biofilm of C...

1-(1-Naphthyl)piperazine (1-NPZ) is a serotonergic derivative of quipazine acting both as antagonist and agonist of different serotonin receptors, with promising results for the management of skin cancer. In this work, we studied the effect of 1-NPZ on human MNT-1 melanoma cells by evaluating it...

Thirteen optically active (αS, βR) 1-naphthyl keto-oxiranes (1-naphthyl-4-yl[3-(substituted phenyl)oxiran-2-yl]methanones) have been synthesised by phase transfer catalysed epoxidation of 1-naphthyl chalcones. The yields of oxiranes are more than 95%. The synthesized oxiranes have been charact...

Deregulation of the receptor tyrosine kinase RET has been implicated in medullary thyroid cancer, a small percentage of lung adenocarcinomas, endocrine-resistant breast cancer and pancreatic cancer. There are several clinically approved multi-kinase inhibitors that target RET as a secondary phar...

Increasing evidences have implicated that sigma-2 receptor is a biomarker and significantly over-expressed in many proliferative cancer cells with no or low expression in normal cells. Sigma-2 receptor selective ligands have been successfully used as valuable tools to study its pharmacological f...

In this study 36 new compounds were synthesized by condensing barbituric acid or thiobarbituric acid and respective anilines (bearing different substituents) in the presence of triethyl orthoformate in good yields. In vitro urease inhibition studies against jack bean urease revealed that barbitu...