Limited supersaturation maintaining duration is the main challenge for amorphous solid dispersion design. Nucleation or crystal growth inhibitors may function in different ways but the combination use of nucleation and crystal growth inhibitors in supersaturated system is rarely explored. Thus, ...

Bimetallic Pd-Ru/C catalysts prepared with different carbon supports were shown to be much more active in the liquid-phase hydrogenation of benzaldehyde in comparison with their monometallic analogs. In the case of systems based on nanoglobular carbon, the synergistic effect manifested itself as...

The objective of this study was to investigate the effects of water tolerant Lewis acids (i.e., In(OTf)3, Yb(OTf)3 and InCl3) on bio-oil and solid residue yields. For this purpose, poplar wood was liquefied at 300 °C with a residence time of 10 min without and with water tolerant Lewis acids in...

The bioactive substance investigation of Balanophora involucrata obtained 15 phenolic acids, including 5 new compounds (1–3, 8, 9), which were determined by various spectroscopic data analyses. Most isolated compounds displayed inhibitory effects on α-Glucosidase in vitro. For the potential in...

Microwave-assisted degradation of alkaline lignin in methanol/formic acid media was investigated, concerning the effect of formic acid (FA) amount, reaction temperature, and reaction time on lignin depolymerization. The highest bio-oil yield of 72.0 wt% including 6.7 wt% monomers was achieved at...

The efficiencies of sinapic acid and its derivatives syringic acid, syringaldehyde, three sinapoyl esters (ethyl, propyl, butyl sinapates), 4-vinylsyringol and sinapine were investigated for prevention of lipid peroxidation in correlation with their interactions with model lipid membrane systems...

A practical and environmentally benign Brønsted acid−catalyzed protocol for the preparation of all-carbon tetrasubstituted allenes, consisting in the direct SNˈ addition of tri- or dimethoxy arenes or allyltrimethylsilane to tertiary propargylic alcohols, has been developed. In addition, a strai...

The absorption and fluorescence spectra of three 2-((phenylimino)methyl)phenol derivatives have been evaluated in a series of organic solvents. The ground state (μg) and excited state (μe) dipole moments are determined by means of Lippert–Mataga, Bakhshiev, Kaski–Chamma–Viallet and Reichard...

The Schiff base compound (E)-2-[(2-(hydroxymethyl)phenylimino)methyl]benzene-1,4-diol has been synthesized and characterized by 1H NMR, 13C NMR, IR, UV–Vis and single-crystal X-ray diffraction. Molecular geometry of the title compound in the ground state have been calculated using the density f...

Inhibition of the corrosion of mild steel in 1.0 M HCl solution by a Schiff base compound named 2-[(4-phenoxy-phenylimino)methyl]-phenol (APS) was investigated at different temperatures (25–55 °C) using electrochemical measurements. The inhibition efficiency increased as APS concentration and ...

The title compound, 2-[((3-iodo-4-methyl)phenylimino)methyl]-5-nitrothiophene, C12H9O2N2I1S1, was synthesized and characterized by IR, UV–Vis and single-crystal X-ray diffraction technique. The molecular structure was optimized at the B3LYP, B3PW91 and PBEPBE levels of the density functional me...

The spacer built up of NC, two CC, and CO bonds between the H-bond donating OH group and H-bond accepting nitrogen atom in the CN bond in Schiff bases exhibits a significant and strongly diversified degree of the π-electron delocalisation. No dependence between the delocalisation of π elec...

The azo-azomethine dyes with a different substitution have been designed from the reaction of 4,4′-diaminodiphenyl sulfone with 2-hydroxy-5-(aryldiazenyl)benzaldehyde. The compounds have been characterized by elemental analysis, Mass, IR, UV–Vis, TGA-DTA and NMR spectroscopy. The solvatochromi...

A Copper(II) complex of condensation production was synthesized and its crystal was also obtained by the reaction of 2-(phenylimino-methyl)-phenol with Cu(CH3COO)2·H2O. The crystal and molecular structure of the complex was determined by single-crystal X-ray diffraction, IR, and HRMS. The Cu(II...

The structure of (E)-2-ethoxy-6-[(phenylimino)methyl]phenol was characterized by X-ray diffraction, IR and electronic spectroscopy. The title compound prefers enol form in solid state as to X-ray and IR results. UV–Vis spectra of the title compound were recorded in various solvents. The results...

We have reported synthesis and characterization of (E)-2-nitro-4-[(phenylimino)methyl]phenol by using X-ray crystallographic method, FT-IR and UV–vis spectroscopies and density functional theory (DFT). Optimized geometry and vibrational frequencies of the title compound in the ground state have...

This work reports synthesis and characterization of a novel compound, 4-Bromo-2-(2,5-dichloro-phenylimino)-phenol (BDP). The crystal structure of this Schiff base is determined and compared with DFT calculations. Density functional theory (DFT) and time dependent density functional theory (TD-DF...

Phosphodiesterase 2 (PDE2) has received much attention for the potential treatment of the central nervous system (CNS) disorders and pulmonary hypertension. Herein, we identified that clofarabine (4), an FDA-approved drug, displayed potential PDE2 inhibitory activity (IC50 = 3.12 ± 0.67 μM) by...

The details of an NMR method of distinguishing between α- and β- anomers of 2′-deoxy-2′-fluoro-arabinofuranosyl nucleosides are presented.

The efficacy of gemcitabine therapy is often insufficient for the treatment of pancreatic cancer. The current study demonstrated that LW6, a chemical inhibitor of hypoxia-inducible factor 1α, is a promising drug for enhancing the chemosensitivity to gemcitabine. LW6 monotherapy and the combinat...