A series of five chromium(III) complexes with tridentate ligands containing S/O-and Se/O-donor groups was obtained by the reaction of [Cr(MeCN)3Cl3] with 2,2′-bis(sulfanylethyl)ethers or 2,2′-bis(selanylethyl)ethers correspondingly. The new [Cr((RSCH2CH2)2O)Cl3] and [Cr((RSeCH2CH2)2O)Cl3] comp...

Several unsymmetrical Schiff-base mononuclear and binuclear manganese(III), cobalt(III) and chromium(III) complexes have been designed, synthesized and applied to the alternating ring-opening copolymerization of cyclohexene oxide and maleic anhydride with the optimized conditions. Experimental r...

An innovative deep eutectic solvent with ultrasound-assisted based dispersive liquid-liquid microextraction method was first time develop for separation and preconcentration of trivalent chromium in environmental water samples. The `deep eutectic solvent with ultrasound-assisted based dispersive...

Treatment of uroporphyrinogen I octamethyl ester with 2-mercaptobenzothiazolylmethyl pyrrole derivative in the presence of silver (I) trifrate under anaerobic condition in dichloromethane for 20 h, followed by aerial oxidation of the products, gave a statistical mixture of uroporphyrin I∼IV oct...

Uroporphyrins I and III have been separated by high performance liquid chromatography on a microporasil column using n-heptane:glacial acetic acid:acetone:water (90:60:30:0.05 by volume). By using uro [3H]porphyrin I and uro[14C]porphyrin III it was shown that less than 2% cross contamination oc...

Triterpenoids are in the focus of scientific interest, and they were evaluated for many pharmacological applications among them their ability to act as inhibitors of cholinesterases. These inhibitors are still of interest as drugs that improve the life quality of patients suffering from age-rela...

The clinical use of potent anticancer drug mitomycin C (MMC) has limited due to side effects and resistance of cancer cells. The aim of this study was to investigate whether lithium chloride (LiCl), as a mood stabilizer, can affect the sensitivity of MDA-MB-231 breast cancer cells to mitomycin C...

IntroductionAlthough evidence supports the use of mitomycin C after transurethral bladder tumor resection in reducing recurrent disease, its adoption has been limited. Examinations of claims data may help in exploring patterns of care and barriers to use. Thus, we analyzed a contemporary populat...

In this work, we report one-step eco-friendly method for the fabrication of fluorescent carbon dots (CDs) using Daucus carota subsp. sativus (carrot) roots as a carbon source. The as-fabricated CDs were characterized by spectroscopic and transmission electron microscopic techniques. The as-synth...

Background: Mitomycin-C (MMC) has been used for treating stricture. Topical MMC has been proven to inhibit fibroblasts proliferation and reduce the number of fibroblasts. Myofibroblasts are originally from fibroblasts. The scarring potential of myofibroblasts has been documented in many anatomic...

Besides the cannabinoid mimetic JWH-073, a novel 4 methylnaphthoyl homologue of JWH-073 was detected in a herbal mixture. The structure of the compound was elucidated after thin layer chromatographic enrichment from the herbal mixture by nuclear magnetic resonance (NMR) and gas chromatographic m...

The five regioisomeric methylated indole ring analogues of JWH-018 can be prepared directly from a common set of precursor materials. These five isomers include 2-methyl-1-n-pentyl-3-(1-naphthoyl)-indole (JWH-007) and its four regioisomeric analogues, 4-, 5-, 6- and 7-methyl substituted indoles....

1-Pentyl-3-(4-methoxy-1-naphthoyl)indole (shortly named JWH-081) (1) and 2-(2-methoxy-phenyl)-1-(1-pentyl-1H-indol-3-yl)-ethanone (shortly named JWH-250) (2), are examples of cannabinoids which were characterized by FTIR, UV–Vis, multinuclear NMR spectroscopy and single crystal X-ray diffractio...

In an effort to improve indole-based CB2 cannabinoid receptor ligands and also to develop SAR for both the CB1 and CB2 receptors, 47 indole derivatives were prepared and their CB1 and CB2 receptor affinities were determined. The indole derivatives include 1-propyl- and 1-pentyl-3-(1-naphthoyl)in...

The GC–MS properties of the synthetic cannabinoid drug of abuse 3-(1-naphthoyl)-1-pentylindole (JWH-018) and all 5 of its’ regioisomeric 1-naphthoyl substituted 1-n-pentylindoles are compared in this report. These compounds have the 1-naphthoyl-group attached at each of the possible substituen...

The six 1-n-pentyl-2-, 3-, 4-, 5-, 6- and 7-(2-naphthoyl)-indoles each have the same substituents attached to the indole ring, identical elemental composition (C24H23NO) yielding identical nominal and accurate masses. The electron ionization mass spectra of the 2-naphthoyl substituted isomers sh...

The compounds in this study are the regioisomeric 2-, 3-, 4-, 5-, 6- and 7-(1-naphthoyl) substituted 1-(5-fluoropentyl)-indoles and the 3-(1-naphthoyl) substituted isomer in this series is also known as AM-2201. These compounds are structurally similar to JWH-018 except for the additional fluori...

PurposePamidronate disodium–associated bone necrosis is poorly understood at the cellular and molecular levels. This study proposes a pathway leading to the pamidronate disodium–mediated inhibition of osteogenic differentiation of human bone marrow mesenchymal stem cells (BMMSCs) derived from ...

The aim of the present study was to develop directly compressed compacts for mucoadhesive delivery of pamidronate disodium for the treatment of osteoporosis in the rat model induced by methylprednisolone. A blend of HPMC-4KM and thiolated chitosan was used as the biodegradable polymers for the f...

N-Chloroacetyl-5-bromoanthranilic acid (1), 3-[4′-(p-chlorophenyl)-thiazol-2′-yl]-2-chloromethyl-6-bromoquinazolin-4-one (2), 3-[4′-(p-chlorophenyl)-thiazol-2′-yl]-2-hydrazinomethyl-6-bromoquinazolin-4-one (3), 3-[4′-(p-chlorophenyl)-thiazol-2′-yl]-2-substitutedbenzylidene aminomethyl-6-br...