PurposeTo evaluate safety and efficacy of the angiostatic agent anecortave acetate, compared with a placebo, for treatment of subfoveal choroidal neovascularization (CNV).

The ocular delivery of anecortave acetate was tested in preclinical and clinical pharmacokinetic and metabolism studies. Results of initial studies led to the design of a new cannula that could effectively deliver anecortave acetate as a posterior juxtascleral depot, providing adequate retinal a...

Anecortave acetate is a unique ocular angiostatic cortisene that has broad-based anti-angiogenic activity in 14 different preclinical models of neovascularization, across multiple species and inducers of neovascularization. Anecortave acetate is being tested clinically for inhibition of choroida...

In drinking water production, phosphonates are frequently applied as antiscalants in order to prevent the precipitation of salts on reverse osmosis membranes. Whereas the nominal constituents are defined, phosphonate-based antiscalants were found to contain significant amounts of undeclared phos...

Graft copolymers of natural rubber and poly(dimethyl(acryloyloxymethyl)phosphonate) (NR-g-PDMAMP), and natural rubber and poly(dimethyl(methacryloyloxyethyl)phosphonate) (NR-g-PDMMEP), were prepared in latex medium via a “grafting from” methodology based on the photopolymerization of dimethyl(...

The palladium catalyzed homogeneous reduction of a variety of phenols with either sodium borohydride or triethylammonium formate are effected as their triflate esters. This transformation extends the usefulness of the benzannulation reaction of chromium carbene complexes with acetylenes and is e...

Appropriate dithiane derivatives of D-threo configuration were prepared starting with D-arabinose and D-galactose, respectively. Their dianions served for nucleophilic additions to model aldehydes, thus comprising syntheses of the complex side chain of chromomycinone. In contrast to former repor...

It has been shown that chromomycinone can be represented by the absolute configurational structure 1. Molecular rotation differences between the acetate and benzoate of secondary alcohols can be employed for deriving the absolute configuration.

The various reactions of chromomycinone, the chromophore of the cancerostatic chromomycins, are described. The structures of several chromomycinone derivatives are also discussed.

The thermodynamics of micellar solubilization were obtained from precise calorimetric measurements for pentan-1-ol in surfactant mixtures of benzyldimethyltetradecylammonium chloride (BzCl) and trimethyltetradecylammonium chloride (TACl) (system I). The partition coefficient P of pentan-1-ol bet...

Molecular dynamics simulations of four different phases of a cationic surfactant dodecyltrimethylammonium chloride (DTAC) are presented. It is shown that when the topology of the initial configuration matches that of the equilibrium structure, the required equilibration times of MD simulations a...

The basicity constant of dodecyltrimethylammonium hydroxide was measured, giving pKb = 2.8901 ± 0.0003 at 25°C. The degree of hydrolysis of the dodecyltrimethylammonium bromide salt was also studied and interpreted.

Changes in a protonated Nafion-112 membrane as a result of the incorporation of the cation n-dodecyltrimethylammonium (DTA+) by proton exchange mechanism are studied. Membrane surface modifications were analysed by AFM, XPS and contact angle measurements in order to obtain information about chan...

Quaternary ammonium compounds (QACs) used as cationic surfactants are intensively released into environment to be pollutants receiving more and more concerns. Sorption of dodecyltrimethylammonium chloride (DTAC), one of commonly used alkyl QACs, to five types of agricultural soils at low concent...

The mixed surfactants of dodecyltrimethylammonium bromide (DTAB) and 1-dodecyl-3-methylimidazolium bromide (C12mimBr) in aqueous solutions were studied by measurement of electrical conductivity and isothermal titration microcalorimetry (ITC). The critical micelle concentrations (cmc) and the deg...

The antagonistic as well as synergetic interaction for dodecyltrimethylammonium bromide (DTAB) and sodiumdodecyl sulfate (SDS) mixed surfactants by using surface tension are investigated on the basis of the results obtained earlier, the efficiency of adsorption (pC20), aggregation number (N), Γ...

The corrosion and passivation behaviors of zinc electrodes in 7.0 M KOH saturated with ZnO in the presence of dodecyltrimethylammonium bromide (DTAB) surfactant were evaluated by Tafel, linear sweep voltammetry, electrochemical impedance spectroscopy (EIS) and field emission scanning electron mi...

The micellization process of the aqueous mixed system triton X-100 (TX100) – dodecyltrimethylammonium bromide (DTAB) has been studied with a battery of techniques: surface tension, static and dynamic light scattering and ion-selective electrodes. Results have been also analysed with two thermod...

The micellization behavior of N-Lauryl sarcosine sodium (NLS, an anionic surfactant) and Dodecyltrimethylammonium bromide (DOTAB, a cationic surfactant) in aqueous solution is investigated by UV–vis spectrophotometric and conductometric methods at 298.15 K. A critical micelle concentration (CMC...

The specific heat capacities at constant pressure cp of aqueous solutions of cationic surfactant: dodecyltrimethylammonium bromide, with addition of co-surfactant: n-hexan-1-ol with the molar ratio of surfactant to co-surfactant 1:1 have been measured within temperature range (278.15–328.15) K ...