Hitherto unknown fluorene-9-malonic acid and some substituted derivatives were easily synthesized in very mild conditions through the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids issued from the corresponding biphenylcarboxaldehydes.

A series of 4-hydroxycoumarin derivatives were designed and synthesized in order to find some more potent antibacterial drugs. Their antibacterial activities against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus were tested. These compounds showed good ant...

To diagnose and investigate neurodegenerative diseases affecting cholinergic neuron density, piperazine derivatives of vesamicol were synthesized and evaluated. Previously, we reported that trans-5-iodo-2-hydroxy-3-[4-phenylpiperazinyl] tetralin (DRC140, 1) possessed high selectivity for vesicul...

A novel series of 4-substituted-piperazine-1-carbodithioate derivatives of 2,4-diaminoquinazoline were synthesized and tested for their antiproliferative activities against five human cancer cell lines including A549 (lung cancer), MCF-7 (breast adenocarcinoma), HeLa (cervical carcinoma), HT29 a...

In this communication, hydrate dissociation data for methane + three liquid hydrocarbons namely 3-methyl-1-butanol, 3,3-dimethyl-2-butanone and 2,3-dimethyl-2-butene are reported. An isochoric pressure-search method was employed to generate the four-phase equilibrium data in the diverse pressure...

Metal complexes of the following uracil series of pyrimidine nitrogen bases were studied to assist in elucidating the effect of metal ions on the double-stranded helical structure of nucleic acids: 5-bromo-uracil-6-carboxylic acid (5-bromoörotic acid), 5-nitroörotic acid, 5-aminoörotic acid and ...

Iron overload secondary to β-thalassemia and other iron-loading anemias is the most serious obstacle to be overcome in the treatment of these diseases, since there is no physiological mechanism for excretion of the excess iron acquired by chronic blood transfusion. Due to the inconvenience and ...

Previous studies have demonstrated that aroylhydrazone iron (Fe) chelators of the pyridoxal isonicotinoyl hydrazone (PIH) class have high Fe chelation efficacy both in vitro and in vivo. Depending on their design, these drugs may have potential as agents for the treatment of Fe overload disease ...

An orally available iron chelator is desirable for the treatment of secondary iron overload. Pyridoxal isonicotinoyl hydrazone (PIH) and its analogs effectively mobilize iron in vivo and in vitro, and are therefore promising candidates for this purpose. PIH analogs undergo significant amino acid...

The antimalarial action of iron chelators is limited by factors related to drug permeation and parasite susceptibility to metal deprivation. In this study we applied iron-chelating isonicotinoyl and benzoyl hydrazones on Plasmodium falciparum cultures and assessed their antimalarial properties. ...

A model consisting of 59Fe-labelled macrophages was developed for screening potential iron-chelating drugs. Mouse peritoneal macrophages, induced by previous intraperitoneal injections of 3% thioglycollate, were labelled in vitro by their exposure to immune complexes of 59Fe-transferrin-antitran...

4,4′-bis(N-carbazolyl)tolan (BCT) and 4,4′-bis[N-(3,6-di-t-butyl)carbazolyl]tolan (BCT-t-Bu) were synthesized as π-expanded analogs of 4,4′-bis(N-carbazolyl)biphenyl. Their photophysical characteristics both in solution and films were thoroughly investigated. Interestingly, the phosphorescen...

Singlet oxygen (1O2, O2 (a1Δg)) quenching by the organic light emitting device (OLED) electron transport material tris(8-hydroxyquinoline)aluminum (Alq3) and hole transport material N,N′-diphenyl-N,N′-bis(3-methylphenyl)-[1,1-biphenyl]-4,4-diamine (TPD) in benzene has been investigated by mea...

Organic-inorganic nanocomposite films consisting of surface functionalized halloysite nanotube (HNT) and poly (vinyl alcohol) (PVA) with improved mechanical and thermal properties were prepared. The surface of HNT was modified with boronic acid by two different methods. In the first method, a bo...

Novel organic-inorganic mesoporous luminescent polymeric composite materials containing lanthanide (Eu3+, Tb3+) complexes covalently bonded to mesoporous silica have been prepared in situ, followed by the polymerization reaction of the monomer 4-vinylphenylboronic acid (VPBA) extending along the...

Two boronic acid copolymers were synthesized by free radical polymerization of 3-acrylamidophenylboronic acid/4-vinylphenylboronic acid with N-acryloyl-l-alanine and vinyl acetate to investigate the role of the boronic acids in the fluorescence response mechanism. The structure and the chemical ...

To develop a reversible forming polymer network system, a polymer complexation was conducted between water-soluble and cytocompatible polymers, namely poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate-co-p-vinylphenylboronic acid) (PMBV) and poly(vinyl alcohol) (PVA). The two...

A novel [4 + 1] cycloaddition protocol for the synthesis of dihydrobenzo(naphtho)furan skeletons from readily available 2-(2-nitrovinyl)-phen(naphth)ols and malonate esters via a tandem Michael addition/iodine-catalyzed oxidative annulation has been developed. This method provides a new and faci...

Zirconia and its modified forms such as 10%Mo(VI)/ZrO2, 10%V(V)/ZrO2, 10%W(VI)/ZrO2 and SO42−/ZrO2 were prepared and characterized for their physico-chemical properties such as BET for surface area, NH3-TPD and n-butylamine back titration method for total surface acidity, PXRD technique for crys...

A highly efficient enantioselective Friedel–Crafts alkylation of indoles with alkylidene malonates has been developed using chiral N,N′-dioxide L4–scandium(III) complex as the catalyst, giving the corresponding products in high yields with excellent enantioselectivities (up to 99% yield and 9...