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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Thioridazine Hydrochloride

Cas:130-61-0

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% thioridazine hydrochloride 130-61-0 GMP manufacturer

Cas:130-61-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s

10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride

Cas:130-61-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Thioridazine hydrochloride

Cas:130-61-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

130-61-0 Thioridazine hydrochloride 1.Large qty in stock 2.High quality 3.Lowest price 4.Best service Our Advantage 1. Risk-free guarantee,15days refund 2. Most of the products in stock,can ship within 7days after the order 3. S

130-61-0 Thioridazine hydrochloride

Cas:130-61-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Thioridazine hydrochloride CAS 130-61-0

Cas:130-61-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 130-61-0 with best quality

Cas:130-61-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride 130-61-0

Cas:130-61-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Thioridazine hydrochloride

Cas:130-61-0

Min.Order:1 Kilogram

FOB Price: $86.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Thioridazine hydrochloride CAS:130-61-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

Thioridazine hydrochloride CAS:130-61-0

Cas:130-61-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride

Cas:130-61-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Thioridazine hydrochloride// Thioridazine hcl factory bulk supply

Cas:130-61-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride

Cas:130-61-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

thioridazine hydrochloride CAS NO.130-61-0

Cas:130-61-0

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride

Cas:130-61-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Thioridazine hydrochloride

Cas:130-61-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride

Cas:130-61-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride

Cas:130-61-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Transporta

10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride

Cas:130-61-0

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Thioridazine hydrochloride

Cas:130-61-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Thioridazinehydrochloride

Cas:130-61-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

thioridazine hydrochloride CAS NO.130-61-0 CAS NO.130-61-0

Cas:130-61-0

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Thioridazine HCl

Cas:130-61-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

thioridazine hydrochloride

Cas:130-61-0

Min.Order:0

Negotiable

Type:Other

inquiry

Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

CAS 130-61-0 Thioridazine hydrochloride

Cas:130-61-0

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Thioridazine hydrochloride

Cas:130-61-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment . Application:API

99% up by HPLC Thioridazine hydrochloride 130-61-0

Cas:130-61-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Thioridazine Hydrochloride (200 mg)

Cas:130-61-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Thioridazine Hydrochloride

Cas:130-61-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

Thioridazine hydrochloride

Cas:130-61-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-{2-[2-(methylthio)-10H-phenothiazin-10-yl]ethyl}piperidine-1-carboxylate

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-{2-[2-(methylthio)-10H-phenothiazin-10-yl]ethyl}piperidine-1-carboxylate

thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

Conditions
ConditionsYield
Stage #1: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-{2-[2-(methylthio)-10H-phenothiazin-10-yl]ethyl}piperidine-1-carboxylate With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 50℃; for 18h; Inert atmosphere;
Stage #2: With hydrogenchloride In ethanol; water
100%
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 0 - 50 °C / Inert atmosphere
2: hydrogenchloride / ethanol; water
View Scheme
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water100%
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

chlorpromazine sulfoxide
969-99-3

chlorpromazine sulfoxide

Conditions
ConditionsYield
With dihydrogen peroxide In water for 72h; Ambient temperature;93%
carbonochloridic acid 1-chloro-ethyl ester
50893-53-3

carbonochloridic acid 1-chloro-ethyl ester

thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

1-chloroethyl 2-(2-(2-(methylthio)-10hphenothiazin-10-yl)ethyl)piperidine-1-carboxylate

1-chloroethyl 2-(2-(2-(methylthio)-10hphenothiazin-10-yl)ethyl)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: thioridazine Hydrochloride With triethylamine In 1,2-dichloro-ethane at 20℃; for 0.333333h; Inert atmosphere;
Stage #2: carbonochloridic acid 1-chloro-ethyl ester In 1,2-dichloro-ethane for 12h; Inert atmosphere; Reflux;
84%
1-methyl-1-propanethiol
513-53-1

1-methyl-1-propanethiol

thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

2-(sec-butylthio)-10-(2-(1-methylpiperidin-2-yl)ethyl)-10H-phenothiazine
96457-89-5

2-(sec-butylthio)-10-(2-(1-methylpiperidin-2-yl)ethyl)-10H-phenothiazine

Conditions
ConditionsYield
With Singacycle A1; lithium hexamethyldisilazane In o-xylene at 160℃; for 12h; Glovebox; Sealed tube;71%
Cyclohexanethiol
1569-69-3

Cyclohexanethiol

thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

2-(cyclohexylthio)-10-(2-(1-methylpiperidin-2-yl)ethyl)-10H-phenothiazine

2-(cyclohexylthio)-10-(2-(1-methylpiperidin-2-yl)ethyl)-10H-phenothiazine

Conditions
ConditionsYield
With Singacycle A1; lithium hexamethyldisilazane In o-xylene at 160℃; for 12h; Glovebox; Sealed tube;62%
1-Adamantanethiol
34301-54-7

1-Adamantanethiol

thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

2-((adamantan-1-yl)thio)-10-(2-(1-methylpiperidin-2-yl)ethyl)-10H-phenothiazine

2-((adamantan-1-yl)thio)-10-(2-(1-methylpiperidin-2-yl)ethyl)-10H-phenothiazine

Conditions
ConditionsYield
With Singacycle A1; lithium hexamethyldisilazane In o-xylene at 160℃; for 12h; Glovebox; Sealed tube;61%
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

phenylmethanethiol
100-53-8

phenylmethanethiol

2-(benzylthio)-10-(2-(1-methylpiperidin-2-yl)ethyl)-10H-phenothiazine
97013-68-8

2-(benzylthio)-10-(2-(1-methylpiperidin-2-yl)ethyl)-10H-phenothiazine

Conditions
ConditionsYield
With Singacycle A1; lithium hexamethyldisilazane In o-xylene at 160℃; for 12h; Glovebox; Sealed tube;56%
1-Bromopentane
110-53-2

1-Bromopentane

thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

1-methyl-2-(2-(2-(methylthio)-10H-phenothiazin-10-yl)ethyl)-1-pentylpiperidin-1-ium bromide

1-methyl-2-(2-(2-(methylthio)-10H-phenothiazin-10-yl)ethyl)-1-pentylpiperidin-1-ium bromide

Conditions
ConditionsYield
In acetonitrile for 24h; Reflux; Inert atmosphere;51%
Octanethiol
111-88-6

Octanethiol

thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(octylthio)-10H-phenothiazine

10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(octylthio)-10H-phenothiazine

Conditions
ConditionsYield
With Singacycle A1; lithium hexamethyldisilazane In o-xylene at 160℃; for 12h; Glovebox; Sealed tube;49%
zinc acetate hydrate

zinc acetate hydrate

thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

ZnC6H4SN((CH2)2C5H9NHCH3)C6H3(SCH3)Cl(2+)*2CH3COO(1-)=[ZnC6H4SN((CH2)2C5H9NHCH3)C6H3(SCH3)Cl](CH3COO)2

ZnC6H4SN((CH2)2C5H9NHCH3)C6H3(SCH3)Cl(2+)*2CH3COO(1-)=[ZnC6H4SN((CH2)2C5H9NHCH3)C6H3(SCH3)Cl](CH3COO)2

Conditions
ConditionsYield
In methanol slow addn. of soln. of ZnCl2 to soln. of ligand (room temp.), stirring (1 h), conctg. (reduced pressure), storing (overnight at 4°C); decanting viscous liq., redissolving in methanol with stirring at 60°C, suction filtn., washing (2-3 times, cold methanol), drying (air),drying (vac.), recrystn. (hot methanol), elem. anal.;48.5%
(1R,2S,5R)-menthyl chloroformate
14602-86-9

(1R,2S,5R)-menthyl chloroformate

thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

A

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-{(2S)-[2-(methylthio)-10H-phenothiazin-10-yl]ethyl}piperidine-1-carboxylate

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-{(2S)-[2-(methylthio)-10H-phenothiazin-10-yl]ethyl}piperidine-1-carboxylate

B

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-{(2R)-[2-(methylthio)-10H-phenothiazin-10-yl]ethyl}piperidine-1-carboxylate

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-{(2R)-[2-(methylthio)-10H-phenothiazin-10-yl]ethyl}piperidine-1-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;A 43%
B 38%
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

zinc(II) chloride
7646-85-7

zinc(II) chloride

Zn(C6H4SN((CH2)2C5H9NHCH3)C6H3(SCH3))2Cl2(2+)*2Cl(1-)*CH3OH=[Zn(C6H4SN((CH2)2C5H9NHCH3)C6H3(SCH3))2Cl2]Cl2*CH3OH

Zn(C6H4SN((CH2)2C5H9NHCH3)C6H3(SCH3))2Cl2(2+)*2Cl(1-)*CH3OH=[Zn(C6H4SN((CH2)2C5H9NHCH3)C6H3(SCH3))2Cl2]Cl2*CH3OH

Conditions
ConditionsYield
In methanol slow addn. of soln. of ZnCl2 to soln. of ligand (room temp.), refluxing (60°C, 1.5-2 h), cooling (overnight to 4°C); decanting oily product, redissolving in methanol with stirring at 60°C, suction filtn., washing (2-3 times, cold methanol), drying (air),drying (vac.), recrystn. (hot methanol), elem. anal.;35.1%
hydrogenchloride
7647-01-0

hydrogenchloride

thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

palladium dichloride

palladium dichloride

((C6H4)(C6H3SCH3)N(CH2CH2C5H9NHCH3)S)Pd2Cl5*2H2O

((C6H4)(C6H3SCH3)N(CH2CH2C5H9NHCH3)S)Pd2Cl5*2H2O

Conditions
ConditionsYield
In methanol dissolving ligand in methanol, slow addn. with stirring to conctd. methanolic soln. of PdCl2 contg. HCl (room temp.), stirring (1 h), cooling (overnight to 4°C); suction filtn., washing (several times, cold water, cold methanol), air drying, drying in vac. over anhydrous CaSO4, recrystn. from hot methanol, elem. anal.;30%
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

C21H27N2S2

C21H27N2S2

Conditions
ConditionsYield
With potassium metaperiodate; phosphoric acid; sulfuric acid In water
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

Thioridazine 5-sulfoxide
7776-05-8

Thioridazine 5-sulfoxide

Conditions
ConditionsYield
With potassium dichromate In water at 25℃; for 1h;
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

thioridazine cation-radical

thioridazine cation-radical

Conditions
ConditionsYield
With iron(III) chloride In water at 25℃; Product distribution; Further Variations:; Temperatures; Reagents;
potassium tetrachloroplatinate(II)
10025-99-7

potassium tetrachloroplatinate(II)

thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

Pt(C6H4SN(CH2CH2C5H9NH(CH3))C6H3SCH3)Cl3
82489-48-3

Pt(C6H4SN(CH2CH2C5H9NH(CH3))C6H3SCH3)Cl3

Conditions
ConditionsYield
In water byproducts: KCl; aq. soln. of ligand mixed with Pt complex; filtered off, washed with H2O, dried in vac. at 100 °C; elem. anal.;
potassium tetrachloropalladate(II)
10025-98-6

potassium tetrachloropalladate(II)

thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

Pd(C6H4SN(CH2CH2C5H9NH(CH3))C6H3SCH3)Cl3
82489-46-1

Pd(C6H4SN(CH2CH2C5H9NH(CH3))C6H3SCH3)Cl3

Conditions
ConditionsYield
In water byproducts: KCl; aq. soln. of ligand mixed with Pd complex; filtered off, washed with H2O, dried in vac. at 100 °C; elem. anal.;
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / 1,2-dichloro-ethane / 0.33 h / 20 °C / Inert atmosphere
1.2: 12 h / Inert atmosphere; Reflux
2.1: water / methanol / 12 h / Reflux; Inert atmosphere
View Scheme
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

10-(2-(1-benzylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine

10-(2-(1-benzylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / 1,2-dichloro-ethane / 0.33 h / 20 °C / Inert atmosphere
1.2: 12 h / Inert atmosphere; Reflux
2.1: water / methanol / 12 h / Reflux; Inert atmosphere
3.1: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
3.2: 24 h / 20 °C / Inert atmosphere
View Scheme
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

2-(methylthio)-10-(2-(1-propylpiperidin-2-yl)ethyl)-10H-phenothiazine

2-(methylthio)-10-(2-(1-propylpiperidin-2-yl)ethyl)-10H-phenothiazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / 1,2-dichloro-ethane / 0.33 h / 20 °C / Inert atmosphere
1.2: 12 h / Inert atmosphere; Reflux
2.1: water / methanol / 12 h / Reflux; Inert atmosphere
3.1: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
3.2: 24 h / 20 °C / Inert atmosphere
View Scheme
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

10-(2-(1-isopropylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine

10-(2-(1-isopropylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / 1,2-dichloro-ethane / 0.33 h / 20 °C / Inert atmosphere
1.2: 12 h / Inert atmosphere; Reflux
2.1: water / methanol / 12 h / Reflux; Inert atmosphere
3.1: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
3.2: 24 h / 20 °C / Inert atmosphere
View Scheme
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

(+)-Thioridazine

(+)-Thioridazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux; Inert atmosphere
View Scheme
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

(-)-Thioridazine

(-)-Thioridazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux; Inert atmosphere
View Scheme
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

(R)-northioridazine

(R)-northioridazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux; Inert atmosphere
3.1: carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere
3.2: 4 h / Reflux; Inert atmosphere
View Scheme
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

(R)-nosyl-northioridazine

(R)-nosyl-northioridazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2: chlorotriisopropylsilane; trifluoroacetic acid / water / 72 h / 110 °C / Sealed tube
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux; Inert atmosphere
3.1: carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere
3.2: 4 h / Reflux; Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere
View Scheme
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

C50H51Cl2N9O6S3

C50H51Cl2N9O6S3

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2.1: chlorotriisopropylsilane; trifluoroacetic acid / water / 72 h / 110 °C / Sealed tube
3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
3.2: 16 h / 20 °C
4.1: water; tert-butyl alcohol / 20 °C
4.2: 33 °C
View Scheme
Multi-step reaction with 5 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux; Inert atmosphere
3.1: carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere
3.2: 4 h / Reflux; Inert atmosphere
4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
4.2: 16 h / 20 °C
5.1: water; tert-butyl alcohol / 20 °C
5.2: 33 °C
View Scheme
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

C49H49Cl2N9O6S3

C49H49Cl2N9O6S3

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2.1: chlorotriisopropylsilane; trifluoroacetic acid / water / 72 h / 110 °C / Sealed tube
3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
3.2: 16 h / 20 °C
4.1: water; tert-butyl alcohol / 20 °C
4.2: 58 h / 33 °C
View Scheme
Multi-step reaction with 5 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux; Inert atmosphere
3.1: carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere
3.2: 4 h / Reflux; Inert atmosphere
4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
4.2: 16 h / 20 °C
5.1: water; tert-butyl alcohol / 20 °C
5.2: 58 h / 33 °C
View Scheme
thioridazine Hydrochloride
130-61-0

thioridazine Hydrochloride

C49H49Cl2N9O6S3

C49H49Cl2N9O6S3

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2.1: chlorotriisopropylsilane; trifluoroacetic acid / water / 72 h / 110 °C / Sealed tube
3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
3.2: 16 h / 20 °C
4.1: water; tert-butyl alcohol / 20 °C
4.2: 58 h / 33 °C
View Scheme
Multi-step reaction with 5 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux; Inert atmosphere
3.1: carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere
3.2: 4 h / Reflux; Inert atmosphere
4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
4.2: 16 h / 20 °C
5.1: water; tert-butyl alcohol / 20 °C
5.2: 58 h / 33 °C
View Scheme
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