The N-heterocyclic carbene silver(I) complex 1,3-bis(4-methylbenzyl)imidazol-2-ylidene silver chloride was applied as the effective catalyst for the three-component carboxylative coupling of terminal alkynes, butyl iodide and carbon dioxide. The reaction proved to be highly efficient when using ...

The boronic acid functional group plays very important roles in sugar recognition, catalysis, organic synthesis, and supramolecular assembly. Therefore, understanding the unique properties of this functional group is very important. 8-Quinolineboronic acid (8-QBA) is found to be capable of self-...

The 8-quinolineboronic acid phosphorescent molecular switch (abbreviated as PMS-8-QBA. Thereinto, 8-QBA is 8-quinolineboronic acid, and PMS is phosphorescent molecular switch) was found for the first time. PMS-8-QBA, which was in the “off” state, could only emit weak room temperature phosphore...

8-Quinolineboronic acid phosphorescent molecular switch (8-QBA-PMS) in the “off” state emitted weak room temperature phosphorescence (RTP) of 8-QBA on the acetylcellulose membrane (ACM) with the perturbation of Pb2+. When 8-QBA-PMS was used to label concanavalin agglutinin (Con A) to form 8-QB...

Activated checkpoint kinase 2 (Chk2) is a tumor suppressor as one of the main enzymes that affect the cell cycle. 2-Biarylbenzimidazoles are potent selective class of Chk2 inhibitors; the structure-based design was applied to synthesize a new series of this class with replacing the lateral aryl ...

Benzimidazoles, such as albendazole, thiabendazole and omeprazole have antiplasmodial activity against Plasmodium falciparum and are widely used as scaffolds for metal-based drug research. Incorporating substituents with various lipophilic and electronic properties can influence trans-membrane i...

Designing of hybrid drugs with specific multitarget profile is a promising line of attack against inflammation. In light of this, a series of benzimidazole scaffold based hybrid molecules were designed by integrating benzimidazoles (containing pharmacophoric elements for COXs and LOXs inhibitors...

Gillisia limnaea strain DSM 15749 (=R-8282T, =LMG21470,=CIP108418) is a Gram-negative, strictly aerobic, psychrophilic, and non-photosynthetic bacterium that belongs to the family Flavobacteriaceae, which was isolated from a microbial mat in Lake Fryxell, Antarctica (Van Trappen et al., 2004). T...

The molecular structural parameters and vibrational frequencies of 5-chloro-N-(3-nitrophenyl)pyrazine-2-carboxamide have been obtained using density functional theory technique in the B3LYP approximation and CC-pVDZ (5D, 7F) basis set. Detailed vibrational assignments of observed FT-IR and FT-Ra...

The title compound was evaluated as catalyst for Suzuki coupling of aryl halides (X = I, Br) with phenylboronic acid at room temperature. The rates of the reactions increase with increasing Hammet sigma constant of m-substituents on the arylhalide. The presence of ortho groups on the arylhalides...

2-Substituted-3-sulfonamino-5-(quinazolin-6-yl or quinolin-6-yl)benzamides have been proposed as novel structures of PI3K inhibitors and anticancer agents based on bioisostere. In the present study, 2-substituted-3-sulfonamino-5-(4-morpholinoquinazolin-6-yl)benzamides and 2-methoxy-3-sulfonamino...

An efficient synthesis of new A-2, A-3, and A-4 analogues from amlodipine (A-1) has been achieved. All synthesized compounds were investigated by elemental analysis, FTIR, EIMS, and 1H NMR techniques. Crystal structures of A-2 and A-3 were determined by single crystal X-ray diffraction method. C...

An extensive study was performed to develop a series of (pyrrolo-pyridin-5-yl)benzamides as reversible MAO-B inhibitors. Compounds 14 (NTZ-2020, hMAO-B IC50 = 1.11 nM, Ki = 0.56 nM, >9000-fold selective versus MAO-A) and 15 (NTZ-2027, hMAO-B IC50 = 3.27 nM, Ki = 1.45 nM, SI > 3058) are identifie...

The depression of hematite in the reverse flotation system of oleate-starch-hematite was investigated at the atomic level by atomic force microscopy (AFM) combined with density functional theory (DFT). AFM imaging and cross-sectional imaging show that the adsorption configurations of oleate and ...

To investigate the recovery of rare earth elements (REE) as a by-product from iron-oxide silicate rich tailings generated from the extraction of other primary commodities, bench scale flotation tests, in rougher-scavenger-cleaner configuration were studied. Preliminary mineralogical characterisa...

Magnetic iron oxide (Fe3−xO4) nanoplates with a high aspect ratio (lateral size/thickness ratio of >50) were synthesized via a facile hydrothermal treatment of an iron-oleate precursor. The magnetic domain configuration of the Fe3−xO4 nanoplates was observed by magnetic force microscopy (MFM). S...

To separate siderite from carbonate-bearing iron ore efficiently, specific adsorption configurations and effective species were investigated to compare the adsorption differences of sodium oleate (NaOL) on siderite and hematite surfaces. The species were analysed in neutral conditions, under whi...

Most articles published on the flotation of iron oxide minerals with oleate involve the effects of pH on the interfacial properties of the iron oxides as a function of pH, together with some attention given to the solution chemistry of the collector. It was the purpose of this study to examine w...

Reaction of [Ru(PPh3)3Cl2] with 2-(methylthio)phenylsalicylaldimine Schiff-base (HL) in tetrahydrofuran (THF) in the presence of triethylamine afforded a ruthenium(II) complex [Ru(ONS-L)(PPh3)2Cl]·CH3OH·2.75H2O (1). Similarly, reaction of [Ru(CO)2Cl2] with HL in N,N′-dimethylformamide (DMF) i...

A new substituted phthalonitrile derivative, 4-(4-(methylthio)phenylthio) phthalonitrile was prepared by nucleophilic displacement reaction between 4-(methylthio)phenylthio and 4-nitrophthalonitrile. Tetra phthalocyanines [M: 2H(2), Zn(II)(3), Co(II)(4)] with four peripheral 4-(methylthio)phenyl...