Sumoylation modulates many proteins implicated in apoptosis such as Fas, TNFR1, Daxx, p53 and its regulator MDM2. Some of these proteins, such as DRP-1, are involved in the intrinsic apoptosis pathway. The intrinsic pathway is regulated at the mitochondrial level by the Bcl-2 family of proteins....

BH3 mimetics, such as BH3I-1, act as Bcl-2 antagonists, promote apoptosis and are used in basic research studies on apoptotic signaling and are currently tested as experimental anti-tumor agents. The present study addresses time- and dose-dependent responses of BH3I-1 on apoptosis, cellular stre...

We produced the vibronically excited but jet-cooled 2-fluoro-5-chlorobenzyl radical by corona discharge of precursor 2-fluoro-5-chlorotoluene with a large amount of carrier gas He using a pinhole-type glass nozzle in a technique of corona excited supersonic jet expansion. The vibronic emission s...

Malathion, one of commonly used organophosphate insecticides, has a wide range of toxic actions in different models. However, the effect of this compound on Ca2+ homeostasis and its related cytotoxicity in glial cells is elusive. This study examined whether malathion evoked intracellular Ca2+ co...

We have developed an efficient one-pot method for the microwave-assisted synthesis of ureas and carbamates via a proposed Lossen rearrangement. Herein we report the first examples of the direct conversion of benzoyl chlorides into N,N′-disubstituted ureas and N-aryl carbamates using hydroxylami...

Type 2 diabetes (T2D) is a severe disease and it is one of the most raising problems worldwide. This study deals with design, synthesis and in vivo determination of a new set of tetralin-sulfonamide derivatives as anti-diabetic and dipeptidyl peptidase-IV (DPP-4) inhibiting agents. Most of the n...

The title compound methyl(2E)-2-{[N-(2-formylphenyl) (4-methylbenzene)sulfonamido]methyl}-3-(4-chlorophenyl) prop-2-enoate (MFMSC) has been synthesized and single crystals were grown by slow evaporation solution growth technique at room temperature. Structural and vibrational spectroscopic studi...

In the present work, the novel Schiff bases (03–20) of 4-chloro-N-[2-(hydrazinocarbonyl) phenyl]benzenesulfonamide (02) were synthesized by reacting it with various aldehydes. 4-Chloro-N-[2-(hydrazinocarbonyl) phenyl]benzenesulfonamide (02) was synthesized by reacting methyl 2-{[(4-chlorophenyl...

BackgroundPreterm birth is the leading cause of neonatal morbidity and mortality in nonanomalous neonates in the United States. Women with a previous early spontaneous preterm birth are at highest risk for recurrence. Weekly intramuscular 17-alpha hydroxyprogesterone caproate reduces the risk of...

The fluorescence behaviour of 4,6,8(14)-trien-3-one steroids, which exhibit fluorescence in protic media but no fluorescence in hydrophobic environments, was used to characterize the molecular nature and temperature-sensitivity of steroid hormone—biomembrane interactions. Since 17α-hydroxyprog...

Representative 2,6-dideoxy sugars, l-cladinose (1), l-mycarose (2), l-oleandrose (3), l-olivose (4), and all of their C-3 epimers, 2,6-dideoxy-3-C-methyl-3-O-methyl-l-arabino-hexopyranose (26), 2,6-dideoxy-3-C-methyl-l-arabino-hexopyranose (l-olivomycose) (27), 2,6-dideoxy-3-O-methyl-l-ribo-hexo...

A general and cost-effective route has been developed to synthesize 1-heteroarylsubstituted cycloalkylamines from readily available heteroarylacetate in good yields. This synthesis features a LHMDS promoted cyclization and one-pot hydrolysis/Curtius rearrangement. This route can be easily carrie...

Bruton's tyrosine kinase (Btk) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) and Fcγ receptor (FcR) signaling pathways, which makes it a uniquely attractive target for the treatment of autoimmune diseases, such as rheumatoid arthritis (RA). We reported a seri...

Rosolic acid has been used as model compound to check the efficiency of different advanced oxidation processes in the abatement of dyestuffs having triphenylmethane structure. Ozone is very effective; even at low flows (17 × 10−3 min−1 for an ozone flow of 0.2 g h−1) important degradation rates...

The mechanism of the formation of p-rosolic acid from trifluoromethoxybenzene under HF/Lewis acid conditions was studied using ab initio methods. A series of cationic intermediates is initiated by the expulsion of a fluorine atom of trifluoromethoxybenzene with anomeric assistance of the trifluo...

Selective antagonism of the orexin 1 (OX1) receptor has been proposed as a potential mechanism for treatment of drug addiction. We have previously reported studies on the structure–activity relationships of tetrahydroisoquinoline-based antagonists. In this report, we elucidated the respective r...

A series of alkyl α-[5-(5-nitro-2-thienyl)-1,3,4-thiadiazole-2-ylthio]acetic acid esters 6a–e were synthesized and evaluated for in vitro antituberculosis activity against Mycobacterium tuberculosis strain H37Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. The antituberculosi...

Phenobarbital and some other enzyme-inducers are known to reduce organophosphate toxicity. One suggested mechanism is the induction of liver cytochrome P450 enzymes catalyzing monooxygenation reactions. The aim of the present study was to elucidate the cytochrome P450 subfamily, or P450 isoenzym...

Compounds 3 and 4 have been prepared by the reaction of 4-nitrocatechol 1 and 4-nitrophthalonitrile 2 by a common method, aromatic nucleophilic subtitution of the nitro group in 4-nitrophthalonitrile. Starting from 4 and 1-bromooctane, their alkylation reaction gave compound 5. Zn(II) 8, Co(II) ...

This study focuses on the green synthesis of the Ag/bone nanocomposite by using Myrica gale L. aqueous extract as a reducing and stabilizing agent and investigation of its catalytic activity in the hydration of cyanamides under environmentally benign reaction conditions in aqueous extract as a g...