Time Efficiency, Cost Effectiveness, Better Possibilities! 1. Better Quality & Competetive Price. 2. Quick & Professional Quotation. 3. Over Three Decades of Experience in This Field. 4. Quick & Safe &am
Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:81103-11-9
Min.Order:1 Kilogram
FOB Price: $20.0 / 500.0
Type:Trading Company
inquiryItems Standard Result Appearance White or almost white crystalline powder white crystalline powder Solubility
Cas:81103-11-9
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
Cas:81103-11-9
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryUnique advantages for Clarithromycin Cas 81103-11-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white crystalline powder Storage:-20°C Freezer Package:25
Cas:81103-11-9
Min.Order:1 Kilogram
FOB Price: $190.0 / 200.0
Type:Trading Company
inquiryXi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi
Cas:81103-11-9
Min.Order:1 Kilogram
FOB Price: $179.0 / 203.0
Type:Manufacturers
inquiryClarithromycin CAS No.:81103-11-9 Name: Clarithromycin Synonyms: 6-O-Methylerythromycin; A-56268; Biaxin; Klacid; TE-03 Molecular Structure Molecular Fo
Cas:81103-11-9
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:81103-11-9
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCustomer services: Custom synthesis(mg to kg scale) Reference compounds Building blocks and scaffolds Synthesis route optimization Appearance:whilt powder Storage:cool and dryer Package:durm Application:
Cas:81103-11-9
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:81103-11-9
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:81103-11-9
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:81103-11-9
Min.Order:1 Kilogram
FOB Price: $1.0 / 3.0
Type:Trading Company
inquiryName:Clarithromycin CAS:81103-11-9 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability
Cas:81103-11-9
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryWelcome to Henan Tianfu Chemical Co., Ltd. website. Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general
Cas:81103-11-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturing
Cas:81103-11-9
Min.Order:1 Kilogram
FOB Price: $15.0 / 50.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:81103-11-9
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:81103-11-9
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam
Cas:81103-11-9
Min.Order:1 Kilogram
FOB Price: $7.0 / 10.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:81103-11-9
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryPhysical Characteristics Appearance White or almost white crystalline powder. Solubility Practically insoluble in water, soluble in acetone and me
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:81103-11-9
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1. Our assay of Clarithromycin reahes 98% and even higher; 2. We control the impurities within the lowest limit; 3. The mesh size of our Clarithromycin can be more than 40 meshes or according to your requirements; 4. Our use Erythromycin t
Cas:81103-11-9
Min.Order:25 Kilogram
Negotiable
Type:Trading Company
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:81103-11-9
Min.Order:1 Kilogram
FOB Price: $260.0 / 300.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:81103-11-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:81103-11-9
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiryThank you for your interest for our products! To get more information, please feel free to contact with us! Thanks! We are ready to serve for you with super zealousness and full effor! Appearance:White crystalline powder Storage:Protected f
Cas:81103-11-9
Min.Order:1 Milligram
Negotiable
Type:Other
inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
Cas:81103-11-9
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiry1.Strong backup of factory:hign ability,favorable quality and competitive price. 2.Most of our products in catalogue are have stock. 3.Free sample could be provided. 4.Suitable package to protect the product the product quality. 5.the lead time
Cas:81103-11-9
Min.Order:1 Kilogram
FOB Price: $162.0 / 175.0
Type:Trading Company
inquiry6-O-methylerythromycin A N-oxide
clarithromycin
Conditions | Yield |
---|---|
Stage #1: 6-O-methylerythromycin A N-oxide With tin(ll) chloride In isopropyl alcohol at 30 - 40℃; for 2h; Stage #2: With sodium hydrogencarbonate In water; isopropyl alcohol | 96% |
With bis(tri-n-butyltin) In tetrahydrofuran for 24h; Heating / reflux; | 95% |
With hydrogen; W4 Raney-nickel In ethanol at 40 - 50℃; for 3h; | 92% |
With potassium hydroxide; nickel-aluminum alloy In methanol; water at 35 - 40℃; for 3.5h; | 92% |
Stage #1: 6-O-methylerythromycin A N-oxide With tin(ll) chloride In dichloromethane at 20℃; for 1.5h; Stage #2: With sodium carbonate In dichloromethane; water | 32% |
clarythromycin 9-O-(2-pyrimidyl)oxime
clarithromycin
Conditions | Yield |
---|---|
With sodium hydrogensulfite In ethanol; water at 80℃; for 6h; | 95% |
Conditions | Yield |
---|---|
Stage #1: 6-O-methylerythromycin A N-oxide With sodium hydrogensulfite In ethanol; water at 20℃; for 1h; Stage #2: With sodium carbonate In ethanol; water Stage #3: formaldehyd With formic acid; sodium carbonate more than 3 stages; | 92% |
Stage #1: 6-O-methylerythromycin A N-oxide With sodium hydrogensulfite In ethanol; water at 20℃; for 1h; Stage #2: With sodium carbonate In ethanol; water Stage #3: formaldehyd With formic acid; ammonia more than 3 stages; | 30% |
clarithromycin 9-oxime
clarithromycin
Conditions | Yield |
---|---|
With sodium disulfide In ethanol Heating; | 68% |
9-deoxo-9-imino-6-O-methylerythromycin A
clarithromycin
Conditions | Yield |
---|---|
With water In methanol at 23℃; pH 12.4 or pH 7; | |
With hydrogenchloride; water In ethanol pH=5 - 6; |
clarithromycin
Conditions | Yield |
---|---|
With sodium metabisulfite; formic acid In ethanol for 0.5h; Hydrolysis; Heating; | 4.32 g |
6-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydro-pyran-2-yloxy)-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione 10-(O-pyrimidin-2-yl-oxime)
clarithromycin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 90 percent / trimethylsilyl-imidazole / CH2Cl2 / 2 h / 0 °C 2: 83 percent / KOH / dimethylsulfoxide 3: 97 percent / HCO2H / ethanol; H2O 4: 95 percent / sodium hydrogen sulfite / ethanol; H2O / 6 h / 80 °C View Scheme |
C48H88N4O13Si2
clarithromycin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 97 percent / HCO2H / ethanol; H2O 2: 95 percent / sodium hydrogen sulfite / ethanol; H2O / 6 h / 80 °C View Scheme |
2',4''-O-bistrimethylsilyl erythromycin A 9-O-(2-pyrimydyl)oxime
clarithromycin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 83 percent / KOH / dimethylsulfoxide 2: 97 percent / HCO2H / ethanol; H2O 3: 95 percent / sodium hydrogen sulfite / ethanol; H2O / 6 h / 80 °C View Scheme |
clarithromycin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 93 percent / t-BuOK / 2 h / 80 °C 2: 90 percent / trimethylsilyl-imidazole / CH2Cl2 / 2 h / 0 °C 3: 83 percent / KOH / dimethylsulfoxide 4: 97 percent / HCO2H / ethanol; H2O 5: 95 percent / sodium hydrogen sulfite / ethanol; H2O / 6 h / 80 °C View Scheme |
6-methoxyerythromycin A 9-oxime
clarithromycin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 25 percent / Bu3P / tetrahydrofuran; dioxane 2: H2O; HCl / ethanol / pH 5 - 6 View Scheme | |
Multi-step reaction with 2 steps 1.1: PySeSePy; Me3P / tetrahydrofuran / 0.17 h / 0 °C 1.2: 80 percent / H2O / pH 10 2.1: H2O; HCl / ethanol / pH 5 - 6 View Scheme |
erythromycin A 9-(E)-oxime
clarithromycin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 90 percent / Et3N / dimethylformamide / 1 h / 20 °C 2: 95.1 percent / 1-trimethylsilylimidazole / ethyl acetate / 1 h / 20 °C 3: 8.82 g / NaH / tetrahydrofuran; dimethylsulfoxide / 1 h / 0 - 5 °C 4: 4.32 g / formic acid; Na2S2O5 / ethanol / 0.5 h / Heating View Scheme |
clarithromycin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 95.1 percent / 1-trimethylsilylimidazole / ethyl acetate / 1 h / 20 °C 2: 8.82 g / NaH / tetrahydrofuran; dimethylsulfoxide / 1 h / 0 - 5 °C 3: 4.32 g / formic acid; Na2S2O5 / ethanol / 0.5 h / Heating View Scheme |
clarithromycin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 8.82 g / NaH / tetrahydrofuran; dimethylsulfoxide / 1 h / 0 - 5 °C 2: 4.32 g / formic acid; Na2S2O5 / ethanol / 0.5 h / Heating View Scheme |
6-O-methyl-N-demethylerythromycin A 9-oxime
clarithromycin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: HCOOH / ethanol / Heating 2: 68 percent / Na2S2 / aq. ethanol / Heating View Scheme |
C60H86N2O17
clarithromycin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: H2 / catalytic hydrogenation 2: HCOOH / ethanol / Heating 3: 68 percent / Na2S2 / aq. ethanol / Heating View Scheme |
C59H84N2O17
clarithromycin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 76 percent / KOH / dimethylsulfoxide; tetrahydrofuran 2: H2 / catalytic hydrogenation 3: HCOOH / ethanol / Heating 4: 68 percent / Na2S2 / aq. ethanol / Heating View Scheme |
C52H78N2O17
clarithromycin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: CHCl3 / isomerization 2: 82 percent / NaH / dimethylformamide 3: 76 percent / KOH / dimethylsulfoxide; tetrahydrofuran 4: H2 / catalytic hydrogenation 5: HCOOH / ethanol / Heating 6: 68 percent / Na2S2 / aq. ethanol / Heating View Scheme |
C52H78N2O17
clarithromycin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 82 percent / NaH / dimethylformamide 2: 76 percent / KOH / dimethylsulfoxide; tetrahydrofuran 3: H2 / catalytic hydrogenation 4: HCOOH / ethanol / Heating 5: 68 percent / Na2S2 / aq. ethanol / Heating View Scheme |
2'-O,3'-N-bis(benzyloxycarbonyl)-N-demethylerythromycin A
clarithromycin
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: NH2OH*HCl, AcONa / methanol 2: CHCl3 / isomerization 3: 82 percent / NaH / dimethylformamide 4: 76 percent / KOH / dimethylsulfoxide; tetrahydrofuran 5: H2 / catalytic hydrogenation 6: HCOOH / ethanol / Heating 7: 68 percent / Na2S2 / aq. ethanol / Heating View Scheme | |
Multi-step reaction with 6 steps 1: 75 percent / NH2OH*HCl, AcONa / methanol 2: 82 percent / NaH / dimethylformamide 3: 76 percent / KOH / dimethylsulfoxide; tetrahydrofuran 4: H2 / catalytic hydrogenation 5: HCOOH / ethanol / Heating 6: 68 percent / Na2S2 / aq. ethanol / Heating View Scheme |
3-O-descladinosyl-9-oxime clarithromycin
clarithromycin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 0.78 g / ammonium acetate, 15percent aq. titanium(III) chloride / methanol / 6 h 2: H2O / methanol / 23 °C / pH 12.4 or pH 7 View Scheme |
Conditions | Yield |
---|---|
Stage #1: (9-E)-deoxo-9-hydroximinoerythromycin A; methyl iodide With 2-Methoxypropene; Pyridine hydrobromide; potassium hexamethylsilazane In dichloromethane Stage #2: With formic acid; sodium hydrogensulfite In ethanol; dichloromethane at 82 - 84℃; |
2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime
clarithromycin
Conditions | Yield |
---|---|
Stage #1: 2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime With formic acid In ethanol; water at 40 - 45℃; for 3h; pH=2.5 - 3.5; Stage #2: With sodium hydrogensulfite In ethanol; water for 1h; Product distribution / selectivity; Heating / reflux; |
clarithromycin acetate
clarithromycin
Conditions | Yield |
---|---|
at 120℃; for 4h; under vacuum; |
clarithromycin
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water at 40℃; for 1h; pH=9 - 11; Product distribution / selectivity; |
clarithromycin
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water at 40℃; for 1h; pH=9 - 11; Product distribution / selectivity; |
clarithromycin
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water at 40℃; for 1h; pH=9 - 11; Product distribution / selectivity; |
2',4"-O-bis (trimethylsilyl)-6-O-methylerythromycin A 9-[O-(1-methoxy-1-methylethyl)oxime]
clarithromycin
Conditions | Yield |
---|---|
Stage #1: 2',4"-O-bis (trimethylsilyl)-6-O-methylerythromycin A 9-[O-(1-methoxy-1-methylethyl)oxime] With formic acid; sodium hydrogensulfite In denatured spirit for 2h; Heating / reflux; Stage #2: With sodium hydroxide In denatured spirit; water at 20℃; pH=10.5; Product distribution / selectivity; |
6-O-methyl-2',4-bis(trimethylsilyl)-erythromycin A 9-O-(2-methoxyprop-2-yl)oxime
clarithromycin
Conditions | Yield |
---|---|
Stage #1: 6-O-methyl-2',4-bis(trimethylsilyl)-erythromycin A 9-O-(2-methoxyprop-2-yl)oxime With sodium metabisulfite; formic acid; water In ethanol at 25 - 63℃; for 10h; pH=3.8 - 4.1; Stage #2: With sodium hydroxide In ethanol; water at 30 - 35℃; for 0.5h; pH=10.5 - 11.0; Product distribution / selectivity; |
clarithromycin
acetic anhydride
2',4''-di-O-acetyl-6-O-methylerythromycin A
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; | 100% |
With dmap; triethylamine In dichloromethane at 20℃; for 17h; | 99% |
With dmap In dichloromethane at 20℃; for 18h; Inert atmosphere; | 99% |
clarithromycin
acetic anhydride
2'-O-acetyl-6-O-methylerythromycin A
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 48h; | 99% |
With triethylamine at 20℃; | 95% |
With triethylamine In dichloromethane at 20℃; for 12h; | 95% |
clarithromycin
3'-N,N-didemethyl-6-O-methylerythromycin A
Conditions | Yield |
---|---|
With iodine; sodium acetate In methanol; water at 20℃; for 0.25h; UV-irradiation; | 99% |
Conditions | Yield |
---|---|
With 2-(dimethylamino)pyrimidine; triethylamine In N,N-dimethyl-formamide at 45℃; for 4h; | 98% |
With dmap; triethylamine In ethyl acetate at 70℃; for 16h; | 97% |
With dmap; triethylamine In dichloromethane | 55% |
clarithromycin
3-O-descladinosylclarithromycin
Conditions | Yield |
---|---|
With hydrogenchloride In water at 20℃; for 0.5h; | 96% |
Stage #1: clarithromycin With hydrogenchloride In methanol; water at 20℃; Stage #2: With sodium hydroxide In methanol; water pH=10 - 11; | 96% |
With hydrogenchloride In water at 20℃; for 3h; | 96% |
clarithromycin
Conditions | Yield |
---|---|
With hydrazinium monoacetate In methanol for 46h; Reflux; | 95.1% |
With hydrazinium monoacetate In methanol for 46h; Reflux; | 70% |
Conditions | Yield |
---|---|
In acetonitrile at 20℃; Inert atmosphere; | 94% |
(E/Z)-crotyl bromide
clarithromycin
Conditions | Yield |
---|---|
In acetonitrile at 20℃; Inert atmosphere; | 94% |
Conditions | Yield |
---|---|
In acetonitrile at 20℃; Inert atmosphere; | 93% |
clarithromycin
N-desmethylclarithromycin
Conditions | Yield |
---|---|
Stage #1: clarithromycin With iodine; sodium acetate In methanol; water at 55 - 60℃; for 3h; Stage #2: With ammonia In methanol; chloroform; water | 92% |
Stage #1: clarithromycin With iodine; sodium acetate In methanol; water at 55 - 60℃; for 3h; Stage #2: With ammonia In methanol; chloroform; water | 92% |
With iodine; sodium acetate In methanol; water at 55 - 60℃; for 3h; | 92% |
clarithromycin
6-O-methylerythromycin A N-oxide
Conditions | Yield |
---|---|
With dihydrogen peroxide In methanol; water at 20℃; for 15h; | 92% |
Conditions | Yield |
---|---|
With dmap In chloroform at 110℃; for 8h; Temperature; | 91% |
Conditions | Yield |
---|---|
In acetonitrile at 20℃; Inert atmosphere; | 91% |
clarithromycin
3-O-descladinosyl-9-oxime clarithromycin
Conditions | Yield |
---|---|
Stage #1: clarithromycin With hydroxylamine hydrochloride; sodium acetate In methanol at 75℃; for 12h; Stage #2: With hydrogenchloride In methanol; water at 75℃; for 5h; | 90% |
With hydroxylamine hydrochloride; triethylamine In methanol for 24h; Heating; | 2.2 g |
Stage #1: clarithromycin With hydroxylamine hydrochloride; sodium carbonate In methanol at 20 - 65℃; for 12 - 24h; Stage #2: With sodium hydroxide In methanol; dichloromethane; water pH=9 - 12; |
clarithromycin
6-methoxyerythromycin A 9-oxime
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride; sodium acetate at 80℃; | 90% |
With hydroxylamine; acetic acid In water; isopropyl alcohol at 40℃; for 120h; Inert atmosphere; | 64% |
Conditions | Yield |
---|---|
In acetonitrile at 20℃; Inert atmosphere; | 89% |
Conditions | Yield |
---|---|
In acetonitrile at 20℃; Inert atmosphere; | 88% |
In N,N-dimethyl-formamide at 20℃; for 1.25h; |
phosgene
clarithromycin
allyl alcohol
4''-O-(allyloxycarbonyl)-N-demethylclarithromycin 2',3'-carbamate-11,12-carbonate
Conditions | Yield |
---|---|
Stage #1: phosgene; clarithromycin With pyridine In dichloromethane; toluene at 20℃; for 5h; Stage #2: allyl alcohol In dichloromethane; toluene at 20℃; for 0.5h; Further stages.; | 87% |
chloro-trimethyl-silane
clarithromycin
6-O-Methyl-2',4''-O-bis(trimethylsilyl)erythromycin A
Conditions | Yield |
---|---|
With 1-(Trimethylsilyl)imidazole In dichloromethane for 0.5h; Ambient temperature; | 80% |
triethylsilyl chloride
clarithromycin
2',4''-di-TES-6-O-methyl-erythromycin A
Conditions | Yield |
---|---|
With dmap; triethylamine In acetonitrile at 0 - 30℃; Inert atmosphere; | 80% |
clarithromycin
3-hydroxy-6-O-methyl-10,11-anhydroerythromycin A
Conditions | Yield |
---|---|
Stage #1: clarithromycin With [1,3]-dioxolan-2-one; triethylamine for 44h; Heating / reflux; Stage #2: With hydrogenchloride In ethanol; water at 20℃; for 24h; Stage #3: With potassium hydroxide In ethanol; water pH=10 - 11; | 74% |
Multi-step reaction with 5 steps 1: hydrogenchloride / water / 2 h / 20 °C 2: dichloromethane / 1 h / 20 °C 3: pyridine / dichloromethane / 9 h / -5 °C 4: potassium tert-butylate; allyl bromide / tetrahydrofuran; dimethyl sulfoxide / 0.5 h / 0 °C 5: methanol / Reflux View Scheme |
clarithromycin
Conditions | Yield |
---|---|
With water-d2; lithium carbonate; triisopropylsilanethiol In 1-methyl-pyrrolidin-2-one at 20℃; Irradiation; | 70% |
clarithromycin
Conditions | Yield |
---|---|
In methanol at 30 - 35℃; for 48h; | 60% |
clarithromycin
Benzyl isothiocyanate
Conditions | Yield |
---|---|
With iodine; sodium hydrogencarbonate; 2-amino-2-hydroxymethyl-1,3-propanediol In acetonitrile for 2h; Irradiation; | 56% |
clarithromycin
Conditions | Yield |
---|---|
With sodium tetrahydroborate In tetrahydrofuran; methanol at 0 - 20℃; for 25h; Inert atmosphere; | 52% |
clarithromycin
methanesulfonyl chloride
2',4''-di-O-methanesulfonyl-6-O-methylerythromycin A
Conditions | Yield |
---|---|
With triethylamine In acetone 1.) 0 to 3 deg C, 30 min, 2.) RT, 2 h; | 41.7% |
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