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Sunmore Healthcare Co., LTD.

Time Efficiency, Cost Effectiveness, Better Possibilities! 1. Better Quality & Competetive Price. 2. Quick & Professional Quotation. 3. Over Three Decades of Experience in This Field. 4. Quick & Safe &am

Clarithromycin

Cas:81103-11-9

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

High purity 99% factory price clarithromycin taste masked

Cas:81103-11-9

Min.Order:1 Kilogram

FOB Price: $20.0 / 500.0

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White or almost white crystalline powder white crystalline powder Solubility

High purity Various Specifications Clarithromycin CAS:81103-11-9

Cas:81103-11-9

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Clarithromycin manufacturer/supplier

Cas:81103-11-9

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Clarithromycin Cas 81103-11-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white crystalline powder Storage:-20°C Freezer Package:25

Factory supply Clarithromycin Cas 81103-11-9 with high quality and best price

Cas:81103-11-9

Min.Order:1 Kilogram

FOB Price: $190.0 / 200.0

Type:Trading Company

inquiry

Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

Veterinary raw materials Clarithromycin powder price CAS 81103-11-9

Cas:81103-11-9

Min.Order:1 Kilogram

FOB Price: $179.0 / 203.0

Type:Manufacturers

inquiry

Hangzhou Think Chemical Co. Ltd

Clarithromycin CAS No.:81103-11-9 Name: Clarithromycin Synonyms: 6-O-Methylerythromycin; A-56268; Biaxin; Klacid; TE-03 Molecular Structure Molecular Fo

High purity Clarithromycin CAS No.:81103-11-9

Cas:81103-11-9

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Clarithromycin

Cas:81103-11-9

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Clarithromycin 81103-11-9 GMP Manufacturer

Cas:81103-11-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

Customer services: Custom synthesis(mg to kg scale) Reference compounds Building blocks and scaffolds Synthesis route optimization Appearance:whilt powder Storage:cool and dryer Package:durm Application:

clarithromycin CAS NO.81103-11-9

Cas:81103-11-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Clarithromycin

Cas:81103-11-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Clarithromycin

Cas:81103-11-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Clarithromycin Manufacturer/High quality/Best price/In stock

Cas:81103-11-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Clarithromycin 81103-11-9

Cas:81103-11-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Trading Company

inquiry

Hubei DiBo chemical co., LTD

Name:Clarithromycin CAS:81103-11-9 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability

High purity Various Specifications Clarithromycin CAS:81103-11-9

Cas:81103-11-9

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Welcome to Henan Tianfu Chemical Co., Ltd. website. Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general

81103-11-9,Clarithromycin

Cas:81103-11-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturing

Clarithromycin CAS:81103-11-9

Cas:81103-11-9

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 81103-11-9 with best quality

Cas:81103-11-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 81103-11-9 ,Clarithromycin

Cas:81103-11-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

Clarithromycin cas81103-11-9

Cas:81103-11-9

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Clarithromycin/ LIDE PHARMA- Factory supply / Best price

Cas:81103-11-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Physical Characteristics Appearance White or almost white crystalline powder. Solubility Practically insoluble in water, soluble in acetone and me

Clarithromycin

Cas:81103-11-9

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality81103-11-9 Clarithromycin with best price

Cas:81103-11-9

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Hefei TNJ chemical industry co.,ltd

1. Our assay of Clarithromycin reahes 98% and even higher; 2. We control the impurities within the lowest limit; 3. The mesh size of our Clarithromycin can be more than 40 meshes or according to your requirements; 4. Our use Erythromycin t

Good Prie for Clarithromycin API USP38

Cas:81103-11-9

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Clarithromycin granules,clarithromycin, CLA Cas:81103-11-9

Cas:81103-11-9

Min.Order:1 Kilogram

FOB Price: $260.0 / 300.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Clarithromycin 81103-11-9

Cas:81103-11-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Hangzhou Maytime Bio-Tech Co.,Ltd.

Thank you for your interest for our products! To get more information, please feel free to contact with us! Thanks! We are ready to serve for you with super zealousness and full effor! Appearance:White crystalline powder Storage:Protected f

Clarithromycin USP28/36 GMP CAS: 81103-11-9

Cas:81103-11-9

Min.Order:1 Milligram

Negotiable

Type:Other

inquiry

Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High Quality Clarithromycin CAS 81103-11-9 For research Use only

Cas:81103-11-9

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

1.Strong backup of factory:hign ability,favorable quality and competitive price. 2.Most of our products in catalogue are have stock. 3.Free sample could be provided. 4.Suitable package to protect the product the product quality. 5.the lead time

High quality,Clarithromycin

Cas:81103-11-9

Min.Order:1 Kilogram

FOB Price: $162.0 / 175.0

Type:Trading Company

inquiry

Synthetic route

6-O-methylerythromycin A N-oxide
118074-07-0

6-O-methylerythromycin A N-oxide

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
Stage #1: 6-O-methylerythromycin A N-oxide With tin(ll) chloride In isopropyl alcohol at 30 - 40℃; for 2h;
Stage #2: With sodium hydrogencarbonate In water; isopropyl alcohol
96%
With bis(tri-n-butyltin) In tetrahydrofuran for 24h; Heating / reflux;95%
With hydrogen; W4 Raney-nickel In ethanol at 40 - 50℃; for 3h;92%
With potassium hydroxide; nickel-aluminum alloy In methanol; water at 35 - 40℃; for 3.5h;92%
Stage #1: 6-O-methylerythromycin A N-oxide With tin(ll) chloride In dichloromethane at 20℃; for 1.5h;
Stage #2: With sodium carbonate In dichloromethane; water
32%
clarythromycin 9-O-(2-pyrimidyl)oxime
930287-49-3

clarythromycin 9-O-(2-pyrimidyl)oxime

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
With sodium hydrogensulfite In ethanol; water at 80℃; for 6h;95%
formaldehyd
50-00-0

formaldehyd

6-O-methylerythromycin A N-oxide
118074-07-0

6-O-methylerythromycin A N-oxide

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
Stage #1: 6-O-methylerythromycin A N-oxide With sodium hydrogensulfite In ethanol; water at 20℃; for 1h;
Stage #2: With sodium carbonate In ethanol; water
Stage #3: formaldehyd With formic acid; sodium carbonate more than 3 stages;
92%
Stage #1: 6-O-methylerythromycin A N-oxide With sodium hydrogensulfite In ethanol; water at 20℃; for 1h;
Stage #2: With sodium carbonate In ethanol; water
Stage #3: formaldehyd With formic acid; ammonia more than 3 stages;
30%
clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
With sodium disulfide In ethanol Heating;68%
9-deoxo-9-imino-6-O-methylerythromycin A
130034-54-7

9-deoxo-9-imino-6-O-methylerythromycin A

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
With water In methanol at 23℃; pH 12.4 or pH 7;
With hydrogenchloride; water In ethanol pH=5 - 6;
2',4''-[O-bis(trimethylsilyl)]clarithromycin 9-[O-(dimethylthexylsilyl)oxime]

2',4''-[O-bis(trimethylsilyl)]clarithromycin 9-[O-(dimethylthexylsilyl)oxime]

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
With sodium metabisulfite; formic acid In ethanol for 0.5h; Hydrolysis; Heating;4.32 g
6-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydro-pyran-2-yloxy)-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione 10-(O-pyrimidin-2-yl-oxime)
930287-46-0

6-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydro-pyran-2-yloxy)-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione 10-(O-pyrimidin-2-yl-oxime)

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 90 percent / trimethylsilyl-imidazole / CH2Cl2 / 2 h / 0 °C
2: 83 percent / KOH / dimethylsulfoxide
3: 97 percent / HCO2H / ethanol; H2O
4: 95 percent / sodium hydrogen sulfite / ethanol; H2O / 6 h / 80 °C
View Scheme
C48H88N4O13Si2
930287-48-2

C48H88N4O13Si2

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 97 percent / HCO2H / ethanol; H2O
2: 95 percent / sodium hydrogen sulfite / ethanol; H2O / 6 h / 80 °C
View Scheme
2',4''-O-bistrimethylsilyl erythromycin A 9-O-(2-pyrimydyl)oxime
930287-47-1

2',4''-O-bistrimethylsilyl erythromycin A 9-O-(2-pyrimydyl)oxime

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 83 percent / KOH / dimethylsulfoxide
2: 97 percent / HCO2H / ethanol; H2O
3: 95 percent / sodium hydrogen sulfite / ethanol; H2O / 6 h / 80 °C
View Scheme
erythromycin A (9E)-oxime hydrochloride

erythromycin A (9E)-oxime hydrochloride

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 93 percent / t-BuOK / 2 h / 80 °C
2: 90 percent / trimethylsilyl-imidazole / CH2Cl2 / 2 h / 0 °C
3: 83 percent / KOH / dimethylsulfoxide
4: 97 percent / HCO2H / ethanol; H2O
5: 95 percent / sodium hydrogen sulfite / ethanol; H2O / 6 h / 80 °C
View Scheme
6-methoxyerythromycin A 9-oxime
127253-06-9

6-methoxyerythromycin A 9-oxime

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 25 percent / Bu3P / tetrahydrofuran; dioxane
2: H2O; HCl / ethanol / pH 5 - 6
View Scheme
Multi-step reaction with 2 steps
1.1: PySeSePy; Me3P / tetrahydrofuran / 0.17 h / 0 °C
1.2: 80 percent / H2O / pH 10
2.1: H2O; HCl / ethanol / pH 5 - 6
View Scheme
erythromycin A 9-(E)-oxime
111321-02-9

erythromycin A 9-(E)-oxime

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 90 percent / Et3N / dimethylformamide / 1 h / 20 °C
2: 95.1 percent / 1-trimethylsilylimidazole / ethyl acetate / 1 h / 20 °C
3: 8.82 g / NaH / tetrahydrofuran; dimethylsulfoxide / 1 h / 0 - 5 °C
4: 4.32 g / formic acid; Na2S2O5 / ethanol / 0.5 h / Heating
View Scheme
erythromycin A 9-[O-(dimethylthexylsilyl)oxime]

erythromycin A 9-[O-(dimethylthexylsilyl)oxime]

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 95.1 percent / 1-trimethylsilylimidazole / ethyl acetate / 1 h / 20 °C
2: 8.82 g / NaH / tetrahydrofuran; dimethylsulfoxide / 1 h / 0 - 5 °C
3: 4.32 g / formic acid; Na2S2O5 / ethanol / 0.5 h / Heating
View Scheme
2',4''-[O-bis(trimethylsilyl)]erythromycin A 9-[O-(dimethylthexylsilyl)oxime]

2',4''-[O-bis(trimethylsilyl)]erythromycin A 9-[O-(dimethylthexylsilyl)oxime]

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 8.82 g / NaH / tetrahydrofuran; dimethylsulfoxide / 1 h / 0 - 5 °C
2: 4.32 g / formic acid; Na2S2O5 / ethanol / 0.5 h / Heating
View Scheme
6-O-methyl-N-demethylerythromycin A 9-oxime
101666-67-5, 127182-43-8

6-O-methyl-N-demethylerythromycin A 9-oxime

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HCOOH / ethanol / Heating
2: 68 percent / Na2S2 / aq. ethanol / Heating
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2 / catalytic hydrogenation
2: HCOOH / ethanol / Heating
3: 68 percent / Na2S2 / aq. ethanol / Heating
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 76 percent / KOH / dimethylsulfoxide; tetrahydrofuran
2: H2 / catalytic hydrogenation
3: HCOOH / ethanol / Heating
4: 68 percent / Na2S2 / aq. ethanol / Heating
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: CHCl3 / isomerization
2: 82 percent / NaH / dimethylformamide
3: 76 percent / KOH / dimethylsulfoxide; tetrahydrofuran
4: H2 / catalytic hydrogenation
5: HCOOH / ethanol / Heating
6: 68 percent / Na2S2 / aq. ethanol / Heating
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 82 percent / NaH / dimethylformamide
2: 76 percent / KOH / dimethylsulfoxide; tetrahydrofuran
3: H2 / catalytic hydrogenation
4: HCOOH / ethanol / Heating
5: 68 percent / Na2S2 / aq. ethanol / Heating
View Scheme
2'-O,3'-N-bis(benzyloxycarbonyl)-N-demethylerythromycin A
81103-09-5

2'-O,3'-N-bis(benzyloxycarbonyl)-N-demethylerythromycin A

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: NH2OH*HCl, AcONa / methanol
2: CHCl3 / isomerization
3: 82 percent / NaH / dimethylformamide
4: 76 percent / KOH / dimethylsulfoxide; tetrahydrofuran
5: H2 / catalytic hydrogenation
6: HCOOH / ethanol / Heating
7: 68 percent / Na2S2 / aq. ethanol / Heating
View Scheme
Multi-step reaction with 6 steps
1: 75 percent / NH2OH*HCl, AcONa / methanol
2: 82 percent / NaH / dimethylformamide
3: 76 percent / KOH / dimethylsulfoxide; tetrahydrofuran
4: H2 / catalytic hydrogenation
5: HCOOH / ethanol / Heating
6: 68 percent / Na2S2 / aq. ethanol / Heating
View Scheme
3-O-descladinosyl-9-oxime clarithromycin
103450-87-9

3-O-descladinosyl-9-oxime clarithromycin

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 0.78 g / ammonium acetate, 15percent aq. titanium(III) chloride / methanol / 6 h
2: H2O / methanol / 23 °C / pH 12.4 or pH 7
View Scheme
(9-E)-deoxo-9-hydroximinoerythromycin A
13127-18-9

(9-E)-deoxo-9-hydroximinoerythromycin A

methyl iodide
74-88-4

methyl iodide

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
Stage #1: (9-E)-deoxo-9-hydroximinoerythromycin A; methyl iodide With 2-Methoxypropene; Pyridine hydrobromide; potassium hexamethylsilazane In dichloromethane
Stage #2: With formic acid; sodium hydrogensulfite In ethanol; dichloromethane at 82 - 84℃;
2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime
791845-56-2

2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
Stage #1: 2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime With formic acid In ethanol; water at 40 - 45℃; for 3h; pH=2.5 - 3.5;
Stage #2: With sodium hydrogensulfite In ethanol; water for 1h; Product distribution / selectivity; Heating / reflux;
clarithromycin acetate
643726-97-0

clarithromycin acetate

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
at 120℃; for 4h; under vacuum;
clarithromycin trifluoroacetate

clarithromycin trifluoroacetate

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 40℃; for 1h; pH=9 - 11; Product distribution / selectivity;
clarithromycin para-toluene sulphonate

clarithromycin para-toluene sulphonate

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 40℃; for 1h; pH=9 - 11; Product distribution / selectivity;
clarithromycin oxalate

clarithromycin oxalate

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 40℃; for 1h; pH=9 - 11; Product distribution / selectivity;
2',4"-O-bis (trimethylsilyl)-6-O-methylerythromycin A 9-[O-(1-methoxy-1-methylethyl)oxime]
119699-81-9

2',4"-O-bis (trimethylsilyl)-6-O-methylerythromycin A 9-[O-(1-methoxy-1-methylethyl)oxime]

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
Stage #1: 2',4"-O-bis (trimethylsilyl)-6-O-methylerythromycin A 9-[O-(1-methoxy-1-methylethyl)oxime] With formic acid; sodium hydrogensulfite In denatured spirit for 2h; Heating / reflux;
Stage #2: With sodium hydroxide In denatured spirit; water at 20℃; pH=10.5; Product distribution / selectivity;
6-O-methyl-2',4-bis(trimethylsilyl)-erythromycin A 9-O-(2-methoxyprop-2-yl)oxime
119685-39-1

6-O-methyl-2',4-bis(trimethylsilyl)-erythromycin A 9-O-(2-methoxyprop-2-yl)oxime

clarithromycin
81103-11-9

clarithromycin

Conditions
ConditionsYield
Stage #1: 6-O-methyl-2',4-bis(trimethylsilyl)-erythromycin A 9-O-(2-methoxyprop-2-yl)oxime With sodium metabisulfite; formic acid; water In ethanol at 25 - 63℃; for 10h; pH=3.8 - 4.1;
Stage #2: With sodium hydroxide In ethanol; water at 30 - 35℃; for 0.5h; pH=10.5 - 11.0; Product distribution / selectivity;
clarithromycin
81103-11-9

clarithromycin

acetic anhydride
108-24-7

acetic anhydride

2',4''-di-O-acetyl-6-O-methylerythromycin A
152235-55-7

2',4''-di-O-acetyl-6-O-methylerythromycin A

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃;100%
With dmap; triethylamine In dichloromethane at 20℃; for 17h;99%
With dmap In dichloromethane at 20℃; for 18h; Inert atmosphere;99%
clarithromycin
81103-11-9

clarithromycin

acetic anhydride
108-24-7

acetic anhydride

2'-O-acetyl-6-O-methylerythromycin A
103461-66-1

2'-O-acetyl-6-O-methylerythromycin A

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 48h;99%
With triethylamine at 20℃;95%
With triethylamine In dichloromethane at 20℃; for 12h;95%
clarithromycin
81103-11-9

clarithromycin

3'-N,N-didemethyl-6-O-methylerythromycin A
118058-75-6

3'-N,N-didemethyl-6-O-methylerythromycin A

Conditions
ConditionsYield
With iodine; sodium acetate In methanol; water at 20℃; for 0.25h; UV-irradiation;99%
clarithromycin
81103-11-9

clarithromycin

benzoic acid anhydride
93-97-0

benzoic acid anhydride

clarithromycin dibenzoate
484670-64-6

clarithromycin dibenzoate

Conditions
ConditionsYield
With 2-(dimethylamino)pyrimidine; triethylamine In N,N-dimethyl-formamide at 45℃; for 4h;98%
With dmap; triethylamine In ethyl acetate at 70℃; for 16h;97%
With dmap; triethylamine In dichloromethane55%
clarithromycin
81103-11-9

clarithromycin

3-O-descladinosylclarithromycin
118058-74-5

3-O-descladinosylclarithromycin

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 0.5h;96%
Stage #1: clarithromycin With hydrogenchloride In methanol; water at 20℃;
Stage #2: With sodium hydroxide In methanol; water pH=10 - 11;
96%
With hydrogenchloride In water at 20℃; for 3h;96%
clarithromycin
81103-11-9

clarithromycin

6-O-methyl-9-hydrazono erythromycin A

6-O-methyl-9-hydrazono erythromycin A

Conditions
ConditionsYield
With hydrazinium monoacetate In methanol for 46h; Reflux;95.1%
With hydrazinium monoacetate In methanol for 46h; Reflux;70%
clarithromycin
81103-11-9

clarithromycin

propargyl bromide
106-96-7

propargyl bromide

C41H72NO13(1+)*Br(1-)

C41H72NO13(1+)*Br(1-)

Conditions
ConditionsYield
In acetonitrile at 20℃; Inert atmosphere;94%
clarithromycin
81103-11-9

clarithromycin

C42H76NO13(1+)*Br(1-)

C42H76NO13(1+)*Br(1-)

Conditions
ConditionsYield
In acetonitrile at 20℃; Inert atmosphere;94%
clarithromycin
81103-11-9

clarithromycin

3-phenylprop-2-en-1-yl bromide
4392-24-9

3-phenylprop-2-en-1-yl bromide

C47H78NO13(1+)*Br(1-)

C47H78NO13(1+)*Br(1-)

Conditions
ConditionsYield
In acetonitrile at 20℃; Inert atmosphere;93%
clarithromycin
81103-11-9

clarithromycin

N-desmethylclarithromycin
101666-68-6

N-desmethylclarithromycin

Conditions
ConditionsYield
Stage #1: clarithromycin With iodine; sodium acetate In methanol; water at 55 - 60℃; for 3h;
Stage #2: With ammonia In methanol; chloroform; water
92%
Stage #1: clarithromycin With iodine; sodium acetate In methanol; water at 55 - 60℃; for 3h;
Stage #2: With ammonia In methanol; chloroform; water
92%
With iodine; sodium acetate In methanol; water at 55 - 60℃; for 3h;92%
clarithromycin
81103-11-9

clarithromycin

6-O-methylerythromycin A N-oxide
118074-07-0

6-O-methylerythromycin A N-oxide

Conditions
ConditionsYield
With dihydrogen peroxide In methanol; water at 20℃; for 15h;92%
adipic anhydride
2035-75-8

adipic anhydride

clarithromycin
81103-11-9

clarithromycin

C44H77NO16

C44H77NO16

Conditions
ConditionsYield
With dmap In chloroform at 110℃; for 8h; Temperature;91%
clarithromycin
81103-11-9

clarithromycin

prenyl bromide
870-63-3

prenyl bromide

C43H78NO13(1+)*Br(1-)

C43H78NO13(1+)*Br(1-)

Conditions
ConditionsYield
In acetonitrile at 20℃; Inert atmosphere;91%
clarithromycin
81103-11-9

clarithromycin

3-O-descladinosyl-9-oxime clarithromycin
103450-87-9

3-O-descladinosyl-9-oxime clarithromycin

Conditions
ConditionsYield
Stage #1: clarithromycin With hydroxylamine hydrochloride; sodium acetate In methanol at 75℃; for 12h;
Stage #2: With hydrogenchloride In methanol; water at 75℃; for 5h;
90%
With hydroxylamine hydrochloride; triethylamine In methanol for 24h; Heating;2.2 g
Stage #1: clarithromycin With hydroxylamine hydrochloride; sodium carbonate In methanol at 20 - 65℃; for 12 - 24h;
Stage #2: With sodium hydroxide In methanol; dichloromethane; water pH=9 - 12;
clarithromycin
81103-11-9

clarithromycin

6-methoxyerythromycin A 9-oxime
127253-06-9

6-methoxyerythromycin A 9-oxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium acetate at 80℃;90%
With hydroxylamine; acetic acid In water; isopropyl alcohol at 40℃; for 120h; Inert atmosphere;64%
3-Bromomethylthiophene
34846-44-1

3-Bromomethylthiophene

clarithromycin
81103-11-9

clarithromycin

C43H74NO13S(1+)*Br(1-)

C43H74NO13S(1+)*Br(1-)

Conditions
ConditionsYield
In acetonitrile at 20℃; Inert atmosphere;89%
clarithromycin
81103-11-9

clarithromycin

allyl bromide
106-95-6

allyl bromide

Br(1-)*C41H74NO13(1+)

Br(1-)*C41H74NO13(1+)

Conditions
ConditionsYield
In acetonitrile at 20℃; Inert atmosphere;88%
In N,N-dimethyl-formamide at 20℃; for 1.25h;
phosgene
75-44-5

phosgene

clarithromycin
81103-11-9

clarithromycin

allyl alcohol
107-18-6

allyl alcohol

4''-O-(allyloxycarbonyl)-N-demethylclarithromycin 2',3'-carbamate-11,12-carbonate
898833-50-6

4''-O-(allyloxycarbonyl)-N-demethylclarithromycin 2',3'-carbamate-11,12-carbonate

Conditions
ConditionsYield
Stage #1: phosgene; clarithromycin With pyridine In dichloromethane; toluene at 20℃; for 5h;
Stage #2: allyl alcohol In dichloromethane; toluene at 20℃; for 0.5h; Further stages.;
87%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

clarithromycin
81103-11-9

clarithromycin

6-O-Methyl-2',4''-O-bis(trimethylsilyl)erythromycin A
130073-49-3

6-O-Methyl-2',4''-O-bis(trimethylsilyl)erythromycin A

Conditions
ConditionsYield
With 1-(Trimethylsilyl)imidazole In dichloromethane for 0.5h; Ambient temperature;80%
triethylsilyl chloride
994-30-9

triethylsilyl chloride

clarithromycin
81103-11-9

clarithromycin

2',4''-di-TES-6-O-methyl-erythromycin A
1009561-37-8

2',4''-di-TES-6-O-methyl-erythromycin A

Conditions
ConditionsYield
With dmap; triethylamine In acetonitrile at 0 - 30℃; Inert atmosphere;80%
clarithromycin
81103-11-9

clarithromycin

3-hydroxy-6-O-methyl-10,11-anhydroerythromycin A
208456-82-0

3-hydroxy-6-O-methyl-10,11-anhydroerythromycin A

Conditions
ConditionsYield
Stage #1: clarithromycin With [1,3]-dioxolan-2-one; triethylamine for 44h; Heating / reflux;
Stage #2: With hydrogenchloride In ethanol; water at 20℃; for 24h;
Stage #3: With potassium hydroxide In ethanol; water pH=10 - 11;
74%
Multi-step reaction with 5 steps
1: hydrogenchloride / water / 2 h / 20 °C
2: dichloromethane / 1 h / 20 °C
3: pyridine / dichloromethane / 9 h / -5 °C
4: potassium tert-butylate; allyl bromide / tetrahydrofuran; dimethyl sulfoxide / 0.5 h / 0 °C
5: methanol / Reflux
View Scheme
clarithromycin
81103-11-9

clarithromycin

C38H62(2)H7NO13

C38H62(2)H7NO13

Conditions
ConditionsYield
With water-d2; lithium carbonate; triisopropylsilanethiol In 1-methyl-pyrrolidin-2-one at 20℃; Irradiation;70%
2-(aminooxy)acetic acid hemihydrochloride

2-(aminooxy)acetic acid hemihydrochloride

clarithromycin
81103-11-9

clarithromycin

9-(O-carboxymethyloxime)clarithromycin

9-(O-carboxymethyloxime)clarithromycin

Conditions
ConditionsYield
In methanol at 30 - 35℃; for 48h;60%
clarithromycin
81103-11-9

clarithromycin

Benzyl isothiocyanate
622-78-6

Benzyl isothiocyanate

2'-O,3'-N-(N-benzylcarbonimidoyl)-3'-N-demethyl-6-O-methylerythromycin A

2'-O,3'-N-(N-benzylcarbonimidoyl)-3'-N-demethyl-6-O-methylerythromycin A

Conditions
ConditionsYield
With iodine; sodium hydrogencarbonate; 2-amino-2-hydroxymethyl-1,3-propanediol In acetonitrile for 2h; Irradiation;56%
clarithromycin
81103-11-9

clarithromycin

9-dihydro-6-O-methylerythromycin A

9-dihydro-6-O-methylerythromycin A

Conditions
ConditionsYield
With sodium tetrahydroborate In tetrahydrofuran; methanol at 0 - 20℃; for 25h; Inert atmosphere;52%
clarithromycin
81103-11-9

clarithromycin

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

2',4''-di-O-methanesulfonyl-6-O-methylerythromycin A
129318-85-0

2',4''-di-O-methanesulfonyl-6-O-methylerythromycin A

Conditions
ConditionsYield
With triethylamine In acetone 1.) 0 to 3 deg C, 30 min, 2.) RT, 2 h;41.7%

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