1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan
Product name: OLMESARTAN MEDOXOMIL Chemical name: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1h-tetazol-5-yl)[1,1'-biphenyl]-4-yl]methyl] Cas No: 144689-63-4 Assay: 98%min Hangzhou Verychem Scienc
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:144689-63-4
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inquiryWe are very compeitive on Olmesartan medoxomil.Our mfr is GMP certified for this item with CEP document. The pharmacological effect of olmesartan medoxomil tablets is that the main ingredient is olmesartan medoxomil, which is a prodrug that is abso
Cas:144689-63-4
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inquiryAppearance:White powder Storage:store in cool and dry Package:according to customers' requirements Application:Pharmaceutical Transportation:by sea or by air Port:all chinese port
Cas:144689-63-4
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inquiryUnique advantages for Olmesartan medoxomil Cas 144689-63-4 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Storage:-20°C Freezer Package:1kg/foil bag, 25kg/dr
Cas:144689-63-4
Min.Order:1 Kilogram
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Type:Trading Company
inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shangha
Cas:144689-63-4
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inquiryHebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car
Cas:144689-63-4
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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Cas:144689-63-4
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:144689-63-4
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inquiryProduct Name: Olmesartan Medoxomil Synonyms: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl-1H-Imidazole-5-carboxylic acid, (5-methyl -2-oxo-1,3-dioxol-4-yl) methyl ester;Benicar;OlmesartanC29H30N
Cas:144689-63-4
Min.Order:1 Kilogram
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:144689-63-4
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:144689-63-4
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:144689-63-4
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:144689-63-4
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inquiryProduction name Olmesartan medoxomil CAS No. 144689-63-4 Appearance White powder Molecular Formula C29H30N6O6 Molecular Weight 558.585 Assay 99% Appearance:White powder Sto
Cas:144689-63-4
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers
Cas:144689-63-4
Min.Order:100 Gram
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inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:144689-63-4
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:144689-63-4
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:144689-63-4
Min.Order:10 Gram
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Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:144689-63-4
Min.Order:1 Kilogram
FOB Price: $398.0 / 430.0
Type:Trading Company
inquiryOlmesartan Medoxomil CAS: 144689-63-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in
Cas:144689-63-4
Min.Order:1 Gram
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:144689-63-4
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inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:144689-63-4
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:144689-63-4
Min.Order:1 Kilogram
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inquiryProduct quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried
Cas:144689-63-4
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
1. Well-equipped, stable and high-quality raw material supply chain, to provide customers with the best quality products. 2.Strict quality inspection process and professional certificate testing to ensure the quality level of the final product. 3.E
Cas:144689-63-4
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inquiryAppearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:packaged in foil bags or tins Application:Use only for laboratory research Transportation:Sea,Air,DHL/TNT/FEdex/UPS/EMS Por
trityl olmesartan medoxomil
olmesartan medoxomil
Conditions | Yield |
---|---|
With acetic acid In water at 25℃; for 1h; | 100% |
With hydrogenchloride In water; toluene at 20℃; for 2.5h; | 98.6% |
With TRILITE SCR-10 gel type In methanol for 6h; Product distribution / selectivity; Reflux; | 94% |
olmesartan medoxomil
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 25℃; for 6h; Time; | 98% |
trityl olmesartan medoxomil
A
triphenylmethyl alcohol
B
olmesartan medoxomil
Conditions | Yield |
---|---|
Stage #1: trityl olmesartan medoxomil With sulfuric acid; water In acetone at 40℃; for 2 - 4h; Stage #2: With sodium hydrogencarbonate at 20℃; for 1h; | A n/a B 90% |
With water In acetone for 14h; Product distribution / selectivity; Heating / reflux; | A n/a B 73% |
With water In acetonitrile for 14h; Product distribution / selectivity; Heating / reflux; | A n/a B 71% |
4-chloromethyl-5-methyl-1,3-dioxol-2-one
ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate
olmesartan medoxomil
Conditions | Yield |
---|---|
Stage #1: ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate With sodium hydroxide In N,N-dimethyl acetamide at 10 - 15℃; for 8h; Stage #2: 4-chloromethyl-5-methyl-1,3-dioxol-2-one With potassium carbonate In N,N-dimethyl acetamide at 0 - 65℃; for 10h; | 90% |
olmesartan medoxomil
Conditions | Yield |
---|---|
With hydrogenchloride In water; toluene at 20℃; for 3h; | 89% |
olmesartan medoxomil
Conditions | Yield |
---|---|
With trifluoroacetic acid at 25℃; for 72h; Temperature; | 83% |
(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2′-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate
olmesartan medoxomil
Conditions | Yield |
---|---|
With acetic acid at 80℃; for 2.5h; | 81% |
With sulfuric acid In water; acetone at 50 - 55℃; for 2h; | 80% |
With acetic acid In water at 55 - 60℃; for 2 - 3h; Product distribution / selectivity; | |
With hydrogenchloride In methanol; dichloromethane at 0 - 5℃; for 1 - 2h; |
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate
olmesartan medoxomil
Conditions | Yield |
---|---|
71% | |
Multi-step reaction with 2 steps 1.1: diisopropylamine; sodium hydroxide / toluene; ISOPROPYLAMIDE / 4 h / 25 - 45 °C 1.2: 8 h / 40 - 70 °C 1.3: 25 - 35 °C / pH ~ 6 - 7 2.1: hydrogenchloride; water / methanol / 1 h / 0 - 35 °C 2.2: 25 - 35 °C / pH ~ 3 - 4 View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium carbonate; water / acetone / 16 h / 20 °C 2.1: potassium carbonate; potassium iodide / acetone / 3 h / 50 - 55 °C 3.1: hydrogenchloride; water / toluene / 3 h / 20 °C 3.2: 15 - 20 °C / pH 4.5 - 5.5 View Scheme |
2-propyl-1H-imidazole-4,5-dicarboxylic acid
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 86 percent / HCl / Ambient temperature 2: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 3: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 4: LiOH*H2O / dioxane; H2O / 20 h / Ambient temperature 5: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C 6: 81 percent / 25percent aq. AcOH / 2.5 h / 80 °C View Scheme |
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: LiOH*H2O / dioxane; H2O / 20 h / Ambient temperature 3: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C 4: 81 percent / 25percent aq. AcOH / 2.5 h / 80 °C View Scheme | |
Multi-step reaction with 4 steps 1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C 2: potassium hydroxide; water / N,N-dimethyl-formamide / 22 h / 54 - 56 °C 3: potassium iodide; potassium carbonate / 20 °C 4: sulfuric acid / water; acetone / 2 h / 50 - 55 °C View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 2: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 3: LiOH*H2O / dioxane; H2O / 20 h / Ambient temperature 4: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C 5: 81 percent / 25percent aq. AcOH / 2.5 h / 80 °C View Scheme |
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: LiOH*H2O / dioxane; H2O / 20 h / Ambient temperature 3: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C 4: 81 percent / 25percent aq. AcOH / 2.5 h / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium carbonate / toluene / 0.75 h / 45 - 50 °C 1.2: 10 h / 60 - 70 °C 2.1: diisopropylamine; sodium hydroxide / toluene; ISOPROPYLAMIDE / 4 h / 25 - 45 °C 2.2: 8 h / 40 - 70 °C 2.3: 25 - 35 °C / pH ~ 6 - 7 3.1: hydrogenchloride; water / methanol / 1 h / 0 - 35 °C 3.2: 25 - 35 °C / pH ~ 3 - 4 View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate / tetrabutylammomium bromide / acetone / 15 h / 50 - 55 °C 2.1: potassium carbonate; water / acetone / 16 h / 20 °C 3.1: potassium carbonate; potassium iodide / acetone / 3 h / 50 - 55 °C 4.1: hydrogenchloride; water / toluene / 3 h / 20 °C 4.2: 15 - 20 °C / pH 4.5 - 5.5 View Scheme |
ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: LiOH*H2O / dioxane; H2O / 20 h / Ambient temperature 2: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C 3: 81 percent / 25percent aq. AcOH / 2.5 h / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium hydroxide; water / N,N-dimethyl-formamide / 22 h / 54 - 56 °C 2: potassium iodide; potassium carbonate / 20 °C 3: sulfuric acid / water; acetone / 2 h / 50 - 55 °C View Scheme |
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C 2: 81 percent / 25percent aq. AcOH / 2.5 h / 80 °C View Scheme |
2-propylimidazole-4,5-dicarbonitrile
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 80 percent / 6N aq. HCl / 8 h / Heating 2: 86 percent / HCl / Ambient temperature 3: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C 4: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 5: LiOH*H2O / dioxane; H2O / 20 h / Ambient temperature 6: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C 7: 81 percent / 25percent aq. AcOH / 2.5 h / 80 °C View Scheme |
olmesartan medoxomil
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water; acetone at 0 - 20℃; for 2 - 3h; pH=5.6; Product distribution / selectivity; |
trityl olmesartan medoxomil
4-chloromethyl-5-methyl-1,3-dioxol-2-one
olmesartan medoxomil
Conditions | Yield |
---|---|
Stage #1: trityl olmesartan medoxomil With hydrogenchloride; ethanol; water at 24 - 26℃; for 3h; Stage #2: 4-chloromethyl-5-methyl-1,3-dioxol-2-one With sodium hydroxide In ethanol; water for 0.25h; pH=5; |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / toluene / 0.75 h / 45 - 50 °C 1.2: 10 h / 60 - 70 °C 2.1: diisopropylamine; sodium hydroxide / toluene; ISOPROPYLAMIDE / 4 h / 25 - 45 °C 2.2: 8 h / 40 - 70 °C 2.3: 25 - 35 °C / pH ~ 6 - 7 3.1: hydrogenchloride; water / methanol / 1 h / 0 - 35 °C 3.2: 25 - 35 °C / pH ~ 3 - 4 View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate / tetrabutylammomium bromide / acetone / 15 h / 50 - 55 °C 2.1: potassium carbonate; water / acetone / 16 h / 20 °C 3.1: potassium carbonate; potassium iodide / acetone / 3 h / 50 - 55 °C 4.1: hydrogenchloride; water / toluene / 3 h / 20 °C 4.2: 15 - 20 °C / pH 4.5 - 5.5 View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium tert-butylate / dimethyl sulfoxide; acetone / 2.5 h / 0 - 5 °C / Reflux 2.1: sodium hydroxide / dimethyl sulfoxide; tetrahydrofuran / 2 h / 17 - 60 °C 2.2: 2.5 h / 70 °C 3.1: hydrogenchloride / acetonitrile; water / 2 h / 5 °C 3.2: pH 5.7 View Scheme |
potassium 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole-5-carboxylate
4-chloromethyl-5-methyl-1,3-dioxol-2-one
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate; potassium iodide / N,N-dimethyl acetamide / 3 h / 0 - 45 °C 2: hydrogenchloride; water / methanol; ethyl acetate / 2 h / 20 °C View Scheme |
benzoyl chloride
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: triethylamine / tetrahydrofuran / 3 h / 2 - 35 °C 2.1: phosphorus pentachloride / dichloromethane / 3 h / -15 - 21 °C 2.2: 4.5 h / -8 - 30 °C 3.1: triphenylphosphine; potassium carbonate; potassium bis(2-ethyl-n-hexyl)phosphate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 / 1-methyl-pyrrolidin-2-one / 8.5 h / 138 - 140 °C / Inert atmosphere 4.1: hydrogen bromide / acetic acid / 18.25 h / 0 - 30 °C 5.1: potassium carbonate; tetrabutylammomium bromide / acetone / 20.25 h / 0 - 45 °C 6.1: ammonium formate; 5% palladium on barium sulphate / isopropyl alcohol; water / 12 h / 55 - 60 °C 7.1: triethylamine / dichloromethane / 15.5 h / 0 - 30 °C 8.1: potassium hydroxide; water / acetone / 5.25 h / 0 - 45 °C 9.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C 9.2: 12 h / 45 - 50 °C 10.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C View Scheme |
N-benzylbenzamide
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: phosphorus pentachloride / dichloromethane / 3 h / -15 - 21 °C 1.2: 4.5 h / -8 - 30 °C 2.1: triphenylphosphine; potassium carbonate; potassium bis(2-ethyl-n-hexyl)phosphate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 / 1-methyl-pyrrolidin-2-one / 8.5 h / 138 - 140 °C / Inert atmosphere 3.1: hydrogen bromide / acetic acid / 18.25 h / 0 - 30 °C 4.1: potassium carbonate; tetrabutylammomium bromide / acetone / 20.25 h / 0 - 45 °C 5.1: ammonium formate; 5% palladium on barium sulphate / isopropyl alcohol; water / 12 h / 55 - 60 °C 6.1: triethylamine / dichloromethane / 15.5 h / 0 - 30 °C 7.1: potassium hydroxide; water / acetone / 5.25 h / 0 - 45 °C 8.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C 8.2: 12 h / 45 - 50 °C 9.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C View Scheme |
1-benzyl-5-phenyl-1H-tetrazole
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: triphenylphosphine; potassium carbonate; potassium bis(2-ethyl-n-hexyl)phosphate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 / 1-methyl-pyrrolidin-2-one / 8.5 h / 138 - 140 °C / Inert atmosphere 2.1: hydrogen bromide / acetic acid / 18.25 h / 0 - 30 °C 3.1: potassium carbonate; tetrabutylammomium bromide / acetone / 20.25 h / 0 - 45 °C 4.1: ammonium formate; 5% palladium on barium sulphate / isopropyl alcohol; water / 12 h / 55 - 60 °C 5.1: triethylamine / dichloromethane / 15.5 h / 0 - 30 °C 6.1: potassium hydroxide; water / acetone / 5.25 h / 0 - 45 °C 7.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C 7.2: 12 h / 45 - 50 °C 8.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 8 steps 1: triphenylphosphine; potassium carbonate; [RhCl2(p-cymene)]2; potassium bis(2-ethyl-n-hexyl)phosphate / 1-methyl-pyrrolidin-2-one / 138 - 140 °C / Inert atmosphere 2: acetic acid; hydrogen bromide / 18 h / 0 - 30 °C 3: potassium carbonate / acetonitrile / 18 h / 84 °C 4: 5% palladium on barium sulphate; sodium formate / water; isopropyl alcohol / 4 h / 55 °C 5: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C 6: potassium hydroxide / isopropyl alcohol / 4 h / 40 °C 7: potassium iodide / butanone / 20 h / 50 °C 8: acetic acid / water / 1 h / 25 °C View Scheme | |
Multi-step reaction with 8 steps 1: triphenylphosphine; potassium carbonate; [RhCl2(p-cymene)]2; potassium bis(2-ethyl-n-hexyl)phosphate / 1-methyl-pyrrolidin-2-one / 12 h / 138 °C / Inert atmosphere 2: 2,2'-azobis(isobutyronitrile); 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / ethyl acetate / 6 h / Reflux 3: potassium carbonate / acetonitrile / 18 h / 84 °C 4: 5% palladium on barium sulphate; sodium formate / water; isopropyl alcohol / 4 h / 55 °C 5: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C 6: potassium hydroxide / isopropyl alcohol / 4 h / 40 °C 7: potassium iodide / butanone / 20 h / 50 °C 8: acetic acid / water / 1 h / 25 °C View Scheme |
4-bromobenzyl benzoate
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: triphenylphosphine; potassium carbonate; potassium bis(2-ethyl-n-hexyl)phosphate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 / 1-methyl-pyrrolidin-2-one / 8.5 h / 138 - 140 °C / Inert atmosphere 2.1: hydrogen bromide / acetic acid / 18.25 h / 0 - 30 °C 3.1: potassium carbonate; tetrabutylammomium bromide / acetone / 20.25 h / 0 - 45 °C 4.1: ammonium formate; 5% palladium on barium sulphate / isopropyl alcohol; water / 12 h / 55 - 60 °C 5.1: triethylamine / dichloromethane / 15.5 h / 0 - 30 °C 6.1: potassium hydroxide; water / acetone / 5.25 h / 0 - 45 °C 7.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C 7.2: 12 h / 45 - 50 °C 8.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 8 steps 1: triphenylphosphine; potassium carbonate; [RhCl2(p-cymene)]2; potassium bis(2-ethyl-n-hexyl)phosphate / 1-methyl-pyrrolidin-2-one / 138 - 140 °C / Inert atmosphere 2: acetic acid; hydrogen bromide / 18 h / 0 - 30 °C 3: potassium carbonate / acetonitrile / 18 h / 84 °C 4: 5% palladium on barium sulphate; sodium formate / water; isopropyl alcohol / 4 h / 55 °C 5: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C 6: potassium hydroxide / isopropyl alcohol / 4 h / 40 °C 7: potassium iodide / butanone / 20 h / 50 °C 8: acetic acid / water / 1 h / 25 °C View Scheme |
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: hydrogen bromide / acetic acid / 18.25 h / 0 - 30 °C 2.1: potassium carbonate; tetrabutylammomium bromide / acetone / 20.25 h / 0 - 45 °C 3.1: ammonium formate; 5% palladium on barium sulphate / isopropyl alcohol; water / 12 h / 55 - 60 °C 4.1: triethylamine / dichloromethane / 15.5 h / 0 - 30 °C 5.1: potassium hydroxide; water / acetone / 5.25 h / 0 - 45 °C 6.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C 6.2: 12 h / 45 - 50 °C 7.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 7 steps 1: acetic acid; hydrogen bromide / 18 h / 0 - 30 °C 2: potassium carbonate / acetonitrile / 18 h / 84 °C 3: 5% palladium on barium sulphate; sodium formate / water; isopropyl alcohol / 4 h / 55 °C 4: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C 5: potassium hydroxide / isopropyl alcohol / 4 h / 40 °C 6: potassium iodide / butanone / 20 h / 50 °C 7: acetic acid / water / 1 h / 25 °C View Scheme |
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: potassium carbonate; tetrabutylammomium bromide / acetone / 20.25 h / 0 - 45 °C 2.1: ammonium formate; 5% palladium on barium sulphate / isopropyl alcohol; water / 12 h / 55 - 60 °C 3.1: triethylamine / dichloromethane / 15.5 h / 0 - 30 °C 4.1: potassium hydroxide; water / acetone / 5.25 h / 0 - 45 °C 5.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C 5.2: 12 h / 45 - 50 °C 6.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 6 steps 1: potassium carbonate / acetonitrile / 18 h / 84 °C 2: 5% palladium on barium sulphate; sodium formate / water; isopropyl alcohol / 4 h / 55 °C 3: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C 4: potassium hydroxide / isopropyl alcohol / 4 h / 40 °C 5: potassium iodide / butanone / 20 h / 50 °C 6: acetic acid / water / 1 h / 25 °C View Scheme |
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: ammonium formate; 5% palladium on barium sulphate / isopropyl alcohol; water / 12 h / 55 - 60 °C 2.1: triethylamine / dichloromethane / 15.5 h / 0 - 30 °C 3.1: potassium hydroxide; water / acetone / 5.25 h / 0 - 45 °C 4.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C 4.2: 12 h / 45 - 50 °C 5.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 5 steps 1: 5% palladium on barium sulphate; sodium formate / water; isopropyl alcohol / 4 h / 55 °C 2: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C 3: potassium hydroxide / isopropyl alcohol / 4 h / 40 °C 4: potassium iodide / butanone / 20 h / 50 °C 5: acetic acid / water / 1 h / 25 °C View Scheme |
ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: triethylamine / dichloromethane / 15.5 h / 0 - 30 °C 2.1: potassium hydroxide; water / acetone / 5.25 h / 0 - 45 °C 3.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C 3.2: 12 h / 45 - 50 °C 4.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C 2: potassium hydroxide / isopropyl alcohol / 4 h / 40 °C 3: potassium iodide / butanone / 20 h / 50 °C 4: acetic acid / water / 1 h / 25 °C View Scheme |
potassium 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole-5-carboxylate
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C 1.2: 12 h / 45 - 50 °C 2.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 2 steps 1: potassium iodide / butanone / 20 h / 50 °C 2: acetic acid / water / 1 h / 25 °C View Scheme |
para-bromotoluene
olmesartan medoxomil
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: triphenylphosphine; potassium carbonate; [RhCl2(p-cymene)]2; potassium bis(2-ethyl-n-hexyl)phosphate / 1-methyl-pyrrolidin-2-one / 12 h / 138 °C / Inert atmosphere 2: 2,2'-azobis(isobutyronitrile); 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / ethyl acetate / 6 h / Reflux 3: potassium carbonate / acetonitrile / 18 h / 84 °C 4: 5% palladium on barium sulphate; sodium formate / water; isopropyl alcohol / 4 h / 55 °C 5: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C 6: potassium hydroxide / isopropyl alcohol / 4 h / 40 °C 7: potassium iodide / butanone / 20 h / 50 °C 8: acetic acid / water / 1 h / 25 °C View Scheme |
olmesartan medoxomil
Conditions | Yield |
---|---|
With water; sodium hydroxide In methanol at 20℃; for 24h; | 96% |
olmesartan medoxomil
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; water at 20 - 30℃; for 20h; | 90% |
In water for 24h; Reflux; | 88% |
With water for 24h; Reflux; | 88% |
With Bis(p-nitrophenyl) phosphate In dimethyl sulfoxide; acetonitrile at 37℃; for 0.0333333h; pH=7.4; Reagent/catalyst; Enzymatic reaction; |
methanol
olmesartan medoxomil
4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-tetrazol-5-yl) phenyl}phenylmethylimidazole-5-carboxylic acid
Conditions | Yield |
---|---|
for 24h; Reflux; | 85% |
for 24h; Reflux; | 85% |
for 24h; Reflux; | 85% |
p-methoxybenzyl chloride
olmesartan medoxomil
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; sodium carbonate In chloroform; water at 10 - 55℃; for 11h; | 20.6% |
olmesartan medoxomil
Conditions | Yield |
---|---|
With water In dimethyl sulfoxide at 20℃; |
olmesartan medoxomil
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl1-((2'-(1H-tetrazol-5-yl) biphenyl-4-yl)methyl)-4-(prop-1-en-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Stage #1: olmesartan medoxomil With sulfuric acid In ISOPROPYLAMIDE at 100℃; for 2.5h; Inert atmosphere; Stage #2: With sodium hydroxide In dichloromethane; ISOPROPYLAMIDE; water at 40℃; pH=4.2; |
olmesartan medoxomil
4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-tetrazol-5-yl) phenyl}phenylmethylimidazole-5-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: water / 24 h / Reflux 2: 24 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: water / 24 h / Reflux 2: 24 h / Reflux View Scheme |
olmesartan medoxomil
A
4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-tetrazol-5-yl) phenyl}phenylmethylimidazole-5-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: water / 24 h / Reflux 2: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 5 h / 20 °C View Scheme |
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