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Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan

Olmesartan Medoxomil

Cas:144689-63-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

hangzhou verychem science and technology co.ltd

Product name: OLMESARTAN MEDOXOMIL Chemical name: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1h-tetazol-5-yl)[1,1'-biphenyl]-4-yl]methyl] Cas No: 144689-63-4 Assay: 98%min Hangzhou Verychem Scienc

OLMESARTAN MEDOXOMIL,manufacturer,99.5%min

Cas:144689-63-4

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Olmesartan medoxomil Manufacturer/High quality/Best price/In stock

Cas:144689-63-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

We are very compeitive on Olmesartan medoxomil.Our mfr is GMP certified for this item with CEP document. The pharmacological effect of olmesartan medoxomil tablets is that the main ingredient is olmesartan medoxomil, which is a prodrug that is abso

factory supply GMP,DMF,CEP Olmesartan

Cas:144689-63-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

Appearance:White powder Storage:store in cool and dry Package:according to customers' requirements Application:Pharmaceutical Transportation:by sea or by air Port:all chinese port

CAS:144689-63-4 Olmesartan medoxomil

Cas:144689-63-4

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Olmesartan medoxomil Cas 144689-63-4 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Storage:-20°C Freezer Package:1kg/foil bag, 25kg/dr

High quality Olmesartan medoxomil Cas 144689-63-4 with factory low price

Cas:144689-63-4

Min.Order:1 Kilogram

FOB Price: $800.0

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shangha

Olmesartan medoxomil CAS No.144689-63-4

Cas:144689-63-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

Factory supply OlmesartanMedoxomiI

Cas:144689-63-4

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Olmesartan Medoxomil

Cas:144689-63-4

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Olmesartan medoxomil 144689-63-4 ISO Producer

Cas:144689-63-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Olmesartan Medoxomil

Cas:144689-63-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: Olmesartan Medoxomil Synonyms: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl-1H-Imidazole-5-carboxylic acid, (5-methyl -2-oxo-1,3-dioxol-4-yl) methyl ester;Benicar;OlmesartanC29H30N

144689-63-4 Olmesartan Medoxomil

Cas:144689-63-4

Min.Order:1 Kilogram

FOB Price: $250.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Olmesartan Medoxomil

Cas:144689-63-4

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 144689-63-4 with competitive price

Cas:144689-63-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Olmesartan Medoxomil/ Benicar

Cas:144689-63-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Olmesartan medoxomil/ LIDE PHARMA- Factory supply / Best price

Cas:144689-63-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Production name Olmesartan medoxomil CAS No. 144689-63-4 Appearance White powder Molecular Formula C29H30N6O6 Molecular Weight 558.585 Assay 99% Appearance:White powder Sto

Olmesartan medoxomil CAS:144689-63-4

Cas:144689-63-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Good Quality Olmesartan Medoxomil CAS 144689-63-4 Omst for Anti-Hypertensive

Cas:144689-63-4

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Olmesartan medoxomil 144689-63-4

Cas:144689-63-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Safe and Fast Delivery Olmesartan Medoxomil powder with Best Price Olmesartan Medoxomil raw powder

Cas:144689-63-4

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Olmesartan Medoxomil 99%

Cas:144689-63-4

Min.Order:1 Kilogram

FOB Price: $398.0 / 430.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Olmesartan Medoxomil CAS: 144689-63-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in

Olmesartan Medoxomil CAS: 144689-63-4

Cas:144689-63-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Olmesartan medoxomil

Cas:144689-63-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

China supplies Olmesartan Medoxomil powder for human

Cas:144689-63-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

olmesartan medoxomil

Cas:144689-63-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried

Olmesartan Medoxomil CAS NO.144689-63-4

Cas:144689-63-4

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Olmesartan medoxomil

Cas:144689-63-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

1. Well-equipped, stable and high-quality raw material supply chain, to provide customers with the best quality products. 2.Strict quality inspection process and professional certificate testing to ensure the quality level of the final product. 3.E

Olmesartan Medoxomi

Cas:144689-63-4

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:packaged in foil bags or tins Application:Use only for laboratory research Transportation:Sea,Air,DHL/TNT/FEdex/UPS/EMS Por

CS-866

Cas:144689-63-4

Min.Order:10 Gram

FOB Price: $1.0 / 10.0

Type:Lab/Research institutions

inquiry

Synthetic route

trityl olmesartan medoxomil
144690-92-6

trityl olmesartan medoxomil

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
With acetic acid In water at 25℃; for 1h;100%
With hydrogenchloride In water; toluene at 20℃; for 2.5h;98.6%
With TRILITE SCR-10 gel type In methanol for 6h; Product distribution / selectivity; Reflux;94%
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-({2'-[1-(2,4-dimethoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylate

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-({2'-[1-(2,4-dimethoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylate

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 25℃; for 6h; Time;98%
trityl olmesartan medoxomil
144690-92-6

trityl olmesartan medoxomil

A

triphenylmethyl alcohol
76-84-6

triphenylmethyl alcohol

B

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Stage #1: trityl olmesartan medoxomil With sulfuric acid; water In acetone at 40℃; for 2 - 4h;
Stage #2: With sodium hydrogencarbonate at 20℃; for 1h;
A n/a
B 90%
With water In acetone for 14h; Product distribution / selectivity; Heating / reflux;A n/a
B 73%
With water In acetonitrile for 14h; Product distribution / selectivity; Heating / reflux;A n/a
B 71%
4-chloromethyl-5-methyl-1,3-dioxol-2-one
80841-78-7

4-chloromethyl-5-methyl-1,3-dioxol-2-one

ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate
172875-59-1

ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Stage #1: ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate With sodium hydroxide In N,N-dimethyl acetamide at 10 - 15℃; for 8h;
Stage #2: 4-chloromethyl-5-methyl-1,3-dioxol-2-one With potassium carbonate In N,N-dimethyl acetamide at 0 - 65℃; for 10h;
90%
trityl olmesartan medoxomil

trityl olmesartan medoxomil

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
With hydrogenchloride In water; toluene at 20℃; for 3h;89%
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-1-({2'-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-2-propyl-1H-imidazole-5-carboxylate

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-1-({2'-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-2-propyl-1H-imidazole-5-carboxylate

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
With trifluoroacetic acid at 25℃; for 72h; Temperature;83%
(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2′-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate
1020157-01-0

(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2′-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
With acetic acid at 80℃; for 2.5h;81%
With sulfuric acid In water; acetone at 50 - 55℃; for 2h;80%
With acetic acid In water at 55 - 60℃; for 2 - 3h; Product distribution / selectivity;
With hydrogenchloride In methanol; dichloromethane at 0 - 5℃; for 1 - 2h;
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate
144690-33-5

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
71%
Multi-step reaction with 2 steps
1.1: diisopropylamine; sodium hydroxide / toluene; ISOPROPYLAMIDE / 4 h / 25 - 45 °C
1.2: 8 h / 40 - 70 °C
1.3: 25 - 35 °C / pH ~ 6 - 7
2.1: hydrogenchloride; water / methanol / 1 h / 0 - 35 °C
2.2: 25 - 35 °C / pH ~ 3 - 4
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate; water / acetone / 16 h / 20 °C
2.1: potassium carbonate; potassium iodide / acetone / 3 h / 50 - 55 °C
3.1: hydrogenchloride; water / toluene / 3 h / 20 °C
3.2: 15 - 20 °C / pH 4.5 - 5.5
View Scheme
2-propyl-1H-imidazole-4,5-dicarboxylic acid
58954-23-7

2-propyl-1H-imidazole-4,5-dicarboxylic acid

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 86 percent / HCl / Ambient temperature
2: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C
3: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h
4: LiOH*H2O / dioxane; H2O / 20 h / Ambient temperature
5: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C
6: 81 percent / 25percent aq. AcOH / 2.5 h / 80 °C
View Scheme
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole
133051-88-4

N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h
2: LiOH*H2O / dioxane; H2O / 20 h / Ambient temperature
3: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C
4: 81 percent / 25percent aq. AcOH / 2.5 h / 80 °C
View Scheme
Multi-step reaction with 4 steps
1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C
2: potassium hydroxide; water / N,N-dimethyl-formamide / 22 h / 54 - 56 °C
3: potassium iodide; potassium carbonate / 20 °C
4: sulfuric acid / water; acetone / 2 h / 50 - 55 °C
View Scheme
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
144689-94-1

2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C
2: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h
3: LiOH*H2O / dioxane; H2O / 20 h / Ambient temperature
4: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C
5: 81 percent / 25percent aq. AcOH / 2.5 h / 80 °C
View Scheme
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h
2: LiOH*H2O / dioxane; H2O / 20 h / Ambient temperature
3: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C
4: 81 percent / 25percent aq. AcOH / 2.5 h / 80 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / toluene / 0.75 h / 45 - 50 °C
1.2: 10 h / 60 - 70 °C
2.1: diisopropylamine; sodium hydroxide / toluene; ISOPROPYLAMIDE / 4 h / 25 - 45 °C
2.2: 8 h / 40 - 70 °C
2.3: 25 - 35 °C / pH ~ 6 - 7
3.1: hydrogenchloride; water / methanol / 1 h / 0 - 35 °C
3.2: 25 - 35 °C / pH ~ 3 - 4
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / tetrabutylammomium bromide / acetone / 15 h / 50 - 55 °C
2.1: potassium carbonate; water / acetone / 16 h / 20 °C
3.1: potassium carbonate; potassium iodide / acetone / 3 h / 50 - 55 °C
4.1: hydrogenchloride; water / toluene / 3 h / 20 °C
4.2: 15 - 20 °C / pH 4.5 - 5.5
View Scheme
ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate
172875-59-1

ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: LiOH*H2O / dioxane; H2O / 20 h / Ambient temperature
2: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C
3: 81 percent / 25percent aq. AcOH / 2.5 h / 80 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium hydroxide; water / N,N-dimethyl-formamide / 22 h / 54 - 56 °C
2: potassium iodide; potassium carbonate / 20 °C
3: sulfuric acid / water; acetone / 2 h / 50 - 55 °C
View Scheme
4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5yl]biphenyl-4-yl]methyl]imidazole-5-carboxylic acid lithium salt

4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5yl]biphenyl-4-yl]methyl]imidazole-5-carboxylic acid lithium salt

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C
2: 81 percent / 25percent aq. AcOH / 2.5 h / 80 °C
View Scheme
2-propylimidazole-4,5-dicarbonitrile
51802-42-7

2-propylimidazole-4,5-dicarbonitrile

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 80 percent / 6N aq. HCl / 8 h / Heating
2: 86 percent / HCl / Ambient temperature
3: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C
4: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h
5: LiOH*H2O / dioxane; H2O / 20 h / Ambient temperature
6: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C
7: 81 percent / 25percent aq. AcOH / 2.5 h / 80 °C
View Scheme
olmesartan medoxomil hydrobromide

olmesartan medoxomil hydrobromide

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; acetone at 0 - 20℃; for 2 - 3h; pH=5.6; Product distribution / selectivity;
trityl olmesartan medoxomil
144690-92-6

trityl olmesartan medoxomil

4-chloromethyl-5-methyl-1,3-dioxol-2-one
80841-78-7

4-chloromethyl-5-methyl-1,3-dioxol-2-one

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Stage #1: trityl olmesartan medoxomil With hydrogenchloride; ethanol; water at 24 - 26℃; for 3h;
Stage #2: 4-chloromethyl-5-methyl-1,3-dioxol-2-one With sodium hydroxide In ethanol; water for 0.25h; pH=5;
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / toluene / 0.75 h / 45 - 50 °C
1.2: 10 h / 60 - 70 °C
2.1: diisopropylamine; sodium hydroxide / toluene; ISOPROPYLAMIDE / 4 h / 25 - 45 °C
2.2: 8 h / 40 - 70 °C
2.3: 25 - 35 °C / pH ~ 6 - 7
3.1: hydrogenchloride; water / methanol / 1 h / 0 - 35 °C
3.2: 25 - 35 °C / pH ~ 3 - 4
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / tetrabutylammomium bromide / acetone / 15 h / 50 - 55 °C
2.1: potassium carbonate; water / acetone / 16 h / 20 °C
3.1: potassium carbonate; potassium iodide / acetone / 3 h / 50 - 55 °C
4.1: hydrogenchloride; water / toluene / 3 h / 20 °C
4.2: 15 - 20 °C / pH 4.5 - 5.5
View Scheme
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / dimethyl sulfoxide; acetone / 2.5 h / 0 - 5 °C / Reflux
2.1: sodium hydroxide / dimethyl sulfoxide; tetrahydrofuran / 2 h / 17 - 60 °C
2.2: 2.5 h / 70 °C
3.1: hydrogenchloride / acetonitrile; water / 2 h / 5 °C
3.2: pH 5.7
View Scheme
potassium 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole-5-carboxylate
936114-12-4

potassium 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole-5-carboxylate

4-chloromethyl-5-methyl-1,3-dioxol-2-one
80841-78-7

4-chloromethyl-5-methyl-1,3-dioxol-2-one

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate; potassium iodide / N,N-dimethyl acetamide / 3 h / 0 - 45 °C
2: hydrogenchloride; water / methanol; ethyl acetate / 2 h / 20 °C
View Scheme
benzoyl chloride
98-88-4

benzoyl chloride

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: triethylamine / tetrahydrofuran / 3 h / 2 - 35 °C
2.1: phosphorus pentachloride / dichloromethane / 3 h / -15 - 21 °C
2.2: 4.5 h / -8 - 30 °C
3.1: triphenylphosphine; potassium carbonate; potassium bis(2-ethyl-n-hexyl)phosphate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 / 1-methyl-pyrrolidin-2-one / 8.5 h / 138 - 140 °C / Inert atmosphere
4.1: hydrogen bromide / acetic acid / 18.25 h / 0 - 30 °C
5.1: potassium carbonate; tetrabutylammomium bromide / acetone / 20.25 h / 0 - 45 °C
6.1: ammonium formate; 5% palladium on barium sulphate / isopropyl alcohol; water / 12 h / 55 - 60 °C
7.1: triethylamine / dichloromethane / 15.5 h / 0 - 30 °C
8.1: potassium hydroxide; water / acetone / 5.25 h / 0 - 45 °C
9.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C
9.2: 12 h / 45 - 50 °C
10.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C
View Scheme
N-benzylbenzamide
1485-70-7

N-benzylbenzamide

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: phosphorus pentachloride / dichloromethane / 3 h / -15 - 21 °C
1.2: 4.5 h / -8 - 30 °C
2.1: triphenylphosphine; potassium carbonate; potassium bis(2-ethyl-n-hexyl)phosphate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 / 1-methyl-pyrrolidin-2-one / 8.5 h / 138 - 140 °C / Inert atmosphere
3.1: hydrogen bromide / acetic acid / 18.25 h / 0 - 30 °C
4.1: potassium carbonate; tetrabutylammomium bromide / acetone / 20.25 h / 0 - 45 °C
5.1: ammonium formate; 5% palladium on barium sulphate / isopropyl alcohol; water / 12 h / 55 - 60 °C
6.1: triethylamine / dichloromethane / 15.5 h / 0 - 30 °C
7.1: potassium hydroxide; water / acetone / 5.25 h / 0 - 45 °C
8.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C
8.2: 12 h / 45 - 50 °C
9.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C
View Scheme
1-benzyl-5-phenyl-1H-tetrazole
28386-90-5

1-benzyl-5-phenyl-1H-tetrazole

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: triphenylphosphine; potassium carbonate; potassium bis(2-ethyl-n-hexyl)phosphate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 / 1-methyl-pyrrolidin-2-one / 8.5 h / 138 - 140 °C / Inert atmosphere
2.1: hydrogen bromide / acetic acid / 18.25 h / 0 - 30 °C
3.1: potassium carbonate; tetrabutylammomium bromide / acetone / 20.25 h / 0 - 45 °C
4.1: ammonium formate; 5% palladium on barium sulphate / isopropyl alcohol; water / 12 h / 55 - 60 °C
5.1: triethylamine / dichloromethane / 15.5 h / 0 - 30 °C
6.1: potassium hydroxide; water / acetone / 5.25 h / 0 - 45 °C
7.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C
7.2: 12 h / 45 - 50 °C
8.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C
View Scheme
Multi-step reaction with 8 steps
1: triphenylphosphine; potassium carbonate; [RhCl2(p-cymene)]2; potassium bis(2-ethyl-n-hexyl)phosphate / 1-methyl-pyrrolidin-2-one / 138 - 140 °C / Inert atmosphere
2: acetic acid; hydrogen bromide / 18 h / 0 - 30 °C
3: potassium carbonate / acetonitrile / 18 h / 84 °C
4: 5% palladium on barium sulphate; sodium formate / water; isopropyl alcohol / 4 h / 55 °C
5: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C
6: potassium hydroxide / isopropyl alcohol / 4 h / 40 °C
7: potassium iodide / butanone / 20 h / 50 °C
8: acetic acid / water / 1 h / 25 °C
View Scheme
Multi-step reaction with 8 steps
1: triphenylphosphine; potassium carbonate; [RhCl2(p-cymene)]2; potassium bis(2-ethyl-n-hexyl)phosphate / 1-methyl-pyrrolidin-2-one / 12 h / 138 °C / Inert atmosphere
2: 2,2'-azobis(isobutyronitrile); 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / ethyl acetate / 6 h / Reflux
3: potassium carbonate / acetonitrile / 18 h / 84 °C
4: 5% palladium on barium sulphate; sodium formate / water; isopropyl alcohol / 4 h / 55 °C
5: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C
6: potassium hydroxide / isopropyl alcohol / 4 h / 40 °C
7: potassium iodide / butanone / 20 h / 50 °C
8: acetic acid / water / 1 h / 25 °C
View Scheme
4-bromobenzyl benzoate
38612-13-4

4-bromobenzyl benzoate

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: triphenylphosphine; potassium carbonate; potassium bis(2-ethyl-n-hexyl)phosphate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 / 1-methyl-pyrrolidin-2-one / 8.5 h / 138 - 140 °C / Inert atmosphere
2.1: hydrogen bromide / acetic acid / 18.25 h / 0 - 30 °C
3.1: potassium carbonate; tetrabutylammomium bromide / acetone / 20.25 h / 0 - 45 °C
4.1: ammonium formate; 5% palladium on barium sulphate / isopropyl alcohol; water / 12 h / 55 - 60 °C
5.1: triethylamine / dichloromethane / 15.5 h / 0 - 30 °C
6.1: potassium hydroxide; water / acetone / 5.25 h / 0 - 45 °C
7.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C
7.2: 12 h / 45 - 50 °C
8.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C
View Scheme
Multi-step reaction with 8 steps
1: triphenylphosphine; potassium carbonate; [RhCl2(p-cymene)]2; potassium bis(2-ethyl-n-hexyl)phosphate / 1-methyl-pyrrolidin-2-one / 138 - 140 °C / Inert atmosphere
2: acetic acid; hydrogen bromide / 18 h / 0 - 30 °C
3: potassium carbonate / acetonitrile / 18 h / 84 °C
4: 5% palladium on barium sulphate; sodium formate / water; isopropyl alcohol / 4 h / 55 °C
5: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C
6: potassium hydroxide / isopropyl alcohol / 4 h / 40 °C
7: potassium iodide / butanone / 20 h / 50 °C
8: acetic acid / water / 1 h / 25 °C
View Scheme
{2'-(1-benzyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl}methyl benzoate

{2'-(1-benzyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl}methyl benzoate

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: hydrogen bromide / acetic acid / 18.25 h / 0 - 30 °C
2.1: potassium carbonate; tetrabutylammomium bromide / acetone / 20.25 h / 0 - 45 °C
3.1: ammonium formate; 5% palladium on barium sulphate / isopropyl alcohol; water / 12 h / 55 - 60 °C
4.1: triethylamine / dichloromethane / 15.5 h / 0 - 30 °C
5.1: potassium hydroxide; water / acetone / 5.25 h / 0 - 45 °C
6.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C
6.2: 12 h / 45 - 50 °C
7.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C
View Scheme
Multi-step reaction with 7 steps
1: acetic acid; hydrogen bromide / 18 h / 0 - 30 °C
2: potassium carbonate / acetonitrile / 18 h / 84 °C
3: 5% palladium on barium sulphate; sodium formate / water; isopropyl alcohol / 4 h / 55 °C
4: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C
5: potassium hydroxide / isopropyl alcohol / 4 h / 40 °C
6: potassium iodide / butanone / 20 h / 50 °C
7: acetic acid / water / 1 h / 25 °C
View Scheme
1-benzyl-5-[4'-(bromomethyl)biphenyl-2-yl]-1H-tetrazole

1-benzyl-5-[4'-(bromomethyl)biphenyl-2-yl]-1H-tetrazole

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate; tetrabutylammomium bromide / acetone / 20.25 h / 0 - 45 °C
2.1: ammonium formate; 5% palladium on barium sulphate / isopropyl alcohol; water / 12 h / 55 - 60 °C
3.1: triethylamine / dichloromethane / 15.5 h / 0 - 30 °C
4.1: potassium hydroxide; water / acetone / 5.25 h / 0 - 45 °C
5.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C
5.2: 12 h / 45 - 50 °C
6.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C
View Scheme
Multi-step reaction with 6 steps
1: potassium carbonate / acetonitrile / 18 h / 84 °C
2: 5% palladium on barium sulphate; sodium formate / water; isopropyl alcohol / 4 h / 55 °C
3: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C
4: potassium hydroxide / isopropyl alcohol / 4 h / 40 °C
5: potassium iodide / butanone / 20 h / 50 °C
6: acetic acid / water / 1 h / 25 °C
View Scheme
ethyl 4-(1-hydroxy-1-methylethyl)-1-({2′-[1-(phenylmethyl)-1H-tetrazol-5-yl][1,1′-biphenyl]-4-yl}methyl)-2-propyl-1H-imidazole-5-carboxylate

ethyl 4-(1-hydroxy-1-methylethyl)-1-({2′-[1-(phenylmethyl)-1H-tetrazol-5-yl][1,1′-biphenyl]-4-yl}methyl)-2-propyl-1H-imidazole-5-carboxylate

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: ammonium formate; 5% palladium on barium sulphate / isopropyl alcohol; water / 12 h / 55 - 60 °C
2.1: triethylamine / dichloromethane / 15.5 h / 0 - 30 °C
3.1: potassium hydroxide; water / acetone / 5.25 h / 0 - 45 °C
4.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C
4.2: 12 h / 45 - 50 °C
5.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C
View Scheme
Multi-step reaction with 5 steps
1: 5% palladium on barium sulphate; sodium formate / water; isopropyl alcohol / 4 h / 55 °C
2: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C
3: potassium hydroxide / isopropyl alcohol / 4 h / 40 °C
4: potassium iodide / butanone / 20 h / 50 °C
5: acetic acid / water / 1 h / 25 °C
View Scheme
ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate
144689-23-6

ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 15.5 h / 0 - 30 °C
2.1: potassium hydroxide; water / acetone / 5.25 h / 0 - 45 °C
3.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C
3.2: 12 h / 45 - 50 °C
4.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C
2: potassium hydroxide / isopropyl alcohol / 4 h / 40 °C
3: potassium iodide / butanone / 20 h / 50 °C
4: acetic acid / water / 1 h / 25 °C
View Scheme
potassium 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole-5-carboxylate
936114-12-4

potassium 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole-5-carboxylate

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium carbonate; potassium iodide / acetone / 0.17 h / 25 - 30 °C
1.2: 12 h / 45 - 50 °C
2.1: sulfuric acid / acetic acid; water / 1 h / 25 - 30 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium iodide / butanone / 20 h / 50 °C
2: acetic acid / water / 1 h / 25 °C
View Scheme
para-bromotoluene
106-38-7

para-bromotoluene

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: triphenylphosphine; potassium carbonate; [RhCl2(p-cymene)]2; potassium bis(2-ethyl-n-hexyl)phosphate / 1-methyl-pyrrolidin-2-one / 12 h / 138 °C / Inert atmosphere
2: 2,2'-azobis(isobutyronitrile); 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / ethyl acetate / 6 h / Reflux
3: potassium carbonate / acetonitrile / 18 h / 84 °C
4: 5% palladium on barium sulphate; sodium formate / water; isopropyl alcohol / 4 h / 55 °C
5: triethylamine / dichloromethane / 4.5 h / 0 - 25 °C
6: potassium hydroxide / isopropyl alcohol / 4 h / 40 °C
7: potassium iodide / butanone / 20 h / 50 °C
8: acetic acid / water / 1 h / 25 °C
View Scheme
olmesartan medoxomil
144689-63-4

olmesartan medoxomil

4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylic acid dipotassium salt

4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylic acid dipotassium salt

Conditions
ConditionsYield
With water; sodium hydroxide In methanol at 20℃; for 24h;96%
olmesartan medoxomil
144689-63-4

olmesartan medoxomil

olmesartan

olmesartan

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 20 - 30℃; for 20h;90%
In water for 24h; Reflux;88%
With water for 24h; Reflux;88%
With Bis(p-nitrophenyl) phosphate In dimethyl sulfoxide; acetonitrile at 37℃; for 0.0333333h; pH=7.4; Reagent/catalyst; Enzymatic reaction;
methanol
67-56-1

methanol

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-tetrazol-5-yl) phenyl}phenylmethylimidazole-5-carboxylic acid
1039762-40-7

4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-tetrazol-5-yl) phenyl}phenylmethylimidazole-5-carboxylic acid

Conditions
ConditionsYield
for 24h; Reflux;85%
for 24h; Reflux;85%
for 24h; Reflux;85%
p-methoxybenzyl chloride
824-94-2

p-methoxybenzyl chloride

olmesartan medoxomil
144689-63-4

olmesartan medoxomil

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-1-({2'-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-2-propyl-1H-imidazole-5-carboxylate

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-1-({2'-[1-(4-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-2-propyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
With tetrabutylammomium bromide; sodium carbonate In chloroform; water at 10 - 55℃; for 11h;20.6%
olmesartan medoxomil
144689-63-4

olmesartan medoxomil

olmesartan medoxomil hemihydrate

olmesartan medoxomil hemihydrate

Conditions
ConditionsYield
With water In dimethyl sulfoxide at 20℃;
olmesartan medoxomil
144689-63-4

olmesartan medoxomil

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl1-((2'-(1H-tetrazol-5-yl) biphenyl-4-yl)methyl)-4-(prop-1-en-2-yl)-2-propyl-1H-imidazole-5-carboxylate
879562-26-2

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl1-((2'-(1H-tetrazol-5-yl) biphenyl-4-yl)methyl)-4-(prop-1-en-2-yl)-2-propyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
Stage #1: olmesartan medoxomil With sulfuric acid In ISOPROPYLAMIDE at 100℃; for 2.5h; Inert atmosphere;
Stage #2: With sodium hydroxide In dichloromethane; ISOPROPYLAMIDE; water at 40℃; pH=4.2;
olmesartan medoxomil
144689-63-4

olmesartan medoxomil

4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-tetrazol-5-yl) phenyl}phenylmethylimidazole-5-carboxylic acid
1039762-40-7

4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-tetrazol-5-yl) phenyl}phenylmethylimidazole-5-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: water / 24 h / Reflux
2: 24 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: water / 24 h / Reflux
2: 24 h / Reflux
View Scheme
olmesartan medoxomil
144689-63-4

olmesartan medoxomil

A

4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-tetrazol-5-yl) phenyl}phenylmethylimidazole-5-carboxylic acid
1039762-40-7

4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-tetrazol-5-yl) phenyl}phenylmethylimidazole-5-carboxylic acid

B

olmesartan methyl ester

olmesartan methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: water / 24 h / Reflux
2: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 5 h / 20 °C
View Scheme

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