Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------
Cas:144689-93-0
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inquiryUnique advantages for Olmesartan medoxomil intermediate Cas 144689-93-0 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:10g,100g,1kg/
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan
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inquiryDayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. As a leading manufacturer and supplier of chemicals in China, Day
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryAbout Product Details
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so
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inquiryOur advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity 鈮 9% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package can
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryName: [5-(1-Hydroxyl-1-methylethyl)-2-propyl-imidazol-4-yl]carboxylic acid ethyl ester Synonyms: 4-(1-hydroxy-1-methylethyl)-2-propyl-1h-imidazole-5-carboxylic acid ethyl ester CAS: 144689-93-0 MF: C12H20N2O3 Appearance:White powder Storage:Store
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inquiryWe are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
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inquiryAppearance:Pale yellow to off-white powder Storage:ln stock Package:25kg/Carton Application:Chemicals Transportation:Express/Sea/Air Port:Any port in china
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Powder Storage:Store in sealed containers at co
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inquiryHanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d
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inquiryHangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac
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Cas:144689-93-0
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inquiryBeluga chemical professional supply Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate CAS 144689-93-0 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryAppearance:Pale Yellow solid Storage:Sealed in dry,2-8°C Application:An Olmesartan (O550000) intermediate Port:QINGDAO
Cas:144689-93-0
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
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inquirymethyl bromide
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
With iodine; magnesium In dichloromethane at 15 - 25℃; for 2h; | 97.5% |
methylmagnesium bromide
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
In diethyl ether; dichloromethane at 10 - 15℃; for 1h; | 95% |
ethanol
C10H14N2O2
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Stage #1: ethanol; C10H14N2O2 With sulfuric acid at 40 - 50℃; Stage #2: With sodium hydrogencarbonate In water; ethyl acetate Product distribution / selectivity; | 92% |
methylmagnesium chloride
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Stage #1: methylmagnesium chloride; diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate In tetrahydrofuran at -10 - 0℃; for 0.166667h; Stage #2: With water; ammonium chloride In tetrahydrofuran; dichloromethane | 85% |
Stage #1: methylmagnesium chloride; diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate In tetrahydrofuran; toluene for 6.5h; Inert atmosphere; Cooling with ice; Stage #2: With hydrogenchloride In tetrahydrofuran; water; toluene pH=7; | |
In tetrahydrofuran at 60℃; for 2h; | 4.81 g |
4-(1-hydroxy-1-methylethyl)-2-propyl imidazole-5-carboxylic acid
ethanol
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Stage #1: 4-(1-hydroxy-1-methylethyl)-2-propyl imidazole-5-carboxylic acid; ethanol With thionyl chloride Reflux; Stage #2: With sodium hydrogencarbonate In water; ethyl acetate Product distribution / selectivity; | 85% |
methylene chloride
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Stage #1: methylene chloride With magnesium In tetrahydrofuran for 0.5h; Reflux; Stage #2: diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate In tetrahydrofuran at 30℃; for 2.5h; Solvent; Temperature; | 80% |
Stage #1: methylene chloride With magnesium at 55 - 60℃; for 1h; Inert atmosphere; Stage #2: diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate at 0℃; for 8h; |
2-propyl-1H-imidazole-4,5-dicarboxylic acid
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 86 percent / HCl / Ambient temperature 2: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C View Scheme |
2-propylimidazole-4,5-dicarbonitrile
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 80 percent / 6N aq. HCl / 8 h / Heating 2: 86 percent / HCl / Ambient temperature 3: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C View Scheme |
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
A
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
B
ethyl 2-butyl-4-(1-hydroxy-1-methylethyl)imidazole-5-carboxylate
Conditions | Yield |
---|---|
With methylmagnesium bromide In tetrahydrofuran |
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydroxide; sodium chloride / water / 1 h / Cooling with ice 2.1: toluene; tetrahydrofuran / 6.5 h / Inert atmosphere; Cooling with ice 2.2: pH 7 View Scheme |
4-(1-hydroxy-1-methylethyl)-2-propyl imidazole-5-carboxylic acid
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dicyclohexyl-carbodiimide / acetone / 48 h / 20 °C 2: sodium hydroxide; water / acetone / Reflux 3: thionyl chloride / Reflux View Scheme |
C10H14N2O2
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide; water / acetone / Reflux 2: thionyl chloride / Reflux View Scheme |
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
trityl olmesartan medoxomil
Conditions | Yield |
---|---|
Stage #1: 5-[4'-(bromomethyl)[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-1H-tetrazole; ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With tert-butylamine hydrobromide; potassium carbonate In acetone at 0 - 55℃; for 32h; Stage #2: 4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one With potassium carbonate; potassium iodide In acetone at 20 - 55℃; for 3h; | 98.5% |
5-(2',3',5',6'-tetra-[2H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2',3',5',6'-tetra-[2H]-2'-(1-trithyl-1H-terazol-5-yl)-biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Stage #1: ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With potassium tert-butylate In N,N-dimethyl-formamide for 0.333333h; Cooling with ice; Stage #2: 5-(2',3',5',6'-tetra-[2H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole In N,N-dimethyl-formamide at 20℃; for 2.5h; | 96.5% |
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol for 16h; Reflux; | 95.3% |
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
4-(1-hydroxy-1-methylethyl)-2-propyl imidazole-5-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With water; sodium hydroxide In acetone for 3h; Reflux; Stage #2: With hydrogenchloride In water at 10℃; pH=6.5; | 95% |
With sodium hydroxide In water; acetone at 110℃; for 3h; | 82% |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With potassium carbonate In butanone at 60℃; for 2h; Stage #2: With N,N-dimethyl acetamide In butanone at 45℃; for 4h; | 93.8% |
With tetrabutylammomium bromide; potassium carbonate In acetone at 50 - 60℃; for 20h; Green chemistry; | 90.7% |
With potassium carbonate In acetonitrile for 7h; Heating / reflux; | 89% |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
A
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate
B
4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid
Conditions | Yield |
---|---|
With potassium phosphate In N,N-dimethyl acetamide at 60 - 65℃; for 6h; Solvent; Reagent/catalyst; | A 89.6% B 0.02% C 0.02% |
1-bromomethyl-4-bromobenzene
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
3-(4-bromobenzyl)-5-(1-hydroxy-1-methylethyl)-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl acetamide at 20℃; for 18h; Product distribution / selectivity; | 89% |
With potassium carbonate In DMA at 20℃; for 18h; Product distribution / selectivity; | 89% |
With potassium carbonate In N,N-dimethyl acetamide for 48h; | 47% |
With sodium hydride In N,N-dimethyl-formamide at 0℃; for 1.16667h; Product distribution / selectivity; | 45% |
Stage #1: ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 1-bromomethyl-4-bromobenzene In N,N-dimethyl-formamide for 1h; Product distribution / selectivity; | 45% |
2'-<2-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-methanol
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 10℃; for 0.5h; Reagent/catalyst; Solvent; Cooling with ice; | 89% |
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 25 - 84℃; for 18h; | 83% |
With potassium carbonate In acetonitrile at 84℃; for 18h; | 83.2% |
With tetrabutylammomium bromide; potassium carbonate In acetone at 0 - 45℃; for 20.25h; | 165 g |
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 20℃; for 24h; | 83% |
With potassium tert-butylate 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h; Yield given. Multistep reaction; | |
Stage #1: ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole In N,N-dimethyl-formamide at 20 - 60℃; for 6h; |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Stage #1: ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With potassium carbonate; tetrabutylammomium bromide In acetone at 20℃; for 1h; Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In acetone for 14h; Heating / reflux; | 80% |
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
4-bromomethylphenylboronic acid pinacol ester
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 60℃; Sealed tube; | 64.9% |
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; potassium carbonate In acetone at 0 - 65℃; for 89h; | 50% |
4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
ethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate
Conditions | Yield |
---|---|
With potassium tert-butylate 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h; Yield given. Multistep reaction; |
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
ethyl 4-isopropenyl-2-propylimidazole-5-carboxylate
Conditions | Yield |
---|---|
With pyridine; trichlorophosphate 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h; Yield given. Multistep reaction; |
1-(2-trimethylsilylethoxymethyl)-5-(4'-bromomethylbiphenyl-2-yl)-1H-tetrazole
2-(2-trimethylsilylethoxy)methyl-5-(4'-bromomethylbiphenyl-2-yl)-2H-tetrazole
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 17h; |
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
ethyl 4-isopropyl-2-propylimidazole-5-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h 2: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature View Scheme |
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h 2: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature 3: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 4: 82 percent / HCl / dioxane / 16 h / Ambient temperature 5: 100 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature View Scheme |
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h 2: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 3: 92 percent / HCl / dioxane / 16 h / Ambient temperature 4: 94 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature View Scheme |
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-isopropyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h 2: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature 3: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 4: 82 percent / HCl / dioxane / 16 h / Ambient temperature View Scheme |
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-isopropenyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h 2: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 3: 92 percent / HCl / dioxane / 16 h / Ambient temperature View Scheme |
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: 92 percent / HCl / dioxane / 16 h / Ambient temperature 3: 91 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature View Scheme |
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h 2: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature 3: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 4: 93 percent / 25percent aq. AcOH / 2.5 h / 80 °C 5: 89 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature View Scheme |
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