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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 144689-93-0 ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Cas:144689-93-0

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Olmesartan medoxomil intermediate Cas 144689-93-0 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:10g,100g,1kg/

High quality Olmesartan medoxomil intermediate Cas144689-93-0 with best price and good service

Cas:144689-93-0

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan

Ethyl-4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Cas:144689-93-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. As a leading manufacturer and supplier of chemicals in China, Day

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Cas:144689-93-0

Min.Order:1 Kilogram

FOB Price: $4.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

High quality Ethyl-4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-Carboxylate CAS NO.144689-93-0

Cas:144689-93-0

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

CHemwill -- Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Cas:144689-93-0

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

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Leader Biochemical Group

About Product Details

China Largest factory Manufacturer Supply Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate CAS 144689-93-0

Cas:144689-93-0

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate/ LIDE PHARMA- Factory supply / Best price

Cas:144689-93-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate cas 144689-93-0

Cas:144689-93-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity 鈮 9% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package can

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate CAS 144689-93-0

Cas:144689-93-0

Min.Order:1 Metric Ton

FOB Price: $5.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 144689-93-0 with fast shipping

Cas:144689-93-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: [5-(1-Hydroxyl-1-methylethyl)-2-propyl-imidazol-4-yl]carboxylic acid ethyl ester Synonyms: 4-(1-hydroxy-1-methylethyl)-2-propyl-1h-imidazole-5-carboxylic acid ethyl ester CAS: 144689-93-0 MF: C12H20N2O3 Appearance:White powder Storage:Store

[5-(1-Hydroxyl-1-methylethyl)-2-propyl-imidazol-4-yl]carboxylic acid ethyl ester

Cas:144689-93-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

1H-Imidazole-5-carboxylicacid, 4-(1-hydroxy-1-methylethyl)-2-propyl-, ethyl esterCAS NO.: 144689-93-0

Cas:144689-93-0

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:Pale yellow to off-white powder Storage:ln stock Package:25kg/Carton Application:Chemicals Transportation:Express/Sea/Air Port:Any port in china

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazo

Cas:144689-93-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Powder Storage:Store in sealed containers at co

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Imidazole-5-carboxylicacid, 4-(1-hydroxy-1-methylethyl)-2-propyl-, ethyl ester 144689-93-0

Cas:144689-93-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Cas:144689-93-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Cas:144689-93-0

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Olmesartan intermediate, Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate CAS:144689-93-0

Cas:144689-93-0

Min.Order:1 Kilogram

FOB Price: $62.0 / 67.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate CAS 144689-93-0 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate CAS 144689-93-0

Cas:144689-93-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Imidazole-5-carboxylicacid, 4-(1-hydroxy-1-methylethyl)-2-propyl-, ethyl ester

Cas:144689-93-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Ethyl 4-(1-Hydroxy-1-Methylethyl)-2-Propyl-Imidazole -5-Carboxylate

Cas:144689-93-0

Min.Order:0

Negotiable

Type:Manufacturers

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Cas:144689-93-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Triumph International Development Limilted

Appearance:Pale Yellow solid Storage:Sealed in dry,2-8°C Application:An Olmesartan (O550000) intermediate Port:QINGDAO

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Cas:144689-93-0

Min.Order:25 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Cas:144689-93-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Cas:144689-93-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

1H-Imidazole-4-carboxylic acid, 5-(1-hydroxy-1-methylethyl)-2-propyl-, ethyl ester

Cas:144689-93-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

4-(1-Hydroxy-1-Methylethyl)-2-Propyl-1H-Imidazole-5-Carboxylic Acid ethyl Ester/High quality/Best price

Cas:144689-93-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Synthetic route

methyl bromide
74-83-9

methyl bromide

2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
144689-94-1

2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
With iodine; magnesium In dichloromethane at 15 - 25℃; for 2h;97.5%
methylmagnesium bromide
75-16-1

methylmagnesium bromide

2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
144689-94-1

2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
In diethyl ether; dichloromethane at 10 - 15℃; for 1h;95%
ethanol
64-17-5

ethanol

C10H14N2O2
849206-42-4

C10H14N2O2

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
Stage #1: ethanol; C10H14N2O2 With sulfuric acid at 40 - 50℃;
Stage #2: With sodium hydrogencarbonate In water; ethyl acetate Product distribution / selectivity;
92%
methylmagnesium chloride
676-58-4

methylmagnesium chloride

2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
144689-94-1

2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
Stage #1: methylmagnesium chloride; diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate In tetrahydrofuran at -10 - 0℃; for 0.166667h;
Stage #2: With water; ammonium chloride In tetrahydrofuran; dichloromethane
85%
Stage #1: methylmagnesium chloride; diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate In tetrahydrofuran; toluene for 6.5h; Inert atmosphere; Cooling with ice;
Stage #2: With hydrogenchloride In tetrahydrofuran; water; toluene pH=7;
In tetrahydrofuran at 60℃; for 2h;4.81 g
4-(1-hydroxy-1-methylethyl)-2-propyl imidazole-5-carboxylic acid
144690-04-0

4-(1-hydroxy-1-methylethyl)-2-propyl imidazole-5-carboxylic acid

ethanol
64-17-5

ethanol

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
Stage #1: 4-(1-hydroxy-1-methylethyl)-2-propyl imidazole-5-carboxylic acid; ethanol With thionyl chloride Reflux;
Stage #2: With sodium hydrogencarbonate In water; ethyl acetate Product distribution / selectivity;
85%
methylene chloride
74-87-3

methylene chloride

2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
144689-94-1

2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
Stage #1: methylene chloride With magnesium In tetrahydrofuran for 0.5h; Reflux;
Stage #2: diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate In tetrahydrofuran at 30℃; for 2.5h; Solvent; Temperature;
80%
Stage #1: methylene chloride With magnesium at 55 - 60℃; for 1h; Inert atmosphere;
Stage #2: diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate at 0℃; for 8h;
2-propyl-1H-imidazole-4,5-dicarboxylic acid
58954-23-7

2-propyl-1H-imidazole-4,5-dicarboxylic acid

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 86 percent / HCl / Ambient temperature
2: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C
View Scheme
2-propylimidazole-4,5-dicarbonitrile
51802-42-7

2-propylimidazole-4,5-dicarbonitrile

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent / 6N aq. HCl / 8 h / Heating
2: 86 percent / HCl / Ambient temperature
3: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C
View Scheme
2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate
144689-94-1

2-propyl-1H-imidazole-4, 5-diethyl azodicarboxylate

A

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

B

ethyl 2-butyl-4-(1-hydroxy-1-methylethyl)imidazole-5-carboxylate
144689-92-9

ethyl 2-butyl-4-(1-hydroxy-1-methylethyl)imidazole-5-carboxylate

Conditions
ConditionsYield
With methylmagnesium bromide In tetrahydrofuran
diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate hydrochloride

diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate hydrochloride

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide; sodium chloride / water / 1 h / Cooling with ice
2.1: toluene; tetrahydrofuran / 6.5 h / Inert atmosphere; Cooling with ice
2.2: pH 7
View Scheme
4-(1-hydroxy-1-methylethyl)-2-propyl imidazole-5-carboxylic acid
144690-04-0

4-(1-hydroxy-1-methylethyl)-2-propyl imidazole-5-carboxylic acid

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dicyclohexyl-carbodiimide / acetone / 48 h / 20 °C
2: sodium hydroxide; water / acetone / Reflux
3: thionyl chloride / Reflux
View Scheme
C10H14N2O2
849206-42-4

C10H14N2O2

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide; water / acetone / Reflux
2: thionyl chloride / Reflux
View Scheme
5-[4'-(bromomethyl)[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-1H-tetrazole

5-[4'-(bromomethyl)[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-1H-tetrazole

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

trityl olmesartan medoxomil
144690-92-6

trityl olmesartan medoxomil

Conditions
ConditionsYield
Stage #1: 5-[4'-(bromomethyl)[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-1H-tetrazole; ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With tert-butylamine hydrobromide; potassium carbonate In acetone at 0 - 55℃; for 32h;
Stage #2: 4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one With potassium carbonate; potassium iodide In acetone at 20 - 55℃; for 3h;
98.5%
5-(2',3',5',6'-tetra-[2H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole
1330277-14-9

5-(2',3',5',6'-tetra-[2H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2',3',5',6'-tetra-[2H]-2'-(1-trithyl-1H-terazol-5-yl)-biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate
1420880-39-2

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2',3',5',6'-tetra-[2H]-2'-(1-trithyl-1H-terazol-5-yl)-biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
Stage #1: ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With potassium tert-butylate In N,N-dimethyl-formamide for 0.333333h; Cooling with ice;
Stage #2: 5-(2',3',5',6'-tetra-[2H]-4'-(bromomethyl)biphenyl-2-yl)-1-trityl-1H-tetrazole In N,N-dimethyl-formamide at 20℃; for 2.5h;
96.5%
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carbohydrazide

4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carbohydrazide

Conditions
ConditionsYield
With hydrazine hydrate In ethanol for 16h; Reflux;95.3%
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

4-(1-hydroxy-1-methylethyl)-2-propyl imidazole-5-carboxylic acid
144690-04-0

4-(1-hydroxy-1-methylethyl)-2-propyl imidazole-5-carboxylic acid

Conditions
ConditionsYield
Stage #1: ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With water; sodium hydroxide In acetone for 3h; Reflux;
Stage #2: With hydrogenchloride In water at 10℃; pH=6.5;
95%
With sodium hydroxide In water; acetone at 110℃; for 3h;82%
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate
144690-33-5

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With potassium carbonate In butanone at 60℃; for 2h;
Stage #2: With N,N-dimethyl acetamide In butanone at 45℃; for 4h;
93.8%
With tetrabutylammomium bromide; potassium carbonate In acetone at 50 - 60℃; for 20h; Green chemistry;90.7%
With potassium carbonate In acetonitrile for 7h; Heating / reflux;89%
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

A

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate
144690-33-5

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate

B

4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid
761404-85-7

4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid

C

C45H42N6O2

C45H42N6O2

Conditions
ConditionsYield
With potassium phosphate In N,N-dimethyl acetamide at 60 - 65℃; for 6h; Solvent; Reagent/catalyst;A 89.6%
B 0.02%
C 0.02%
1-bromomethyl-4-bromobenzene
589-15-1

1-bromomethyl-4-bromobenzene

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

3-(4-bromobenzyl)-5-(1-hydroxy-1-methylethyl)-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester
685091-51-4

3-(4-bromobenzyl)-5-(1-hydroxy-1-methylethyl)-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl acetamide at 20℃; for 18h; Product distribution / selectivity;89%
With potassium carbonate In DMA at 20℃; for 18h; Product distribution / selectivity;89%
With potassium carbonate In N,N-dimethyl acetamide for 48h;47%
With sodium hydride In N,N-dimethyl-formamide at 0℃; for 1.16667h; Product distribution / selectivity;45%
Stage #1: ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: 1-bromomethyl-4-bromobenzene In N,N-dimethyl-formamide for 1h; Product distribution / selectivity;
45%
2'-<2-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-methanol
135050-95-2

2'-<2-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-methanol

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate
172875-59-1

ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 10℃; for 0.5h; Reagent/catalyst; Solvent; Cooling with ice;89%
1-benzyl-5-[4'-(bromomethyl)biphenyl-2-yl]-1H-tetrazole

1-benzyl-5-[4'-(bromomethyl)biphenyl-2-yl]-1H-tetrazole

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

ethyl 1-{[2′-(1-benzyl-1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl}-4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylate

ethyl 1-{[2′-(1-benzyl-1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl}-4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 25 - 84℃; for 18h;83%
With potassium carbonate In acetonitrile at 84℃; for 18h;83.2%
With tetrabutylammomium bromide; potassium carbonate In acetone at 0 - 45℃; for 20.25h;165 g
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole
133051-88-4

N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate
172875-59-1

ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 20℃; for 24h;83%
With potassium tert-butylate 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h; Yield given. Multistep reaction;
Stage #1: ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole In N,N-dimethyl-formamide at 20 - 60℃; for 6h;
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate
172875-59-1

ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
Stage #1: ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With potassium carbonate; tetrabutylammomium bromide In acetone at 20℃; for 1h;
Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In acetone for 14h; Heating / reflux;
80%
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

4-bromomethylphenylboronic acid pinacol ester
138500-85-3

4-bromomethylphenylboronic acid pinacol ester

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-1H-imidazole-5-carboxylate

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
With potassium carbonate In acetone at 60℃; Sealed tube;64.9%
5-[4'-(chloromethyl)biphenyl-2-yl]-1-(2,4-dimethoxybenzyl)-1Htetrazole

5-[4'-(chloromethyl)biphenyl-2-yl]-1-(2,4-dimethoxybenzyl)-1Htetrazole

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

ethyl 1-({2'-[1-(2,4-dimethoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylate

ethyl 1-({2'-[1-(2,4-dimethoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)-4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In acetone at 0 - 65℃; for 89h;50%
4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester
114772-40-6

4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

ethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate
144689-20-3

ethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate

Conditions
ConditionsYield
With potassium tert-butylate 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h; Yield given. Multistep reaction;
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

ethyl 4-isopropenyl-2-propylimidazole-5-carboxylate
157356-73-5

ethyl 4-isopropenyl-2-propylimidazole-5-carboxylate

Conditions
ConditionsYield
With pyridine; trichlorophosphate 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h; Yield given. Multistep reaction;
1-(2-trimethylsilylethoxymethyl)-5-(4'-bromomethylbiphenyl-2-yl)-1H-tetrazole
1004758-90-0

1-(2-trimethylsilylethoxymethyl)-5-(4'-bromomethylbiphenyl-2-yl)-1H-tetrazole

2-(2-trimethylsilylethoxy)methyl-5-(4'-bromomethylbiphenyl-2-yl)-2H-tetrazole
1004758-92-2

2-(2-trimethylsilylethoxy)methyl-5-(4'-bromomethylbiphenyl-2-yl)-2H-tetrazole

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

A

ethyl 5-(1-hydroxy-1-methylethyl)-2-propyl-3-[[4-[2-(2-(2-trimethylsilylethoxymethyl)-2H-tetrazol-5-yl)phenyl]phenyl]methyl]-3H-imidazole-4-carboxylate

ethyl 5-(1-hydroxy-1-methylethyl)-2-propyl-3-[[4-[2-(2-(2-trimethylsilylethoxymethyl)-2H-tetrazol-5-yl)phenyl]phenyl]methyl]-3H-imidazole-4-carboxylate

B

ethyl 5-(1-hydroxy-1-methylethyl)-2-propyl-3-[[4-[2-(1-(2-trimethylsilylethoxymethyl)-1H-tetrazol-5-yl)phenyl]phenyl]methyl]-3H-imidazole-4-carboxylate

ethyl 5-(1-hydroxy-1-methylethyl)-2-propyl-3-[[4-[2-(1-(2-trimethylsilylethoxymethyl)-1H-tetrazol-5-yl)phenyl]phenyl]methyl]-3H-imidazole-4-carboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 17h;
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

ethyl 4-isopropyl-2-propylimidazole-5-carboxylate
172875-51-3

ethyl 4-isopropyl-2-propylimidazole-5-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h
2: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature
View Scheme
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-isopropyl-2-propyl-3H-imidazole-4-carboxylic acid

3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-isopropyl-2-propyl-3H-imidazole-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h
2: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature
3: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h
4: 82 percent / HCl / dioxane / 16 h / Ambient temperature
5: 100 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature
View Scheme
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-isopropenyl-2-propyl-3H-imidazole-4-carboxylic acid

3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-isopropenyl-2-propyl-3H-imidazole-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h
2: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h
3: 92 percent / HCl / dioxane / 16 h / Ambient temperature
4: 94 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature
View Scheme
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-isopropyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester
172875-76-2

3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-isopropyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h
2: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature
3: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h
4: 82 percent / HCl / dioxane / 16 h / Ambient temperature
View Scheme
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-isopropenyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester
172875-80-8

3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-isopropenyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h
2: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h
3: 92 percent / HCl / dioxane / 16 h / Ambient temperature
View Scheme
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

1-[(2'-carboxybiphenyl-4-yl)methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid

1-[(2'-carboxybiphenyl-4-yl)methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h
2: 92 percent / HCl / dioxane / 16 h / Ambient temperature
3: 91 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature
View Scheme
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

XF 818

XF 818

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1.) POCl3, 2.) pyridine / 1.) benzene, reflux, 1 h, 2.) benzene, reflux, 1 h
2: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature
3: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h
4: 93 percent / 25percent aq. AcOH / 2.5 h / 80 °C
5: 89 percent / LiOH*H2O / dioxane; H2O / 5 h / Ambient temperature
View Scheme
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