Attention Deficit Hyperactivity Disorder (ADHD) causes impaired visuospatial working memory (VWM), which primarily maps to the prefrontal cortex. However, little is known about the synaptic processes underlying cognitive loss in ADHD, or those ultimately involved in the preventive effect observe...

Background: Atteention-deficit/hyperactivity disorder (ADHD) occurs in ∼3% to 10% of the pediatric population. Most of the drugs typically used to treat ADHD are stimulants, which, because of their addictive properties and potential for abuse, are controlled substances. Although these drugs are...

The development of an ion-pairing HPLC method and associated system suitability parameters for the analysis of atomoxetine hydrochloride (LY139603 HCl) using a quality by design approach is described. Potential method conditions were evaluated for their ability to meet design requirements and st...

Two benzoic acid derivatives, methoxybenzoic acid (MOBA) and formylbenzoic acid (FBA), on whose benzene ring, an electron-donating substituent group (methoxy group) and an electron-withdrawing substituent group (formyl group) exist, respectively, were bonded onto the side chains of polystyrene (...

A series of aryloxy organotin compounds Ph3Sn(CH2)3OC6H4R (5: R = H; 6: R = Ph; 7: R = OCH3, 8: R = CF3), Ph2ClSn(CH2)3OC6H4R (9: R = H; 10: R = Ph) and PhCl2Sn(CH2)3OC6H4R (12: R = H; 13: R = Ph) have been synthesized and characterised by NMR (1H, 13C, 119Sn) spectroscopy. X-ray structure deter...

This study revealed that the existence of heterojunction of ZrTiO4/ZrTi2O6/TiO2 in the photocatalyst system has significantly enhanced the photodegradation of paraquat dichloride with respect to the increment of it thermal stability as shown in the XRD and XPS analyses. Several parameters such a...

Neutral complexes with generic formula [PtCl2(PPh3)(L)] were efficiently oxidized to [PtCl4(PPh3)(L)] (L = dibenzylamine, p-toluidine, diethanolamine, pyridine and acetonitrile) using PhICl2 The anionic complex [TBA][PtCl3(PPh3)] (TBA = Tetrabutylammonium) was also oxidized to [TBA][PtCl5(PPh3)]...

Human sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacylase, and is implicated in human diseases including cancer. Selective small-molecule inhibitors for SIRT2 are sought as chemical tools and potential therapeutics. Here we report the X-ray crystal structure guide...

The reaction of 2-(2-oxo-1,2-diphenyl)ethoxy- and 2-(2-methylcarbonyl)phenyloxybenzo[d]-1,3,2-dioxaphospholes with diethyl acetylenedicarboxylate was used to synthesise 5,6-bis(ethoxycarbonyl)-3,4-diphenyl-1,1-phenylenedioxy-1-phospha-2,7-dioxabicyclo[2.2.11,4]hept-5-ene and 5-methyl-6,7-bis(eth...

Reaction of 5-substituted (Z)-2-en-4-ynoic acids with iodine and NaHCO3 in CH3CN or with ICl in CH2Cl2 affords mixtures of (E)-5-(1-iodoylidene)-2(5H)-furanones and 6-substituted 5-iodo-2(2H)-pyranones in which these last compounds are the major products. The 5-iodo-2(2H)-pyranones, which are ea...

New measurements of the viscosity of three ionic liquids (ILs), 1-ethyl-3-methylimidazoliumethylsulfate, 1-butyl-3-methylpyridinium bis(trifluoromethylsulfonyl)imide and butyltrimethylammonium bis(trifluoromethylsulfonyl)imide were carried out in two laboratories by using three different devices...

Enantioselectivity in separation and toxicity of chiral pesticides has become important research areas in environmental science, because these studies give a deeper insight into the environmental effect of chiral pesticides. In this study, enantiomeric separation of the organophosphorus pesticid...

The structure–activity relationships (SARs) of acylthiocarbamates (ATCs), a new class of non-nucleoside HIV-1 reverse transcriptase inhibitors, have been expanded. Sixty-six new analogues were prepared by parallel solution-phase synthesis. In general, the potency of new ATCs was better than tha...

A sensitive and selective high-performance liquid chromatographic method has been developed and validated for the determination of nateglinide in human plasma. Nateglinide and the internal standard, undecylenic acid, were extracted from plasma by liquid–liquid extraction using a mixture of ethy...

To better understand mechanisms for the growth of polycyclic aromatic hydrocarbons (PAH) under conditions relevant to the pre-combustion environments of future-high-speed-aircraft fuels, we have performed supercritical pyrolysis experiments with the model fuel n-decane, to which 1-methylphenanth...

4-Quinolylmethyl (4-QUI) esters are reduced by palladium-catalyzed hydrogenolysis by formate anion. The reaction conditions are compatible with reducible substituents or functional groups as aromatic bromo, alkene, aldehyde, ketone, nitrile, ethyl and benzyl esters. An allyl ester is cleaved sel...

In order to investigate growth mechanisms of polycyclic aromatic hydrocarbons (PAH) that can lead to solids formation in the pre-combustion environments of future high-speed aircraft, we have performed supercritical pyrolysis experiments with the model alkane fuel n-decane (critical temperature,...

Intramolecular excimer formation of poly(1-naphthylmethyl methacrylate) and a series of 1-naphthylmethyl methacrylate/methyl methacrylate copolymers has been investigated using steady-state fluorescence spectroscopy and the time-correlated single-photon counting technique. A linear relationship ...

A series of 6-naphthylmethyl substituted S-alkylated dihydroalkoxybenzyloxopyrimidine (S-DABO) analogues with a β-carbonyl group on the C-2 side chain were synthesized. All of the new compounds were evaluated for their anti-HIV activities in MT-4 cells. The most active compound, 5-isopropyl-2-[...

An efficient route for the synthesis of substituted naphthalenes, phenanthrenes and other polynuclear aromatic hydrocarbons has been developed. The methodology involves 1,2- (or sequential 1,4- and 1,2-) addition of either benzyl, 1-(naphthylmethyl) or 2-(naphthylmethyl) magnesium halides to α-...