A method for the determination of methylmalonic acid in urine has been developed. The method consists of essentially two operations: (1) A separation of methylmalonic acid from most of the urinary components by ion-exchange chromatography. (2) A gas chromatographic determination of methylmalonic...

In this study, we have investigated the supramolecular pattern in two dicarboxylic acids, namely isopropylmalonic acid (1) and n-butylmalonic acid (2), via the presence of different hydrogen bonding patterns and aliphatic chains associated with the respective acids. The crystal structure is form...

The in vitro metabolism of an inverse agonist of the peripheral cannabinoid receptor (CB2), indomethacin morpholinylamide (BML-190), has been characterized using rat liver microsomal incubation. BML-190 was found to yield at least 15 metabolic products as identified by HPLC–MS/MS analysis. Four...

The aminoalkylindole BML-190 and diarylpyrazole AM251 ligands have previously been shown to bind to cannabinoid CB2 and CB1 receptors, respectively. In HEK-293 cells stably expressing the human CB2 receptor, BML-190 and AM251 potentiated the forskolin-stimulated accumulation of cAMP. Moreover, t...

Tetraethylene glycol dimethyl ether (tetraglyme) was used for the first time to induce the activation of silver nitrate resulting in the step-by-step formation of complexes with diallyldiphenylsilane (DADPS). Two crystal compounds of this series were examined by FTIR spectroscopy and X-ray diffr...

The cis and trans-methyl-1-(4-hydroxy-3-methoxyphenyl)-1,2,3,4-tetrahydro-9H-β-carboline-3-carboxylates were prepared and 1H and 13C NMR spectra were recorded for both isomers. Conformational and NBO analysis were carried out for the cis and trans isomers. Conformer structures were pre-optimize...

1,4-Diaza-8,8,8-trimethoxy-8-silaoctane (1) loses methanol upon heating and gives an eight-membered silatrane-like silaheterocyle, 1,6-diaza-2,2-dimethoxy-2-silacyclooctane (2).

The present study covers equilibrium solubilities of a homologous series of 1,4-bis-(alkylamino)-9,10-anthraquinones (with alkyl from methyl to octadecyl) and additionally of the more polar anthraquinone derivatives 1-amino-4-hydroxy-2-phenoxy-9,10-anthraquinone (C. I. Disperse Red 60) and 1,4-d...

Indirubin, an active component in the traditional Chinese medicine formula Danggui Longhui Wan, shows promising anticancer effects. Meisoindigo is an analog derived from indirubin, which is less toxic and appears to be even more potent against cancer. In considering meisoindigo as a structural t...

The title compound potentially can exist as four isomers in solution. Recently Lycka has proposed a protocol for distinguishing two of them based on 15N NMR. This approach has been confirmed theoretically, in the current study, and further developed into a logical scheme that allows the existenc...

Thiourea methyl-derivatives photocatalytic degradation has been studied by adopting titanium dioxide as a photocatalyst. A combined study has been performed and had involved: (1) the study of (methyl)thioureas degradation rate; (2) the identification of intermediate compounds, obtained by HPLC t...

Four novel C2-symmetric enantiomerically pure, chiral pyridine-18-crown-6 type macrocycles containing lipophilic chains at the stereogenic centers were prepared. The enantioselectivity of the new ligands toward the enantiomers of d-,l-amino acid methyl ester derivatives were also determined by 1...

Publisher SummaryThis chapter discusses the physical properties, synthesis, stability, metabolism and pharmacokinetics, and method of the analysis of phenylpropanolamine hydrochloride. Phenylpropanolamine hydrochloride belongs to the sympathomimetic amine class of drugs and is structurally relat...

A capillary electrophoresis method was developed and validated for the determination of the purity of dapoxetine with regard to the related substances (3S)-3-amino-3-phenylpropan-1-ol, (3S)-3-(dimethylamino)-3-phenylpropan-1-ol, 1-naphthol and the enantiomer (R)-dapoxetine. The separation was ba...

Two diastereoselective, scaleable routes towards trans-3,4-disubstituted piperidines with a 4-hydroxymethyl-3-hydroxy or 4-aminomethyl-3-hydroxy substitution pattern are being described. In the first route, the 3,4-trans configuration was introduced regio- and diastereoselectively via a hydrobor...

The preparation and properties of the copper(II) complex Cu(MK-H)2·2H2O are reported for the anti- inflammatory drug 2-aminomethyl-4(1,1-dimethylethyl) -6-iodophenol (MK-447). The diffuse reflectance spectra and magnetic moments are consistent with a tetragonally distorted pseudo-octahedral env...

Some new compounds of 6,7-dimethyl-2,3-di(2-pyridyl)quinoxaline with cobalt(II), nickel(II), copper(II) and zinc(II) have been prepared in toluene. The cobalt and zinc compounds have tetrahedral structures while the nickel and copper complexes have octahedral structures. The thermal behaviour of...

Syntheses, structures, and magnetic properties of two dicyanamide (dca) bridged compounds of manganese(II), [MnII(DMeDPQ)(μ1,5-dca)2]n (1) and [Mn2II(TPT)2(μ1,5-dca)2(H2O)2](ClO4)2(2), have been described (DMeDPQ = 6,7-dimethyl-2,3-di(2-pyridyl)quinoxaline; TPT = 2,4,6-tri(2-pyridyl)-1,3,5-tri...

The assisted transfer of Cu(II) by interfacial complexation with 6,7-dimethyl-2,3-di(2-pyridyl)quinoxaline (DMDPQ) is studied at the polarised water|1,2-dichloroethane junction. Thermodynamic and kinetic aspects were addressed by cyclic voltammetry and in situ spectrophotometric measurements. Th...

An approach to combine the advantages of random and of focused combinatorial libraries in pharmaceutical research is described with the example of a solid phase synthesis of 2,5-disubstituted thiadiazole ethers. Key steps of synthesis are the introduction of the heterocycle by selective, sequent...