The impact of the chip design and the mixing mechanisms using six different 3D printed microfluidic chips were investigated. The study was conducted using novel 3D printed droplet based microfluidics. A multi-mixing approach was utilized to enhance the CL signal of the CL system under investigat...

Biomaterials based on peptide-coupled alginates must provide both optimal biological environments and tuneable stability/degradation profiles. The present work investigates the degradation pattern and kinetics of peptide-coupled alginates prepared via the periodate oxidation reductive amination ...

A modified analytical method was developed which can accurately quantitate calcium gluconate and its pharmaceutical preparations in the presence of other calcium compounds or other cations able to complex with EDTA. The proposed method was based on the principle of the Malaprade reaction, accord...

The birch cellulose is effectively oxidized to the dialdehyde cellulose (DAC) at elevated temperatures by sodium periodate. Even though periodate decomposes at 55 °C and above with time, higher temperatures can be used if the oxidation time is sufficiently short and it has now been shown that t...

Limited periodate oxidation (0–8%) of alginates results in enhanced degradability, extending the range of applications of alginates as biomaterials, e.g. in tissue engineering. Oxidation produces dialdehydes that are highly sensitive to alkaline β-elimination, even under physiological conditio...

A series of 4-nitrophenyl (pNP) and 4-methylumbelliferyl (4MU) substrate analogues of phosphatidyl choline (PC) and phosphatidic acid (PA) were synthesized from 4-bromo-1-butene by ether formation, olefin epoxidation and ring opening with the phosphate head group. The pNP PC analogue, 4-(4-nitro...

Periodate salts are being developed as potential replacements for perchlorate due to potential health hazards associated with exposure to perchlorate. The aim of this study was to investigate acute and subacute effects of periodate salts in rats. Acute oral toxicity of potassium and sodium perio...

2-Phenyl-5-(1-propynyl)thiophene (1), isolated from Coreopsis grandiflora, and 2-(1-propynyl)thiophene (5), an immediate precursor in the synthesis of junipal (2), were synthesized in high yield by a Pd-catalyzed reaction between propyne and 2-iodo-5-phenylthiophene (4) or 2-iodothiophene (6), r...

Marein, flavanomarein and taxifolin-7-O-β-D-glucopyranoside (TDG) are functional compounds in capitula of Coreopsis tinctoria (CCT). This study demonstrated the above glycosides could be partially deglycosylated to okanin, isookanin and taxifolin, respectively, in cell free extracts from rat an...

Hydnocarpus alpina Wt. (Flacourtiaceae) (H. alpina) is a large tree traditionally used to treat leprosy; it also posses antidiabetic property. The present study was undertaken to isolate, characterize and to evaluate the antidiabetic effect of 2R, 3R taxifolin 3-O-rhamnoside. (rhamnoside) and it...

Variously substituted 2-hydroxy-N-(arylalkyl)benzamides were prepared and screened for antiproliferative and cytotoxic activity in cancer cell lines in vitro. Five compounds, out of 33 showed single-digit micromolar IC50 values against several human cancer cell lines. One of the most potent comp...

This paper describes the synthesis of new enantiomerically pure 2-cyanoethyl-oxazolines in one step starting from a wide range of amino alcohols and 4-ethoxy-4-iminobutanenitrile with high to good yields (73–96%) via an appropriate procedure which can be used for a selective synthesis of mono-o...

Pretreatment of tobacco callus (Nicotiana tabacum L.) with glyphosate and related compounds promoted to a different degree the metabolism of radiolabeled indole-3-acetic acid ([2-14C]IAA) by increasing both conjugation and oxidation, and consequently lowered the level of free [2-14C]IAA. At iden...

Indole-3-acetic acid (IAA) or an oxidative metabolite is believed to be a growth hormone in plants. IAA is also found in the mammalian central nervous system although its biological roles, if any, are presently unknown. In this investigation the electrochemically driven and peroxidase/O2-mediate...

In the present work, a combined experimental and theoretical study on ground state molecular structure, spectroscopic and nonlinear optical properties of the chalcone derivative 3-(2-Chloro-6-fluorophenyl)-1-(2-thienyl) prop-2-en-1-one (2C6F2SC) is reported. Initial geometry generated from singl...

The 4-methoxybenzyl (MPM) protecting group for hydroxy functions is readily removed with DDQ in dichloromethane containing a small amount of water at room temperature. Under these neutral conditions, several other protecting and functional groups remained unchanged. 3,4-Dimethoxybenzyl (DMPM) gr...

The 3,4-dimethoxybenzyl group has been used to protect 2-imino-imidazolidine derivatives, so we could realize selective O-alkylation, to obtain new clonidine derivatives.

Synthesis of a series of 3,6-disubstituted-bis-1,2,4-triazolo-[4,3-b][3′,4′-f]pyridazines (4) was accomplished by the oxidative intramolecular cyclization of 6-arylidenehydrazino-3-aryl-1,2,4-triazolo[4,3-b]pyridazine (3) using iodobenzene diacetate (IBD), as a green oxidant, in dichloromethan...

7-Chloro-9-(2'-chlorophenyl)-2,3-dihydroacridin-4(1H)-one (3a) and 7-chloro-9-(2'-fluorophenyl)-2,3-dihydroacridin-4-(1H)-one (3b) were synthesized from 2-amino-2′,5-dichlorobenzophenone (1a) and 2-amino-5-chloro-2'-fluorobenzophenone (1b) respectively with 1,2-cyclohexanedione (...

The reaction of testosterone-17β-acetate (3) with heptafluorobutyric anhydride in high purity and anhydrous acetone at room temperature leads to the preferential formation of 1 with less than 1% of the isomeric 2,4-diene. The reaction is pseudo-unimolecular and after 30 min, 99% of the starting...