The effects of inhaled D-D (1,3-dichloropropene/1,2-dichloropropane) on reproduction were studied in rats of both sexes. The rats inhaled nominal concentrations of 0, 10, 30, or 90 ppm (v/v) D-D for 6 hr/day, 5 days/week for 10 weeks. Treated males of proven fertility were paired with untreated ...

Eicosanoids play crucial roles in mediating insect immune responses. In vertebrates, phospholipase A2 (PLA2) releases arachidonic acid (AA) from phospholipids (PLs) for biosynthesis of various eicosanoids. However, little AA is found in PLs of lepidopteran insects. Spodoptera exigua, a lepidopte...

Oocyte quality is closely related to female fertility. Nevertheless, core nutritional metabolites influencing oocyte quality are unclear. Herein, comprehensive metabolomics analysis of follicular fluid, serum, and urine from low reproductive performance (LRP) and normal reproductive performance ...

In the western diet there is an oversupply of n-6 fatty acids. This adverse trend can be balanced by the consumption of rapeseed and flaxseed oils rich in α-linolenic acid (n-3). However, the high share of this fatty acid contributes to low oxidative stability of oil. Oxidation decreases n-3 fa...

The effect of 20 fatty acids in erythrocyte cell membranes on the extent of inflammatory response and cell oxidative stress was evaluated using multidimensional statistical data analysis in 54 patients suffering from ischemic heart disease undergoing percutaneous coronary intervention with coron...

γ-aminobutyric acid (GABA) is a free amino acid, which helps to counteract biotic and abiotic stresses in plants. In the present study, two concentrations of GABA, i.e., 0.5 mM and 1 mM were applied to examine the tolerance of rice seedlings against As(III) (25 µM) toxicity, through the modula...

A new technique—photoacoustic spectroscopy (PAS—was applied for the study of the electronic transitions in three isomers, 2,3-, 2,4- and 2,5-dimethylbenzonitriles. The PAS spectra were compared with solution and vapour phase spectra. A probable detection of S → T absorption in the molecules i...

The FT-IR and FT-Raman spectra of N-(3-iodo-4-methylphenyl)pyrazine-2-carboxamide were recorded and the experimentally observed wavenumbers are compared with the theoretically obtained wavenumbers. The redshift of the NH stretching mode in the IR spectrum from the computed value indicated the we...

In this study, the reaction conditions of poly-4-[(2-methylphenyl)iminomethyl]phenol (P-2-MPIMP) were studied by using oxidants such as air O2, H2O2 and NaOCl in an aqueous alkaline medium between 50 and 90 °C. The structures of the synthesized monomer and polymer were confirmed by FT-IR, UV–v...

To visualize fatty acid amide hydrolase (FAAH) in brain in vivo, we developed a novel positron emission tomography (PET) ligand N-(3,4-dimethylisoxazol-5-yl)piperazine-4-[4-(2-fluoro-4-[11C]methylphenyl)thiazol-2-yl]-1-carboxamide ([11C]DFMC, [11C]1). DFMC (1) was shown to have high binding affi...

A specific enzyme immunoassay (EIA) has been developed for 4-hydroxy-2-(4-methylphenyl)benzothiazole (KB-2714) (1), an active metabolite of 4-acetoxy-2-(4-methylphenyl)benzothiazole (KB-2683) (2) which is a promising anti-rheumatic agent. The EIA was based upon antiserum elicited against 5-(2-ca...

To search for novel compounds with potent anti-angiogenic activity, a series of N1-(substituted benzyl)-3-(4-methylphenyl)-1H-indazoles (16, 18, 20, 22, 24, 26, 28, 30, 32) and N2-(substituted benzyl)-3-(4-methylphenyl)-2H-indazoles (17, 19, 21, 23, 25, 27, 29, 31, and 33) were synthesized. The ...

Reaction of a bulky Schiff base, 2,6-dibenzhydryl-N-4-((2,6-dibenzhydryl-4-methylphenyl)imino)pent-2-en-2-yl)-4-methylaniline (Ar2NacNacH (Ar = 2,6-dibenzhydryl-4-methylphenyl)) with PdCl2 in toluene under reflux condition affords dinuclear [(Ar2NacNac)Pd (μ-Cl)]2 (1). Complex 1 upon crystalliz...

Organic compound (4-hydroxypiperidin-1-yl)(4-methylphenyl) methanone[HPMP] with molecular formula C13H17N O2 was synthesized using Scholten-Boumann condensation reaction method. The single crystals were grown using slow evaporation solution growth technique. Single crystal XRD study shows that t...

Five novel 1H-pyrrolo[2,3-b]pyridine or 1H-pyrazolo[3,4-b]pyridine derivatives, with a methylene, sulfur, sulfoxide or cyclopropyl group as a linker, were designed, synthesized and biologically evaluated against c-Met and ALK. The development of these methods of compound synthesis may provide an...

A New and efficient magnetic nanocatalyst has been fabricated via covalent grafting of an aza-crown ether Cu(II) complex on silica coated iron oxide support. The above mentioned magnetic nanocatalyst has been characterized by various techniques such as SEM, TEM, XRD, FT-IR, TGA and ICP. After pr...

A new glycosyl donor possessing an anomeric O-(1-phenyltetrazol-5-yl) group is prepared from 2,3,4,6-tetra- O-benzyl-d-glucose (2) and commercially available 5-chloro-1-phenyl-1H-tetrazole (1). The synthesis of glycosides derived from the donor and a few primary and secondary alcohols is reported.

During the cyclization reaction of benzyl alcohol containing amides, using NaN3 and SiCl4, additional unique chlorination development was observed to yield the novel azoles 1-[4-chloromethylphenyl]-5-[4-(methylsulfonyl)benzyl]-1H-tetrazole (3a) and 1-[4-chloromethylphenyl]-5-[4-(aminosulfonyl)ph...

A promising Mg-Zn-Y alloy with the long-period stacking ordered (LPSO) second phase has been developed for about twenty years. Because the LPSO phase has the unique 18R crystal structure, particularly for its packing sequence along [0001], as well as it plays an important role in strengthening m...

Cu-Zn-Al shape-memory alloy single crystals can have two sequential, stress-induced martensitic transitions, depending on their chemical composition and crystallographic orientation: first, the β-18R transition and, as the load increases, the 18R-6R transition. At electronic concentration e/a=1...