The preparation of infrared windows grade zinc selenide (ZnSe) by the reactive diffusion process between liquid zinc and selenium was the goal of present work. In this regards, high purity zinc and Se elements with a nominal composition of Zn50Se50 were capsulated in quartz ampoule and annealed ...

This article presents synthetic strategies of different phases and morphologies of nickel selenide in terms of solid state reactions, solvothermal and hydrothermal processes, electrodeposition, precipitation reactions, colloidal synthesis, chemical bath deposition, chemical vapor deposition, sol...

Dirhodium(II)-catalyzed oxonium ylide formation–[2,3]-sigmatropic rearrangement of 6-allyloxy-2-diazo-3-ketoesters possessing a C-6 substituent is described. The reaction of 6-alkyl- or 6-aryl-substituted 6-allyloxy-2-diazo-3-ketoesters with a catalytic amount of Rh2(S-PTTL)4 proceeded in a che...

Phosphoniosilylation of α,β-enones with TBSOTf and triphenyl-phosphine at 0 °C affords 3-tert-butyldimethylsilyloxyalk-2-enylphosphonium salts, which undergo facile nucleophilic substitution with various nucleophiles to give 3-substituted silyl enol ethers in good yields.

Tert-butyl and tert-amyl ethers afford the corresponding tert-butyldimethylsilyl ethers when treated by one equivalent of tert-butyldimethylsilyl triflate (TBDMSOTf), followed by one equivalent of 2,6-lutidine. However, treatment by a catalytic amount of TBDMSOTf without base, led to the corresp...

Reaction of (S)-2-benzenesulfonyl-4-(tert-butyldimethylsilyloxy)-2-cyclopentenone (2) and a 2-methoxycarbonyl congener (3) with R2CuLi or RMgBr-CuI stereoselectively gave (2S,3R,4S)-3-alkyl-2-benzenesulfonyl-4-(tert-butyldimethylsilyloxy)cyclopentanone (4) and its (2S,3S,4S)-2-methoxycarbonyl de...

Conjugate addition of the homochiral ammonia equivalent lithium N-tert-butyldimethylsilyloxy-N-(α-methylbenzyl)amide to a range of α,β-unsaturated esters gives the corresponding β-amino esters in moderate to good levels of diastereoselectivity. O-Desilylation and cyclisation furnishes homoch...

Titanium-mediated aldol reactions based on (S)-2-tert-butyldimethylsilyloxy-3-pentanone, a lactate-derived chiral ketone, provide the corresponding 2,4-syn-4,5-syn adducts in high yields and diastereomeric ratios with a wide array of achiral and chiral aldehydes. Furthermore, spectroscopic studi...

Herein we report the asymmetric synthesis of (3S)-(tert-butyldimethylsilyloxy)methylcyclopentan-1-one (S)-3 as a practical chiral synthon for a wide range of pharmaceutical and/or natural products, using Lipshutz’s asymmetric copper-catalyzed conjugate reduction. This method makes it feasible t...

Squamulosone (aromadendr-1(10)-en-9-one), isolated in large quantity from the plant Hyptis verticillata Jacq. (Labiatae), was incubated with the fungus Curvularia lunata ATCC 12017 in two different growth media. Six metabolites were isolated from each medium, with five of the products being comm...

The analogs of N-[4-(piperazin-1-yl)phenyl]cinnamamide were designed and synthesized by molecular hybridization approach in which part C of the designed molecule was linked through amide and carbamate functionality that improves the physicochemical properties and govern the pharmacokinetic and p...

A new series of derivatives of 3-(7-chloro-5-(2-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanoic acid were designed and synthesized as analgesic modulating for Transient receptor potential vanilloid 1. They were investigated for TRPV1 antagonistic activity in vitro, analge...

The Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA) catalyzes hydride transfer to long-chain enoyl thioester substrates. MtInhA is a member of the mycobacterial type II dissociated fatty acid biosynthesis system, and is the bona fide target for isoniazid, ...

Molecular structure and conformational equilibria of 1-methoxy- 1 and 1-hydroxy-1-phenylsilacyclohexanes 2 were studied by quantum chemical (QC) calculations and combined gas electron diffraction/mass spectrometry (GED/MS). Both molecules may exist in 5 or 6 forms, differing from each other by t...

Aberrant activation of the Wnt/β-catenin has been shown to promote progression in various cancers, including ovarian cancer. However, the molecular mechanisms involved in Wnt/β-catenin activation are not well elucidated. In the work, we identify that R-spondin 1 is an upstream regulator in Wnt...

(R)-3-amino-1-butanol is a key intermediate of Dolutegravir for the treatment of HIV/AIDS and its green and efficient biosynthesis has attracted a great deal of attention. Transaminases are currently used as promising biocatalyst for the synthesis of chiral amines. However, many transaminases ha...

In this investigation the synthesis of diazenylthiazoles (3a-e) by the reaction of arylthiosemicarbazides with ω-bromoacetophenones via Eschenmoser-coupling reaction in acetonitrile and equimolar amounts of triethylamine and triphenylphosphine. Upon heating 1,4-disubstituted thiosemicarbazides ...

Syntheses of 5-nitro-2-(2-phenylhydrazinyl)pyridine (5-nitro-2-phenylhydrazopyridine), 3-methyl-5-nitro-2-(2-phenylhydrazinyl)pyridine (3-methyl-5-nitro-2-phenylhydrazopyridine), 4-methyl-5-nitro-2-(2-phenylhydrazinyl)pyridine (4-methyl-5-nitro-2-phenylhydrazopyridine) and 6-methyl-5-nitro-2-(2-...

Aryl radicals, generated by the reaction of aryl bromide with tributyltinhydride and AIBN, have been coupled intramolecularly to an aryl ring.

A new synthesis of aporphines by tributyltinhydride-induced intramolecular radical cyclization of bromobenzylisoquinolines is described. This route to aporphines also allowed the first total synthesis of a 5-oxoaporphine.