Seven new copper(I) complexes containing 3-amino-5,6-dimethyl-1,2,4-triazine (ADMT), [Cu(μ-Cl)(ADMT)(PPh3)]2 (1), [Cu(μ-NCS)(ADMT)(PPh3)]2 (2), [Cu(ADMT)(PPh3)2Cl] (3), [Cu(ADMT)(PPh3)2Br] (4), [Cu(μ-Cl)(ADMT)(AsPh3)]2 (5), [Cu(μ-Br)(ADMT)(AsPh3)]2 (6) and [Cu(ADMT)(AsPh3)2I] (7) have been s...

A series of pyrazoles and pyrazolo[3,4-d]pyridazinones were synthesized and evaluated for their PDE4 inhibitory activity. All the pyrazoles were found devoid of activity, whereas some of the novel pyrazolo[3,4-d]pyridazinones showed good activity as PDE4 inhibitors. The most potent compounds in ...

The synthesis of a series of 2-phenyl- and 2-(p-chlorophenyl)imidazo[1,2-a]pyrazine-3-carboxylic esters and acids is described. The structures of the new compounds were supported by 1H- and 13C-NMR spectra. These compounds were evaluated in vivo for their antiinflammatory and analgesic activitie...

The identification and optimization of a novel series of centrally efficacious gamma secretase modulators (GSMs) offering an alternative to the privileged aryl imidazole motif is described. Chiral bicyclic tetrahydroindazolyl amine substituted triazolopyridines were identified as structurally di...

α-(Trifluoromethyl)phenylacetic acid (1) was synthesized in good overall yield starting from the cyanohydrin of ααα-trifluoroaceto-phenone, via hydrogenolysis of α-mesyloxy-α-(trifluoromethyl)phenylacetamide or ethyl α-mesyloxy-α-(trifluoromethyl)phenylacetate followed by acidic hydrolysis.

The cysteine protease, falcipain-2 is an important drug target in human malaria parasite Plasmodium falciparum. A new series of 2-(4-(substituted benzoyl)-1,4-diazepan-1-yl)-N-phenylacetamide derivatives 5(a–t) were designed as per pharmacophoric requirements of falcipain-2 inhibitors using lig...

The absolute configuration of 5-chloro-2-methoxy-N-phenylbenzamide single crystal [compound (1)] and the effect of introducing –[CH2]n–, n = 1,2 group adjacent to the amide group [compounds (2) and (3)], were studied. Furthermore, the replacement of the methoxy group with a hydroxy group [comp...

A small library of novel 3H-imidazo[4,5-b]pyridine and 1H-imidazo[4,5-c]pyridine derivatives was designed and synthesized as non-sulfonamide 5-HT6 receptor ligands. In vitro evaluation allowed to identify compound 17 (2-ethyl-3-(3-fluorobenzyl)-7-(piperazin-1-yl)-3H-imidazo[4,5-b]pyridine) as po...

In the last few years, cannabinoid type-2 receptor (CB2R) selective ligands have shown a great potential as novel therapeutic drugs in several diseases. With the aim of discovering new selective cannabinoid ligands, a series of pyridazinone-4-carboxamides was designed and synthesized, and the ne...

A mild and efficient copper-mediated trifluoromethylthiolation of acid chlorides using (bpy)CuSCF3 has been developed. A wide range of S-trifluoromethyl esters were synthesized in good to excellent yields and various functional groups, including cyano, ether, ester, halide, nitro, et al. were we...

The increasing international interest in contemporary architecture has drawn attention to the numerous listed buildings made of reinforced concrete in Europe, and especially in France. The main source of deterioration of this cultural heritage is the corrosion of rebars through carbonation or ch...

Destabilization and release of bound chlorides in reinforced concrete structures (RCS) cause accelerated corrosion of steel bars, posing an attendant risk to the durability of the whole structure. This problem is exacerbated by an aggressive environment where chloride and sulfate coexist, and st...

The effects of curing temperature (20 °C or 38 °C), slag composition and slag content on the hydration and chloride binding characteristics of ground granulated blast-furnace slag (ggbs) – blended cements have been studied. Two slags (CaO/SiO2 = 1.05 or 0.94) were each blended with CEM I 52.5...

This paper presents a new chloride diffusion model for concrete exposed to marine environment, which considers the effects of different types of chloride binding. The present model has following new features. (1) The bound chlorides are divided into two types. One is reversible, which is related...

The first weakly coordinating anion (WCA) with reactive p-block cation (rPBC) type of [(Bi4Cl16)4-{(LSeSeL)2+}2], L = 1,3-bis(2-benzhydryl-4,6-dimethylphenyl)-1H-imidazole-2(3H), ion pair is reported. The tetranuclear anionic bismuth(III) cluster shows a new type of ladder structure with two dif...

The binding of admixed chlorides in the concrete can delay the corrosion of reinforcing steel and extend the service life of reinforced concrete structures. Although extensive research has been conducted to study the chloride binding capacity of cementitious systems subject to external chlorides...

Passive films on duplex stainless steels are heterogeneous, with properties depending on the two-phase microstructure. Accordingly, the interaction of chloride ions with the passive films on either of the two phases ought to vary. These issues have been investigated by some indirect methods, not...

This paper investigated the effect of electric current on the stability of bound chlorides and dissected its underlying mechanisms. The results showed that at the early stage of electrochemical desalination, increasing the current density decreased both the residual free chloride concentration a...

Alkali activated cementitious material (AACM) concrete and conventional concrete specimens of similar strength, developed for structural applications, were exposed to a 5% NaCl solution. Bound chloride concentrations (water and acid soluble) were determined up to 270 days of chloride exposure. C...

In this work a method of estimation of sublimation enthalpies of benzoic acid derivatives and aromatic or heteroaromatic carboxylic acids was developed. The method is based on calculation of sublimation enthalpy from fusion enthalpy of studied compound and of benzoic acid at corresponding meltin...