Convenient and efficient syntheses of ethyl 4-(3-hydroxy-4-methoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate (1d) and 10-(3,4-dimethoxyphenyl)-7,8-dimethoxy-2H-pyridazino[4,5-b]quinolin-1-one (1e), metabolites of TAK-603 (1), have been achieved. Use of the methanes...

(3,4-Dimethoxyphenyl)(2,3,4-trimethoxyphenyl)methanone was synthesized and its bromination was investigated in different conditions. Nine new products (bromophenol derivatives) were isolated in the reactions. These bromophenol derivatives were obtained by selective O-demethylation in its bromina...

From the microbiological reduction of ethyl 3-oxo-3-(3,4-dimethoxyphenyl)-propionate, (+)-(3R)-ethyl 3-hydroxy-3-(3,4-dimethoxyphenyl)propionate was prepared on a quantitative scale. The absolute configuration was assigned by X-ray structural determination of the crystallized camphanate derivative.

In Hungary, N-ethyl-hexedrone (NEH) was the most frequently seized stimulant designer drug in 2017, while among synthetic cannabinoids ADB-FUBINACA and AB-FUBINACA were the most popular. Symptoms of intoxication by these substances are well known but less is known about the pathology of overdose...

Nonlinear optical organic crystal of ethyl-4-(3,4-dimethoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate were grown by the slow evaporation technique. Its structure was determined by X-ray diffraction method further it was characterized by FT-IR, FT-Raman, and NMR spec...

A synthesis and biological evaluation of new benzimidazole derivatives, related to 2,3-disubstituted acrylonitriles, benzimidazo[1,2-a]quinoline-6-carbonitriles and heteroaromatic fluorenes was described. The molecular and crystal structures of three compounds 4, 16 and 17 reveal that non-fused ...

A dipole moment analysis of (Z)-α-phenyl-β-(2-furyl)-acrylonitrile and (Z)-α-phenyl-β-(2-thienyl)-acrylonitrile enables rotational isomerism to be elucidated in these compounds. The electric dipole moments of (Z)-α,β-diphenyl-acrylonitrile and (Z)-α-(4-chlorophenyl)-β-(4′-nitrophenyl)-a...

Recently, 1-(1,4-dioxaspiro[4,5]dec-2-ylmethyl)-4-(2-methoxyphenyl)piperazine (1) was reported as a highly selective and potent 5-HT1AR ligand. In the present work we adopted an in-parallel synthetic strategy to rapidly explore a new set of arylpiperazine (7–32) that is structurally related to ...

The α-lipoic acid (α-LA) is a novel feed additive to improve growth, antioxidant capacity and lipid metabolism in animal husbandry. In this study, isonitrogenous and isoenergetic diets were formulated at seven levels of α-LA (0, 300, 600, 1200, 2400, 4800, or 9600 mg/kg) and fed to the Chines...

Infrared spectra were recorded in situ of octadecanol (A), octadecylamine (B), and octadecanedioic acid (C) adsorbed from CC14 solutions onto highly degassed silica. Adsorbed A interacted with silanols and caused a shift, ΔvOH, of the silanol band of ∼275 cm−1; the data suggest that A dimers i...

Two series of novel oligo(ester amide)s based on sebacic acid/1,6-hexanediamine/ɛ-caprolactone and octadecanedioic acid/1,6-hexanediamine/ɛ-caprolactone were synthesized. The determination of the molecular weights with both gel permeation chromatography and 1H nuclear magnetic resonance (n.m.r.)...

Main-chain liquid crystalline PB-18 polyester composed of 4,4'-dihydroxybiphenyl and octadecanedioic acid forms two distinct crystalline phases, K1 and K2, and smectic H (SH) phase in the order of increasing temperature. The detailed structures of the three phases were studied by 13C solid-...

Liquid phase selective homogeneous catalytic oxidation of stearic acid (SA) was carried out to obtain industrially important carbon neutral high-added value octadecanedioic acid (ODDA). The oxidation was carried using air, cobalt(II)-acetate, manganese(II)-acetate and HBr catalyst in acetic acid...

Two new luminescent supramolecular complexes (SC); [Ni(EIN)4(NCS)2] SC1 and [Ni2(EN)8(NCS)4] SC2, (EIN = ethyl isonicotinate, EN = ethyl nicotinate), have been synthesized by self-assembly method and structurally characterized by X-ray single crystal, FT-IR and UV-Vis spectra, PXRD, elemental an...

The cytotoxicity and antiproliferative effect of phytochemicals presenting in the fruits of Chinese hawthorn (Crataegus pinnatifida) were evaluated. Shanlihong (Crataegus pinnatifida Bge. var. major N.E.Br.) variety possessed significant levels of flavonoids and triterpenoids, and showed potent ...

Lapatinib, one of the tyrosine kinase inhibitors (TKIs), is used to reduce epidermal growth factor family proteins overexpression. This study aims to assess the cytotoxic and genotoxic effects of lapatinib on the triple negative breast cancer cell line “MDA-MB-231”. We investigated the cytotox...

Methylene blue (MB) is a dye widely used as an optical redox indicator in analytical chemistry, whose color change is also affected by pH. It was irreversibly adsorbed on polymeric carbon nitride (g-C3N4) prepared either from urea or from melamine cyanurate. Electron spin resonance (ESR) showed ...

A label-free and ultrasensitive electrochemical impedance cytosensor was developed to specifically detect the breast cancer cells MDA-MB-231 via the interaction between the mannosyl glassy carbon electrode (GCE) and the overexpressed mannose receptors on the target cell surface. The mannosyl GCE...

We recently developed a novel aryl-urea fatty acid (CTU; 16({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoic acid) that impaired the viability of MDA-MB-231 breast cancer cells in vitro and in mouse xenograft models in vivo. At present there is a deficiency of information on the...

AimUlcerative colitis and Crohn's disease are two important chronic Inflammatory bowel diseases (IBD) characterized by prominent intestinal inflammation. Probiotics are the bacteria that promote the host health by its immunomodulatory activity. The present study investigated the correlation...