A novel imidazolium-dysprosium-based magnetic nanomaterial, i.e. [C16mim]5[Dy(SCN)8] nanoGUMBOS (nanomaterials fabricated from a group of uniform material based on organic salts), was prepared using a facile method for selective hemoglobin (Hb) isolation. In this nanomaterial, the imidazolium ca...

BackgroundHuman hemoglobin is an allosteric protein that exerts exquisite control over ligand binding through large-scale conformational changes. The two-state model without intermediates offers a simple qualitative description of the allosteric behavior of hemoglobin, as presented in textbooks....

ObjectiveWe tested the hypothesis that low hemoglobin levels are associated with acute seizures after aneurysmal subarachnoid hemorrhage (aSAH).

ObjectiveThis study compared the values of variables measured by pulse co-oximetry (Masimo Radical 7; Masimo Europe Limited, UK) with those measured by a co-oximeter-enabled blood gas analyser (Siemens Rapid-point 500; Siemens Healthcare Limited, UK) in anaesthetized horses.

We investigate non-perturbative corrections to the large N expansion of the homogeneous electron gas. These are associated with instanton solutions to the effective action of the plasmon field. We show that, although the large field behavior of that action dominates the quadratic bare Coulomb te...

The mutual diffusion coefficients of binary mixtures, 3–methyl–1–butanol + n–heptane and 2–methyl–1–butanol + n–heptane, were measured over the mass fraction from 0.05 to 0.95 at temperatures T = 288.15 K, 298.15 K, 308.15 K and 318.15 K under atmospheric pressure. A digital holographic ...

SummarySemiconducting single-walled carbon nanotubes (SWNTs) with controlled chirality (n, m) and band gaps are expected to create a new era of electronics. Here, we report a rational design to enable SWNTs’ near-equilibrium nucleation and then grow a new family of semiconducting SWNTs: (n, n −...

Let L be the operator given by L{an}n≥0={an+12−anan+2}n≥0. A sequence {an}n≥0 is called asymptotically r-log-convex if Lk{an}n≥N are non-negative sequences for 1≤k≤r and a certain integer N. Based on asymptotic analysis, we present a method for proving the asymptotic r-log-convexity of a s...

Structure–activity relationships of 2-phenyl-imidazo[2,1-i]purin-5-ones as ligands for human A3 adenosine receptors (ARs) were investigated. An ethyl group in the 8-position of the imidazoline ring of 4-methyl-2-phenyl-imidazopurinone leading to chiral compounds was found to increase affinity f...

The peptide hormone ghrelin mediates through action on its receptor, the growth hormone secretagogue receptor (GHSR), and is known to play an important role in a variety of metabolic functions including appetite stimulation, weight gain, and suppression of insulin secretion. In light of the fact...

A series of 4-(2-fluorophenoxy)quinoline derivatives containing an acylhydrazone moiety were designed, synthesized and evaluated for their in vitro biological activities against c-Met kinase and five cancer cell lines (A549, H460, HT-29, MKN-45, and U87MG). Most compounds showed weak to excellen...

In our efforts to develop novel dual c-Met/VEGFR-2 inhibitors as potential anticancer agents, a series of 2-substituted-4-(2-fluorophenoxy) pyridine derivatives bearing pyrazolone scaffold were designed and synthesized. The cell proliferation assay in vitro demonstrated that most target compound...

Hamster DDT1 MF-2 smooth muscle cells natively express α1B-adrenoceptors which are linked to phosphatidylinositol hydrolysis. We studied the relationship between α1B-adrenoceptor density and response in this cell line by stable transfection with an isopropyl-β-D-thiogalactoside (IPTG)-inducib...

The major metabolite of 1-propyl-3,5-diethyl-6-chlorouracil has been identified as 6,8-diethyl-2-methyl-tetrahydrooxazolo[3,2-c]pyrimidine-5,7(4H,6H)-dione. The biotransformation to this bicyclic barbituric acid derivative takes place via substitution of the chlorine by ß- and not by α-hydroxy ...

The TALSPEAK process (Trivalent Actinide Lanthanide Separations by Phosphorus-reagent Extraction from Aqueous Komplexes) has been demonstrated in several pilot-scale operations to be effective at separating trivalent actinides (An3+) from trivalent lanthanides (Ln3+). However, fundamental studie...

The 1H, 13C and 15N NMR spectra of N-(2-hydroxyethyl)-morpholine (1), N-(2-hydroxyethyl)-morpholinium chloride (2), N-(2-hydroxyethyl)-morpholine betaine (3), N-morpholinyl-spiro-morpholactone chloride (4) and N-morpholinyl-spiro-morpholactone picrate (5) have been recorded and analyzed. The inf...

Traces of certain heavy metals are crucial for the metabolism of living beings, but poisoning occurs when their concentration increases. On the other hand, heavy metals such as lead, mercury, and cadmium lack functionality in higher organisms, resulting in considerable toxicity. Their long-term ...

2-Phenylaminothiazolines 3 were synthesized from N-(2-hydroxyethyl)-N′-phenylthioureas 2 by a one-pot reaction using p-toluenesulfonyl chloride (TsCl) and NaOH or Et3N.

Porous strong base anion exchanger (SBAEx) microspheres bearing either N,N-dimethyl 2-hydroxyethyl ammonium, or N,N-diethyl 2-hydroxyethyl ammonium functional groups attached to styrene-divinylbenzene matrix were comparatively used as sorbents for the removal of Cr(VI) oxyanions from aqueous sol...

The high melting point of a large number of organic salts with potential ionic liquid-like properties, hinders their applicability as solvents. Considering the success of cholinium chloride on lowering the melting temperature of several substances and its success on forming deep eutectic solvent...