Aldehydes reacted with 3-bromo-3,3-difluoropropene at the α-position in the presence of indium to afford 1-substituted-2,2-difluorobut-3-en-1-ols. Ketones and other electrophiles are inert under the examined conditions. The reaction of bromodifluoromethylacetylene derivatives with an aldehyde i...

3-Bromo-3,3-difluoropropene was seeded within a pulsed, supersonic expansion of argon gas. In this state, the microwave spectrum of the title molecule was recorded between the limits of 7.8 GHz and 14.2 GHz using a chirped pulse Fourier transform microwave spectrometer. Only the gauche conformer...

Human parainfluenza virus 3 (PIV3) and respiratory syncytial virus (RSV) are major causative agents of serious respiratory tract illness in newborns and infants. Maternal vaccination could be a promising approach to provide immediate protection against severe PIV3 and RSV infection in young infa...

BackgroundHuman parainfluenza virus 3 (hPIV-3) causes respiratory tract infection.

Human parainfluenza virus type 2 phosphoprotein (P) is an essential component of viral polymerase. The P gene encodes both P and accessory V proteins by a specific gene editing mechanism. Therefore, the N-terminal 164 amino acids of P protein are common to V protein. Interestingly, while P prote...

Tight junctions enable epithelial cells to form physical barriers that act as an innate immune defense against respiratory infection. However, the involvement of tight junction molecules in paramyxovirus infections, which include various respiratory pathogens, has not been examined in detail. Hu...

We previously reported that human parainfluenza virus type 2 (hPIV-2) promoted RhoA activation and subsequent filamentous actin (F-actin) formation. Actin-binding proteins, such as profilin and cofilin, are involved in the regulation of F-actin formation by RhoA signaling. In the present study, ...

Methitural sodium, a new short-acting thiobarbiturate anesthetic favorable for use in the oral surgery office as an intravenous anesthetic, demonstrates some noticeable advantages in that it shows a lessened recovery time with more complete mental alertness upon recovery. Side effects observed i...

The reaction of FeCl2 and xylyl isocyanide (L) (L = 2,6-Me2C6H3NC) gives two products viz. purple FeCl2L4 (1) and orange Fe2Cl5L5 (2). The structural identity of these complexes has been determined by single crystal X-ray diffraction studies. Crystal of 1 are tetragonal, space group P4nc, Z = 2,...

Electrochemical copolymerization of o-anisidine with ethyl 4-aminobenzoate was carried out in aqueous 0.1 M HClO4 by employing cyclic voltammetry. Copolymer films were grown for different molar concentration ratios of ethyl 4-aminobenzoate. Electrochemical homopolymerizations of o-anisidine and ...

An efficient synthetic approach to furan fatty acids starting from the biomass-derived platform chemical 5-(chloromethyl)furfural (CMF) is described. The route involves seven steps and has a 60% overall yield. Furan fatty acids are dietary antioxidants that occur naturally in fish and are propos...

The (R)- and (S)-enantiomers of 4-chloromethyl-1,3,2-dioxathiolane-2-oxide were used as ‘epoxide-like’ synthons in the asymmetric alkylation of the enantiomers of oxazinone-derived glycine equivalents. The configurations of the obtained spiro compounds were easily determined using 2D nuclear O...

Hypholoma sublateritium is a basidiomycete that produces the antitumor compound clavaric acid. We cloned a gene encoding an oxidosqualene cyclase (occ) that is involved in the conversion of oxidosqualene to clavaric acid. Mutants disrupted in occ by gene replacement were unable to synthesize cla...

A facile synthesis of trisubstituted imidazoles containing furan rings was reported. Imidazoles were produced from 1,2-di(furan-2-yl)-2-oxoethyl carboxylates over solid alumina as solid support impregnated with ammonium acetate under solvent-free microwave-assisted conditions. The method possess...

5-, 6-, 7- and 8-Amino-2-(N,N-di-n-propylamino)-1,2,3,4-tetrahydronaphthalene were synthesized and compared with the corresponding phenolic compounds in vivo and in vitro for their effects on central serotonergic (5-HT1A) and dopaminergic (D2) systems. The 5- and 8-amino isomers surprisingly sho...

A processable poly[(n-propylamino/methylamino)borazine] (PPAB) has been pyrolyzed in Ar to study its thermal decomposition behavior. The structural evolution and chemical composition change during pyrolysis were characterized by chemical analysis, thermal gravimetry–mass spectrometry (TG–MS), ...

Specifically deuterated 4-((propylamino)methyl)benzoic acid-grafted silica (PAMBA-silica) was prepared by benzylation of propylamino-grafted silica (PA-silica) by either in situ reduction by sodium cyanoborodeuteride (NaCNBD3) of the Schiff base, formed by the reaction between PA-silica and 4-fo...

Aluminium chlorofluoride (ACF, AlClxF3-x, x = 0.05-0.3) and high-surface aluminium fluoride (HS-AlF3) were tested as heterogeneous catalysts for the reactivity towards 2-chloro-1,1,1,2-tetrafluoropropane (HCFC-244bb), which is a potent greenhouse gas. Selective activation and dehydrofluorination...

Reactions of 4′-(4-(anthracen-9-yl)phenyl)-4,2′:6′,4″-terpyridine (2) with zinc(II) acetate lead to helical one-dimensional polymers [{Zn(OAc)2(2)}n] which crystallize either as racemates or the homochiral polymer containing mononuclear {Zn(OAc)2} nodes linked by divergent 4,2′:6′,4″-terp...

Two mesityl bridged bis-1H-imidazolium salts having bromide/hexafluorophosphate counter ions have been prepared, compared with similar ortho-xylyl bridged salts and characterized by various spectral and X-ray diffraction techniques. The salt having 2-cyanoethyl substituents undergoes hydrolysis ...