The enantioselective hydrogenation of ethyl pyruvate using a Pt/SiO2 catalyst modified with six different chiral modifiers was studied. The chiral modifiers chosen were: (S)-(+)-1-aminoindan, (R)-(−)-1-aminoindan, (1R,2S)-(+)-cis-1- amino-2-indanol, (1S,2R)-(−)-cis-1-amino-2-indanol, (S)-(+)-1-i...

Plasma-catalytic decomposition of low concentration ethyl acetate with LaMO3 (M = Co, Mn and Fe) perovskite catalyst was investigated in a coaxial dielectric barrier discharge (DBD) reactor. The combination of perovskite catalyst and plasma enhanced ethyl acetate decomposition, and the activity ...

In this study, the Ag/CeO2 catalysts with three different morphologies of ceria nanocubes (CeO2-c), nanorods (CeO2-r) and nano-octahedra (CeO2-o) as supports were prepared by wet impregnation. Various characterizations such as XRD, BET, TEM/HRTEM, HAADF-STEM, XPS and H2-TPR were conducted, and a...

Chiral lithium methyl[o-(cyclohexyldimethylaminomethyl)phenyl]cuprate reacts with methyl 3-phenyl-2-propenoate and 4-phenyl-3-buten-2-one to give the conjugate addition products, viz. methyl 3-phenylbutanoate and 4-phenylpentan-2-one respectively. The reaction rates and chemical yields (30–60%)...

Groups of 15 male and 15 female rats were given diets to provide intakes of 0 (control), 10, 40 or 160 mg 4-methyl-1-phenylpentan-2-ol/kg/day for 13 wk. No effects attributable to treatment were seen in the 10-mg/kg/day dose group. At 40 mg/kg/day the only finding was a decrease in serum glucose...

We have reported potent peptidic and non-peptidic BACE1 inhibitors with a hydroxymethylcarbonyl (HMC) isostere as a substrate transition-state mimic. However, our potent inhibitors possess a tetrazole ring at the P1′ position. It is desirable that central nervous system (CNS) drugs do not posse...

A new carboxylic acid reductase (CAR) gene from Segniliparus rotundus DSM 44985 was overexpressed in Escherichia coli. The recombinant enzyme exhibited high activity toward a variety of aromatic and aliphatic carboxylic acids. Especially, it effectively reduced 4-hydroxybenzoic acid (8a) and 4-n...

The synthesis, characterization of novel peripherally 4-{2-[3-trifluoromethyl)phenoxy]ethoxy} groups substituted metal-free, Cu(II), Ti(IV), Co(II), Fe(II) phthalocyanines have been reported for the first time in this study. All the new compounds were characterized by a combination of IR, 1H NMR...

The interest in the oxo-enol tautomerism of 1,3-dioxo compounds is justified by their usefulness in many synthetic fields. A series of new 1,3-bis(1-adamantyl)propan-1,3-diones with a variably substituted phenyl ring at the C2 position was prepared either by the reaction of an appropriate Grigna...

Temperature dependence of the heat capacity of 5-(1-adamantyl)tetrazole was studied between (5 and 370) K in a vacuum adiabatic calorimeter. From obtained data the thermodynamic properties of the compound in the condensed state were evaluated over the range of (0–370) K. The crystal structure o...

Diels-Alder reactions of the title 3-vinylindole 2 with N-phenylmaleimide, maleimide, DEAD and DMAD are described. From Compound 10, obtained from 2 and DMAD, Carbazomycin B (1) was prepared.

Considerably improved total syntheses of the carbazole antibiotics carbazomycin A and B are reported using a convergent iron-mediated one-pot construction of the carbazole framework by oxidative cyclization in the air.

Iodination of 2-methoxy-3,4-dimethyl-5-nitrophenol followed by acetylation yields (6-iodo-2-methoxy-3,4-dimethyl-5-nitrophenyl) acetate. Reduction with iron and acetic acid followed by reaction with methyl chloroformate then provides N-methoxycarbonyl-3-acetoxy-2-iodo-4-methoxy-5,6-dimethylanili...

Poly[3-(2-methoxyphenyl)thiophene] (PMP-Th) nanowires array was fabricated by electrochemical deposition method using anodic aluminum oxide (AAO) membrane with various diameters as template. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were employed to characteri...

Photochemical oxidative cyclization of 3-[(E)-2-(3,4-di-methoxyphenyl)vinyl]thiophene and its 15-crown-5-analogue (15-[(E)-2-(3-thienyl)vinyl]-2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-benzopentaoxacyclopentadecine) affords the isomeric thiophene-containing fused aromatic compounds demonstrating p...

Electropolymerization of 3,5-bis(4-methoxyphenyl)dithieno[3,2-b;2′,3′-d]thiophene BMPhDTT, having strong electron-donating methoxy groups, was performed, utilizing potentiodynamic method. The homopolymer was characterized by cyclic voltammetry (CV), Fourier transform infrared (FTIR) and UV–vi...

Enzymatic resolution of a series of enantiomerically pure ethyl 3-hydroxy-2(1′substituted-methylidene)-butyrates was performed using Pseudomonas cepacia lipase (EC 3.1.1.3) as a catalyst. Optically active ethyl 3-hydroxy-2(1′substituted-methylidene)-butyrates, as well as their acetates, were o...

A combination of intramolecularization and tandem reaction methodologies has been applied to the synthesis of diethylammonium[1-hydroxy-1-(2-hydroxyphenyl)ethyl]phosphonates and -phosphinates, which were found to be unavailable through a standard intermolecular hydrophosphonylation/hydrolysis se...

Two chromatographic methods were suggested for the simultaneous determination of a binary mixture containing Saxagliptin HCl (SAG) and Metformin HCl (MET). First method was RP-HPLC method. Chromatographic separation was done on Kinetex™ column–C18 (4.6 × 150 mm, 2.6 µm) using mobile phase con...

3-(o-Trifluoroacetamidoaryl)-1-propargylic esters have been used as common synthetic intermediates for the preparation of a variety of 3-unsubstituted 2-substituted indoles. Treating ethyl 3-(o-trifluoroacetamidoaryl)-1-propargylic carbonates unsubstituted or containing an aryl substituent at th...