A series of novel 1,2,4-triazole thione and bis(1,2,4-triazole thione) derivatives containing phenylpyrazole and substituted piperazine moieties have been conveniently synthesized via Mannich reaction using various 1,2,4-triazole thiols, substituted piperazines, and formaldehyde at room temperat...

A multi-component reaction of 2-alkynylbenzaldehyde, 4-methylbenzenesulfonohydrazide, carbodiimide, and bromine is reported, which generates 1-(4-bromoisoquinolin-1-yl)guanidines in good yields under mild conditions. The products could be further elaborated via a palladium-catalyzed Suzuki–Miya...

In this paper we report the SAR studies of a series of N-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)amide and N-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)sulfonamide derivatives 6(a–o) and 7(a–o), were synthesized in good yields and characterized by 1H NMR, 13C NMR and mass spectral a...

Nickel, as a heavy metal, is toxic for many living species. Thus, the determination of trace amounts of nickel in environmental samples is of great importance. In the present study, new, sensitive, simple and validated solid phase extraction method is developed for the determination of nickel. I...

Complex formation between oxovanadium(IV) and five quinoline derivatives, 8-hydroxyquinoline (8-HQ), 8-hydroxyquinoline-5-sulphonic acid (8-HQS), 2-methyl-8-hydroxyquinoline (8-HQD), 8-hydroxyquinoline-N-oxide (8-HQNO), and 8-quinolinecarboxylic acid (8-QC), was studied in aqueous solution throu...

New ligands containing a heterocyclic ring, L1 (1-anilino-2-(2-pyridyl)-naphth[1,2-d]imidazol-1-io-3-ide), L2 (2-phenyl-3-(2-pyridyl)-3,4-dihydro-naphtho[2,1-e][1,2,4]triazin-1-io-4-ide), and L3 (1-anilino-2-(2-quinolyl)-naphth[1,2-d]imidazol-1-io-3-ide), and their palladium (II) complexes have ...

The reaction of the dimer complex [{Ru(CO)3Cl2}2] with the ligands 4,6-dichloroquinoline-5,8-dione and 6-methoxybenzo[g]quinoline-5,10-dione in ethanol solution led to the neutral mononuclear complexes of general formula [Ru(CO)2Cl2(κ2-quinolinedione-N,O)]. The complexes were characterized by e...

Reaction of 2-(phenylazo)pyridine (pap) with [Os(PPh3)3Br2] afforded a mixed ligand complex of the type [Os(PPh3)2(pap)Br2]. The structure of this complex was determined by X-ray crystallography. The PPh3 ligands are trans and the bromides are in cis positions. The pap ligand is coordinated to o...

A number of bis-[5-(4′-R-phenylazo)-8-hydroxy-quinolinato] vanadyl(IV) compounds (R=H, CH3, C2H5, n-C3H7, n-C4H9) have been synthesized and characterized by elemental analyses and IR, EPR and UV–Vis spectroscopies. Data from the above show that they exist in two isomeric solid forms (which wer...

A series of novel bidentate azodye quinoline ligands were synthesized with various p-aromatic amines like p-(OCH3, CH3, H, Cl and NO2). All ligands and their complexes have been characterized on the basis of elemental analysis, IR, 1H and 13C NMR data and spectroscopic studies. IR and 1H NMR stu...

A novel series of (5-(4′-derivatives phenyl azo)-8-hydroxy-7-quinolinecarboxaldehyde) (AQLn) (n = 1, p-OCH3; n = 2, R = H; and n = 3; p-NO2) and their complexes [Cu(AQLn)2]·5H2O are synthesized and investigated. The optimized bond lengths, bond angles and the calculated quantum chemical parame...

In this study, the optical and dielectrical properties of a novel series of quinoline azodyes (5-(4′-derivatives phenyl azo)-8-hydroxy-7-quinolinecarboxaldehyde) (AQL1–AQL5) were investigated and the obtained results were analyzed. The X-ray diffraction (XRD) patterns of AQLn show that the mat...

Free rotating azo type ligand in different types of metal complexes give trans-cis isomerism in presence of photon irradiation by UV light. For this connection one new iridium complex has been synthesized with 8-hydroxyquinoline-5-phenylazo ligand in which the azo part of the ligand is free from...

The herbicide, 5-bromo-3-sec-butyl-6-methyluracil (bromacil) exhibited a low order of acute toxicity as evaluated by oral, dermal, and inhalation studies in mammals and by fish and wildlife studies. Bromacil fed to pregnant New Zealand white rabbits on days 8–16 of gestation at dietary levels o...

Photoirradiation of 5-t-butyl-1-methyluracil at 254 nm results in the production of a 1,2-dihydro-1-methyl-pyrimidin-2-one in high yield. The structure was confirmed by X-ray analysis. When subjected to alkaline conditions, a bathochromic shift in the UV spectrum accompanied by an increase in mo...

In the present study, a series of novel 2-(substituted benzylidene)-7-(4-chlorophenyl)-5-(furan-2-yl)-2H-thiazolo[3,2-a]pyrimidin-3(7H)-one derivatives (4a–i) were designed and synthesized to meet the structural requirements essential for antiepileptic activity. Antiepileptic screening was perf...

The present work follows our preliminary discovery of biphenyl diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. Further structural optimization of biphenyl-DAPYs led to the identification of a new series of biphenyl-substituted thiophene[3,2-d]pyrimidine analogu...

The design, synthesis, and structure activity relationships of the novel class of pyrazolylethylbenzamide orexin receptor 1-selective antagonists are described. Further derivatization of the prototype dual orexin receptor 1/2 antagonist lead (1) by installing a (S)-methyl group into the ethyl li...

Nucleophilic substitution of 5-bromotriazoloisoquinoline (3) and of 7-bromo-3-methyltriazolopyridine (6) proceeds readily to give a range of 5-substituted triazoloisoquinolines (4a)-(4e), and of 7-substituted triazolopyridines (7a)-(7h) respectively. Triazoloisoquinolines have been converted int...

Powder XRD, EPR, optical,NLO activity and Biological activities of Fe(III)doped Mn(II)L-Histidine Hydrochloride Monohydrate (LHICl) was carried out at room temperature to ascertain the structural properties. In EPR, the angular variation of Fe(III) hyperfine lines indicated a single site, with s...