Stellite 6 is a cobalt-base alloy commonly used for coatings useful in wear and corrosion protection of several components over a wide range of temperatures.Stellite coatings can be obtained by many deposition techniques: plasma transferred arc (PTA) is certainly an optimal choice that gives thi...

This paper aims at studying microstructure and mechanical properties of spark plasma sintered (SPSed) Stellite®-6 cobalt-based superalloy. SPS is a sintering technique, based on a relatively fast resistance heating using a pulsed current. Fast sintering process, associated with minimum grain gro...

Cobalt-based alloys such as Stellite 3 and Stellite 6 are widely used to protect stainless steel surfaces in primary circuit nuclear reactor applications where high resistance to wear and corrosion are required. In this study, self-mated sliding wear of Stellite 3 and Stellite 6 consolidated by ...

In contrast to biological evaluation methods the use of high-performance liquid chromatography has allowed the quantitation of five nikkomycin components from the filtrate of the fermentation broth in which they are cultured.

Nikkomycin, a nucleoside-peptide analog of UDP-N-acetylglucosamine, is a potent chitin synthase inhibitor produced by the bacterium Streptomyces tendae. The HPLC profile of fermentation products in culture broths of a non-producing mutant, Nik 15, was compared with nikkomycin standards. Nikkomyc...

Publisher SummaryThis chapter provides an overview of nikkomycins and polyoxins. The detection, isolation, purification methods of nikkomycins and polyoxins are described in the chapter. The isolation procedure of polyoxins is similar to that of nikkomycins. The separation of polyoxins can be ac...

Acting as competitive inhibitors of chitin synthase, nikkomycins and polyoxins are potent antibiotics against pathogenic fungi. Taking advantage of the structural similarities between these two peptidyl nucleoside antibiotics, genes required for the biosynthesis of the dipeptidyl moiety of polyo...

Electroreduction of pyridinedicarboxylic acid derivatives 1a–g in methanol containing ammonium chloride using a divided cell brought about highly selective hydrogenation to give the corresponding dihydropyridines in good yields. From the electrolysis of dimethyl 2,3- and 2,5-pyridinedicarboxyla...

Hydrazones obtained from α-diazo esters were converted to pyrroles when heated with thionyl chloride in alcohol. Among hydrazones, those substituted with a benzene ring on the β-carbon to the ester are likely to give pyrroles in good yields.

A method to determine caffeoylquinic acids (CQAs) in three sources (herbal extract, feed additive and finished feed) using for the first time focused ultrasound solid–liquid extraction (FUSLE) followed by ultra-high performance liquid chromatography (UPLC) coupled to quadrupole-time of flight m...

The ring opening of 1,2-(gem-dibromo)cyclopropyl carbohydrates by two different modes leads to either 2-C-(bromomethylene)pyranosides (using base) or 2-bromooxepines (using silver salts), as shown previously by us for a d-glucal-derived cyclopropane. The base-promoted ring opening is extended to...

There are many drugs that affect postoperative cognitive function in patients under general anesthesia. Pentanethaquine hydrochloride (PHC), as a new type of anti-cholinergic drug, has been widely used. In clinical practice, many patients, especially elderly patients, have suffered from obvious ...

Study the effect of stachydrine hydrochloride to prostatic hyperplasia in mice which made of the urogenital sinus implantation. KM male mices were selected.The group was given the respective drugs for gavage, the group of BG and MG were given the distilled water which the same amount as the drug...

Antimicrobial electrospun nonwoven Eudragit L-100 nanofibrous mats containing Moxifloxacin hydrochloride (MOX-HCL) were fabricated for fast dissolving drug delivery systems (DDSs) associated with wound infection. The morphological characterization of nanofibers using ESEM revealed that the avera...

For the first time, the solubilities of sertraline hydrochloride in SC-CO2, as a binary system, and SC-CO2 + menthol, as a ternary system, were determined. Experimental data was achieved at 308, 318, 328 and 338 K at different pressures ranging from 12 to 30 MPa. The solubility of sertraline in ...

L-cysteine hydrochloride monohydrate crystals, C3H7NO2S·HCl·H2O, were studied by Raman spectroscopy as a function of pressure in a diamond anvil cell up to 6.2 GPa in the spectral range 3500−30 cm−1. From the analysis of the results, we inferred that the crystal is structurally stable in this ...

Management of chronic pain is restricted by the lack of effective tools. This study evaluated the efficacies of sinomenine combined gabapentin or ligustrazine hydrochloride in treating peripheral and central chronic neuropathic pain.The study was conducted in mice with photochemically induced sc...

Highly purified calf hemodialysate (HPCH) known as Actovegin® or Solcoseryl® is one of the most controversial drugs currently marketed worldwide. It is not registered as drug in some countries and therefore its medical use there is illegal, while in others it is often among the top 10 of the bes...

PurposeA multi-center prospective randomized trial was conducted to evaluate the efficacy and safety of Actovegin in the prevention and treatment of chemoradiotherapy-induced acute oral mucositis.

This article reviews the mechanisms of action of Actovegin in the context of its preclinical effects and new concepts in the pharmacological treatment of neurological disorders. Actovegin is an ultrafiltrate of calf blood, composed of more than 200 biological substances. The drug is used for a b...