Temperature dependences of vapor pressures for 2-, 3-, and 4-bromobenzoic acid, as well as for five isomeric bromo-methylbenzoic acids were studied by the transpiration method. Melting temperatures and enthalpies of fusion for all isomeric bromo-methylbenzoic acids and 4-bromobenzoic acid were m...

We synthesized 12 derivatives of 2,3-bis(bromomethyl)quinoxaline with substituents at the 6- and/or 7-positions, and evaluated their activities against bacteria and fungi. Of the 12 compounds, nine (1a-h, 1j, and 1k) showed antibacterial activity. The derivative 1g, which bears a trifluoromethyl...

5-Bromomethyl-4-nitroimidazoles have utility as bioreductive trigger precursors for the preparation of hypoxia-selective prodrugs. Here we describe an efficient two-step synthesis of 5-(bromomethyl)-1-methyl-4-nitro-1H-imidazole, a preferred precursor, employing an N-bromosuccinimide mediated ra...

The FTIR and FT-Raman spectra of 4-bromomethyl-5-methyl-1,3-dioxol-2-one and 4,5-bis(bromomethyl)-1,3-dioxol-2-one have been recorded in the regions 4000–400 and 4000–100 cm−1, respectively. The geometry of the compounds are optimised with B3LYP method using 6-311++G∗∗ and cc-pVTZ basis sets t...

This study investigated the oxidative debromination of 2,2-bis(bromomethyl)-1,3-propanediol (BBMP), a widely used brominated flame retardant, and the corresponding formation of brominated by-products by the UV/persulfate process. The debromination of BBMP by the UV/persulfate process was primari...

The solubility of 4′-bromomethyl-2-cyanobiphenyl (OTBNBr) in binary solvent mixtures of {acetone + (ethanol, n-propanol, and n-butanol)} was experimentally determined within the temperature range 278.15–313.15 K by using a gravimetrical method under atmospheric pressure (P = 0.1 MPa). The resu...

Some new compounds of 2-phenyl-4-quinolinecarboxylic acid with cobalt, nickel and copper were prepared. The thermal behaviour of these compounds together with that of the 2-phenyl-4-quinolinecarboxylic acid were studied by thermogravimetry and differential thermal analysis. The transition metal ...

The structures of soulameanone, 1,12-di-O-acetyl soulameanone and Δ2-Picrasin B, new quassinoids from Soulamea muelleri (Simaroubaceae), were determined by spectrometric methods and chemical correlation, and that of Soulameanone confirmed by single crystal X-ray analysis.

An enantioselective total synthesis of (+)-picrasin B (1) from the R-(-)-enantiomer of the Wieland-Miescher ketone (4) employed an A-AB-ABC-ABCD sequence to assemble the tetracyclic skeleton and relied upon a free radical cyclization of an α-bromoacetal to an enone in order to introduce the D r...

The regioselective reductive demethylation of the O-methyldiosphenol functionality in the A ring of quassin (3) with chlorotrimethylsilane and sodium iodide furnished picrasin B (1). Swern oxidation of 1 furnished Δ2-picrasin B (2), and O-methylation of 2 regenerated quassin (3).

1,1-Dihydro-1-tolylsulfonyl polyfluoroalkan-2-ones react with phthalimidosulfenyl chloride to form sulfenylated products on the active methylene group, 1-phthalimidothio-1-tolylsulfonyl polyfluoroalkan-2-ones. Decomposition of the latter leads to formation of 1-thioxo-1-tolylsulfonyl polyfluoroa...

Besides partial methylation of the phosphate group, especially above pH6, adenosine 5′-phosphate is methylted on N-i by dimethyl sulphate to yield N1-methyl-adenosine 5′-phosphate (II; R = H). The latter is quantitatively rearranged, by mild treatment with base, to 6-methylaminopurinerboside 5...

One of the latest trends is search for the new anti-psychotic drugs among coumarin derivatives with piperazine moiety. Their therapeutic potential can be hampered by poor physico-chemical parameters as low brain penetration or limited transport in the body fluid. Herein, we predicted the drug li...

An alpidem-insensitive benzodiazepine binding site in the rat spinal cord has recently been identified in our laboratory. We report here the binding of 23 1,4-benzodiazepines to this site using [3H]Ro15-4513 (ethyl-8-azido-6-dihydro-5-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate) in...

The inclusion behaviors of 4-Sulfonatocalix[n]arenes (SCXn) (n = 4, 6, 8) with 1-(4-nitrophenyl)piperazine (NPP) were investigated by UV spectroscopy and fluorescence spectroscopy at different pH values (pH = 3.05, 6.50, 8.40). The UV absorption and fluorescence intensity of NPP remarkably incre...

In this present work, the target compound, 2-amino-4- (4-nitrophenyl) −5,6-dihydrobenzo [h] quinoline-3-carbonitrile, has been synthesized and characterized by FT-IR, 1H-NMR, 13C-NMR, and X-Ray single crystal determination as experimental. The title compound crystallizes in the monoclinic space ...

Electrochemical properties of 4-nitrophenyl triazole labeled 2′-deoxycytidine (dCTRNO2) and 7-deazaadenosine (dATRNO2) were studied using alumina-polished boron doped diamond (BDD) electrode in acetate buffer pH 5.0. Cyclic voltammetry revealed peak-shaped signals for reduction of the nitro gro...

In this paper, 13 4-N-nitrophenyl substituted amino-4H-1,2,4-triazole derivatives were synthesized and their aromatase inhibitory activities were measured. The results show that the substitution of the groups on benzyl group can further improve their bioactivity and the compound with Cl on the p...

Four 4-nitrophenyl-functionalized benzofuran (BF1, BF2) and benzodifuran (BDF1, BDF2) compounds were synthesized by a convenient route based on the Craven reaction. All the compounds underwent a detailed chemical-physical characterization to evaluate their structural, thermal and optical propert...

Quantum chemistry calculations have been performed by using Gaussian03 program to compute optimized geometry, harmonic vibrational frequency. Atomic charges at HF/6-31G(d, p), B3LYP/6-31G(d, p) and B3LYP/6-311++G(d, p) levels for 1-(2,6-Dichloro-4-nitrophenyl)-5-amino-4-cyanopyrazole (C10H10Cl2N...