Heterogeneous Fenton oxidation using Fe-zeolite catalyst (of ZSM5 type) was investigated for the removal of ibuprofen (20 mg/L) in water. In particular, the effects of catalyst concentration, oxidant dosage, temperature, solution pH, and water matrix on pollutant conversion and mineralization we...

Widespread occurrence of trace pharmaceutical residues in aquatic environments is of great concerns due to the potential chronic toxicity of certain pharmaceuticals including ibuprofen on aquatic organisms even at environmental levels. In this study, the phytoextraction, phytotransformation and ...

Fenton based reactions are effective for pharmaceutical removals, but traditional Fenton processes have drawbacks of pH adjustment and large amount of produced iron sludge. To overcome these challenges, a heterogeneous electro-Fenton process was proposed for effective contaminant degradation at ...

Ibuprofen (IBU) and its major metabolites, hydroxyibuprofen (OH-IBU) and carboxyibuprofen (CA-IBU) were monitored from November 2015 to March 2017 at four full-scale constructed wetlands with horizontal subsurface flow treating municipal wastewater in the Czech Republic. During the seven samplin...

Worldwide, aspirin and ibuprofen are the most commonly used non-steroidal anti-inflammatory drugs (NSAIDs). Some adverse reactions, including gastrointestinal reactions, have been concerned extensively. Nevertheless, the mechanism of liver injury remains unclear. In the present study, we focused...

An experimental and theoretical approach toward enhanced photocatalytic efficiency of N-doped BiVO4 synthesized by facile microwave-assisted hydrothermal process was investigated. The photocatalytic efficiency was determined by the degradation of ibuprofen. The degradation attains 90% with an N-...

Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID) that exerts analgesic and anti-inflammatory actions. The transient receptor potential ankyrin 1 (TRPA1) channel, expressed primarily in nociceptors, mediates the action of proalgesic and inflammatory agents. Ibuprofen metabo...

The plasticity-related gene 1 (PRG1) modulates bioactive lipids at the postsynaptic density and is a novel player in neuronal plasticity and regulation of glutamatergic transmission at principal neurons. PRG1, a neuronal molecule, is highly expressed during development and regeneration processes...

Twenty-nine examples of 2-(9H-carbazol-1-yl)anilines were obtained in yields from 27 to 95% by refluxing 2,3′-biindolyl (1 equiv.) and ketones (1 equiv.) in ethanolic HCl. Alkyl, cyclic, and aryl ketones were found to be compatible with this method, however, aldehydes are not. Because the react...

A series of 2-arylimidazo[1,2-a]pyrimidines has been prepared and evaluated for inotropic activity. Three of these heterocycles, ether 19, sulphide 21 and mesylate 24 displayed more potent inotropic effects in vitro than isomazole. The in vivo inotropic potencies of 4′-mesylate 24 and 4′-carbo...

The structural investigations of a series of new bioactive imidazo[1,2-a]pyrimidines 1–6 were undertaken using IR, 1H and 13C NMR spectroscopic analysis, X-ray crystal structure determinations and theoretical calculations. The compounds 1–6 were obtained by condensation of the respective 1-ary...

A water soluble boronated amino acid containing a cascade polyol, 1-amino-3-[2-(7-{3-[2-(2-hydroxymethyl-ethoxy)-1-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)ethoxy]propyl}-1,7-di-carba-closo-dodecaboran-1-yl)ethyl]cyclobutanecarboxylic acid, has been developed. The key step in the synthesis is the...

Background and aimsMolecular basis of abdominal pain in IBD is not fully characterized. Serotonin (5-HT) increases visceral pain severity and contributes to exacerbation of inflammation. Moreover, it is well established that decreased anandamide (AEA) signaling in the gut increases visceral pain...

Following the discovery of the endocannabinoid arachidonoyl ethanolamide (anandamide) and other N-acyl-ethanolamines, several other compounds have been found in which amino acids or neurotransmitters rather than ethanolamide are linked to fatty acids. Studies have shown that the local availabili...

Conjugates of fatty acids and amines, including endocannabinoids, are known to play important roles as endogenous signaling molecules. Among these, the ethanolamine conjugate of the n-3 poly unsaturated long chain fatty acid (PUFA) docosahexaenoic acid (22:6n-3) (DHA) was shown to possess strong...

Fatty acid amides (FAAs), conjugates of fatty acids with ethanolamine, mono-amine neurotransmitters or amino acids are a class of molecules that display diverse functional roles in different cells and tissues. Recently we reported that one of the serotonin-fatty acid conjugates, docosahexaenoyl ...

Lignin contains around 50 wt% of aromatic hydrocarbons, which can be transformed in fuels and chemicals. Many processes convert lignin in phenols and alcohols, needing further oxidation to be converted in high-value products. This work reports a study on the catalytic oxidation of some model alc...

Unambiguous routes to five aminochlorobenzenesulphonic acids are described. Two of these isomers have not been described before and this work shows that the literature on the other three is confused. The 13C-n.m.r. spectra of all ten isomers have been measured. The isomers have been used to iden...

2-Chloro-5-nitrobenzenesulphonic-1 acid, 1,3-propylenediamine, chloranil and cyanuric chloride were used as raw materials to synthesise several reactive dyes, derivatives of 6,13-dichlorotriphenodioxazine. Spectroscopic and application properties of the dyes were determined.

S-nitrosoglutathione reductase is the primary enzyme responsible for the metabolism of S-nitrosoglutathione (GSNO), the body’s main source of bioavailable nitric oxide. Through its catabolic activity, GSNO reductase (GSNOR) plays a central role in regulating endogenous S-nitrosothiol levels and...