Copper reagents react with secondary and tertiary aldehyde tosylhydrazones to give unique, hindered cuprates which are alkylated in a one-flask procedure.
Stilbenes are readily prepared in good yields via homocoupling of aryl aldehyde tosylhydrazones in the presence of lithium tert-butoxide and trimethyl borate under reflux in THF.
The diastereoselective ruthenium(II) porphyrin catalyzed cyclopropanation of a variety of alkenes with aryl diazomethanes generated in situ from stable tosylhydrazone derivatives, was achieved in good to excellent yields (up to 92%) and product turnovers. The practical utility of [RuII(p-Cl-TPP)...
Heating the dilithium or disodium salts of the bistosylhydrazones 5ab of the 2-(2-formylphenyl)benzaldehydes 1ab affords the phenanthrenes 2ab in fair to good yields.
Reaction of tosylhydrazones 1a,b with cyanoalkenes 3a,b, carried out in the presence of concentrated aq. sodium hydroxide in dioxane, afforded either cyanocyclopropanes 5, 9 or pyrazoles 13, 14 and 16, 17. The process takes place via generation of diazocompounds 2a,b from 1a,b their [3+2] cycloa...
Treatment of benzaldehyde tosylhydrazone (I) with sodium methoxide in various solvents under irradiation and/or heating yields products arising from phenylcarbene (IV) which is produced by photolytic or pyrolytic decomposition of initially formed phenyldiazomethane (III). Reaction products origi...
Transition-metal-catalyzed cross-coupling reactions have experienced considerable growth in the past decades. These reactions have proved to be powerful tools for assembling structurally complex molecules for use in applications ranging from medicines to materials. Among these transformations, c...
A simple metal-free route for the N-alkylation of tosylhydrazones is described via the NaOMe-promoted reductive coupling of tosylhydrazones under mild conditions. A wide variety of N-alkylated tosylhydrazones were obtained in moderate to good yields.
N-tosylhydrazones derived from a wide variety of aryl, alkyl and heteroaryl aldehydes undergo smooth coupling with 5,5-dimethylcyclohexane-1,3-dione under transition metal and base free conditions to generate tetraketo compounds in high yields. In presence of a base, the coupling reaction genera...
Efficient and general copper catalyzed oxidative cyclization of ortho-vinylaniline has been accomplished employing N-tosylhydrazone as coupling partner. Various substituted quinoline derivatives of biological importance were achieved in good to excellent yield. The important features are the hig...
Oxidative stress is implicated in the pathogenesis of diabetes mellitus. Selenium supplementation has some benefits in experimental models of diabetes mellitus. This study evaluated whether dietary diphenyl diselenide, a simple synthetic organoselenium compound with antioxidant properties, reduc...
Toxoplasma gondii, an intracellular protozoan, may cause chronic infection in the brain tissue of the host inducing a systemic pro-inflammatory profile. Chronic infections can induce numerous physiological changes, such as alterations in the immune and oxidative profiles. Diphenyl diselenide (Ph...
Anxiety-related disorders are frequently observed in the population. Because the available pharmacotherapies for anxiety can cause side effects, new anxiolytic compounds have been screened using behavioral tasks. For example, diphenyl diselenide (PhSe)2, a simple organoselenium compound with neu...
The effects of 4,4′-dichloro-diphenyl diselenide (ClPhSe)2 on the toxicity induced by mercuric chloride (HgCl2) were investigated and compared with diphenyl diselenide (PhSe)2. Mice received HgCl2 for three days and, on the third day, received (PhSe)2 or (ClPhSe)2. The results verified that the...
In the present study we investigated the effects of Diphenyl Diselenide (DPDS) on behavioral and biochemical parameters in Drosophila melanogaster (DM). We also tried to explore the gender differences in response to DPDS treatment. One of the salient features of the present report is that, at th...
BackgroundGliomas are the most aggressive malignant tumors of the central nervous system. The diphenyl diselenide [(PhSe)2] is an organoselenium compound that has multiple pharmacological properties. Previous reports showed that (PhSe)2 nanoencapsulation potentiates its in vitro antitumoral acti...
Diabetes mellitus (DM) is a chronic metabolic disease that may comorbid with various psychiatric disorders, such as anxiety and depression. The search for effective therapeutics to alleviate hyperglycemia and complications resulting from DM is continuous. Here we investigate the effects of diphe...
Exposure to pesticide chlorpyrifos (CPF) has been implicated in reproductive deficits in both humans and animals. Diphenyl diselenide (DPDS) is an organoselenium compound widely reported to elicit potent pharmacological activities in several chemically-induced toxicity and disease models. Howeve...
Exposure to pesticide chlorpyrifos (CPF) is associated with neurodevelopmental toxicity both in humans and animals. Diphenyl diselenide (DPDS) is a simple synthetic organoselenium well reported to possess antioxidant, anti-inflammatory and neuroprotective effects. However, there is paucity of in...
Chemical investigation of the mangrove-derived fungus Aspergillus sp. AV-2 following fermentation on solid rice medium led to the isolation of a new phenyl pyridazine derivative (1) and a new prenylated benzaldehyde derivative, dioxoauroglaucin (2), together with fourteen known compounds (3-16)....
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