The well-known benzene-1,2-diamine structure is considered to be a good model for the development of fluorescence-quenching chemosensors through simple and convenient syntheses. Herein, an original and simple chemosensor molecule, 2-((E)-(-2-aminophenylimino)methyl)-6-isopropyl-3-methylphenol (3...
A series of novel oxazoline-substituted imidazolium salts with planar and central chirality has been successfully synthesized and applied to copper-catalyzed enantioselective 1,2-silylation of N-tosylaldimines. The oxazoline–carbene copper complex generated in situ by the reaction of the oxazol...
Reacting an 1:1 stoichiometric molar ratio of ferrocenecarboxaldehyde and 2,2,2-trimethoxy-4,5-dimethyl-1,3,2-dioxaphospholene, neat, at room temperature for one week, leads to the diastereoselective formation of a bis-ferrocenyl 1,3-dioxolane complex 1-(4-methyl-2,5-diferrocenyl-1,3-dioxolan-4-...
An isocratic stability indicating RP-HPLC–UV method is presented for the determination of metaxalone (MET) in the presence of its degradation products. The method uses Dr. Maisch C18 column (250 mm×4.6 mm, 5 μm) with mobile phase consisting of acetonitrile–potassium dihydrogen orthophosphate...
The solubilities of three active pharmaceutical ingredients (APIs) in supercritical carbon dioxide were measured in this study using a semi-flow apparatus. These APIs are chlormezanone (C11H12ClNO3S), metaxalone (C12H15NO3) and methocarbamol (C11H15NO5) that are all used as skeletal muscle relax...
Metaxalone (Met), a drug for treatment of pain and stiffness due to muscular injuries, was covalently linked to poly(ethylene glycols) (PEG) via a chloroacetyl chloride spacer. The average weight molecular weights used for PEG are 4000, 6000 and 10,000, respectively, and the procedure of chemica...
Metaxalone is a skeletal muscle relaxant, an approved drug for pain relief. Published bioanalytical methods lacked detailed stability evaluation in blood and plasma. An accurate, precise, high-throughput tandem mass spectroscopic method has been developed and validated. Following solid phase ext...
A solvent-assisted grinding approach was used to investigate the possible cocrystal formation between metaxalone and short-chain dicarboxylic acids (HOOC(CH2)nCOOH, n = 0–3). Differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) microspectroscopy, and powder X-ray diffracti...
A case is presented of a 54-year-old white female found dead in a secured apartment. Postmortem toxicologic analysis of the heart blood identified acetaminophen (97 mg/L), citalopram (0.4 mg/L), gabapentin (24 mg/L) and metaxalone (21 mg/L). The metaxalone concentration is within the range of pr...
A simple and rapid method using liquid chromatography–mass spectrometry (LC-MS) for the determination of metaxalone in human plasma has been developed and validated. Letrozole was used as the internal standard (IS). The plasma samples were simply treated with acetonitrile which allowed the prec...
Study objectivePatients with low back pain are often treated with nonsteroidal anti-inflammatory drugs and skeletal muscle relaxants. We compare functional outcomes and pain among patients with acute low back pain who were randomized to a 1-week course of ibuprofen plus placebo versus ibuprofen ...
Supramolecular reactions between a muscle relaxant drug, Metaxalone, 5-[(3,5-dimethylphenoxy)methyl]-2-oxazolidinone with a few carboxamides like nicotinamide, isonicotinamide, salicylamide and carboxylic acid coformers such as 3-hydroxybenzoic acid, 4-hydroxybenzoic acid resulted binary cocryst...
An efficient synthesis of 1,2,4-oxadiazinan-5-ones via [3+3] cycloaddition of in situ generated aza-oxyallyl cations with nitrones has been developed. The protocol features easy operation, excellent yields, excellent diastereo-control, broad substrate scope and good functional group tolerance.
Using a structure-based design approach, we have developed a new series of imidazo[1,2-b]pyridazines, targeting the calcium-dependent protein kinase-1 (CDPK1) from Toxoplasma gondii. Twenty derivatives were thus synthesized. Structure-activity relationships and docking studies confirmed the bind...
The fractionation of carbon and chlorine stable isotopes of dichloromethane (CH2Cl2, DCM) upon dechlorination by cells of the aerobic methylotroph Methylobacterium extorquens DM4 and by purified DCM dehalogenases of the glutathione S-transferase family was analyzed. Isotope effects for individua...
A catalyst based on mixed V-Ni oxides supported on TiO2 (Ni–V/TiO2) was obtained using the sol–gel method. Its catalytic performance relative to dichloromethane (DCM) degradation was investigated. Characterization and analysis were conducted using transmission electron microscopy, H2 temperatu...
BackgroundThe incidence of childhood cancers has been increasing and environmental exposure to air toxics has been suggested as a possible risk factor. This study aims to explore ambient exposure to dichloromethane (methylene chloride).
Efficient removal of chlorinated volatile organic compounds (CVOCs) has received great attention because of the considerable harm that they cause to the environment and to human health. Developing novel catalysts and exploring the catalytic activation and deconstruction mechanism of CVOCs molecu...
FexZr1-x-S mixed oxide catalysts were prepared by precipitation of FeSO4 and ZrOCl2, and used in catalytic oxidation of dichloromethane (DCM). Analyses by a series of characterization technologies reveal that Fe-O-Zr solid solution with tetragonal ZrO2 or α-Fe2O3 structure can be formed, depend...
Chloromethane and dichloromethane were measured in the air of marine environment and in seawater during a cruise from the Port of Spain to Rio de Janeiro in the tropical Atlantic Ocean in April and May of 2009. Variation of chloromethane and dichloromethane concentrations was analysed as a funct...
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