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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 15307-79-6 ,Diclofenac sodium

Cas:15307-79-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White or slightly yellow powder Storage:R.T Package:25kg/drum Application:Anti-inflammatory and analgesic Transportation:Express/Sea/Air Port:Any port in China

API Diclofenac sodium cas 15307-79-6

Cas:15307-79-6

Min.Order:25 Kilogram

Negotiable

Type:Lab/Research institutions

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HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Product Name:Diclofenac sodium CAS No:15307-79-6 Sy

Diclofenac sodium

Cas:15307-79-6

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Kono Chem Co.,Ltd

Specifications CAS No.: 15307-79-6 Other Names: diclofenac sodium, diclofenac sodium MF: 15307-79-6 EINECS No.: 15307-79-6

Diclofenac sodium 99% powder

Cas:15307-79-6

Min.Order:1 Kilogram

Negotiable

Type:Other

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) W

99% up Diclofenac sodium 15307-79-6

Cas:15307-79-6

Min.Order:1 Kilogram

FOB Price: $825.0 / 1100.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

Top Supplier Diclofenac sodium 99%(low price)

Cas:15307-79-6

Min.Order:25 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

Pharmaceutical API Diclofenac sodium Powder CAS 15307-79-6

Cas:15307-79-6

Min.Order:1 Kilogram

FOB Price: $9.5 / 9.8

Type:Trading Company

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Strict quality control: good raw materials, good quality, Zenuo Biology has always regarded quality as the life of the enterprise. Zenuo Biology has an independent quality control department and long-term cooperation with the third-party detection

Diclofenac sodium Manufactuered in China best price

Cas:15307-79-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Josun International Limited

Best quality! Competitive Price!! Long-term stable Supply!!! Experienced shipment Service!!!! Excellent after-sales Service!!!!! JOSUN INTERNATIONAL LIMITED is a pharmaceutical company which is integrated with manufacturing, marketing, RD in C

Diclofenac sodium

Cas:15307-79-6

Min.Order:25 Kilogram

Negotiable

Type:Other

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance A white or or slightly yellowish crystalline powder White crystalline powder

High purity Diclofenac sodium with high quality and best price cas:15307-79-6

Cas:15307-79-6

Min.Order:1 Kilogram

FOB Price: $12.0 / 15.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

CAS : 15307-79-6 Diclofenac sodium

Cas:15307-79-6

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Diclofenac sodium Cas 15307-79-6 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Cream colour powder with characteristic odour Storage:-20°C Freezer Pac

Top quality Diclofenac sodium Cas 15307-79-6 with best price and fast delivery

Cas:15307-79-6

Min.Order:25 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

Factory directly supply Diclofenac sodium Price cas:15307-79-6

Cas:15307-79-6

Min.Order:1 Kilogram

FOB Price: $8.0 / 12.0

Type:Manufacturers

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Hefei TNJ chemical industry co.,ltd

Good quality Competitive price On time delivery Our Advantages: Full experience of large numbers containers loading in main Chinese seaports Packing with pallet as buyer's special request Best service after shipment with e-mail

Good quality Diclofenac sodium//15307-79-6

Cas:15307-79-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Sodium [2-[(2,6-dichlorophenyl)amino]phenyl]acetate

Cas:15307-79-6

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 15307-79-6 Diclofenac Sodium Manufacturer

Cas:15307-79-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chengdu Lemeitian Pharmaceutical Technology Co,. Ltd

ADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,

Diclofenac Sodium Salt

Cas:15307-79-6

Min.Order:5 Milligram

Negotiable

Type:Manufacturers

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Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

1.Competitive price with high quality material along with proper and complete documents; 2.Your stable supply channel for your choice; Earliest delivery time ; 3.Supply full range of APIs & Chemicals to reduce your many varieties of purchas

Diclofenac sodium CAS NO.15307-79-6

Cas:15307-79-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Diclofenac sodium

Cas:15307-79-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Diclofenac Sodium

Cas:15307-79-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Diclofenac sodium Manufacturer Factory CAS 15307-79-6 Diclofenac sodium Manufacturer High quality Best price In stock factory CAS 15307-79-6 Diclofenac sodium COA TDS price MSDS Diclofenac sodium Chemical Properties Melting point 288-290&de

Diclofenac sodium Manufacturer Factory CAS 15307-79-6

Cas:15307-79-6

Min.Order:5 Kiloliter

FOB Price: $3.5 / 5.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Diclofenac sodium

Cas:15307-79-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hubei DiBo chemical co., LTD

Name:Diclofenac Sodium Name:Diclofenac Sodium CAS no:15307-79-6 Grade:Medical chemical industry Molecular formula:C14H10Cl2NNaO2 Molecular weight: 318.14 Product Quality 12 years of chemical raw materials Mature operation of the indu

Diclofenac Sodium/cas:15307-79-6/raw material/high-quality

Cas:15307-79-6

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Diclofenac sodium

Cas:15307-79-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Diclofenac Sodium CAS: 15307-79-6

Cas:15307-79-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

Diclofenac sodium

Cas:15307-79-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 15307-79-6 with best quality

Cas:15307-79-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Diclofenac sodium/ LIDE PHARMA- Factory supply / Best price

Cas:15307-79-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Product Name: Diclofenac Sodium CAS No: 15307-79-6 EC No: 239-346-4 Molecular Formula: C14H10CL2NNaO2 Molecular Weight: 318.13 Appearance: White Powder Storage:Store in cool and dry place, away from sun light. Package: 25 KG/Wov

Diclofenac Sodium

Cas:15307-79-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

Synthetic route

2-[(2,6-dichlorophenyl)amino]phenylacetic acid methyl ester
15307-78-5

2-[(2,6-dichlorophenyl)amino]phenylacetic acid methyl ester

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
With sodium hydroxide In water; N,N-dimethyl-formamide at 80℃; for 24h;96.1%
1-(2,6-dichlorophenyl)indolin-2-one
15362-40-0

1-(2,6-dichlorophenyl)indolin-2-one

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water for 4h; Heating;93%
With sodium dithionite; water; sodium hydroxide for 6h; Reflux;92.3%
With sodium hydroxide In ethanol for 3h; Heating;85%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In toluene for 10h; Reflux;83.6%
With sodium hydroxide for 2h; Temperature; Reflux;4.035 g
C22H17Cl2NO3

C22H17Cl2NO3

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
With water; sodium hydroxide In methanol for 6h; Solvent; Reflux;86%
potassium 2-iodophenylacetate
100754-92-5

potassium 2-iodophenylacetate

2,6-Dichloroaniline
608-31-1

2,6-Dichloroaniline

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one; copper; potassium carbonate at 120℃; for 22h;56%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

2,6-Dichloroaniline
608-31-1

2,6-Dichloroaniline

butan-1-ol
71-36-3

butan-1-ol

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
With sodium hydroxide; potassium iodide; copper(I) iodide; potassium carbonate In N,N-dimethyl-formamide42.9%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

2,6-Dichloroaniline
608-31-1

2,6-Dichloroaniline

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Stage #1: 2'-chloro-benzeneacetic acid; 2,6-Dichloroaniline With copper(l) iodide; iodine; potassium carbonate; potassium iodide In N,N-dimethyl-formamide for 12h; Inert atmosphere; Schlenk technique; Reflux;
Stage #2: With sodium hydroxide In water for 4h; Reflux;
31%
2-(2-((2,6-dichlorophenyl)amino)phenyl)-2-oxoacetic acid
66156-75-0

2-(2-((2,6-dichlorophenyl)amino)phenyl)-2-oxoacetic acid

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
With sodium methylate; hydrazine hydrate In 2-methoxy-ethanol 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h; Yield given;
N-phenyl-2,6-dichloroaniline
15307-93-4

N-phenyl-2,6-dichloroaniline

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: benzene / 6 h / Heating
2: 91 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / Ambient temperature
3: 84 percent / p-toluenesulfonic acid / benzene / 0.5 h / Heating
4: 97 percent / Zn / acetic acid / 4 h / Heating
5: 85 percent / 20percent NaOH / ethanol / 3 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: benzene / 6 h / Heating
2: N-chlorosuccinimide / CCl4 / 1 h / Ambient temperature
3: SnCl4 / CCl4 / 0.83 h / Ambient temperature
4: 97 percent / Zn / acetic acid / 4 h / Heating
5: 85 percent / 20percent NaOH / ethanol / 3 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: benzene / 2 h / Ambient temperature
2: AlCl3 / various solvent(s) / 20 h / Ambient temperature
3: 1 N NaOH / ethanol; H2O / 0.17 h / Heating
4: hydrazine hydrate, NaOCH3 / 2-methoxy-ethanol / 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h
View Scheme
Multi-step reaction with 3 steps
1: 66 percent / 16 h / Heating
2: 75.4 percent / AlCl3 / 2 h / 160 °C
3: 93 percent / 2 N NaOH / ethanol; H2O / 4 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: toluene / 3 h / 120 °C
2: triethylamine hydrochloride-aluminum trichloride / 4.5 h / 20 - 60 °C
3: sodium hydroxide / 2 h / Reflux
View Scheme
N-(2,6-dichlorophenyl)-α-(methylthio)acetanilide
83281-93-0

N-(2,6-dichlorophenyl)-α-(methylthio)acetanilide

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 91 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / Ambient temperature
2: 84 percent / p-toluenesulfonic acid / benzene / 0.5 h / Heating
3: 97 percent / Zn / acetic acid / 4 h / Heating
4: 85 percent / 20percent NaOH / ethanol / 3 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: N-chlorosuccinimide / CCl4 / 1 h / Ambient temperature
2: SnCl4 / CCl4 / 0.83 h / Ambient temperature
3: 97 percent / Zn / acetic acid / 4 h / Heating
4: 85 percent / 20percent NaOH / ethanol / 3 h / Heating
View Scheme
1-(2,6-dichlorophenyl)-3-(methylthio)oxindole
83281-94-1

1-(2,6-dichlorophenyl)-3-(methylthio)oxindole

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 97 percent / Zn / acetic acid / 4 h / Heating
2: 85 percent / 20percent NaOH / ethanol / 3 h / Heating
View Scheme
N-(2,6-dichlorophenyl)-α-(methylsulfinyl)acetanilide
83281-96-3

N-(2,6-dichlorophenyl)-α-(methylsulfinyl)acetanilide

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 84 percent / p-toluenesulfonic acid / benzene / 0.5 h / Heating
2: 97 percent / Zn / acetic acid / 4 h / Heating
3: 85 percent / 20percent NaOH / ethanol / 3 h / Heating
View Scheme
α-chloro-N-(2,6-dichlorophenyl)-α-(methylthio)acetanilide

α-chloro-N-(2,6-dichlorophenyl)-α-(methylthio)acetanilide

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: SnCl4 / CCl4 / 0.83 h / Ambient temperature
2: 97 percent / Zn / acetic acid / 4 h / Heating
3: 85 percent / 20percent NaOH / ethanol / 3 h / Heating
View Scheme
1-(2,6-Dichlorphenyl)-2,3-indoldion
24542-74-3

1-(2,6-Dichlorphenyl)-2,3-indoldion

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1 N NaOH / ethanol; H2O / 0.17 h / Heating
2: hydrazine hydrate, NaOCH3 / 2-methoxy-ethanol / 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h
View Scheme
[(2,6-Dichloro-phenyl)-phenyl-amino]-oxo-acetyl chloride
24542-55-0

[(2,6-Dichloro-phenyl)-phenyl-amino]-oxo-acetyl chloride

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: AlCl3 / various solvent(s) / 20 h / Ambient temperature
2: 1 N NaOH / ethanol; H2O / 0.17 h / Heating
3: hydrazine hydrate, NaOCH3 / 2-methoxy-ethanol / 1.) from 60 deg C to 150 deg C, 2.) 150 deg C, 1 h
View Scheme
2-chloro-N-(2',6'-dichlorophenyl)-N-phenylacetamide
15308-01-7

2-chloro-N-(2',6'-dichlorophenyl)-N-phenylacetamide

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 75.4 percent / AlCl3 / 2 h / 160 °C
2: 93 percent / 2 N NaOH / ethanol; H2O / 4 h / Heating
View Scheme
N-(2,6-dichlorophenyl)phenylacetamide

N-(2,6-dichlorophenyl)phenylacetamide

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tert-butylhypochlorite / dichloromethane / 10 h / 25 °C / Cooling with ice
2: aluminum (III) chloride / dichloromethane / 12 h / 20 °C / Cooling with ice
3: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / toluene / 10 h / Reflux
View Scheme
2,6-Dichloroaniline
608-31-1

2,6-Dichloroaniline

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: calcium chloride; pyridine / 4 h / Reflux; Cooling with ice
2: tert-butylhypochlorite / dichloromethane / 10 h / 25 °C / Cooling with ice
3: aluminum (III) chloride / dichloromethane / 12 h / 20 °C / Cooling with ice
4: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / toluene / 10 h / Reflux
View Scheme
phenylacetyl chloride
103-80-0

phenylacetyl chloride

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: calcium chloride; pyridine / 4 h / Reflux; Cooling with ice
2: tert-butylhypochlorite / dichloromethane / 10 h / 25 °C / Cooling with ice
3: aluminum (III) chloride / dichloromethane / 12 h / 20 °C / Cooling with ice
4: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / toluene / 10 h / Reflux
View Scheme
(2-benzoylamino-phenyl)-acetic acid methyl ester
3559-26-0

(2-benzoylamino-phenyl)-acetic acid methyl ester

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / 3 h / Reflux
1.2: 3 h / Cooling with ice; Reflux
2.1: diphenylether / 3 h / Reflux
3.1: sodium hydroxide; water / methanol / 6 h / Reflux
View Scheme
methyl (2-nitrophenyl)acetate
30095-98-8

methyl (2-nitrophenyl)acetate

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: palladium on activated charcoal; hydrogen / toluene / 5 °C / 760.05 Torr
2.1: triethylamine / toluene / 2 h / 0 °C
3.1: thionyl chloride / 3 h / Reflux
3.2: 3 h / Cooling with ice; Reflux
4.1: diphenylether / 3 h / Reflux
5.1: sodium hydroxide; water / methanol / 6 h / Reflux
View Scheme
benzeneacetic acid methyl ester
101-41-7

benzeneacetic acid methyl ester

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: nitric acid / dichloromethane / 24 h / 0 - 20 °C
2.1: palladium on activated charcoal; hydrogen / toluene / 5 °C / 760.05 Torr
3.1: triethylamine / toluene / 2 h / 0 °C
4.1: thionyl chloride / 3 h / Reflux
4.2: 3 h / Cooling with ice; Reflux
5.1: diphenylether / 3 h / Reflux
6.1: sodium hydroxide; water / methanol / 6 h / Reflux
View Scheme
2-aminophenylacetic acid methyl ester
35613-44-6

2-aminophenylacetic acid methyl ester

diclofenac sodium
15307-79-6

diclofenac sodium

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethylamine / toluene / 2 h / 0 °C
2.1: thionyl chloride / 3 h / Reflux
2.2: 3 h / Cooling with ice; Reflux
3.1: diphenylether / 3 h / Reflux
4.1: sodium hydroxide; water / methanol / 6 h / Reflux
View Scheme
didecyldimethylammonium chloride
7173-51-5

didecyldimethylammonium chloride

diclofenac sodium
15307-79-6

diclofenac sodium

diclofenac didecyldimethylammonium salt
934544-42-0

diclofenac didecyldimethylammonium salt

Conditions
ConditionsYield
In water at 20℃; for 0.5h; Product distribution / selectivity;100%
diclofenac sodium
15307-79-6

diclofenac sodium

cadmium(II) chloride
10108-64-2

cadmium(II) chloride

{Cd(C6H3Cl2NHC6H4CH2COO)2(H2O)}
149753-43-5

{Cd(C6H3Cl2NHC6H4CH2COO)2(H2O)}

Conditions
ConditionsYield
With H2O; KOH In water byproducts: NaCl; mixing aq. soln. of the components, adjusting to pH 5.5-7.5 with KOH and stirring at room temp. for 4-6 h; filtn., washing with water, drying over silica gel (vac.) and over P4O10 at 90°C (vac.);100%
diclofenac sodium
15307-79-6

diclofenac sodium

zinc(II) chloride
7646-85-7

zinc(II) chloride

{Zn(C6H3Cl2NHC6H4CH2COO)2(H2O)}
149753-42-4

{Zn(C6H3Cl2NHC6H4CH2COO)2(H2O)}

Conditions
ConditionsYield
With H2O; KOH In water byproducts: NaCl; mixing aq. soln. of the components, adjusting to pH 5.5-7.5 with KOH and stirring at room temp. for 4-6 h; filtn., washing with water, drying over silica gel (vac.) and over P4O10 at 90°C (vac.);100%
diclofenac sodium
15307-79-6

diclofenac sodium

[2-(2,6-dichloroanilino)phenyl]acetic acid
15307-86-5

[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions
ConditionsYield
With hydrogenchloride In water; acetone at 20 - 45℃; for 3h; pH=1.4 - 1.6; Solvent;99%
With hydrogenchloride In water Cooling with ice;90%
With hydrogenchloride In water at 0 - 20℃;70%
diclofenac sodium
15307-79-6

diclofenac sodium

1-(2,6-dichlorophenyl)-1,3-dihydro-indol-2-one-[3,3,5,7-D4]
1401311-49-6

1-(2,6-dichlorophenyl)-1,3-dihydro-indol-2-one-[3,3,5,7-D4]

Conditions
ConditionsYield
With water-d2; hydrogen chloride at 160℃; for 0.333333h; Microwave irradiation;96%
choline chloride
67-48-1

choline chloride

diclofenac sodium
15307-79-6

diclofenac sodium

(2-hydroxyethyl)tri-methylammonium [o-(2,6-dichloroanilino)phenyl]acetate
148439-51-4

(2-hydroxyethyl)tri-methylammonium [o-(2,6-dichloroanilino)phenyl]acetate

Conditions
ConditionsYield
In ethanol at 20℃; for 1h;96%
diclofenac sodium
15307-79-6

diclofenac sodium

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide
572-09-8

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide

1-O-<2-<(2,6-dichlorophenyl)amino>phenylacetyl>-2,3,4,6-tetra-O-acetyl-β-D-glucopyranose
87906-12-5

1-O-<2-<(2,6-dichlorophenyl)amino>phenylacetyl>-2,3,4,6-tetra-O-acetyl-β-D-glucopyranose

Conditions
ConditionsYield
citrimide In water; 1,2-dichloro-ethane Ambient temperature;95%
bromoacetic acid tert-butyl ester
5292-43-3

bromoacetic acid tert-butyl ester

diclofenac sodium
15307-79-6

diclofenac sodium

2-((2,6-dichlorophenyl)amino)phenylacetoxyacetic acid tert-butyl ester
139272-68-7

2-((2,6-dichlorophenyl)amino)phenylacetoxyacetic acid tert-butyl ester

Conditions
ConditionsYield
With potassium iodide In ethanol at 61 - 65℃; for 3h; Temperature; Large scale;94.45%
With potassium iodide In acetonitrile at 30℃; for 0.25h; Microwave irradiation;91.6%
With tetra(n-butyl)ammonium hydrogensulfate; potassium iodide In water; acetone at 60 - 65℃; for 2h;17.3 g
In N,N-dimethyl-formamide at 20 - 45℃;
diclofenac sodium
15307-79-6

diclofenac sodium

Reaxys ID: 15741354

Reaxys ID: 15741354

Conditions
ConditionsYield
In dimethyl sulfoxide at 20℃;94%
diclofenac sodium
15307-79-6

diclofenac sodium

C14H3(2)H6Cl2NO

C14H3(2)H6Cl2NO

Conditions
ConditionsYield
With trifluoroacetic acid-d1 at 110℃; for 16h; Sealed tube;94%
4,4'-bipyridine
553-26-4

4,4'-bipyridine

diclofenac sodium
15307-79-6

diclofenac sodium

silver nitrate

silver nitrate

Ag(2-(2,6-dicholoroanilino)phenylacetic acid)(4,4'-bipyridine)

Ag(2-(2,6-dicholoroanilino)phenylacetic acid)(4,4'-bipyridine)

Conditions
ConditionsYield
In water; acetonitrile at 50℃;94%
diclofenac sodium
15307-79-6

diclofenac sodium

3-(bromomethyl)-4-methyl-1,2,5-oxadiazole-2-oxide
169614-77-1

3-(bromomethyl)-4-methyl-1,2,5-oxadiazole-2-oxide

[2-(2,6-dichlorophenylamino)-phenyl]-acetic acid 4-methyl-2-oxy-furazan-3-ylmethyl ester

[2-(2,6-dichlorophenylamino)-phenyl]-acetic acid 4-methyl-2-oxy-furazan-3-ylmethyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20 - 25℃; for 2h;93%
2-(2-Hydroxyethyl)pyridine
103-74-2

2-(2-Hydroxyethyl)pyridine

diclofenac sodium
15307-79-6

diclofenac sodium

copper(II) acetate monohydrate
6046-93-1

copper(II) acetate monohydrate

C42H36Cl4Cu2N4O6

C42H36Cl4Cu2N4O6

Conditions
ConditionsYield
In methanol at 50℃;91%
diclofenac sodium
15307-79-6

diclofenac sodium

N,N-didecyl-N,N-dimethylammonium bromide
2390-68-3

N,N-didecyl-N,N-dimethylammonium bromide

diclofenac didecyldimethylammonium salt
934544-42-0

diclofenac didecyldimethylammonium salt

Conditions
ConditionsYield
With sodium hydrogencarbonate; sodium hydroxide In methanol; water at 20℃; for 0.5h;91%
diclofenac sodium
15307-79-6

diclofenac sodium

methyl iodide
74-88-4

methyl iodide

2-[(2,6-dichlorophenyl)amino]phenylacetic acid methyl ester
15307-78-5

2-[(2,6-dichlorophenyl)amino]phenylacetic acid methyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide90%
In acetone Heating;
copper(ll) sulfate pentahydrate

copper(ll) sulfate pentahydrate

diclofenac sodium
15307-79-6

diclofenac sodium

2C14H10Cl2NO2(1-)*Cu(2+)*2H2O

2C14H10Cl2NO2(1-)*Cu(2+)*2H2O

Conditions
ConditionsYield
In water at 20℃;90%
tert-Butyl chloroacetate
107-59-5

tert-Butyl chloroacetate

diclofenac sodium
15307-79-6

diclofenac sodium

2-((2,6-dichlorophenyl)amino)phenylacetoxyacetic acid tert-butyl ester
139272-68-7

2-((2,6-dichlorophenyl)amino)phenylacetoxyacetic acid tert-butyl ester

Conditions
ConditionsYield
With sodium iodide In acetonitrile at 77 - 78℃; for 2h;89.6%
In acetonitrile for 4h; Reflux;
With potassium iodide In N,N-dimethyl-formamide for 2h; Reflux; Large scale;25.5 g
diclofenac sodium
15307-79-6

diclofenac sodium

6-bromomethyl-benzo[1,2,5]oxadiazole-1-oxide

6-bromomethyl-benzo[1,2,5]oxadiazole-1-oxide

[2-(2,6-dichlorophenylamino)-phenyl]-acetic acid 1-oxy-benzo[1,2,5]oxadiazol-6-ylmethyl ester

[2-(2,6-dichlorophenylamino)-phenyl]-acetic acid 1-oxy-benzo[1,2,5]oxadiazol-6-ylmethyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20 - 25℃; for 2h;89%
diclofenac sodium
15307-79-6

diclofenac sodium

5-(bromomethyl)benzofuroxan
175609-21-9

5-(bromomethyl)benzofuroxan

given name is incorrect
883738-54-3

given name is incorrect

Conditions
ConditionsYield
With N-Bromosuccinimide; dibenzoyl peroxide In N,N-dimethyl-formamide at 25℃; for 2h;89%
2-(2-Hydroxyethyl)pyridine
103-74-2

2-(2-Hydroxyethyl)pyridine

nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

diclofenac sodium
15307-79-6

diclofenac sodium

[Ni(diclofenac)2(2-pyridineethanol)2]

[Ni(diclofenac)2(2-pyridineethanol)2]

Conditions
ConditionsYield
In methanol at 50℃;89%
methanol
67-56-1

methanol

diclofenac sodium
15307-79-6

diclofenac sodium

copper(II) nitrate

copper(II) nitrate

tetrakis{μ-2-[2-(2,6-dichloroanilino)phenyl]acetato-κ2O:O'}bis(methanol-κO)copper(II)

tetrakis{μ-2-[2-(2,6-dichloroanilino)phenyl]acetato-κ2O:O'}bis(methanol-κO)copper(II)

Conditions
ConditionsYield
In water at 20℃;89%
1H-imidazole
288-32-4

1H-imidazole

diclofenac sodium
15307-79-6

diclofenac sodium

copper(II) nitrate

copper(II) nitrate

bis{2-[2-(2,6-dichloroanilino)phenyl]acetato-κ2O,O'}bis(1H-imidazole-κN3)copper(II)

bis{2-[2-(2,6-dichloroanilino)phenyl]acetato-κ2O,O'}bis(1H-imidazole-κN3)copper(II)

Conditions
ConditionsYield
In methanol; water at 20℃;89%
didecyldimethylammonium acesulfamate
934544-25-9

didecyldimethylammonium acesulfamate

diclofenac sodium
15307-79-6

diclofenac sodium

diclofenac didecyldimethylammonium salt
934544-42-0

diclofenac didecyldimethylammonium salt

Conditions
ConditionsYield
In acetone at 60℃; for 2h; Product distribution / selectivity;88%
diclofenac sodium
15307-79-6

diclofenac sodium

silver nitrate

silver nitrate

silver(I) diclofenac

silver(I) diclofenac

Conditions
ConditionsYield
In water87%
In methanol at 20℃; for 1h; Darkness;85%
With ammonia In ethanol; water at 20℃; for 0.25h; pH=8;
isopropyloxycarbonyloxymethyl iodide
258841-42-8

isopropyloxycarbonyloxymethyl iodide

diclofenac sodium
15307-79-6

diclofenac sodium

1-[(1-methylethoxy)carbonyloxy]methyl 2-[(2,6-dichlorophenyl)amino]phenylacetate
1264635-62-2

1-[(1-methylethoxy)carbonyloxy]methyl 2-[(2,6-dichlorophenyl)amino]phenylacetate

Conditions
ConditionsYield
Stage #1: diclofenac sodium With sodium carbonate In N,N-dimethyl acetamide at 30℃; for 0.166667h; Inert atmosphere;
Stage #2: isopropyloxycarbonyloxymethyl iodide In N,N-dimethyl acetamide at -10℃; for 0.75h; Inert atmosphere;
86.4%
trimethyltin(IV)chloride
1066-45-1

trimethyltin(IV)chloride

diclofenac sodium
15307-79-6

diclofenac sodium

(CH3)3SnOC(O)CH2C6H4NHC6H3Cl2

(CH3)3SnOC(O)CH2C6H4NHC6H3Cl2

Conditions
ConditionsYield
In chloroform byproducts: sodium chloride; under inert atmosphere; 1 equiv. of sodium salt of ligand refluxed withSn compd. in dry CHCl3 for 6-7 h; cooled to room temp.; filtered; solvent removed from filtrate by rotary evaporator; crystd. from CH2Cl2-hexane; elem. anal.;86%
1-(2-aminoethyl)pyrrolidine
7154-73-6

1-(2-aminoethyl)pyrrolidine

nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

diclofenac sodium
15307-79-6

diclofenac sodium

[Ni(diclofenac)2(1-(2-aminoethyl)pyrrolidine)2]
1596252-87-7

[Ni(diclofenac)2(1-(2-aminoethyl)pyrrolidine)2]

Conditions
ConditionsYield
Stage #1: nickel(II) chloride hexahydrate; diclofenac sodium In ethanol at 50℃;
Stage #2: 1-(2-aminoethyl)pyrrolidine In ethanol at 20℃;
86%
diclofenac sodium
15307-79-6

diclofenac sodium

water
7732-18-5

water

zinc(II) chloride
7646-85-7

zinc(II) chloride

C28H24Cl4N2O6Zn

C28H24Cl4N2O6Zn

Conditions
ConditionsYield
In water at 20℃; for 3h;86%
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