1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryHangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well. *We own a
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inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan
Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
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inquiryBeluga chemical professional supply Letrozole China factory CAS:112809-51-5 Why choose Beluga chemical 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabil
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inquiry1.High Quality: Quality is life. Quality is the most important element for all goods. We have a lab doing research in Wuhan China and produce sarms in bulk quantity. We have 8 years experience making all kinds of sarms. And all our old customers
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inquiryHigh Quality Raw Materials powders Letrozole CAS NO.112809-51-5 Letrozole is an oral inhibitor for the treatment of hormonally-responsive breast cancer after surgery. Letrozole prevents the aromatase from producing estrogens by competitive, reversi
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inquiry1) Specialized in pharmaceutical industry since from 1987 2) ISO 9001:2015 & SGS audited supplier 3) Accept better payment terms : T.T 30-60 days.on the basic of pass SINOSURE credit investigation. 5) We have warehouse in USA with quickly shi
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inquiryPioneerbiotech is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best quality in your
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inquiryReason for Choosing us: 1): Superior Quality and Competitive Price: Our company is a renowned pharmaceutical manufacturer with more than 15 years experiences in China and all powders are supplying from our factory directly. 2): Fast ,Sa
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Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Letrozole CAS no:112809-51-5 Grade:Medical, scientific research and export Molecular formula:CC17H11N5 Molecular weight:285.31 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquirycas 112809-51-5 99% purity Letrozole powder Product Name: Letrozole CAS: 112809-51-5 MF: C17H11N5 MW: 285.3 EINECS: 675-034-8 Appearance:white Storage:room Package:drum Application:Artemisia annua is used as antimalarial drugs.
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inquiryName:Letrozole CAS No.:112809-51-5 Molecular Formula:C7H11N5 Purity:99% Synonyms:letrozolex ;Lelrozol;1-[BIS(4-CYANOPHENYL)METHYL]-1,2,4-TRIAZOLE; 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile Molecular Weight:285.3 Appearanc
Appearance:white to off-white powder Storage:R T Package:25kg/Barrel Application:Pyrrole aromatase inhibitors. Used to treat breast cancer. Transportation:Express/Sea/Air Port:Any port in China
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White powder Storage:Store in sealed containers at cool & dr
Cas:112809-51-5
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inquiry1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Letrozole Molecular Structure: Formula: C17H11N5 Molecular Weight : 285.3 Synonyms: LetrozoleUsp28;Letrozole99%;CGS-20267, Femara;LETRAZOLE;letrozolex;Lelr
Cas:112809-51-5
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inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
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inquiry1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) reasonable &
Cas:112809-51-5
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inquirySpecification Product Name:Letrozole Product number:BJM-006 CAS:112809-51-5 Molecular formula:C17H11N5 Molecular weight:285.3 Content:99.0%min Alisa:4,4'-(1H-1,2,4-TRIAZOL-1-YLMETHYLENE) BIS-BENZONITRILE;FEMARA;CGS-20267;LETROZOL;LETROZOLE;Let
Cas:112809-51-5
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Type:Lab/Research institutions
inquiry4-(1H-1,2,4-triazol-1-ylmethyl)benzonitrile hydrochloride
4-fluorobenzonitrile
letrozol
Conditions | Yield |
---|---|
Stage #1: 4-(1H-1,2,4-triazol-1-ylmethyl)benzonitrile hydrochloride With potassium tert-butylate In N,N-dimethyl-formamide at -25 - -20℃; for 1.08333h; Inert atmosphere; Stage #2: 4-fluorobenzonitrile In N,N-dimethyl-formamide at -25 - -20℃; for 1.08333h; | 98.6% |
Stage #1: 4-(1H-1,2,4-triazol-1-ylmethyl)benzonitrile hydrochloride With potassium tert-butylate In N,N-dimethyl-formamide at -25 - -20℃; for 1.08333h; Stage #2: 4-fluorobenzonitrile In N,N-dimethyl-formamide at -25 - -20℃; for 1.08333h; Stage #3: With hydrogenchloride In water; N,N-dimethyl-formamide at -20 - 0℃; for 0.5h; pH=6.0 - 6.5; Product distribution / selectivity; | 55% |
1,2,4-Triazole
toluene-4-sulfonic acid bis-(4-cyano-phenyl)-methyl ester
letrozol
Conditions | Yield |
---|---|
Stage #1: 1,2,4-Triazole With tetrabutylammomium bromide; potassium carbonate In water; 4-methyl-2-pentanone for 2h; Stage #2: toluene-4-sulfonic acid bis-(4-cyano-phenyl)-methyl ester In water; 4-methyl-2-pentanone at 20 - 30℃; for 48h; Stage #3: With hydrogenchloride In water; 4-methyl-2-pentanone for 1h; | 97.42% |
Conditions | Yield |
---|---|
Stage #1: potassium cyanide With acetic acid In ethylene glycol Sealed tube; Stage #2: 1-(bis(4-bromophenyl)methyl)-1H-1,2,4-triazole With P(t-Bu)3 Palladacycle Gen. 3; potassium acetate In 1,4-dioxane; water at 60℃; for 16h; Concentration; Sealed tube; | 97% |
letrozol
Conditions | Yield |
---|---|
With trifluoroacetic anhydride In 1,4-dioxane at 0 - 20℃; for 1h; | 90% |
Conditions | Yield |
---|---|
Stage #1: 4-amino-1,2,4-triazole; 4,4'-dicyanodiphenylbromomethane In acetonitrile for 24h; Reflux; Stage #2: With hydrogenchloride; sodium nitrite In water; acetonitrile at 0 - 5℃; for 6h; Solvent; Time; | 88.7% |
letrozol
Conditions | Yield |
---|---|
With sodium carbonate In water; N,N-dimethyl-formamide at 120℃; for 24h; | 87% |
Conditions | Yield |
---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; water; bis(dibenzylideneacetone)-palladium(0) In N,N-dimethyl-formamide at 120℃; for 15h; Inert atmosphere; | 86% |
4-fluorobenzonitrile
sodium triazole
4-cyanobenzyl bromide
letrozol
Conditions | Yield |
---|---|
Stage #1: sodium triazole; 4-cyanobenzyl bromide With potassium tert-butylate In N,N-dimethyl-formamide at -5 - 5℃; for 2.5h; Stage #2: 4-fluorobenzonitrile In N,N-dimethyl-formamide at -5 - 5℃; for 2.5h; Product distribution / selectivity; | 85% |
Stage #1: sodium triazole; 4-cyanobenzyl bromide In N,N-dimethyl-formamide at -10 - 0℃; for 1h; Stage #2: 4-fluorobenzonitrile With sodium hexamethyldisilazane In tetrahydrofuran; N,N-dimethyl-formamide at -10 - -5℃; Product distribution / selectivity; | |
Stage #1: sodium triazole; 4-cyanobenzyl bromide In ISOPROPYLAMIDE at -15 - 0℃; for 2.5h; Stage #2: 4-fluorobenzonitrile With sodium hexamethyldisilazane In tetrahydrofuran; ISOPROPYLAMIDE at -8 - 0℃; for 1h; Product distribution / selectivity; |
triphenylphosphine
B
letrozol
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 48h; | A 75% B n/a |
1,2,4-Triazole
4-(alpha-chloro-4'-cyanobenzyl)-benzonitrile
letrozol
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide; toluene at 60 - 80℃; for 4h; | 74.4% |
4-fluorobenzonitrile
letrozol
Conditions | Yield |
---|---|
Stage #1: 4-((1H-1,2,4-triazole-1-yl)methyl)benzonitrile With potassium tert-butylate In N,N-dimethyl-formamide at -5 - 0℃; for 2h; Stage #2: 4-fluorobenzonitrile In N,N-dimethyl-formamide at 0 - 10℃; for 0.25h; Product distribution / selectivity; | 73% |
Stage #1: 4-((1H-1,2,4-triazole-1-yl)methyl)benzonitrile With lithium hexamethyldisilazane In tetrahydrofuran at -30 - -25℃; for 0.666667h; Stage #2: 4-fluorobenzonitrile In tetrahydrofuran at -20 - -15℃; for 1.25h; Product distribution / selectivity; |
1,3,5-Triazine
2-(propan-2-ylidine)-1-[di-(4-cyanophenyl)methyl]hydrazine
letrozol
Conditions | Yield |
---|---|
Stage #1: 2-(propan-2-ylidine)-1-[di-(4-cyanophenyl)methyl]hydrazine With hydrogenchloride In methanol at 20℃; Stage #2: 1,3,5-Triazine In methanol Reflux; | 70.7% |
1,2,4-Triazole
4,4'-dicyanodiphenylbromomethane
A
4-[α-(4-cyano-phenyl)-1-(1,3,4-triazol-1-yl)-methyl]-benzonitrile
B
letrozol
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide; toluene at 60 - 80℃; for 1.5h; Product distribution / selectivity; | A 3.5% B 70.5% |
Conditions | Yield |
---|---|
With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; nickel(II) chloride hexahydrate; zinc In acetonitrile at 80℃; for 4h; Inert atmosphere; Sealed tube; | 68% |
With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; nickel(II) chloride hexahydrate; zinc In acetonitrile at 80℃; for 4h; Inert atmosphere; Glovebox; Sealed tube; | 68% |
4-((1H-1,2,4-triazole-1-yl)methyl)benzonitrile
2-(4-fluorobenzene)-1,3,4-oxadiazole
letrozol
Conditions | Yield |
---|---|
Stage #1: 4-((1H-1,2,4-triazole-1-yl)methyl)benzonitrile With potassium tert-butylate In N,N-dimethyl-formamide at -5℃; Inert atmosphere; Stage #2: 2-(4-fluorobenzene)-1,3,4-oxadiazole In N,N-dimethyl-formamide at -5℃; for 7.5h; Inert atmosphere; | 64% |
Conditions | Yield |
---|---|
Stage #1: 4-[1-(1,2,4-triazol-1-yl)methyl] benzonitrile; 4-fluorobenzonitrile With potassium tert-butylate In DMF (N,N-dimethyl-formamide) at -10 - -5℃; for 4h; Stage #2: With hydrogenchloride In DMF (N,N-dimethyl-formamide); water pH=7.5 - 8.0; | 58% |
1,2,4-Triazole
4-(bromomethyl)benzaldehyde
4-chlorobenzaldehyde
letrozol
Conditions | Yield |
---|---|
Stage #1: 4-(bromomethyl)benzaldehyde; 4-chlorobenzaldehyde With ammonium hydroxide; copper diacetate In dimethyl sulfoxide at 70℃; for 12h; Stage #2: 1,2,4-Triazole With potassium carbonate; potassium iodide In dimethyl sulfoxide; acetone at 50℃; for 10h; Inert atmosphere; | 43% |
1,2,4-Triazole
4-(bromomethyl)benzaldehyde
4-bromo-benzaldehyde
letrozol
Conditions | Yield |
---|---|
Stage #1: 4-(bromomethyl)benzaldehyde; 4-bromo-benzaldehyde With ammonium hydroxide; copper diacetate In dimethyl sulfoxide at 70℃; for 10h; Stage #2: 1,2,4-Triazole With potassium carbonate; potassium iodide In dimethyl sulfoxide; acetone at 50℃; for 10h; Inert atmosphere; | 35% |
1,2,4-Triazole
4-chloromethylbenzaldehyde
4-chlorobenzaldehyde
letrozol
Conditions | Yield |
---|---|
Stage #1: 4-chloromethylbenzaldehyde; 4-chlorobenzaldehyde With ammonium hydroxide; copper diacetate In dimethyl sulfoxide at 70℃; for 10h; Stage #2: 1,2,4-Triazole With potassium carbonate; potassium iodide In dimethyl sulfoxide; acetone at 50℃; for 10h; Inert atmosphere; | 34% |
1,2,4-Triazole
4-chloromethylbenzaldehyde
4-bromo-benzaldehyde
letrozol
Conditions | Yield |
---|---|
Stage #1: 4-chloromethylbenzaldehyde; 4-bromo-benzaldehyde With ammonium hydroxide; copper diacetate In dimethyl sulfoxide at 70℃; for 10h; Stage #2: 1,2,4-Triazole With potassium carbonate; potassium iodide In dimethyl sulfoxide; acetone at 50℃; for 10h; Inert atmosphere; | 33% |
1,2,4-Triazole
4-iodomethylbenzaldehyde
4-bromo-benzaldehyde
letrozol
Conditions | Yield |
---|---|
Stage #1: 4-iodomethylbenzaldehyde; 4-bromo-benzaldehyde With ammonium hydroxide; copper diacetate In dimethyl sulfoxide at 70℃; for 10h; Stage #2: 1,2,4-Triazole With potassium carbonate; potassium iodide In dimethyl sulfoxide; acetone at 50℃; for 10h; Inert atmosphere; | 32% |
1,2,4-Triazole
4-(bromomethyl)benzaldehyde
4-fluorobenzaldehyde
letrozol
Conditions | Yield |
---|---|
Stage #1: 4-(bromomethyl)benzaldehyde; 4-fluorobenzaldehyde With ammonium hydroxide; copper diacetate In dimethyl sulfoxide at 70℃; for 12h; Stage #2: 1,2,4-Triazole With potassium carbonate; potassium iodide In dimethyl sulfoxide; acetone at 50℃; for 10h; Inert atmosphere; | 32% |
1,2,4-Triazole
4-iodomethylbenzaldehyde
4-chlorobenzaldehyde
letrozol
Conditions | Yield |
---|---|
Stage #1: 4-iodomethylbenzaldehyde; 4-chlorobenzaldehyde With ammonium hydroxide; copper diacetate In dimethyl sulfoxide at 70℃; for 10h; Stage #2: 1,2,4-Triazole With potassium carbonate; potassium iodide In dimethyl sulfoxide; acetone at 50℃; for 10h; Inert atmosphere; | 21% |
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; potassium carbonate In isopropyl alcohol for 8 - 9h; Product distribution / selectivity; Heating / reflux; | |
With potassium carbonate In isopropyl alcohol for 8 - 9h; Product distribution / selectivity; Heating / reflux; |
Conditions | Yield |
---|---|
With potassium tert-butylate In N-methyl-acetamide |
4-fluorobenzonitrile
4-((1H-1,2,4-triazole-1-yl)methyl)benzonitrile
letrozol
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at -15℃; for 7 - 8h; Product distribution / selectivity; | |
With lithium hexamethyldisilazane In tetrahydrofuran at -20 - -5℃; for 2h; Product distribution / selectivity; | |
Stage #1: 4-((1H-1,2,4-triazole-1-yl)methyl)benzonitrile With potassium tert-butylate In N,N-dimethyl-formamide at 0 - 5℃; for 1.5h; Stage #2: 4-fluorobenzonitrile In N,N-dimethyl-formamide at 0 - 5℃; for 1.5h; |
4-[(1-(1,3,4-triazolyl)-methyl)]benzonitrile
4-fluorobenzonitrile
4-((1H-1,2,4-triazole-1-yl)methyl)benzonitrile
A
4-[α-(4-cyano-phenyl)-1-(1,3,4-triazol-1-yl)-methyl]-benzonitrile
B
letrozol
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at -15℃; for 3h; Product distribution / selectivity; |
letrozol
Conditions | Yield |
---|---|
With acetic anhydride for 8 - 10h; Product distribution / selectivity; Heating / reflux; | |
With sodium acetate; acetic anhydride; acetic acid at 20℃; for 3 - 4h; Product distribution / selectivity; Heating / reflux; |
letrozol
Conditions | Yield |
---|---|
In ethanol; water High Pressure; mixt. of letrozole, CoCl2, EtOH and H2O sealed in stainless steel reactor, heated to 120°C for 24 h, slowly cooled to room temp.; elem. anal.; | 97.8% |
In ethanol; water CoCl2 and letrozole dissolved in EtOH/H2O; mixt. stirred at room temp. for 1 h; filtered, soln. kept at room temp. for 4 d; elem. anal.; | 33.5% |
letrozol
Conditions | Yield |
---|---|
Stage #1: letrozol With sodium hydroxide In water for 6h; Reflux; Stage #2: With hydrogenchloride In water | 94.9% |
Stage #1: letrozol With potassium hydroxide In ethanol; water for 36h; Reflux; Stage #2: With hydrogenchloride In water pH=2; | 86.1% |
Stage #1: letrozol With sodium hydroxide In N,N-dimethyl-formamide at 120℃; for 12h; Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide pH=1; | 77% |
With [Rh(6,7-dihydrotribenzo-[e,i,m][1,4,7,12]-ioxadiazacyclotetradecine)]Cl; water; sodium hydroxide at 70℃; for 0.25h; Reagent/catalyst; Time; | 97.43 %Spectr. |
Alkaline conditions; |
letrozol
Conditions | Yield |
---|---|
In ethanol; water High Pressure; mixt. of letrozole, NiCl2, EtOH and H2O sealed in stainless steel reactor, heated to 120°C for 24 h, slowly cooled to room temp.; elem. anal.; | 94.8% |
In ethanol; water NiCl2 and letrozole dissolved in EtOH/H2O; mixt. stirred at room temp. for 1 h; filtered, soln. kept at room temp. for 4 d; elem. anal.; | 45.3% |
trans-Cl2Pd(H2NCH2C6H5)2
letrozol
Conditions | Yield |
---|---|
Stage #1: trans-Cl2Pd(H2NCH2C6H5)2; silver nitrate In acetone at 25℃; for 2h; Darkness; Stage #2: letrozol In acetone | 78.5% |
dichloro(benzene)ruthenium(II) dimer
letrozol
Conditions | Yield |
---|---|
In ethanol for 1h; Reflux; | 73% |
letrozol
Conditions | Yield |
---|---|
With 2,3,4,5,7,8,9,10-octahydropyrimido[1,2-a]azepin-1-ium acetate; sodiumsulfide nonahydrate In neat (no solvent) at 20℃; for 2h; Green chemistry; | 73% |
ethanol
letrozol
Conditions | Yield |
---|---|
With acetyl chloride at 20℃; Cooling with ice; | 72% |
Sodium trans-Bis(dimethhyl sulfoxide) tetrachlororuthenate(III)
letrozol
Conditions | Yield |
---|---|
In acetone Inert atmosphere; Schlenk technique; | 66% |
letrozol
Conditions | Yield |
---|---|
With 2,3,4,5,7,8,9,10-octahydropyrimido[1,2-a]azepin-1-ium acetate; sodiumsulfide nonahydrate In neat (no solvent) at 20℃; for 2h; Green chemistry; | 64% |
letrozol
4,4'-dicyanodiphenylmethane
Conditions | Yield |
---|---|
With tetraethylammonium perchlorate; triethylamine In dimethyl sulfoxide at 20℃; for 6h; Electrolysis; Green chemistry; | 55% |
letrozol
Conditions | Yield |
---|---|
In ethanol; water at 120℃; for 72h; | 47% |
chloroform
letrozol
Cu(I)(1-[bis(4-cyanophenyl)methyl]-1,2,4-triazole)BF4*CHCl3
Conditions | Yield |
---|---|
In chloroform; benzene solvothermal treatment of Cu-complex with ligand in benzene and CHCl3 for 3 ds at 100°C; elem. anal.; | 40% |
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