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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Letrozole 112809-51-5 GMP Manufacturer

Cas:112809-51-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Letrozole CAS:112809-51-5 CAS NO.112809-51-5

Cas:112809-51-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Hysen Pharma co.,Ltd.

Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well. *We own a

Letrozole factory

Cas:112809-51-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Terui OP New Material Technology Co., Ltd.

Superiority We generally use secure shipping methods that do not require you to do any customs clearance. Free shipping to your address without worrying about any customs issues. We have a professional customs clearance team to 100% guarantee the

Letrozole CAS 112809-51-5 with Wholesale price

Cas:112809-51-5

Min.Order:1 Kilogram

FOB Price: $60.0 / 70.0

Type:Trading Company

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Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan

Letrozole

Cas:112809-51-5

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

Letrozole CAS 112809-51-5

Cas:112809-51-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply Letrozole China factory CAS:112809-51-5 Why choose Beluga chemical 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabil

Letrozole China factory CAS:112809-51-5

Cas:112809-51-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Wuhan Wonda Pharm Limited

1.High Quality: Quality is life. Quality is the most important element for all goods. We have a lab doing research in Wuhan China and produce sarms in bulk quantity. We have 8 years experience making all kinds of sarms. And all our old customers

High Quality Raw Materials powders Letrozole

Cas:112809-51-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Saiwante (shanghai) New Material Technology Co., Ltd.

High Quality Raw Materials powders Letrozole CAS NO.112809-51-5 Letrozole is an oral inhibitor for the treatment of hormonally-responsive breast cancer after surgery. Letrozole prevents the aromatase from producing estrogens by competitive, reversi

High Quality Raw Materials powders Letrozole CAS NO.112809-51-5

Cas:112809-51-5

Min.Order:1 Kilogram

FOB Price: $8.0 / 11.0

Type:Trading Company

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Sinoway Industrial Co., Ltd.

1) Specialized in pharmaceutical industry since from 1987 2) ISO 9001:2015 & SGS audited supplier 3) Accept better payment terms : T.T 30-60 days.on the basic of pass SINOSURE credit investigation. 5) We have warehouse in USA with quickly shi

Letrozole CAS:112809-51-5

Cas:112809-51-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

Pioneerbiotech is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best quality in your

High quality Latrozole with low price bulk in supply

Cas:112809-51-5

Min.Order:1 Kilogram

FOB Price: $190.0 / 200.0

Type:Other

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Hebei yanxi chemical co.,LTD.

Reason for Choosing us: 1): Superior Quality and Competitive Price: Our company is a renowned pharmaceutical manufacturer with more than 15 years experiences in China and all powders are supplying from our factory directly. 2): Fast ,Sa

Letrozole Anti Estrogen Letrozole for Treating Breast Cancer CAS NO.112809-51-5

Cas:112809-51-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

1.High quality : the purity is 99% min . through multiple producing procedures. 2.Competitive price : low price because of our skilled production technolpgy ,save the production cost at most , and give big profit room to our customers 3.Safe

Letrozole CAS 112809-51-5

Cas:112809-51-5

Min.Order:100 Gram

FOB Price: $50.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Letrozole

Cas:112809-51-5

Min.Order:1

Negotiable

Type:Other

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality letrozole

Cas:112809-51-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Letrozole

Cas:112809-51-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Letrozole CAS no:112809-51-5 Grade:Medical, scientific research and export Molecular formula:CC17H11N5 Molecular weight:285.31 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data

Letrozole/cas:112809-51-5/high quality/ Letrozole material

Cas:112809-51-5

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

high quality Letrozole

Cas:112809-51-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Letrozole

Cas:112809-51-5

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Letrozol CAS 112809-51-5

Cas:112809-51-5

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

letrozole CAS112809-51-5

Cas:112809-51-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hubei Vanz Pharm Co.,Ltd

cas 112809-51-5 99% purity Letrozole powder Product Name: Letrozole CAS: 112809-51-5 MF: C17H11N5 MW: 285.3 EINECS: 675-034-8 Appearance:white Storage:room Package:drum Application:Artemisia annua is used as antimalarial drugs.

cas 112809-51-5 99% purity Letrozole powder

Cas:112809-51-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name:Letrozole CAS No.:112809-51-5 Molecular Formula:C7H11N5 Purity:99% Synonyms:letrozolex ;Lelrozol;1-[BIS(4-CYANOPHENYL)METHYL]-1,2,4-TRIAZOLE; 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile Molecular Weight:285.3 Appearanc

Letrozole

Cas:112809-51-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:white to off-white powder Storage:R T Package:25kg/Barrel Application:Pyrrole aromatase inhibitors. Used to treat breast cancer. Transportation:Express/Sea/Air Port:Any port in China

Cheap Price Ready Stock Letrozole

Cas:112809-51-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White powder Storage:Store in sealed containers at cool & dr

HANWAYS CHEMPHARM CO.,LIMITED

1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Letrozole Molecular Structure: Formula: C17H11N5 Molecular Weight : 285.3 Synonyms: LetrozoleUsp28;Letrozole99%;CGS-20267, Femara;LETRAZOLE;letrozolex;Lelr

Factory Supply Letrozole

Cas:112809-51-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr

99.9% Letrozole / Femara/CAS:112809-51-5 for tumor Treatment

Cas:112809-51-5

Min.Order:1 Gram

FOB Price: $11.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

A nonsteroidal aromatase inhibitor,Antineoplastic drugs LetrozoleCAS:112809-51-5

Cas:112809-51-5

Min.Order:1 Kilogram

FOB Price: $1012.0 / 1026.0

Type:Trading Company

inquiry

Changchun Artel lmport and Export trade company

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) reasonable &amp

Buy Letrozole Supplier In China CAS NO.112809-51-5

Cas:112809-51-5

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Wuhan BJM Pharm Inc.

Specification Product Name:Letrozole Product number:BJM-006 CAS:112809-51-5 Molecular formula:C17H11N5 Molecular weight:285.3 Content:99.0%min Alisa:4,4'-(1H-1,2,4-TRIAZOL-1-YLMETHYLENE) BIS-BENZONITRILE;FEMARA;CGS-20267;LETROZOL;LETROZOLE;Let

Letrozole 112809-51-5

Cas:112809-51-5

Min.Order:1 Kilogram

FOB Price: $15.0 / 20.0

Type:Lab/Research institutions

inquiry

Synthetic route

4-(1H-1,2,4-triazol-1-ylmethyl)benzonitrile hydrochloride
112809-26-4

4-(1H-1,2,4-triazol-1-ylmethyl)benzonitrile hydrochloride

4-fluorobenzonitrile
1194-02-1

4-fluorobenzonitrile

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
Stage #1: 4-(1H-1,2,4-triazol-1-ylmethyl)benzonitrile hydrochloride With potassium tert-butylate In N,N-dimethyl-formamide at -25 - -20℃; for 1.08333h; Inert atmosphere;
Stage #2: 4-fluorobenzonitrile In N,N-dimethyl-formamide at -25 - -20℃; for 1.08333h;
98.6%
Stage #1: 4-(1H-1,2,4-triazol-1-ylmethyl)benzonitrile hydrochloride With potassium tert-butylate In N,N-dimethyl-formamide at -25 - -20℃; for 1.08333h;
Stage #2: 4-fluorobenzonitrile In N,N-dimethyl-formamide at -25 - -20℃; for 1.08333h;
Stage #3: With hydrogenchloride In water; N,N-dimethyl-formamide at -20 - 0℃; for 0.5h; pH=6.0 - 6.5; Product distribution / selectivity;
55%
1,2,4-Triazole
288-88-0

1,2,4-Triazole

toluene-4-sulfonic acid bis-(4-cyano-phenyl)-methyl ester
935477-95-5

toluene-4-sulfonic acid bis-(4-cyano-phenyl)-methyl ester

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
Stage #1: 1,2,4-Triazole With tetrabutylammomium bromide; potassium carbonate In water; 4-methyl-2-pentanone for 2h;
Stage #2: toluene-4-sulfonic acid bis-(4-cyano-phenyl)-methyl ester In water; 4-methyl-2-pentanone at 20 - 30℃; for 48h;
Stage #3: With hydrogenchloride In water; 4-methyl-2-pentanone for 1h;
97.42%
potassium cyanide

potassium cyanide

1-(bis(4-bromophenyl)methyl)-1H-1,2,4-triazole

1-(bis(4-bromophenyl)methyl)-1H-1,2,4-triazole

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
Stage #1: potassium cyanide With acetic acid In ethylene glycol Sealed tube;
Stage #2: 1-(bis(4-bromophenyl)methyl)-1H-1,2,4-triazole With P(t-Bu)3 Palladacycle Gen. 3; potassium acetate In 1,4-dioxane; water at 60℃; for 16h; Concentration; Sealed tube;
97%
4-((4-cyanophenyl)(1H-1,2,4-triazol-1-yl)methyl)benzamide

4-((4-cyanophenyl)(1H-1,2,4-triazol-1-yl)methyl)benzamide

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
With trifluoroacetic anhydride In 1,4-dioxane at 0 - 20℃; for 1h;90%
4-amino-1,2,4-triazole
584-13-4

4-amino-1,2,4-triazole

4,4'-dicyanodiphenylbromomethane
69545-39-7

4,4'-dicyanodiphenylbromomethane

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
Stage #1: 4-amino-1,2,4-triazole; 4,4'-dicyanodiphenylbromomethane In acetonitrile for 24h; Reflux;
Stage #2: With hydrogenchloride; sodium nitrite In water; acetonitrile at 0 - 5℃; for 6h; Solvent; Time;
88.7%
potassiumhexacyanoferrate(II) trihydrate

potassiumhexacyanoferrate(II) trihydrate

1-(bis(4-bromophenyl)methyl)-1H-1,2,4-triazole

1-(bis(4-bromophenyl)methyl)-1H-1,2,4-triazole

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
With sodium carbonate In water; N,N-dimethyl-formamide at 120℃; for 24h;87%
zinc cyanide

zinc cyanide

1-(bis(4-bromophenyl)methyl)-1H-1,2,4-triazole

1-(bis(4-bromophenyl)methyl)-1H-1,2,4-triazole

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; water; bis(dibenzylideneacetone)-palladium(0) In N,N-dimethyl-formamide at 120℃; for 15h; Inert atmosphere;86%
4-fluorobenzonitrile
1194-02-1

4-fluorobenzonitrile

sodium triazole
41253-21-8

sodium triazole

4-cyanobenzyl bromide
17201-43-3

4-cyanobenzyl bromide

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
Stage #1: sodium triazole; 4-cyanobenzyl bromide With potassium tert-butylate In N,N-dimethyl-formamide at -5 - 5℃; for 2.5h;
Stage #2: 4-fluorobenzonitrile In N,N-dimethyl-formamide at -5 - 5℃; for 2.5h; Product distribution / selectivity;
85%
Stage #1: sodium triazole; 4-cyanobenzyl bromide In N,N-dimethyl-formamide at -10 - 0℃; for 1h;
Stage #2: 4-fluorobenzonitrile With sodium hexamethyldisilazane In tetrahydrofuran; N,N-dimethyl-formamide at -10 - -5℃; Product distribution / selectivity;
Stage #1: sodium triazole; 4-cyanobenzyl bromide In ISOPROPYLAMIDE at -15 - 0℃; for 2.5h;
Stage #2: 4-fluorobenzonitrile With sodium hexamethyldisilazane In tetrahydrofuran; ISOPROPYLAMIDE at -8 - 0℃; for 1h; Product distribution / selectivity;
C40H28ClN10Ru(1+)*BF4(1-)

C40H28ClN10Ru(1+)*BF4(1-)

triphenylphosphine
603-35-0

triphenylphosphine

A

C41H32ClN5PRu(1+)*BF4(1-)

C41H32ClN5PRu(1+)*BF4(1-)

B

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
In dichloromethane at 20℃; for 48h;A 75%
B n/a
1,2,4-Triazole
288-88-0

1,2,4-Triazole

4-(alpha-chloro-4'-cyanobenzyl)-benzonitrile
112809-57-1

4-(alpha-chloro-4'-cyanobenzyl)-benzonitrile

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide; toluene at 60 - 80℃; for 4h;74.4%
4-fluorobenzonitrile
1194-02-1

4-fluorobenzonitrile

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
Stage #1: 4-((1H-1,2,4-triazole-1-yl)methyl)benzonitrile With potassium tert-butylate In N,N-dimethyl-formamide at -5 - 0℃; for 2h;
Stage #2: 4-fluorobenzonitrile In N,N-dimethyl-formamide at 0 - 10℃; for 0.25h; Product distribution / selectivity;
73%
Stage #1: 4-((1H-1,2,4-triazole-1-yl)methyl)benzonitrile With lithium hexamethyldisilazane In tetrahydrofuran at -30 - -25℃; for 0.666667h;
Stage #2: 4-fluorobenzonitrile In tetrahydrofuran at -20 - -15℃; for 1.25h; Product distribution / selectivity;
1,3,5-Triazine
290-87-9

1,3,5-Triazine

2-(propan-2-ylidine)-1-[di-(4-cyanophenyl)methyl]hydrazine
1280504-38-2

2-(propan-2-ylidine)-1-[di-(4-cyanophenyl)methyl]hydrazine

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
Stage #1: 2-(propan-2-ylidine)-1-[di-(4-cyanophenyl)methyl]hydrazine With hydrogenchloride In methanol at 20℃;
Stage #2: 1,3,5-Triazine In methanol Reflux;
70.7%
1,2,4-Triazole
288-88-0

1,2,4-Triazole

4,4'-dicyanodiphenylbromomethane
69545-39-7

4,4'-dicyanodiphenylbromomethane

A

4-[α-(4-cyano-phenyl)-1-(1,3,4-triazol-1-yl)-methyl]-benzonitrile
112809-52-6

4-[α-(4-cyano-phenyl)-1-(1,3,4-triazol-1-yl)-methyl]-benzonitrile

B

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide; toluene at 60 - 80℃; for 1.5h; Product distribution / selectivity;A 3.5%
B 70.5%
zinc(II) cyanide
557-21-1

zinc(II) cyanide

1--1H-1,2,4-triazole
102994-04-7

1--1H-1,2,4-triazole

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; nickel(II) chloride hexahydrate; zinc In acetonitrile at 80℃; for 4h; Inert atmosphere; Sealed tube;68%
With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; nickel(II) chloride hexahydrate; zinc In acetonitrile at 80℃; for 4h; Inert atmosphere; Glovebox; Sealed tube;68%
4-((1H-1,2,4-triazole-1-yl)methyl)benzonitrile
112809-25-3

4-((1H-1,2,4-triazole-1-yl)methyl)benzonitrile

2-(4-fluorobenzene)-1,3,4-oxadiazole
595567-05-8

2-(4-fluorobenzene)-1,3,4-oxadiazole

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
Stage #1: 4-((1H-1,2,4-triazole-1-yl)methyl)benzonitrile With potassium tert-butylate In N,N-dimethyl-formamide at -5℃; Inert atmosphere;
Stage #2: 2-(4-fluorobenzene)-1,3,4-oxadiazole In N,N-dimethyl-formamide at -5℃; for 7.5h; Inert atmosphere;
64%
4-[1-(1,2,4-triazol-1-yl)methyl] benzonitrile

4-[1-(1,2,4-triazol-1-yl)methyl] benzonitrile

4-fluorobenzonitrile
1194-02-1

4-fluorobenzonitrile

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
Stage #1: 4-[1-(1,2,4-triazol-1-yl)methyl] benzonitrile; 4-fluorobenzonitrile With potassium tert-butylate In DMF (N,N-dimethyl-formamide) at -10 - -5℃; for 4h;
Stage #2: With hydrogenchloride In DMF (N,N-dimethyl-formamide); water pH=7.5 - 8.0;
58%
1,2,4-Triazole
288-88-0

1,2,4-Triazole

4-(bromomethyl)benzaldehyde
51359-78-5

4-(bromomethyl)benzaldehyde

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
Stage #1: 4-(bromomethyl)benzaldehyde; 4-chlorobenzaldehyde With ammonium hydroxide; copper diacetate In dimethyl sulfoxide at 70℃; for 12h;
Stage #2: 1,2,4-Triazole With potassium carbonate; potassium iodide In dimethyl sulfoxide; acetone at 50℃; for 10h; Inert atmosphere;
43%
1,2,4-Triazole
288-88-0

1,2,4-Triazole

4-(bromomethyl)benzaldehyde
51359-78-5

4-(bromomethyl)benzaldehyde

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
Stage #1: 4-(bromomethyl)benzaldehyde; 4-bromo-benzaldehyde With ammonium hydroxide; copper diacetate In dimethyl sulfoxide at 70℃; for 10h;
Stage #2: 1,2,4-Triazole With potassium carbonate; potassium iodide In dimethyl sulfoxide; acetone at 50℃; for 10h; Inert atmosphere;
35%
1,2,4-Triazole
288-88-0

1,2,4-Triazole

4-chloromethylbenzaldehyde
73291-09-5

4-chloromethylbenzaldehyde

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
Stage #1: 4-chloromethylbenzaldehyde; 4-chlorobenzaldehyde With ammonium hydroxide; copper diacetate In dimethyl sulfoxide at 70℃; for 10h;
Stage #2: 1,2,4-Triazole With potassium carbonate; potassium iodide In dimethyl sulfoxide; acetone at 50℃; for 10h; Inert atmosphere;
34%
1,2,4-Triazole
288-88-0

1,2,4-Triazole

4-chloromethylbenzaldehyde
73291-09-5

4-chloromethylbenzaldehyde

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
Stage #1: 4-chloromethylbenzaldehyde; 4-bromo-benzaldehyde With ammonium hydroxide; copper diacetate In dimethyl sulfoxide at 70℃; for 10h;
Stage #2: 1,2,4-Triazole With potassium carbonate; potassium iodide In dimethyl sulfoxide; acetone at 50℃; for 10h; Inert atmosphere;
33%
1,2,4-Triazole
288-88-0

1,2,4-Triazole

4-iodomethylbenzaldehyde
112812-08-5

4-iodomethylbenzaldehyde

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
Stage #1: 4-iodomethylbenzaldehyde; 4-bromo-benzaldehyde With ammonium hydroxide; copper diacetate In dimethyl sulfoxide at 70℃; for 10h;
Stage #2: 1,2,4-Triazole With potassium carbonate; potassium iodide In dimethyl sulfoxide; acetone at 50℃; for 10h; Inert atmosphere;
32%
1,2,4-Triazole
288-88-0

1,2,4-Triazole

4-(bromomethyl)benzaldehyde
51359-78-5

4-(bromomethyl)benzaldehyde

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
Stage #1: 4-(bromomethyl)benzaldehyde; 4-fluorobenzaldehyde With ammonium hydroxide; copper diacetate In dimethyl sulfoxide at 70℃; for 12h;
Stage #2: 1,2,4-Triazole With potassium carbonate; potassium iodide In dimethyl sulfoxide; acetone at 50℃; for 10h; Inert atmosphere;
32%
1,2,4-Triazole
288-88-0

1,2,4-Triazole

4-iodomethylbenzaldehyde
112812-08-5

4-iodomethylbenzaldehyde

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
Stage #1: 4-iodomethylbenzaldehyde; 4-chlorobenzaldehyde With ammonium hydroxide; copper diacetate In dimethyl sulfoxide at 70℃; for 10h;
Stage #2: 1,2,4-Triazole With potassium carbonate; potassium iodide In dimethyl sulfoxide; acetone at 50℃; for 10h; Inert atmosphere;
21%
1,2,4-Triazole
288-88-0

1,2,4-Triazole

4,4'-dicyanodiphenylbromomethane
69545-39-7

4,4'-dicyanodiphenylbromomethane

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In isopropyl alcohol for 8 - 9h; Product distribution / selectivity; Heating / reflux;
With potassium carbonate In isopropyl alcohol for 8 - 9h; Product distribution / selectivity; Heating / reflux;
4-[1-(1,2,4-triazolyl)methyl]-benzonitrile

4-[1-(1,2,4-triazolyl)methyl]-benzonitrile

4-fluorobenzonitrile
1194-02-1

4-fluorobenzonitrile

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
With potassium tert-butylate In N-methyl-acetamide
4-fluorobenzonitrile
1194-02-1

4-fluorobenzonitrile

4-((1H-1,2,4-triazole-1-yl)methyl)benzonitrile
112809-25-3

4-((1H-1,2,4-triazole-1-yl)methyl)benzonitrile

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at -15℃; for 7 - 8h; Product distribution / selectivity;
With lithium hexamethyldisilazane In tetrahydrofuran at -20 - -5℃; for 2h; Product distribution / selectivity;
Stage #1: 4-((1H-1,2,4-triazole-1-yl)methyl)benzonitrile With potassium tert-butylate In N,N-dimethyl-formamide at 0 - 5℃; for 1.5h;
Stage #2: 4-fluorobenzonitrile In N,N-dimethyl-formamide at 0 - 5℃; for 1.5h;
4-[(1-(1,3,4-triazolyl)-methyl)]benzonitrile
112809-27-5

4-[(1-(1,3,4-triazolyl)-methyl)]benzonitrile

4-fluorobenzonitrile
1194-02-1

4-fluorobenzonitrile

4-((1H-1,2,4-triazole-1-yl)methyl)benzonitrile
112809-25-3

4-((1H-1,2,4-triazole-1-yl)methyl)benzonitrile

A

4-[α-(4-cyano-phenyl)-1-(1,3,4-triazol-1-yl)-methyl]-benzonitrile
112809-52-6

4-[α-(4-cyano-phenyl)-1-(1,3,4-triazol-1-yl)-methyl]-benzonitrile

B

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at -15℃; for 3h; Product distribution / selectivity;
α-(1H-[1,2,4]triazol-1-yl)-4,4'-diformaldoxime-diphenylmethane

α-(1H-[1,2,4]triazol-1-yl)-4,4'-diformaldoxime-diphenylmethane

letrozol
112809-51-5

letrozol

Conditions
ConditionsYield
With acetic anhydride for 8 - 10h; Product distribution / selectivity; Heating / reflux;
With sodium acetate; acetic anhydride; acetic acid at 20℃; for 3 - 4h; Product distribution / selectivity; Heating / reflux;
cobalt(II) chloride hexahydrate

cobalt(II) chloride hexahydrate

letrozol
112809-51-5

letrozol

CoCl2(1-[bis(4-cyanophenyl)methyl]-1,2,4-triazole)*H2O

CoCl2(1-[bis(4-cyanophenyl)methyl]-1,2,4-triazole)*H2O

Conditions
ConditionsYield
In ethanol; water High Pressure; mixt. of letrozole, CoCl2, EtOH and H2O sealed in stainless steel reactor, heated to 120°C for 24 h, slowly cooled to room temp.; elem. anal.;97.8%
In ethanol; water CoCl2 and letrozole dissolved in EtOH/H2O; mixt. stirred at room temp. for 1 h; filtered, soln. kept at room temp. for 4 d; elem. anal.;33.5%
letrozol
112809-51-5

letrozol

4,4′-(1H-1,2,4-triazol-1-yl)methylene-bis(benzoic acid)

4,4′-(1H-1,2,4-triazol-1-yl)methylene-bis(benzoic acid)

Conditions
ConditionsYield
Stage #1: letrozol With sodium hydroxide In water for 6h; Reflux;
Stage #2: With hydrogenchloride In water
94.9%
Stage #1: letrozol With potassium hydroxide In ethanol; water for 36h; Reflux;
Stage #2: With hydrogenchloride In water pH=2;
86.1%
Stage #1: letrozol With sodium hydroxide In N,N-dimethyl-formamide at 120℃; for 12h;
Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide pH=1;
77%
With [Rh(6,7-dihydrotribenzo-[e,i,m][1,4,7,12]-ioxadiazacyclotetradecine)]Cl; water; sodium hydroxide at 70℃; for 0.25h; Reagent/catalyst; Time;97.43 %Spectr.
Alkaline conditions;
nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

letrozol
112809-51-5

letrozol

NiCl2(1-[bis(4-cyanophenyl)methyl]-1,2,4-triazole)*H2O

NiCl2(1-[bis(4-cyanophenyl)methyl]-1,2,4-triazole)*H2O

Conditions
ConditionsYield
In ethanol; water High Pressure; mixt. of letrozole, NiCl2, EtOH and H2O sealed in stainless steel reactor, heated to 120°C for 24 h, slowly cooled to room temp.; elem. anal.;94.8%
In ethanol; water NiCl2 and letrozole dissolved in EtOH/H2O; mixt. stirred at room temp. for 1 h; filtered, soln. kept at room temp. for 4 d; elem. anal.;45.3%
trans-Cl2Pd(H2NCH2C6H5)2
19046-92-5, 55176-74-4

trans-Cl2Pd(H2NCH2C6H5)2

silver nitrate

silver nitrate

letrozol
112809-51-5

letrozol

[Pd(PhCH2NH2)2(4,4'-((1H-1,2,4-triazol-1-yl)methylene)dibenzonitrile)2](NO3)2

[Pd(PhCH2NH2)2(4,4'-((1H-1,2,4-triazol-1-yl)methylene)dibenzonitrile)2](NO3)2

Conditions
ConditionsYield
Stage #1: trans-Cl2Pd(H2NCH2C6H5)2; silver nitrate In acetone at 25℃; for 2h; Darkness;
Stage #2: letrozol In acetone
78.5%
dichloro(benzene)ruthenium(II) dimer
37366-09-9

dichloro(benzene)ruthenium(II) dimer

ammonium tetrafluoroborate

ammonium tetrafluoroborate

letrozol
112809-51-5

letrozol

C40H28ClN10Ru(1+)*BF4(1-)

C40H28ClN10Ru(1+)*BF4(1-)

Conditions
ConditionsYield
In ethanol for 1h; Reflux;73%
letrozol
112809-51-5

letrozol

C17H15N5S2

C17H15N5S2

Conditions
ConditionsYield
With 2,3,4,5,7,8,9,10-octahydropyrimido[1,2-a]azepin-1-ium acetate; sodiumsulfide nonahydrate In neat (no solvent) at 20℃; for 2h; Green chemistry;73%
ethanol
64-17-5

ethanol

letrozol
112809-51-5

letrozol

diethyl 4,4′-(1H-1,2,4-triazol-1-ylmethanediyl)dibenzenecarboximidate

diethyl 4,4′-(1H-1,2,4-triazol-1-ylmethanediyl)dibenzenecarboximidate

Conditions
ConditionsYield
With acetyl chloride at 20℃; Cooling with ice;72%
Sodium trans-Bis(dimethhyl sulfoxide) tetrachlororuthenate(III)
131759-88-1, 61779-28-0

Sodium trans-Bis(dimethhyl sulfoxide) tetrachlororuthenate(III)

letrozol
112809-51-5

letrozol

Na[trans-RuCl4(letrozole)(dimethyl sulfoxide)]

Na[trans-RuCl4(letrozole)(dimethyl sulfoxide)]

Conditions
ConditionsYield
In acetone Inert atmosphere; Schlenk technique;66%
letrozol
112809-51-5

letrozol

C17H13N5S

C17H13N5S

Conditions
ConditionsYield
With 2,3,4,5,7,8,9,10-octahydropyrimido[1,2-a]azepin-1-ium acetate; sodiumsulfide nonahydrate In neat (no solvent) at 20℃; for 2h; Green chemistry;64%
letrozol
112809-51-5

letrozol

4,4'-dicyanodiphenylmethane
10466-37-2

4,4'-dicyanodiphenylmethane

Conditions
ConditionsYield
With tetraethylammonium perchlorate; triethylamine In dimethyl sulfoxide at 20℃; for 6h; Electrolysis; Green chemistry;55%
copper(II) choride dihydrate

copper(II) choride dihydrate

letrozol
112809-51-5

letrozol

[Cu(1-[bis(4-cyano-phenyl)methyl]-1,2,4-triazole)3Cl2]

[Cu(1-[bis(4-cyano-phenyl)methyl]-1,2,4-triazole)3Cl2]

Conditions
ConditionsYield
In ethanol; water at 120℃; for 72h;47%
tetrakis(acetonitrile)copper(I)tetrafluoroborate

tetrakis(acetonitrile)copper(I)tetrafluoroborate

chloroform
67-66-3

chloroform

letrozol
112809-51-5

letrozol

Cu(I)(1-[bis(4-cyanophenyl)methyl]-1,2,4-triazole)BF4*CHCl3
364594-74-1

Cu(I)(1-[bis(4-cyanophenyl)methyl]-1,2,4-triazole)BF4*CHCl3

Conditions
ConditionsYield
In chloroform; benzene solvothermal treatment of Cu-complex with ligand in benzene and CHCl3 for 3 ds at 100°C; elem. anal.;40%
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