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Baoding Faithful Industry Co., Ltd.

Sales: 1.24hours to reply your E-mail 2.Market information trend share with customers Suggestion for purchase decision Reputation: 1.Implementing contract terms strictly 2.Timely solve any discrepancy or goods claims Take our responsibility for loss

Supply 100% Pure Pearl Powder factory

Cas:501-30-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c

Kojic acid 501-30-4 /manufacturer/low price/high quality/in stock

Cas:501-30-4

Min.Order:1 Kilogram

FOB Price: $10.0 / 11.0

Type:Lab/Research institutions

inquiry

Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

99% Kojic Acid Whitening cream Raw material Kojic Acid powder for soap whitening

Cas:501-30-4

Min.Order:1 Kilogram

FOB Price: $14.0 / 21.0

Type:Manufacturers

inquiry

Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards. 2. Now we have established long-term stab

Kojic acid

Cas:501-30-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Wuhan ZeShanCheng Biomedical Technology Co., Ltd.

Kojic acid CAS No.: 501-30-4 Molecular formula: C6H6O4 Molecular weight: one hundred and forty-two point one one Properties: colorless prismatic crystal, white crystalline powder. Product performance: kojic acid is fermented by glucose, which ca

2-(hydroxymethyl)-5-hydroxy-4H-pyran-4-one

Cas:501-30-4

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Trading Company

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Strict quality control: good raw materials, good quality, Zenuo Biology has always regarded quality as the life of the enterprise. Zenuo Biology has an independent quality control department and long-term cooperation with the third-party detection

Kojic acid manufacturer supplier high quality

Cas:501-30-4

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Kojic acid

Cas:501-30-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

Kojic acid

Cas:501-30-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

HANGZHOU CLAKE BIOTECH CO.,LTD

1. ISO AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Appearance:white crystalline powder Package:as request Application:active pharmaceutical ingredient Transportation:air sea both ok

Kojic acid

Cas:501-30-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

DB BIOTECH CO., LTD

roduct name Kojic Acid Grade Cosmetic Grade Specification 99% Appearance Light yellow to off white crystalline powder Test Me

Kojic acid for Skin Whitening

Cas:501-30-4

Min.Order:1 Kilogram

FOB Price: $15.0 / 20.0

Type:Trading Company

inquiry

Zhonghe Fountain(Tianjin)Biotech Ltd.

Zhonghe Fountain is striving for R&D,production and distribution cosmetic active ingredients for personal care industry. Zhonghe Fountain always maintains a keen insight into industry and focuses on the market demand trends to expand its invests

Skin whitening and lightening agent Kojic Acid factory fermented Kojic

Cas:501-30-4

Min.Order:1 Kilogram

FOB Price: $13.0 / 20.0

Type:Trading Company

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up by HPLC Cosmetic grade Kojic Acid 501-30-4

Cas:501-30-4

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance Almost white crystalline powder Complies Assay 99%min

High purity Kojic acid with high quality and best price cas:501-30-4

Cas:501-30-4

Min.Order:1 Kilogram

FOB Price: $20.0 / 35.0

Type:Manufacturers

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Kojic Acid supplier in China

Cas:501-30-4

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

Kojic acid Kojic Acid is widely used in whiten cosmetic applied as a skin lightening agent due to its potential to inhibit the enzyme tyrosinase. Tyrosinase is necessary for the synthesis of melanin, which offers skin its coloring Kojic Acid al

High Qualiy Kojic Acid with Best Price

Cas:501-30-4

Min.Order:1 Kilogram

FOB Price: $19.0 / 20.0

Type:Other

inquiry

Jinan Finer Chemical Co., Ltd

Product description: Product name Kojic acid CAS number 501-30-4 Assay ≥99% Appearance White crystalline powder Capacity 1000mt/year Application Cosmetic whitening additive,f

Kojic acid

Cas:501-30-4

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Kojic Acid 99% CAS NO.501-30-4

Cas:501-30-4

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Kojic acid Cas 501-30-4 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White Powder Storage:Refrigerator Package:1kg/foil bag, 25kg/drum or as

Bottom price high quality Kojic acid Cas 501-30-4 with best purity and fast delivery

Cas:501-30-4

Min.Order:1 Kilogram

FOB Price: $90.0

Type:Trading Company

inquiry

Hefei TNJ chemical industry co.,ltd

Kojic acid crystal is prism shape, acicular, colorless. Kojic acid is soluble in water, alcohol, acetone, slightly soluble in ether, ethyl acetate, chloroform and pyridine, insoluble in most other solvent. Crystallization can be in acetone, ethyl a

High quality Kojic Acid

Cas:501-30-4

Min.Order:1 Metric Ton

Negotiable

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Kojic Acid

Cas:501-30-4

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Content Natural Extract Kojic acid HACCP manufacturer

Cas:501-30-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medic

Stable Stocks Fast Delivery High Purity Kojic Acid Powder

Cas:501-30-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Pribolab PTE.LTD

Accurate valued; NRM, HPLC, Lc-MS/MS methods valued and certified, ensure the accurate purity; All the standards attached COA and MSDS; More than 80 kinds of mycotoxin standards can be provided; Competitive price; Professional technical team to

STD#9104 Kojic acid /dried down

Cas:501-30-4

Min.Order:1 Milliliter

FOB Price: $2.0 / 5.0

Type:Trading Company

inquiry

Shanxi Zorui Biotechnology Co.Ltd.

Zorui combines R&D, production and sales into its operations, While continuously providing high-quality raw materials, we also provide and optimize technical solutions for customers to achieve mutual benefit. We adhere to the "quality, integ

Skin Whitening Cosmetic Raw Materials Kojic Acid Powder CAS 501-30-4

Cas:501-30-4

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Kojic Acid

Cas:501-30-4

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Kojic acid -- CHemwill

Cas:501-30-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Kojic acid Basic information Organic acids Physicochemical properties Food additives Add whitening whitening cosmetics and kojic acid in food Pest control and crop yield Microbial fermentation of kojic acid Appli

Kojic acid__

Cas:501-30-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

CAS 501-30-4 Skin Whitening 99% Kojic Acid Powder

Cas:501-30-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 501-30-4 with best quality

Cas:501-30-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: High quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot-selling Cosmetic Grade Kojic Acid with CAS 501-30-4 for Skin-Whitening

Cas:501-30-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

5-acetoxy-2-acetoxymethyl-4H-pyran-4-one
26209-93-8

5-acetoxy-2-acetoxymethyl-4H-pyran-4-one

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions
ConditionsYield
With sodium methylate In methanol for 1h;95%
With methanol; ammonia
chlorokojic acid
7559-81-1

chlorokojic acid

acetone
67-64-1

acetone

A

allomaltol
644-46-2

allomaltol

B

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

C

iodokojic acid
16065-34-2

iodokojic acid

D

iodoacetone
3019-04-3

iodoacetone

Conditions
ConditionsYield
With sodium iodide at 45℃; for 24h; Substitution;A n/a
B n/a
C 78%
D n/a
5-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)-2-(((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)methyl)-4H-pyran-4-one

5-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)-2-(((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)methyl)-4H-pyran-4-one

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions
ConditionsYield
With silica gel In methanol at 60℃; for 3h; Inert atmosphere;70%
2-keto-D-glucose

2-keto-D-glucose

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions
ConditionsYield
Stage #1: 2-keto-D-glucose With sodium acetate; acetic anhydride In N,N-dimethyl-formamide for 23h;
Stage #2: With sodium methylate In methanol for 1h;
20%
D-xylose
58-86-6

D-xylose

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions
ConditionsYield
With Aspergillus oryzae Bei der Vergaerung;
D-sorbitol
50-70-4

D-sorbitol

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions
ConditionsYield
durch Aspergillus oryzae;
D-galactitol
608-66-2

D-galactitol

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions
ConditionsYield
bei der Einw.von Aspergillus oryzae;
L-arabinose
5328-37-0

L-arabinose

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions
ConditionsYield
With Aspergillus oryzae Bei der Vergaerung;
glycerol
56-81-5

glycerol

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions
ConditionsYield
With aspergillus glaucus Bei der Vergaerung;
bei der Einw.von Aspergillus glaucus;
D-xylose
58-86-6

D-xylose

aspergillus flavus

aspergillus flavus

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

D-glucose
50-99-7

D-glucose

aspergillus flavus

aspergillus flavus

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

D-myo-inositol
87-89-8

D-myo-inositol

aspergillus oryzae

aspergillus oryzae

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

5‑benzyloxy‑4H‑pyran‑4‑one‑2‑ylmethyl adamantan‑1‑ylacetate

5‑benzyloxy‑4H‑pyran‑4‑one‑2‑ylmethyl adamantan‑1‑ylacetate

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen under 258.776 Torr; for 0.166667h;
comenic acid
499-78-5

comenic acid

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: neat (no solvent) / 30 °C / Inert atmosphere; Schlenk technique; Glovebox
2: silica gel / methanol / 3 h / 60 °C / Inert atmosphere
View Scheme
D-Glucose
2280-44-6

D-Glucose

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: ammonium hydroxide / 0.75 h / pH 6 / Enzymatic reaction
2.1: sodium acetate; acetic anhydride / N,N-dimethyl-formamide / 23 h
2.2: 1 h
View Scheme
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

5-methanesulfonyloxy-2-methanesulfonyloxymethyl-pyran-4-one
5443-45-8

5-methanesulfonyloxy-2-methanesulfonyloxymethyl-pyran-4-one

Conditions
ConditionsYield
In dichloromethane at 0℃; for 0.5h;100%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

chlorokojic acid
7559-81-1

chlorokojic acid

Conditions
ConditionsYield
With thionyl chloride at 20℃; for 0.166667h;100%
With 1-chloro-1-(dimethylamino)-2-methyl-1-propene In dichloromethane for 3h; Inert atmosphere; chemoselective reaction;100%
With thionyl chloride at 20℃; for 3h;98%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

ethyl (E)-3-(4-chlorophenyl)-2-cyanoacrylate
2169-68-8

ethyl (E)-3-(4-chlorophenyl)-2-cyanoacrylate

ethyl 2-amino-4-(4-chlorophenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carboxylate

ethyl 2-amino-4-(4-chlorophenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carboxylate

Conditions
ConditionsYield
With piperidine In ethanol for 0.166667h; Heating;99%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Benzylidenemalononitrile
2700-22-3

Benzylidenemalononitrile

2-amino-4-(phenyl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran-3-carbonitrile

2-amino-4-(phenyl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran-3-carbonitrile

Conditions
ConditionsYield
With piperidine In ethanol for 0.166667h; Product distribution; Heating; reaction with arylmethylenemalonitrile derivatives;99%
With piperidine In ethanol for 0.166667h; Heating;99%
With β‐cyclodextrin In water at 70℃; for 1h; Reagent/catalyst; Green chemistry;96%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

4-chlorobenzylidenemalonodinitrile
1867-38-5

4-chlorobenzylidenemalonodinitrile

2-amino-4-(4-chlorophenyl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran-3-carbonitrile

2-amino-4-(4-chlorophenyl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran-3-carbonitrile

Conditions
ConditionsYield
With piperidine In ethanol for 0.166667h; Heating;99%
In water at 100℃; Michael Addition; Microwave irradiation; Sealed tube; Green chemistry;96%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

ethyl (2E)-2-cyano-3-(4-methoxyphenyl)acrylate
2017-87-0

ethyl (2E)-2-cyano-3-(4-methoxyphenyl)acrylate

ethyl 2-amino-6-(hydroxymethyl)-4-(4-methoxyphenyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carboxylate

ethyl 2-amino-6-(hydroxymethyl)-4-(4-methoxyphenyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carboxylate

Conditions
ConditionsYield
With piperidine In ethanol for 0.166667h; Heating;99%
With piperidine In ethanol for 4h; Cycloaddition; Heating;28%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

benzyl bromide
100-39-0

benzyl bromide

5-benzyloxy-2-hydroxymethyl-4H-pyran-4-one
15771-06-9

5-benzyloxy-2-hydroxymethyl-4H-pyran-4-one

Conditions
ConditionsYield
With sodium hydroxide In methanol at 80℃;99%
With potassium carbonate In ethanol; water for 2h; Reflux;98%
With caesium carbonate In N,N-dimethyl-formamide at 70℃; for 0.5h;90%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

vinyl acetate
108-05-4

vinyl acetate

7-O-acetylkojic acid
25552-08-3

7-O-acetylkojic acid

Conditions
ConditionsYield
novozyme 435 In acetonitrile at 50℃; Enzymatic reaction;99%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

2,2',2''-triaminotriethylamine
4097-89-6

2,2',2''-triaminotriethylamine

6,6',6"-(((nitrilotris(ethane-2,1-diyl))tris(azanediyl))tris(methylene))tris(3-hydroxy-4H-pyran-4-one)

6,6',6"-(((nitrilotris(ethane-2,1-diyl))tris(azanediyl))tris(methylene))tris(3-hydroxy-4H-pyran-4-one)

Conditions
ConditionsYield
In ethanol; chloroform at 20℃; for 1h;98.5%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

p-methoxybenzyl chloride
824-94-2

p-methoxybenzyl chloride

5-p-methoxybenzyloxy-2-hydroxymethyl-4-pyrone
118708-61-5

5-p-methoxybenzyloxy-2-hydroxymethyl-4-pyrone

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 3h;98%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 3h;98%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 4h; Reflux;90%
dichloro(benzene)ruthenium(II) dimer
37366-09-9

dichloro(benzene)ruthenium(II) dimer

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

(η6-C6H6)RuCl(5-hydroxy-2-(hydroxymethyl)-4-pyrone)
1204169-40-3

(η6-C6H6)RuCl(5-hydroxy-2-(hydroxymethyl)-4-pyrone)

Conditions
ConditionsYield
With NaOMe In methanol byproducts: NaCl; kojic acid and NaOMe in dry MeOH stirred for 10 min; Ru complex added, stirred for 5 h; rotary evapd. to dryness; taken in CH2Cl2; soln. filtered, concd. to 3 ml, then Et2O excess added; left for 2 h at room temp.; ppt. collected, washed with Et2O; dried in vac.;98%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

m-tolyl aldehyde
620-23-5

m-tolyl aldehyde

malononitrile
109-77-3

malononitrile

2-amino-6-(hydroxymethyl)-8-oxo-4-m-tolyl-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile
876710-04-2

2-amino-6-(hydroxymethyl)-8-oxo-4-m-tolyl-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene immobilized on silica In neat (no solvent) at 20℃; for 0.05h;98%
In water at 50℃; for 0.0833333h; Sonication;97%
With nanozeolite clinoptilolite In water at 95℃; for 0.333333h; Green chemistry;95%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

malononitrile
109-77-3

malononitrile

2-amino-4-(4-fluorophenyl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran-3-carbonitrile
797028-50-3

2-amino-4-(4-fluorophenyl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran-3-carbonitrile

Conditions
ConditionsYield
In water at 50℃; for 0.1h; Sonication;98%
With nanozeolite clinoptilolite In water at 95℃; for 0.25h; Green chemistry;96%
With nano-silica sulfuric acid In water for 0.416667h; Reflux; Green chemistry;95%
3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

malononitrile
109-77-3

malononitrile

2-amino-4-(pyridine-3-yl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran-3-carbonitrile
625376-09-2

2-amino-4-(pyridine-3-yl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran-3-carbonitrile

Conditions
ConditionsYield
In water at 50℃; for 0.0833333h; Sonication;98%
With Ca9.5Mg0.5(PO4)5.5(SiO4)0.5F1.5 In ethanol for 0.833333h; Reflux; Green chemistry;85%
furfural
98-01-1

furfural

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

malononitrile
109-77-3

malononitrile

2-amino-4-(furan-2-yl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile
873570-71-9

2-amino-4-(furan-2-yl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

Conditions
ConditionsYield
In water at 50℃; for 0.0833333h; Sonication;98%
With nanozeolite clinoptilolite In water at 95℃; for 0.333333h; Green chemistry;97%
With β‐cyclodextrin In water at 70℃; for 1h; Green chemistry;93%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

malononitrile
109-77-3

malononitrile

2-amino-4-(4-chlorophenyl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran-3-carbonitrile

2-amino-4-(4-chlorophenyl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran-3-carbonitrile

Conditions
ConditionsYield
With nanozeolite clinoptilolite In water at 95℃; for 0.3h; Green chemistry;98%
With nano Fe3O4(at) SiO2(at)BenzIm-Fc[Cl]/ZnCl2 In ethanol; water at 20℃; for 0.133333h; Sonication;98%
With sulfonic acid functionalized MCM-41 In water at 90℃; for 0.666667h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Green chemistry;97%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

malononitrile
109-77-3

malononitrile

2-amino-4-(4-methylphenyl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran3-carbonitrile

2-amino-4-(4-methylphenyl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran3-carbonitrile

Conditions
ConditionsYield
With nano Fe3O4(at) SiO2(at)BenzIm-Fc[Cl]/ZnCl2 In ethanol; water at 20℃; for 0.133333h; Sonication;98%
With 1,8-diazabicyclo[5.4.0]undec-7-ene immobilized on silica In neat (no solvent) at 20℃; for 0.05h;97%
With ferrocene functionalized ionic liquid supported on silica coated Fe3O4 magnetic nanoparticles In ethanol; water at 25℃; for 0.166667h; Catalytic behavior; Solvent; Sonication;95%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

malononitrile
109-77-3

malononitrile

4-chloro-3-nitro-benzaldehyde
16588-34-4

4-chloro-3-nitro-benzaldehyde

2-amino-4-(4-chloro-3-nitrophenyl)-6-hydroxymethyl-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile
1613234-40-4

2-amino-4-(4-chloro-3-nitrophenyl)-6-hydroxymethyl-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile

Conditions
ConditionsYield
With nano-silica sulfuric acid In water for 0.2h; Reflux; Green chemistry;98%
With s-triazinium-based ionic liquid immobilized on silica-coated Fe3O4 magnetic nanoparticles In water at 100℃; for 0.5h; Green chemistry;98%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

4-cyanobenzaldehyde
105-07-7

4-cyanobenzaldehyde

malononitrile
109-77-3

malononitrile

2-amino-4-(4-cyanophenyl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran3-carbonitrile
1613234-41-5

2-amino-4-(4-cyanophenyl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran3-carbonitrile

Conditions
ConditionsYield
With sulfonic acid functionalized MCM-41 In water at 90℃; for 0.583333h; Green chemistry;98%
With nano-silica sulfuric acid In water for 0.25h; Reflux; Green chemistry;94%
With Ca9.5Mg0.5(PO4)5.5(SiO4)0.5F1.5 In ethanol for 0.25h; Reflux; Green chemistry;92%
With β‐cyclodextrin In water at 70℃; for 1h; Green chemistry;90%
With lipase from Aspergillus niger In ethanol; water at 20℃; for 3.5h; Enzymatic reaction;90%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

2-((4-fluorophenyl)(hydroxy)methyl)-3-hydroxy-6-(hydroxymethyl)-4H-pyran-4-one

2-((4-fluorophenyl)(hydroxy)methyl)-3-hydroxy-6-(hydroxymethyl)-4H-pyran-4-one

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane In 1,4-dioxane; water at 20℃; for 24h;98%
With potassium modified alumina catalysts (CAT3) In 1,4-dioxane; water at 20℃; for 24h; Aldol Condensation; Green chemistry;98%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

1-naphthaldehyde
66-77-3

1-naphthaldehyde

malononitrile
109-77-3

malononitrile

2‑amino‑6‑hydroxymethyl‑4‑(naphthalen‑1‑yl)‑8‑oxo‑4,8‑dihydropyrano[3,2‑b]pyran‑3‑carbonitrile

2‑amino‑6‑hydroxymethyl‑4‑(naphthalen‑1‑yl)‑8‑oxo‑4,8‑dihydropyrano[3,2‑b]pyran‑3‑carbonitrile

Conditions
ConditionsYield
With s-triazinium-based ionic liquid immobilized on silica-coated Fe3O4 magnetic nanoparticles In water at 100℃; for 0.5h; Green chemistry;98%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

malononitrile
109-77-3

malononitrile

2‑amino‑6‑(hydroxymethyl)‑4‑(4‑nitrophenyl)‑8‑oxo‑4,8‑dihydropyrano[3,2‑b]pyran‑3‑carbonitrile

2‑amino‑6‑(hydroxymethyl)‑4‑(4‑nitrophenyl)‑8‑oxo‑4,8‑dihydropyrano[3,2‑b]pyran‑3‑carbonitrile

Conditions
ConditionsYield
With s-triazinium-based ionic liquid immobilized on silica-coated Fe3O4 magnetic nanoparticles In water at 100℃; for 0.333333h; Green chemistry;98%
With sulfonic acid functionalized MCM-41 In water at 90℃; for 0.583333h; Green chemistry;98%
With C5H6NO3S(1+)*F6P(1-) In neat (no solvent) at 90℃; for 0.25h; Reagent/catalyst;92%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

formaldehyd
50-00-0

formaldehyd

1-(4-fluorophenylmethyl)piperazine
70931-28-1

1-(4-fluorophenylmethyl)piperazine

2-((4-(4-fluorobenzyl)piperazin-1-yl)methyl)-3-hydroxy-6-(hydroxymethyl)-4H-pyran-4-one

2-((4-(4-fluorobenzyl)piperazin-1-yl)methyl)-3-hydroxy-6-(hydroxymethyl)-4H-pyran-4-one

Conditions
ConditionsYield
In methanol at 20℃; Mannich Aminomethylation;98%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

2-Amino-6-methylpyridine
1824-81-3

2-Amino-6-methylpyridine

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

C18H17N3O4

C18H17N3O4

Conditions
ConditionsYield
With hyper-cross-linked β-cyclodextrin nanosponge In ethanol for 0.25h; Solvent; Time; Mannich Aminomethylation; Reflux;98%
piperazine
110-85-0

piperazine

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

formaldehyd
50-00-0

formaldehyd

6,6'-(piperazine-1,4-diylbis(methylene))bis(5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one)

6,6'-(piperazine-1,4-diylbis(methylene))bis(5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one)

Conditions
ConditionsYield
Stage #1: piperazine; formaldehyd In ethanol at 20℃; for 0.5h;
Stage #2: 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one In ethanol for 5h;
97%
1) EtOH, H2O, 30 min, 2) EtOH, H2O, room temperature, 1 h; Yield given. Multistep reaction;
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

4-(trifluoromethylthio)benzaldehyde
4021-50-5

4-(trifluoromethylthio)benzaldehyde

malononitrile
109-77-3

malononitrile

6-amino-7-cyano-2-hydroxymethyl-8-[(4-trifluoromethylthio)phenyl]-4,8-dihydropyrano[3,2-b]pyran-4-one

6-amino-7-cyano-2-hydroxymethyl-8-[(4-trifluoromethylthio)phenyl]-4,8-dihydropyrano[3,2-b]pyran-4-one

Conditions
ConditionsYield
With triethylamine In ethanol for 0.25h; Heating;97%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

propionic acid anhydride
123-62-6

propionic acid anhydride

2-propionyloxymethyl-4H-pyran-4-on-5-yl propionate
1092474-58-2

2-propionyloxymethyl-4H-pyran-4-on-5-yl propionate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;97%
indole
120-72-9

indole

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

benzaldehyde
100-52-7

benzaldehyde

2-((1H-indol-3-yl)(phenyl)methyl)-3-hydroxy-6-(hydroxymethyl)-4H-pyran-4-one
1261077-99-9

2-((1H-indol-3-yl)(phenyl)methyl)-3-hydroxy-6-(hydroxymethyl)-4H-pyran-4-one

Conditions
ConditionsYield
Stage #1: 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one; benzaldehyde With FAU zeolite nanoparticles In neat (no solvent) at 110℃; for 0.166667h; Green chemistry;
Stage #2: indole In neat (no solvent) Temperature; Green chemistry;
97%
With Zn4O(BDC)3 supported on NiFe2O4 nanoparticles In neat (no solvent) at 110℃; for 1h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Concentration;92%
With indium(III) chloride at 120℃; for 1.08333h; neat (no solvent);85%
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

malononitrile
109-77-3

malononitrile

2-amino-4-(thiophen-2-yl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran-3-carbonitrile
625376-15-0

2-amino-4-(thiophen-2-yl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran-3-carbonitrile

Conditions
ConditionsYield
In water at 50℃; for 0.1h; Sonication;97%
With s-triazinium-based ionic liquid immobilized on silica-coated Fe3O4 magnetic nanoparticles In water at 100℃; for 0.416667h; Green chemistry;95%
With nanozeolite clinoptilolite In water at 95℃; for 0.3h; Green chemistry;92%
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
501-30-4

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

indole-2,3-dione
91-56-5

indole-2,3-dione

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

ethyl 2'-amino-6'-(hydroxymethyl)-2,8'-dioxo-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-3'-carboxylate
884213-99-4

ethyl 2'-amino-6'-(hydroxymethyl)-2,8'-dioxo-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-3'-carboxylate

Conditions
ConditionsYield
With N-doped graphene quantum dots modified with CuO (0D)/ZnO (1D) heterojunction In water for 0.25h;97%
With 1,4-diaza-bicyclo[2.2.2]octane In methanol at 60℃; for 12h; Catalytic behavior; Reagent/catalyst; Temperature; Time; Solvent;94%
With copper(II) bis(trifluoromethanesulfonate) In 1,2-dichloro-ethane for 0.583333h; Reflux;89%
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