The rapid rise of shale gas development has triggered environmental and human health concerns due to its impacts on water resources, especially on disinfection byproduct (DBP) formation upon chlorination. Despite the recently reported results on bromide, the effects of non-bromide ions in produc...

Two new barium borate bromide crystals, Ba2BO3Br and Ba3BO3Br3, have been obtained by spontaneous crystallization. Ba2BO3Br crystallizes in P−3m1 space group, with cell parameters of a = 5.5157(10) Å, c = 11.019(4) Å, and Z = 2, its structure is build up by alternately stacking along c-axis of [...

The palladium catalyzed cross-coupling reaction of thiol esters with bis(iodozincio)methane or 1,1-bis(iodozincio)ethane gave Reformatsky-type enolates. They can react with some electrophiles to give the corresponding adducts and were also trapped by silylation reagents to afford silyl enol ethe...

We have studied the effects of selective and non-selective adenosine receptor agonists and antagonists in audiogenic-seizure-sensitive DBA/2 mice, an animal model of generalized reflex epilepsy. With the exception of the adenosine A3 receptor agonist, N6-(3-iodobenzyl)-5′-N-methylcarboxamidoade...

[Zn(fpedtc)2] (1), [Zn(fpedtc)2(py)] (2), [Zn(fpedtc)2(1,10-phen)] (3) and [Zn(fpedtc)2(2,2′-bipy)] (4) (where fpedtc = N-furfuryl-N-(2-phenylethyl)dithiocarbamate, py = pyridine, 1,10-phen = 1,10-phenanthroline and 2,2′-bipy = 2,2′-bipyridine) were synthesized. Characterization of the comple...

The organocatalytic enantioselective conjugate reaction of 2-fluoro-1,3-diketones to nitroalkenes promoted by chiral binaphthyl-modified squaramide has been achieved. Treatment of 2-fluoro-1,3-diketones with nitroalkenes under mild reaction conditions afforded the corresponding Michael products ...

An efficient base-free one-pot synthesis of 1,2-dihydrobenzo[b][1,8]naphthyridines from BH acetates of 2-chloro-3-formylquinolines and activated alkenes followed by their acetylation, with different amines have been reported. These reactions are completed in very short time and provided the prod...

Synthesis of isomeric 3-oxadiazolyl/triazolyl morpholines was performed based on a common intermediate on the gram scale. The target compounds were designed as novel scaffolds for the medicinal chemistry. The key reaction was an electrochemical CH-oxidation of N-Boc morpholine.

Herein, we report the first examples of the Mitsunobu alkylation of β-alkoxycarbonyl 2-nitrobenzenesulfones. Wang resin was acylated with α-halocarboxylic acids followed by the reaction with 2-nitrothiophenols. After oxidation with m-chloroperbenzoic acid, the immobilized β-alkoxycarbonyl 2-n...

The melting properties and the heat capacity of the solid state and the melt state 4’-bromomethyl-2-cyanobiphenyl (OTBNBr) were determined. The enthalpy, entropy and Gibbs free energy of fusion were also calculated. The solubility of OTBNBr in eight organic solvents was experimentally measured ...

The design and synthesis of a novel class of 7-azaspiro[3.5]nonane GPR119 agonists are described. In this series, optimization of the right piperidine N-capping group (R2) and the left aryl group (R3) led to the identification of compound 54g as a potent GPR119 agonist. Compound 54g showed a des...

Two polymorphs of 2,5-bis(cyclohexylamino)-1,4-benzoquinone (BCBQI&BCBQII) are synthesized by an efficient alternate method which includes the oxidation of an aromatic aldehyde to benzoquinone moiety followed by its nucleophilic substitution in a single pot. The synthesized polymorphs have been ...

The ketene Claisen rearrangement of chiral (2S,3E)-5-(isopropylsulfanyl)-3-penten-2-amines has been investigated by the semi-empirical AM1 method. The observed efficient direction of the 1,2-asymmetric induction in the ketene Claisen rearrangement has been modelled from comparison of the energie...

The description and operation of a novel cyclic electrowinning/precipitation (CEP) system for the simultaneous removal of mixtures of heavy metals from aqueous solutions are presented. CEP combines the advantages of electrowinning in a spouted particulate electrode (SPE) with that of chemical pr...

Effects of slight La- or Y-doping on the magnetic properties, especially an unusual magnetic phase diagram, of CeP have been studied mainly through specific heat measurements under magnetic fields up to 10 T on (Ce0.90La0.10)P and (Ce0.95Y0.05)P. In spite of essentially similar behavior in the p...

We evaluated the clinical performance of anti-CEP-1 in a Chinese rheumatoid arthritis (RA) cohort. A total of 264 subjects were tested, including 101 RA patients, 38 juvenile idiopathic arthritis (JIA) patients, 46 disease control (DC) and 79 healthy controls (HC). The presence of anti-CEP-1 in ...

The aim of this study was to develop a new drug substance with low toxicity and effective inhibitory activity against cisplatin-resistant oral cancer. The naturally produced pterostilbene was selected as the lead compound for design and synthesis of a series of bis(hydroxymethyl)propionate-based...

Novel bis(hydroxymethyl) alkanoate curcuminoid derivatives were designed, synthesized and screened for in vitro antiproliferative and in vivo antitumor activity. Selected new compound 9a and curcumin were further evaluated for inhibitory activity against ER+/PR+ breast cancer (MCF-7, T47D), HER ...

The first stereocontrolled synthesis of (3R,4R,5R,6S)-2,2-bis-(hydroxymethyl)azepane-3,4,5,6-tetraol is described herein. The method involves a novel double Henry reaction of the 3,5-di-O-benzyl-6-deoxy-1,2-O-isopropylidene-6-nitro-α-d-glucofuranose with formaldehyde followed by a reductive rin...

A series of homoleptic metal complexes containing the pentaerythritol-functionalized ligand 1 (4′-(2,2,2-tris(hydroxymethyl)ethoxy)-2,2′:6′,2″-terpyridine) has been synthesized. In MeOH and under microwave conditions, the 2,2,2-tris(hydroxymethyl)ethoxy substituent is cleaved and replaced by...