N-[(4-bromo-3,5-difluorine)phenyl]maleimide(BDPM) is a new monomer for polyreaction. Its densities and viscosities of BDPM + DMF(vol = 30%) + Toluene(vol = 70%) and BDPM + DMF(vol = 30%) + Ethanol(vol = 70%) have been determined experimentally under normal atmospheric pressure over the entire mo...

The optimized molecular structure, vibrational frequencies, corresponding vibrational assignments of 5-tert-Butyl-6-chloro-N-[(4-(trifluoromethyl)phenyl]pyrazine-2-carboxamide have been investigated experimentally and theoretically using Gaussian09 software package. Potential energy distribution...

The piperazine derivatives correspond to an extensive chemical class of compounds with numerous neuropharmacological activities, including antidepressant (e.g., nefazodone, trazodone) and anxiolytic (e.g., buspirone) properties. Therefore, aiming to identify a new antidepressant and antianxiety ...

Practical synthesis of (±)-α-alkylserines and tert-butyl benzamidoacrylate from tert-butyl 2-phenyl-2-oxazoline-4-carboxylate (6) were developed. The α-alkylation and β-elimination of 6 are dramatically dependent upon base conditions. The phase-transfer catalytic condition bearing solid KOH ...

Oxidation of 1,1′-methylenebis[4-tert-butyl-2-(diphenylphosphino) benzene] by H2O2 or S8 in toluene affords two new PCP-type pincer ligands. The methylene group deprotonation in the new ligands as well as in their precursor by n-BuLi or LiCH2SiMe3 failed, while the methylene group in the precur...

4-(((3-(tert-Butyl)-(1-phenyl)pyrazol-5-yl)imino)methyl)phenol (4-OHFPz) was synthesized and characterized by FT-IR, MS, NMR, and single-crystal X-ray diffraction. Optimization of molecular geometry, vibrational frequencies, and chemical shifts were calculated by using the methods of density fun...

A novel fluorinated diamine monomer with the tert-buty group, 4-tert-butyl-[1,2-bis(4-amino-2-trifluoromethylphenoxy)phenyl]benzene (2), was prepared through the nucleophilic substitution reaction of 2-chloro-5-nitrobenzotrifluoride with 4-tert-butylcatechol in the presence of potassium carbonat...

Due to steric promotion of CH bond activation, the direct ortho-palladation of (S)-4-tert-butyl-2-phenyl-2-oxazoline using Pd(OAc)2 in AcOH provided (S,S)-di-μ-acetatobis-[2-(2-(4-tert-butyl)oxazolinyl)phenyl-C,N]dipalladium(II) (2) in an excellent yield. This complex was converted into its c...

The cothermolysis of benzoyl(tert-butyl)bis(trimethylsilyl)silane with 2,3-dimethylbutadiene in a sealed tube at 140 °C for 24 h afforded cis- and trans-1-tert-butyl-4,5-dimethyl-2-phenyl-2-(trimethylsiloxy)-1-(trimethylsilyl)-1-silacyclohex-4-ene (2 and 3) in a ratio of approximately 1:1 in 66...

The (tert-butyl isocyanide)(5,10,15,20-{tetrakis-[4-(benzoyloxy)phenyl]porphyrinato}iron(II) coordination compound with the formula [FeII(TPBP)(t-BuNC)2] (I) was prepared by the reduction of the triflato iron(III) starting material [FeIII(TPBP)(SO3CF3)] using a large excess of tert-butyl isocyan...

An efficient, high yields and rapid synthesis of N-tert-butyl-4-(4-substituted phenyl)-2-((substituted-2-oxo-2H-chromen-4-yl)methylthio)-6-oxo-1,6-dihydropyrimidine-5-carboxamide derivatives (4a–4j) under microwave-irradiation has been described. All the newly synthesized compounds (4a–4j) wer...

A chiral pyridylphosphine ligand (2R,4R)-2,4-bis[di-3′-(2′,6′-dimethoxypyridyl)phosphino]pentane was synthesized. The rhodium catalyzed asymmetric hydrogenation of 2-(6′-methoxy-2′-naphthyl)propenoic acid was studied by using this ligand in comparison with the structurally similar Skewphos ...

1-(6′-Methoxy-2′-naphthyl)ethanol is asymmetrically carbonylated to the methyl ester of (S)-naproxen in a PdCl2CuCl2-DDPPI (DDPPI: 1,4:3,6-dianhydro-2,5-dideoxy-2,5-bis(diphenylphosphino)-L-iditol) catalytic system with a chemical yield of 90% and an optical yield of 81% e.e.. The reaction w...

An efficient stereocontrolled synthesis of the potent C17,20-lyase inhibitor, (1S)-1-(1H-imidazol-4-yl)-1-(6-methoxy-2-naphthyl)-2-methyl-1-propanol 1, has been established. The stereogenic center of 1 was successfully constructed by a highly diastereoselective Grignard reaction of 2, while a su...

(+)- and (−)-4-(6-methoxy-2-naphthyl)-2-butyl chloroformate (NAB-C) were prepared from the prochiral nonsteroidal anti-inflammatory agent nabumetone with the aim of developing easily detectable chloroformate reagents for the enantiospecific HPLC analysis of amino compounds in biogenic matrices o...

The structure and several spectroscopic features along with reactivity parameters of the compound 4-(6-methoxy-2-naphthyl)-2-butanone (Nabumetone) have been studied using experimental techniques and tools derived from quantum chemical calculations. Structure optimization is followed by force fie...

Almost all carbon-based materials as counter electrode (CE) for dye-sensitized solar cells (DSSCs) with good performance have been identified in previous studies. Unfortunately, the device with fullerene (C60) or its derivative on fluorine doped tin oxide (FTO) substrate prepared by spin-coating...

Pd promoted Ni supported on C60 derivative was prepared and employed to catalyze the hydrogenation of nitrobenzene (NB). The effects of the function groups of C60 derivatives and Pd on the catalytic performance of Ni-based catalyst were investigated. The characterizations illustrated that the fu...

The preparation of E-5-(1-bromo-2-aryl-vinyl)-3-methyl-4-nitro-isoxazoles and their reaction with 1,3-dicarbonyl compounds to give cyclopropanes or dihydrofurans is described.

In present study, a series of N-(2-methoxy-5-(3-substituted quinazolin-4(3H)-one-6-yl)-pyridin-3-yl)phenylsulfonamide were synthesized. Their antiproliferative activities in vitro were evaluated via MTT assay against HCT116 and MCF-7 cancer cell lines. The SAR of title compounds was discussed. T...