The adsorption ability and photoactivity of a photocatalyst largely determine the mineralization efficiency of antibiotics. Herein, aiming to enhance the adsorption and mineralization of antibiotics, we constructed a hierarchical porous core-shell structure by filling amorphous TiO2 in the pores...

As a broad-spectrum antibacterial agent, tetracycline hydrochloride (TCHC) was widely used in medical treatment and animal husbandry. However, the TCHC in various systems such as the soil, rivers and foods, had caused great harm to the environment and human health. Among the many methods for tre...

Densities ρ, have been measured for l-Proline in aqueous Metformin Hydrochloride solutions of (0.05, 0.10, 0.15 and 0.20 M) mol kg−1 at T = 298.15–318.15 K. Apparent molal volumes Vφ have been determined from the experimental densities. These data have been used to calculate several thermodyn...

A panel of divalent oseltamivir and guanidino oseltamivir analogues with esterification on the carboxyl acid group as potent inhibitors of influenza virus neuraminidase was prepared via click reaction. The primary structure activity relationship study demonstrated that appropriate distance betwe...

Oseltamivir phosphate (OP) is an antiviral drug that is used in the treatment and prophylaxis of both influenza A and influenza B. It is effective against all known influenza viruses that can infect humans, including pandemic influenza viruses and may be the most appropriate antiviral option aga...

Oseltamivir phosphate (OP) is the first line therapy for influenza, and its primary metabolite oseltamivir carboxylate (OC) is the active agent via inhibition of neuraminidase of influenza virus. Dosages of OP and OC might affect human causing nausea and vomiting and it is therefore necessary to...

The p-nitrophenacyl esters of a number of closely related and isomeric prostaglandins were resolved by HPLC on a microparticulate silica gel column (Zorbax-Sil®, DuPont). Ten F-series prostaglandin analogs, eight E-series prostaglandin analogs, the isomeric 15(R)- and 15(S)- methyl prostaglandin...

This chapter introduces two new phototriggers for caging nucleotides, amino acids, peptides, and related functional group derivatives, potentially including higher-order homologs. These new phototriggers have several advantages that favor them over the conventional o-nitrobenzyl derivatives, inc...

Penicillin esters substituted at C-6 with a variety of functionalities are reported as human leukocyte elastase (HLE) inhibitors. The structure activity relations for the esters and C-6 derivatives are discussed and compared to the known cephalosporin structures.

Analysis and purification of boronic acid pinacol esters by RPLC is very challenging due to their degradation in aqueous and alcoholic solvents. These compounds are difficult to purify by SFC too as they are equally sensitive to traditional co-solvents like methanol, ethanol, and 2-propanol. 2,2...

Starting from the phase II clinical FGFR inhibitor lucitanib (2), we conducted a medicinal chemistry approach by opening the central quinoline skeleton coupled with a scaffold hopping process thus leading to a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives. Com...

2′,7′-Bis-(3-carboxypropyl)-5-(and-6)-carboxyfluorescein (BCPCF) was prepared and characterized as a new polar dual-excitation and dual-emission pH indicator with a pKa of 7.0.

E. coli tRNAPhe was modified at its 3-(3-amino-3-carboxypropyl)uridine residue with the N-hydroxysuccinimide ester of N-4-azido-2-nitrophenyl)glycine. Exclusive modification of this base was shown by two-dimensional TLC analysis of the T1 oligonucleotide and nucleoside products of nuclease diges...

The damage to DNA caused by N-butyl-N-(3-carboxypropyl)-nitrosamine (BCPN), saccharin and caffeine in the urinary bladder epithelium of female rats and its subsequent repair was investigated using alkaline sucrose density gradient analysis with a fluorimetric procedure for DNA determination and ...

1α(3′-Carboxypropyl)-4-androsten-17β-ol-3-one (2), a novel hapten, was prepared from boldenone (3) via addition of 4-pentenyl magnesium bromide in the presence of CuBr, as a key step in >95% epimeric excess and 13.8% overall yield. Two immunogens (7,8) and three fluorescent tracers (11,18,19)...

Alkylation of 3,17β-bis(2-trimethylsilyl)ethoxymethyl-1,3,5(10) estratriene-6-one (2) with 5-bromo-1-pentene using NaHMDS in THF afforded 3,17β-bis(2-trimethylsilyl)ethoxymethyl-7-α-(4′-pentenyl)-1,3,5(10)estratriene-6-one (3) in excellent stereoselectivity (>95% epimeric excess). Functional...

The screening of potential affinity ligands and the development of a two-stage affinity purification of an S-adenosylmethionine-dependent 3-amino-3-carboxypropyl transferase involved in the biosynthesis of the β-lactam antibiotic nocardicin A is described from a cell-free extract of Nocardia un...

SummaryMitochondria are essential in long axons to provide metabolic support and sustain neuron integrity. A healthy mitochondrial pool is maintained by biogenesis, transport, mitophagy, fission, and fusion, but how these events are regulated in axons is not well defined. Here, we show that the ...

Reduction of a mixture of 2,3-bis(bromomethyl)-1,4-dibromo-2-butene (1) and dimethyldichlorosilane (or germane) with alkali metals (Li, Na, K) yields 1,2,3,4,5,6-hexahydro-2,2,5,5-tetramethyl-2,5-disila (or digerma) pentalene.Reduction of a mixture of 1 and dimethyldichlorosilane with activated ...

In the solvent system N,N-dimethyl acetamide/LiCl homogeneously synthesized p-toluenesulfonyl starch samples were subsequently peracetylated and perpropionylated in order to evaluate their molecular structure by means of NMR spectroscopy. The total degree of substitution of tosyl groups (DSTos) ...