Hydrate formation is a major flow assurance challenge plaguing the oil and gas industry. Hydrates are non-stoichiometric crystalline compounds formed at elevated pressure and low temperature in the presence of water and gas. Hydrates are capable of depositing along the line causing flow restrict...

The radical copolymerization of 2-(N,N-dimethylamino)ethyl methacrylate (DMAEMA, M1) as the inimer and electron-deficient monomers (M2, including methyl methacrylate (MMA), acrylamide (AAm) and N,N-dimethylacrylamide (DMAAm)) with transition-metal salts (such as copperII and ironIII) as the oxid...

Cyclic voltammetry and controlled-potential (bulk) electrolysis have been employed to investigate the direct electrochemical reductions of 2-bromo-N-phenylacetamide (1a) and 2-iodo-N-phenylacetamide (1b) at glassy carbon cathodes in dimethylformamide containing tetramethylammonium tetrafluorobor...

The hybrid complex of inorganic-organic [DAMS]2[CdI4] [[DAMS =4‐N, N‐dimethylamino‐N‐methyl‐stilbazolium iodide] was synthesized by metathesization of the 4-N,N-dimethylamino -N-methyl stilbazolium iodide [DAMS.I-] salt with cadmium acetate. The [DAMS]2[CdI4] single crystals were grown by s...

(2E,3Z)-2-(1-Methyl-2,5-dioxoimidazolidin-4-ylidene)-3-[(arylamino- or heteroarylamino)methylene]succinate 5 obtained by [2+2] cycloaddition of (5Z)-5-[(dimethylamino)methylene]-3-methylimidazolidine-2,4-dione (1) and dimethyl acetylenedicarboxylate (2) followed by substitution of the dimethylam...

A comprehensive study was performed for the first time to compare two structurally related substance classes, namely indazole-5-carboxamides (11–16) and (indazole-5-yl)methanimines (17–22). Both chemical entities are potent, selective and reversible MAO-B inhibitors and, therefore, may serve a...

HCV infections are the leading causes for hepatocellular carcinoma and liver transplantation in the United States. Recent advances in drug discovery have identified direct acting antivirals which have significantly improved cure rates in patients. Current efforts are directed towards identificat...

Pyridine-based Factor XIa (FXIa) inhibitor (S)-2 was optimized by modifying the P2 prime, P1, and scaffold regions. This work resulted in the discovery of the methyl N-phenyl carbamate P2 prime group which maintained FXIa activity, reduced the number of H-bond donors, and improved the physicoche...

Synthetic cannabinoids, recently used as alternatives to Cannabis sativa, are among the most frequently abused drugs. Identified in 2014, the synthetic cannabinoids N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide (5F-AB-PINACA) and methyl [1-(5-fluoropentyl)-1H-...

We have recently discovered imidazo[1,5-c]imidazol-3-one derivative 1 as a potent, selective, and orally bioavailable factor Xa (FXa) inhibitor. In this study, we have synthesized metabolites of 1 and evaluated their biological activities. As a result, we identified the active metabolites S-5 an...

This paper describes a hybrid capacitor based on identical activated carbon (AC) electrodes and the 1-ethyl-3-methylimidazolium selenocyanate, [EMIm][SeCN], liquid salt as redox-active electrolyte. [EMIm][SeCN] is a fluorine-free ionic liquid (IL) which combines good charge and mass transport pr...

Several new 1-methyl-5-[substituted-4-oxo-1,2,3-benzotriazin-3-yl]-1H-pyrazole-4-acetic acids and their ethyl ester derivatives were prepared. The compounds were tested for analgesic and antiinflammatory activities, acute toxicity, ulcerogenic effect, and as in vitro inhibitors of 3α-hydroxyste...

In the present work, nonlinear optical (NLO) and optoelectronic investigations of four 2,5-dibenzylidenecyclopentan-1-one (bischalcone) analogues 1 (4-F), 2(4-Cl), 3(4-Br) and 4(3-NO2) with push-pull substituents (Donor-π-Acceptor-π-Donor) are studied. The third-order nonlinear optical measure...

A Cs2CO3-catalyzed alkylation reaction of indoles with trifluoromethyl ketones was presented. Both alicyclic and aromatic trifluoromethyl ketones as well as various substituted indoles are compatible with the methodology. Good to excellent yields of the corresponding trifluoromethyl substituted ...

A new and efficient method for the synthesis of 2-trifluoromethyl-2-hydroxy-2H-chromenes was developed via intermolecular cyclization of (Z)-trifluoromethyl alkenyl triflates and salicylaldehydes. A series of 2-trifluoromethyl-2-hydroxy-2H-chromenes with aryl or alkyl groups at 3-position have b...

A sensitive method for the determination of the bismuth concentration in human serum is described. Analyses were carried out by inductively coupled plasma-mass spectrometry (ICP-MS), after a simple dilution of the samples with nitric acid. The detection limit of the applied method is 0.007 μg/l...

Results of investigations on the graphite-rubidium system under high pressure (up to 25 kbar) are presented. In this system new graphite intercalation compounds of C4.3−6.0Rb compositions have been obtained. These compounds have been shown to be unstable under normal conditions and to decompose ...

Single crystals of K3BiAs6Se12 were obtained from the reaction of Bi, with in situ formed fluxes of K2Se3, As2Se3, and Se at 500 °C. The compound crystallizes in the trigonal space group P 3¯ (No. 147) with a = 9.7478(7), c = 7.6525(6) Å, V = 629.72(8) Å3, Z = 1. The [Bi(As3Se6)2]3− anion poss...

Monocation Bi+ isomorphically substitutes potassium in KAlCl4 and KMgCl3 chlorides. Having the unique 6p2 open-shell electronic configuration, Bi+ possesses a number of low-lying excited states, and displays broadband long-lived NIR photoluminescence in ternary chloride crystals.

Evaporative co-crystallization of MCl (M = Na, K, Rb, Cs) with BiOCl in aqueous HCl produces double salts: MxBiyCl(x+3y)·zH2O. The sodium salt, Na2BiCl5·5H2O (monoclinic P21/c, a = 8.6983(7) Å, b = 21.7779(17) Å, c = 7.1831(6) Å, β = 103.0540(10)°, V = 1325.54(19) Å3, Z = 4) is composed of z...