As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryItems Standard Result Appearance Light yellow crystalline powder Complies Identification A:The re
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inquiryWe are very compeitive on tetracycline base.Our mfr is GMP certified for this item with DMF document. Product Name: Tetracycline CAS: 60-54-8 MF: C22H24N2O8
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,
Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryWe are a professional chemicals, APIs and plant extract leading manufacturer in China. We are specialized in chemical synthesis, process development of pharmaceutical intermediates, active pharmaceutical ingredients (APIs), plant extract and rare
Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) reasonable & compet
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inquiryWe are one of the domestic largest manufacturers of API; We are always supplier of products with higher quality and at more competitive price; We are supplier of safe and ecofriendly products ; We provide stable supply and efficient servic
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryAbout us Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad.
Tetracycline CAS:60-54-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Tetracycline Chemical Properties Melting point 175-177 °C(lit.) alpha D25 -257.9° (0.1N HCl); D25 -239° (methanol) storage temp. 2-8°C solubility 95% ethanol: soluble12.5mg/mL
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryHangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu
6-deoxy-6-hydroperoxy-5a,11a-dehydrotetracycline
TETRACYCLINE
Conditions | Yield |
---|---|
With hydrogen; platinum In 1,4-dioxane under 2280 Torr; for 8h; Catalytic hydrogenation; | 62% |
Conditions | Yield |
---|---|
With palladium on activated charcoal; 2-methoxy-ethanol; triethylamine Hydrogenation; | |
With 1,4-dioxane; methanol; palladium on activated charcoal Hydrogenation; |
TETRACYCLINE
Conditions | Yield |
---|---|
With water at 19.85℃; Kinetics; Further Variations:; Temperatures; |
TETRACYCLINE
Conditions | Yield |
---|---|
With hydrogen; palladium In 1,4-dioxane at 23℃; under 760 Torr; for 2h; | 16.0 mg |
TETRACYCLINE
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: m-chloroperoxybenzoic acid / CH2Cl2 / -78 - 0 °C 1.2: air / CHCl3 2.1: 16.0 mg / H2 / Pd / dioxane / 2 h / 23 °C / 760 Torr View Scheme |
TETRACYCLINE
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 77 percent / o-iodoxybenzoic acid / dimethylsulfoxide / 18 h / 35 °C 2.1: m-chloroperoxybenzoic acid / CH2Cl2 / -78 - 0 °C 2.2: air / CHCl3 3.1: 16.0 mg / H2 / Pd / dioxane / 2 h / 23 °C / 760 Torr View Scheme |
TETRACYCLINE
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 76 percent / triethylamine trihydrofluoride / tetrahydrofuran / 12 h / 23 °C 2.1: 77 percent / o-iodoxybenzoic acid / dimethylsulfoxide / 18 h / 35 °C 3.1: m-chloroperoxybenzoic acid / CH2Cl2 / -78 - 0 °C 3.2: air / CHCl3 4.1: 16.0 mg / H2 / Pd / dioxane / 2 h / 23 °C / 760 Torr View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 16 steps 1.1: 80 percent / LDA / tetrahydrofuran / 0.25 h / -40 °C 2.1: 90 percent / SOCl2; TEA / CH2Cl2 / 0.17 h / -30 °C 3.1: BBr3 / CH2Cl2 / 0.25 h / -78 °C 4.1: H2; TEA / Pd-black / dioxane; H2O / 1 h 5.1: 72 percent / i-Pr2NEt / tetrahydrofuran; methanol / 2 h 6.1: 85 percent / Br2; (Bu3Sn)2O; MS-4A / CH2Cl2 / 0.25 h / -78 °C 7.1: 91 percent / Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h 8.1: Zn / acetic acid / 0.03 h 9.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h 9.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C 10.1: NH2OH*HCl; TEA / methanol / 0.5 h 11.1: CDI / tetrahydrofuran / 0.75 h 12.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C 13.1: 80 percent / formic acid / 1 h / 80 °C 14.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C 15.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation 16.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr View Scheme |
anhydrotetracycline
TETRACYCLINE
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation 2: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr View Scheme |
(4S,4aS,12aS)-4-Dimethylamino-3,11,12a-trihydroxy-10-methoxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydro-naphthacene-2-carboxylic acid amide
TETRACYCLINE
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C 2: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation 3: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr View Scheme |
(4S,4aS,12aS)-4-Amino-3,11,12a-trihydroxy-10-methoxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydro-naphthacene-2-carboxylic acid amide
TETRACYCLINE
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 80 percent / formic acid / 1 h / 80 °C 2: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C 3: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation 4: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr View Scheme |
((1S,2S,3S,12aR)-2,6-Dihydroxy-3-hydroxymethyl-4,7-dimethoxy-11-methyl-5-oxo-1,2,3,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid tert-butyl ester
TETRACYCLINE
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1.1: 85 percent / Br2; (Bu3Sn)2O; MS-4A / CH2Cl2 / 0.25 h / -78 °C 2.1: 91 percent / Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h 3.1: Zn / acetic acid / 0.03 h 4.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h 4.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C 5.1: NH2OH*HCl; TEA / methanol / 0.5 h 6.1: CDI / tetrahydrofuran / 0.75 h 7.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C 8.1: 80 percent / formic acid / 1 h / 80 °C 9.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C 10.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation 11.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr View Scheme |
((1S,4aS,12aR)-6-Hydroxy-3-hydroxymethyl-4,7-dimethoxy-11-methyl-2,5-dioxo-1,2,4a,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid tert-butyl ester
TETRACYCLINE
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h 1.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C 2.1: NH2OH*HCl; TEA / methanol / 0.5 h 3.1: CDI / tetrahydrofuran / 0.75 h 4.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C 5.1: 80 percent / formic acid / 1 h / 80 °C 6.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C 7.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation 8.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr View Scheme |
((1S,4aS,12aS)-3-Formyl-2,4a,6-trihydroxy-7-methoxy-11-methyl-4,5-dioxo-1,4,4a,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid tert-butyl ester
TETRACYCLINE
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: NH2OH*HCl; TEA / methanol / 0.5 h 2: CDI / tetrahydrofuran / 0.75 h 3: 68 percent / polyposphoric acid / 0.75 h / 100 °C 4: 80 percent / formic acid / 1 h / 80 °C 5: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C 6: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation 7: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr View Scheme |
((1S,2S,3S,12aR)-2,4,6-Trihydroxy-3-hydroxymethyl-7-methoxy-11-methyl-5-oxo-1,2,3,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid tert-butyl ester
TETRACYCLINE
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1.1: 72 percent / i-Pr2NEt / tetrahydrofuran; methanol / 2 h 2.1: 85 percent / Br2; (Bu3Sn)2O; MS-4A / CH2Cl2 / 0.25 h / -78 °C 3.1: 91 percent / Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h 4.1: Zn / acetic acid / 0.03 h 5.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h 5.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C 6.1: NH2OH*HCl; TEA / methanol / 0.5 h 7.1: CDI / tetrahydrofuran / 0.75 h 8.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C 9.1: 80 percent / formic acid / 1 h / 80 °C 10.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C 11.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation 12.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr View Scheme |
TETRACYCLINE
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: Zn / acetic acid / 0.03 h 2.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h 2.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C 3.1: NH2OH*HCl; TEA / methanol / 0.5 h 4.1: CDI / tetrahydrofuran / 0.75 h 5.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C 6.1: 80 percent / formic acid / 1 h / 80 °C 7.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C 8.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation 9.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr View Scheme |
((1S,4aS,12aS)-3-Cyano-2,4a,6-trihydroxy-7-methoxy-11-methyl-4,5-dioxo-1,4,4a,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid tert-butyl ester
TETRACYCLINE
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 68 percent / polyposphoric acid / 0.75 h / 100 °C 2: 80 percent / formic acid / 1 h / 80 °C 3: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C 4: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation 5: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr View Scheme |
TETRACYCLINE
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: CDI / tetrahydrofuran / 0.75 h 2: 68 percent / polyposphoric acid / 0.75 h / 100 °C 3: 80 percent / formic acid / 1 h / 80 °C 4: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C 5: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation 6: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr View Scheme |
C27H32BrNO8
TETRACYCLINE
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: 91 percent / Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h 2.1: Zn / acetic acid / 0.03 h 3.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h 3.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C 4.1: NH2OH*HCl; TEA / methanol / 0.5 h 5.1: CDI / tetrahydrofuran / 0.75 h 6.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C 7.1: 80 percent / formic acid / 1 h / 80 °C 8.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C 9.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation 10.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr View Scheme |
TETRACYCLINE
Conditions | Yield |
---|---|
Multi-step reaction with 13 steps 1.1: H2; TEA / Pd-black / dioxane; H2O / 1 h 2.1: 72 percent / i-Pr2NEt / tetrahydrofuran; methanol / 2 h 3.1: 85 percent / Br2; (Bu3Sn)2O; MS-4A / CH2Cl2 / 0.25 h / -78 °C 4.1: 91 percent / Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h 5.1: Zn / acetic acid / 0.03 h 6.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h 6.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C 7.1: NH2OH*HCl; TEA / methanol / 0.5 h 8.1: CDI / tetrahydrofuran / 0.75 h 9.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C 10.1: 80 percent / formic acid / 1 h / 80 °C 11.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C 12.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation 13.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr View Scheme |
((1S,2S,3S,12aR)-2-Benzyloxy-3-benzyloxymethyl-4,6-dihydroxy-7-methoxy-11-methyl-5-oxo-1,2,3,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid benzyl ester
TETRACYCLINE
Conditions | Yield |
---|---|
Multi-step reaction with 14 steps 1.1: BBr3 / CH2Cl2 / 0.25 h / -78 °C 2.1: H2; TEA / Pd-black / dioxane; H2O / 1 h 3.1: 72 percent / i-Pr2NEt / tetrahydrofuran; methanol / 2 h 4.1: 85 percent / Br2; (Bu3Sn)2O; MS-4A / CH2Cl2 / 0.25 h / -78 °C 5.1: 91 percent / Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h 6.1: Zn / acetic acid / 0.03 h 7.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h 7.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C 8.1: NH2OH*HCl; TEA / methanol / 0.5 h 9.1: CDI / tetrahydrofuran / 0.75 h 10.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C 11.1: 80 percent / formic acid / 1 h / 80 °C 12.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C 13.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation 14.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr View Scheme |
((1S,2S,3S,12aR)-2-Benzyloxy-3-benzyloxymethyl-4,6,11-trihydroxy-7-methoxy-11-methyl-5-oxo-1,2,3,5,11,11a,12,12a-octahydro-naphthacen-1-yl)-carbamic acid benzyl ester
TETRACYCLINE
Conditions | Yield |
---|---|
Multi-step reaction with 15 steps 1.1: 90 percent / SOCl2; TEA / CH2Cl2 / 0.17 h / -30 °C 2.1: BBr3 / CH2Cl2 / 0.25 h / -78 °C 3.1: H2; TEA / Pd-black / dioxane; H2O / 1 h 4.1: 72 percent / i-Pr2NEt / tetrahydrofuran; methanol / 2 h 5.1: 85 percent / Br2; (Bu3Sn)2O; MS-4A / CH2Cl2 / 0.25 h / -78 °C 6.1: 91 percent / Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h 7.1: Zn / acetic acid / 0.03 h 8.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h 8.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C 9.1: NH2OH*HCl; TEA / methanol / 0.5 h 10.1: CDI / tetrahydrofuran / 0.75 h 11.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C 12.1: 80 percent / formic acid / 1 h / 80 °C 13.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C 14.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation 15.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr View Scheme |
TETRACYCLINE
Conditions | Yield |
---|---|
With hydrogen; palladium In 1,4-dioxane at 23℃; under 760.051 Torr; for 2.08333h; |
omeprazole
TETRACYCLINE
Conditions | Yield |
---|---|
In water pH=9; pH-value; Cooling; |
formaldehyd
TETRACYCLINE
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Conditions | Yield |
---|---|
In ethanol for 0.05h; Mannich reaction; microwave irradiation; | 78% |
TETRACYCLINE
Conditions | Yield |
---|---|
With hydrogenchloride; N-chloro-succinimide In water at 25℃; for 0.5h; | 74.4% |
Conditions | Yield |
---|---|
In ethanol for 0.05h; Mannich reaction; microwave irradiation; | 69% |
Conditions | Yield |
---|---|
In ethanol for 0.05h; Mannich reaction; microwave irradiation; | 61% |
TETRACYCLINE
methyl iodide
1,4,4a,5,5a,6,11,12a-octahydro-2-aminocarbonyl-3,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxonaphthacene-4-trimethylammonium iodide
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 96h; | 57% |
In tetrahydrofuran at 20℃; for 144h; |
Conditions | Yield |
---|---|
In ethanol for 0.05h; Mannich reaction; microwave irradiation; | 54% |
TETRACYCLINE
Conditions | Yield |
---|---|
In further solvent(s) the soln. of salt in ethanol/triethyl orthoformate was heated at 40-50°C, added tetracycline, refluxed for 24-48 h, concn. by heating under reduced prdssure, cooled to room temp.; filtered, washed with cold EtOH, dried in vac. over anhyd. CaCl2; | 42% |
Conditions | Yield |
---|---|
Stage #1: TETRACYCLINE With ethylenediaminetetraacetic acid; silver carbonate In N,N-dimethyl-formamide at 37℃; for 48h; Molecular sieve; Stage #2: With dipotassium hydrogenphosphate; water; edetate disodium In N,N-dimethyl-formamide; acetonitrile at 0 - 20℃; for 8h; pH=5.5; Stage #3: In chloroform at 0 - 5℃; for 168h; | A n/a B 42% |
Conditions | Yield |
---|---|
In tetrahydrofuran for 4h; Inert atmosphere; Reflux; | 36% |
In tetrahydrofuran for 4h; Reflux; Inert atmosphere; | 36% |
Conditions | Yield |
---|---|
With acetic acid In ethanol at 20℃; for 12h; Mannich Aminomethylation; | 31% |
TETRACYCLINE
Conditions | Yield |
---|---|
With mercury(II) diacetate; acetic acid at 50℃; for 48h; | A 30% B 10% |
TETRACYCLINE
Conditions | Yield |
---|---|
In further solvent(s) the soln. of salt in ethanol/triethyl orthoformate was heated 40-50°C, added tetracycline, refluxed for 24-48 h, concn. by heating underreduced pressure, cooled to room temp.; filtered, washed with cold EtOH, dried in vac. over anhyd. CaCl2; | 28% |
TETRACYCLINE
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In methanol for 0.0833333h; Solvent; Inert atmosphere; Cooling with ice; | 27% |
TETRACYCLINE
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 30℃; for 48h; | 26% |
Conditions | Yield |
---|---|
With acetic acid In ethanol at 20℃; for 12h; Mannich Aminomethylation; | 24% |
morpholine
TETRACYCLINE
Glyoxilic acid
(4-dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carbonylamino)-morpholin-4-yl-acetic acid
Conditions | Yield |
---|---|
In tert-butyl alcohol Heating; |
Conditions | Yield |
---|---|
With 1,1,1,3,3,3-hexamethyl-disilazane In pyridine at 20℃; for 0.0166667h; |
Conditions | Yield |
---|---|
With 1,1,1,3,3,3-hexamethyl-disilazane In pyridine at 20℃; for 12h; |
TETRACYCLINE
Conditions | Yield |
---|---|
(i) DMF, (ii) piperidine; Multistep reaction; |
Conditions | Yield |
---|---|
In water at 23℃; formation constant; further solvents;; |
Conditions | Yield |
---|---|
In water at 23℃; formation constant; further solvents;; |
Conditions | Yield |
---|---|
With 2-hydroxyethanethiol at 4℃; Irradiation; Title compound not separated from byproducts; |
Conditions | Yield |
---|---|
In water at 23℃; formation constant; further solvents;; |
Conditions | Yield |
---|---|
In water at 23℃; formation constant; further solvents;; |
Conditions | Yield |
---|---|
In water at 23℃; formation constant; further solvents;; |
Conditions | Yield |
---|---|
In water at 23℃; formation constant; further solvents;; |
Conditions | Yield |
---|---|
In water at 23℃; formation constant; further solvents;; |
Conditions | Yield |
---|---|
In water at 23℃; formation constant; further solvents;; |
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