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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Tetracycline

Cas:60-54-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance Light yellow crystalline powder Complies Identification A:The re

High quality Tetracycline with best price cas: 60-54-8

Cas:60-54-8

Min.Order:1 Kilogram

FOB Price: $25.0 / 50.0

Type:Manufacturers

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Sinoway Industrial Co., Ltd.

We are very compeitive on tetracycline base.Our mfr is GMP certified for this item with DMF document. Product Name: Tetracycline CAS: 60-54-8 MF: C22H24N2O8

factory supply GMP,DMF tetracycline base

Cas:60-54-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Tetracycline

Cas:60-54-8

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Tetracycline 60-54-8 GMP Manufacturer

Cas:60-54-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chengdu Lemeitian Pharmaceutical Technology Co,. Ltd

ADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,

Tetracycline

Cas:60-54-8

Min.Order:5 Milligram

Negotiable

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Tetracycline

Cas:60-54-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Tetracycline (base and/or unspecified salts)

Cas:60-54-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

We are a professional chemicals, APIs and plant extract leading manufacturer in China. We are specialized in chemical synthesis, process development of pharmaceutical intermediates, active pharmaceutical ingredients (APIs), plant extract and rare

Tetracycline

Cas:60-54-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

60-54-8 Tetracycline

Cas:60-54-8

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 60-54-8 with competitive price

Cas:60-54-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) reasonable & compet

Tetracycline CAS NO.:60-54-8

Cas:60-54-8

Min.Order:100 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hefei TNJ chemical industry co.,ltd

We are one of the domestic largest manufacturers of API; We are always supplier of products with higher quality and at more competitive price; We are supplier of safe and ecofriendly products ; We provide stable supply and efficient servic

Manufacturer of Tetracycline at Factory Price

Cas:60-54-8

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Baoji Guokang Healthchem co.,ltd

About us Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad.

Tetracycline

Cas:60-54-8

Min.Order:1 Kilogram

FOB Price: $5.0 / 7.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Tetracycline CAS:60-54-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Tetracycline CAS:60-54-8

Cas:60-54-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Tetracycline

Cas:60-54-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Tetracycline with lowest price

Cas:60-54-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Tetracycline

Cas:60-54-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Tetracycline

Cas:60-54-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products Tetracycline

Cas:60-54-8

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Wuhan Xinhao Biotechnology Co., Ltd.

1. We can provide customers with "one-stop"packaging service,from research,development,production,export and so on 2. Powerful R&D strength let our technology in a leading level,forever,in turn,to provide customers with better service .

High quality Tetracycline with best price cas: 60-54-8 CAS NO.60-54-8

Cas:60-54-8

Min.Order:100 Gram

FOB Price: $10.0 / 100.0

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Tetracycline

Cas:60-54-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Tetracycline

Cas:60-54-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Tetracycline Chemical Properties Melting point 175-177 °C(lit.) alpha D25 -257.9° (0.1N HCl); D25 -239° (methanol) storage temp. 2-8°C solubility 95% ethanol: soluble12.5mg/mL

60-54-8 Tetracycline

Cas:60-54-8

Min.Order:1 Metric Ton

FOB Price: $20.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Tetracycline

Cas:60-54-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

High quality, competitive price, fast delivery and first-class service we possesses have won the trust and praise of customers. Standard: BP/USP/EP The purity is equal or greater than 99%. As a supplier, we can provide high-quality products. Cle

Tetracycline.99%

Cas:60-54-8

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Tetracycline with lowest price

Cas:60-54-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

Tetracycline

Cas:60-54-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

6-deoxy-6-hydroperoxy-5a,11a-dehydrotetracycline
102851-25-2

6-deoxy-6-hydroperoxy-5a,11a-dehydrotetracycline

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
With hydrogen; platinum In 1,4-dioxane under 2280 Torr; for 8h; Catalytic hydrogenation;62%
Chlortetracycline
57-62-5

Chlortetracycline

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
With palladium on activated charcoal; 2-methoxy-ethanol; triethylamine Hydrogenation;
With 1,4-dioxane; methanol; palladium on activated charcoal Hydrogenation;
rolitetracycline

rolitetracycline

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
With water at 19.85℃; Kinetics; Further Variations:; Temperatures;
3,7-bis-benzyloxy-13-dimethylamino-11-hydroperoxy-4a-hydroxy-11-methyl-12a,13-dihydro-4aH,11H,12H-1-oxa-2-aza-cyclopenta[b]naphthacene-4,5,6-trione

3,7-bis-benzyloxy-13-dimethylamino-11-hydroperoxy-4a-hydroxy-11-methyl-12a,13-dihydro-4aH,11H,12H-1-oxa-2-aza-cyclopenta[b]naphthacene-4,5,6-trione

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
With hydrogen; palladium In 1,4-dioxane at 23℃; under 760 Torr; for 2h;16.0 mg
3,7-bis-benzyloxy-13-dimethylamino-4a-hydroxy-11-methyl-5a-phenylsulfanyl-11a,12,12a,13-tetrahydro-4aH,5aH,11H-1-oxa-2-aza-cyclopenta[b]naphthacene-4,5,6-trione

3,7-bis-benzyloxy-13-dimethylamino-4a-hydroxy-11-methyl-5a-phenylsulfanyl-11a,12,12a,13-tetrahydro-4aH,5aH,11H-1-oxa-2-aza-cyclopenta[b]naphthacene-4,5,6-trione

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: m-chloroperoxybenzoic acid / CH2Cl2 / -78 - 0 °C
1.2: air / CHCl3
2.1: 16.0 mg / H2 / Pd / dioxane / 2 h / 23 °C / 760 Torr
View Scheme
(4aR,5aR,6R,11R,11aS,12aS)-3,7-Bis-benzyloxy-13-dimethylamino-4a,6-dihydroxy-11-methyl-5a-phenylsulfanyl-6,11,11a,12,12a,13-hexahydro-4aH,5aH-1-oxa-2-aza-cyclopenta[b]naphthacene-4,5-dione

(4aR,5aR,6R,11R,11aS,12aS)-3,7-Bis-benzyloxy-13-dimethylamino-4a,6-dihydroxy-11-methyl-5a-phenylsulfanyl-6,11,11a,12,12a,13-hexahydro-4aH,5aH-1-oxa-2-aza-cyclopenta[b]naphthacene-4,5-dione

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 77 percent / o-iodoxybenzoic acid / dimethylsulfoxide / 18 h / 35 °C
2.1: m-chloroperoxybenzoic acid / CH2Cl2 / -78 - 0 °C
2.2: air / CHCl3
3.1: 16.0 mg / H2 / Pd / dioxane / 2 h / 23 °C / 760 Torr
View Scheme
(4aR,5aR,6R,11R,11aS,12aS,13S)-3,7-Bis-benzyloxy-13-dimethylamino-4a-hydroxy-11-methyl-5a-phenylsulfanyl-6-triethylsilanyloxy-6,11,11a,12,12a,13-hexahydro-4aH,5aH-1-oxa-2-aza-cyclopenta[b]naphthacene-4,5-dione

(4aR,5aR,6R,11R,11aS,12aS,13S)-3,7-Bis-benzyloxy-13-dimethylamino-4a-hydroxy-11-methyl-5a-phenylsulfanyl-6-triethylsilanyloxy-6,11,11a,12,12a,13-hexahydro-4aH,5aH-1-oxa-2-aza-cyclopenta[b]naphthacene-4,5-dione

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 76 percent / triethylamine trihydrofluoride / tetrahydrofuran / 12 h / 23 °C
2.1: 77 percent / o-iodoxybenzoic acid / dimethylsulfoxide / 18 h / 35 °C
3.1: m-chloroperoxybenzoic acid / CH2Cl2 / -78 - 0 °C
3.2: air / CHCl3
4.1: 16.0 mg / H2 / Pd / dioxane / 2 h / 23 °C / 760 Torr
View Scheme
7-Methoxy-3-methylphthalide
4938-06-1

7-Methoxy-3-methylphthalide

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 16 steps
1.1: 80 percent / LDA / tetrahydrofuran / 0.25 h / -40 °C
2.1: 90 percent / SOCl2; TEA / CH2Cl2 / 0.17 h / -30 °C
3.1: BBr3 / CH2Cl2 / 0.25 h / -78 °C
4.1: H2; TEA / Pd-black / dioxane; H2O / 1 h
5.1: 72 percent / i-Pr2NEt / tetrahydrofuran; methanol / 2 h
6.1: 85 percent / Br2; (Bu3Sn)2O; MS-4A / CH2Cl2 / 0.25 h / -78 °C
7.1: 91 percent / Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h
8.1: Zn / acetic acid / 0.03 h
9.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h
9.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C
10.1: NH2OH*HCl; TEA / methanol / 0.5 h
11.1: CDI / tetrahydrofuran / 0.75 h
12.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C
13.1: 80 percent / formic acid / 1 h / 80 °C
14.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C
15.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation
16.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr
View Scheme
anhydrotetracycline
1665-56-1, 7518-17-4

anhydrotetracycline

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation
2: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr
View Scheme
(4S,4aS,12aS)-4-Dimethylamino-3,11,12a-trihydroxy-10-methoxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydro-naphthacene-2-carboxylic acid amide
286961-75-9

(4S,4aS,12aS)-4-Dimethylamino-3,11,12a-trihydroxy-10-methoxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydro-naphthacene-2-carboxylic acid amide

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C
2: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation
3: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr
View Scheme
(4S,4aS,12aS)-4-Amino-3,11,12a-trihydroxy-10-methoxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydro-naphthacene-2-carboxylic acid amide
286961-84-0

(4S,4aS,12aS)-4-Amino-3,11,12a-trihydroxy-10-methoxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydro-naphthacene-2-carboxylic acid amide

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 80 percent / formic acid / 1 h / 80 °C
2: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C
3: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation
4: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr
View Scheme
((1S,2S,3S,12aR)-2,6-Dihydroxy-3-hydroxymethyl-4,7-dimethoxy-11-methyl-5-oxo-1,2,3,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid tert-butyl ester
286961-69-1

((1S,2S,3S,12aR)-2,6-Dihydroxy-3-hydroxymethyl-4,7-dimethoxy-11-methyl-5-oxo-1,2,3,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid tert-butyl ester

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: 85 percent / Br2; (Bu3Sn)2O; MS-4A / CH2Cl2 / 0.25 h / -78 °C
2.1: 91 percent / Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h
3.1: Zn / acetic acid / 0.03 h
4.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h
4.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C
5.1: NH2OH*HCl; TEA / methanol / 0.5 h
6.1: CDI / tetrahydrofuran / 0.75 h
7.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C
8.1: 80 percent / formic acid / 1 h / 80 °C
9.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C
10.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation
11.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr
View Scheme
((1S,4aS,12aR)-6-Hydroxy-3-hydroxymethyl-4,7-dimethoxy-11-methyl-2,5-dioxo-1,2,4a,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid tert-butyl ester
286961-71-5

((1S,4aS,12aR)-6-Hydroxy-3-hydroxymethyl-4,7-dimethoxy-11-methyl-2,5-dioxo-1,2,4a,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid tert-butyl ester

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h
1.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C
2.1: NH2OH*HCl; TEA / methanol / 0.5 h
3.1: CDI / tetrahydrofuran / 0.75 h
4.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C
5.1: 80 percent / formic acid / 1 h / 80 °C
6.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C
7.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation
8.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr
View Scheme
((1S,4aS,12aS)-3-Formyl-2,4a,6-trihydroxy-7-methoxy-11-methyl-4,5-dioxo-1,4,4a,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid tert-butyl ester
286961-73-7

((1S,4aS,12aS)-3-Formyl-2,4a,6-trihydroxy-7-methoxy-11-methyl-4,5-dioxo-1,4,4a,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid tert-butyl ester

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: NH2OH*HCl; TEA / methanol / 0.5 h
2: CDI / tetrahydrofuran / 0.75 h
3: 68 percent / polyposphoric acid / 0.75 h / 100 °C
4: 80 percent / formic acid / 1 h / 80 °C
5: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C
6: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation
7: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr
View Scheme
((1S,2S,3S,12aR)-2,4,6-Trihydroxy-3-hydroxymethyl-7-methoxy-11-methyl-5-oxo-1,2,3,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid tert-butyl ester
286961-82-8

((1S,2S,3S,12aR)-2,4,6-Trihydroxy-3-hydroxymethyl-7-methoxy-11-methyl-5-oxo-1,2,3,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid tert-butyl ester

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1.1: 72 percent / i-Pr2NEt / tetrahydrofuran; methanol / 2 h
2.1: 85 percent / Br2; (Bu3Sn)2O; MS-4A / CH2Cl2 / 0.25 h / -78 °C
3.1: 91 percent / Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h
4.1: Zn / acetic acid / 0.03 h
5.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h
5.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C
6.1: NH2OH*HCl; TEA / methanol / 0.5 h
7.1: CDI / tetrahydrofuran / 0.75 h
8.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C
9.1: 80 percent / formic acid / 1 h / 80 °C
10.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C
11.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation
12.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr
View Scheme
C27H30BrNO8

C27H30BrNO8

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: Zn / acetic acid / 0.03 h
2.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h
2.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C
3.1: NH2OH*HCl; TEA / methanol / 0.5 h
4.1: CDI / tetrahydrofuran / 0.75 h
5.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C
6.1: 80 percent / formic acid / 1 h / 80 °C
7.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C
8.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation
9.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr
View Scheme
((1S,4aS,12aS)-3-Cyano-2,4a,6-trihydroxy-7-methoxy-11-methyl-4,5-dioxo-1,4,4a,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid tert-butyl ester
286961-74-8

((1S,4aS,12aS)-3-Cyano-2,4a,6-trihydroxy-7-methoxy-11-methyl-4,5-dioxo-1,4,4a,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid tert-butyl ester

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 68 percent / polyposphoric acid / 0.75 h / 100 °C
2: 80 percent / formic acid / 1 h / 80 °C
3: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C
4: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation
5: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr
View Scheme
[(1S,4aS,12aS)-2,4a,6-Trihydroxy-3-(hydroxyimino-methyl)-7-methoxy-11-methyl-4,5-dioxo-1,4,4a,5,12,12a-hexahydro-naphthacen-1-yl]-carbamic acid tert-butyl ester

[(1S,4aS,12aS)-2,4a,6-Trihydroxy-3-(hydroxyimino-methyl)-7-methoxy-11-methyl-4,5-dioxo-1,4,4a,5,12,12a-hexahydro-naphthacen-1-yl]-carbamic acid tert-butyl ester

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: CDI / tetrahydrofuran / 0.75 h
2: 68 percent / polyposphoric acid / 0.75 h / 100 °C
3: 80 percent / formic acid / 1 h / 80 °C
4: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C
5: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation
6: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr
View Scheme
C27H32BrNO8
286961-70-4

C27H32BrNO8

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: 91 percent / Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h
2.1: Zn / acetic acid / 0.03 h
3.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h
3.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C
4.1: NH2OH*HCl; TEA / methanol / 0.5 h
5.1: CDI / tetrahydrofuran / 0.75 h
6.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C
7.1: 80 percent / formic acid / 1 h / 80 °C
8.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C
9.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation
10.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr
View Scheme
((1S,2S,3S,12aR)-2,4,6-Trihydroxy-3-hydroxymethyl-7-methoxy-11-methyl-5-oxo-1,2,3,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid benzyl ester

((1S,2S,3S,12aR)-2,4,6-Trihydroxy-3-hydroxymethyl-7-methoxy-11-methyl-5-oxo-1,2,3,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid benzyl ester

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1.1: H2; TEA / Pd-black / dioxane; H2O / 1 h
2.1: 72 percent / i-Pr2NEt / tetrahydrofuran; methanol / 2 h
3.1: 85 percent / Br2; (Bu3Sn)2O; MS-4A / CH2Cl2 / 0.25 h / -78 °C
4.1: 91 percent / Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h
5.1: Zn / acetic acid / 0.03 h
6.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h
6.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C
7.1: NH2OH*HCl; TEA / methanol / 0.5 h
8.1: CDI / tetrahydrofuran / 0.75 h
9.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C
10.1: 80 percent / formic acid / 1 h / 80 °C
11.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C
12.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation
13.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr
View Scheme
((1S,2S,3S,12aR)-2-Benzyloxy-3-benzyloxymethyl-4,6-dihydroxy-7-methoxy-11-methyl-5-oxo-1,2,3,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid benzyl ester
286961-68-0

((1S,2S,3S,12aR)-2-Benzyloxy-3-benzyloxymethyl-4,6-dihydroxy-7-methoxy-11-methyl-5-oxo-1,2,3,5,12,12a-hexahydro-naphthacen-1-yl)-carbamic acid benzyl ester

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 14 steps
1.1: BBr3 / CH2Cl2 / 0.25 h / -78 °C
2.1: H2; TEA / Pd-black / dioxane; H2O / 1 h
3.1: 72 percent / i-Pr2NEt / tetrahydrofuran; methanol / 2 h
4.1: 85 percent / Br2; (Bu3Sn)2O; MS-4A / CH2Cl2 / 0.25 h / -78 °C
5.1: 91 percent / Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h
6.1: Zn / acetic acid / 0.03 h
7.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h
7.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C
8.1: NH2OH*HCl; TEA / methanol / 0.5 h
9.1: CDI / tetrahydrofuran / 0.75 h
10.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C
11.1: 80 percent / formic acid / 1 h / 80 °C
12.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C
13.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation
14.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr
View Scheme
((1S,2S,3S,12aR)-2-Benzyloxy-3-benzyloxymethyl-4,6,11-trihydroxy-7-methoxy-11-methyl-5-oxo-1,2,3,5,11,11a,12,12a-octahydro-naphthacen-1-yl)-carbamic acid benzyl ester
286961-67-9

((1S,2S,3S,12aR)-2-Benzyloxy-3-benzyloxymethyl-4,6,11-trihydroxy-7-methoxy-11-methyl-5-oxo-1,2,3,5,11,11a,12,12a-octahydro-naphthacen-1-yl)-carbamic acid benzyl ester

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
Multi-step reaction with 15 steps
1.1: 90 percent / SOCl2; TEA / CH2Cl2 / 0.17 h / -30 °C
2.1: BBr3 / CH2Cl2 / 0.25 h / -78 °C
3.1: H2; TEA / Pd-black / dioxane; H2O / 1 h
4.1: 72 percent / i-Pr2NEt / tetrahydrofuran; methanol / 2 h
5.1: 85 percent / Br2; (Bu3Sn)2O; MS-4A / CH2Cl2 / 0.25 h / -78 °C
6.1: 91 percent / Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h
7.1: Zn / acetic acid / 0.03 h
8.1: Dess-Martin periodinane / acetonitrile; CH2Cl2 / 0.25 h
8.2: 60 percent / dimethyldioxirane; (R,R)-(PhCH-NTs)2BCl; TEA / CH2Cl2 / 0.5 h / -78 °C
9.1: NH2OH*HCl; TEA / methanol / 0.5 h
10.1: CDI / tetrahydrofuran / 0.75 h
11.1: 68 percent / polyposphoric acid / 0.75 h / 100 °C
12.1: 80 percent / formic acid / 1 h / 80 °C
13.1: 88 percent / BBr3 / CH2Cl2 / 15 h / 0 - 20 °C
14.1: 75 percent / O2; TPP / CHCl3 / 0.17 h / 20 - 40 °C / Irradiation
15.1: 62 percent / H2 / Pt-black / dioxane / 8 h / 2280 Torr
View Scheme
C36H32N2O9

C36H32N2O9

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
With hydrogen; palladium In 1,4-dioxane at 23℃; under 760.051 Torr; for 2.08333h;
omeprazole
73590-58-6

omeprazole

TETRACYCLINE
60-54-8

TETRACYCLINE

tetracycline hydrochloride
64-75-5

tetracycline hydrochloride

TETRACYCLINE
60-54-8

TETRACYCLINE

Conditions
ConditionsYield
In water pH=9; pH-value; Cooling;
formaldehyd
50-00-0

formaldehyd

TETRACYCLINE
60-54-8

TETRACYCLINE

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

7-(4-{[(4-dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carbonyl)-amino]-methyl}-piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

7-(4-{[(4-dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carbonyl)-amino]-methyl}-piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
In ethanol for 0.05h; Mannich reaction; microwave irradiation;78%
TETRACYCLINE
60-54-8

TETRACYCLINE

C20H17NO9

C20H17NO9

Conditions
ConditionsYield
With hydrogenchloride; N-chloro-succinimide In water at 25℃; for 0.5h;74.4%
formaldehyd
50-00-0

formaldehyd

TETRACYCLINE
60-54-8

TETRACYCLINE

1-cyclopropyl-7-(4-{[(4-dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carbonyl)-amino]-methyl}-3-methyl-piperazin-1-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

1-cyclopropyl-7-(4-{[(4-dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carbonyl)-amino]-methyl}-3-methyl-piperazin-1-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
In ethanol for 0.05h; Mannich reaction; microwave irradiation;69%
formaldehyd
50-00-0

formaldehyd

TETRACYCLINE
60-54-8

TETRACYCLINE

ciprofloxacin
85721-33-1

ciprofloxacin

1-cyclopropyl-7-(4-{[(4-dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carbonyl)-amino]-methyl}-piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

1-cyclopropyl-7-(4-{[(4-dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carbonyl)-amino]-methyl}-piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
In ethanol for 0.05h; Mannich reaction; microwave irradiation;61%
TETRACYCLINE
60-54-8

TETRACYCLINE

methyl iodide
74-88-4

methyl iodide

1,4,4a,5,5a,6,11,12a-octahydro-2-aminocarbonyl-3,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxonaphthacene-4-trimethylammonium iodide
6602-90-0

1,4,4a,5,5a,6,11,12a-octahydro-2-aminocarbonyl-3,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxonaphthacene-4-trimethylammonium iodide

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 96h;57%
In tetrahydrofuran at 20℃; for 144h;
formaldehyd
50-00-0

formaldehyd

TETRACYCLINE
60-54-8

TETRACYCLINE

lomefloxacin
98079-51-7

lomefloxacin

7-(4-{[(4-dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carbonyl)-amino]-methyl}-3-methyl-piperazin-1-yl)-1-ethyl-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

7-(4-{[(4-dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carbonyl)-amino]-methyl}-3-methyl-piperazin-1-yl)-1-ethyl-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
In ethanol for 0.05h; Mannich reaction; microwave irradiation;54%
manganese(II) perchlorate hydrate

manganese(II) perchlorate hydrate

TETRACYCLINE
60-54-8

TETRACYCLINE

Mn(C22H24O8N2)2(OClO3)(1+)*ClO4(1-)=[Mn(C22H24O8N2)2(OClO3)]ClO4

Mn(C22H24O8N2)2(OClO3)(1+)*ClO4(1-)=[Mn(C22H24O8N2)2(OClO3)]ClO4

Conditions
ConditionsYield
In further solvent(s) the soln. of salt in ethanol/triethyl orthoformate was heated at 40-50°C, added tetracycline, refluxed for 24-48 h, concn. by heating under reduced prdssure, cooled to room temp.; filtered, washed with cold EtOH, dried in vac. over anhyd. CaCl2;42%
TETRACYCLINE
60-54-8

TETRACYCLINE

A

C20H17NO9

C20H17NO9

B

4-Oxo-4-dedimethylaminotetracyclin-hemiketal-(4.6)
3764-23-6

4-Oxo-4-dedimethylaminotetracyclin-hemiketal-(4.6)

Conditions
ConditionsYield
Stage #1: TETRACYCLINE With ethylenediaminetetraacetic acid; silver carbonate In N,N-dimethyl-formamide at 37℃; for 48h; Molecular sieve;
Stage #2: With dipotassium hydrogenphosphate; water; edetate disodium In N,N-dimethyl-formamide; acetonitrile at 0 - 20℃; for 8h; pH=5.5;
Stage #3: In chloroform at 0 - 5℃; for 168h;
A n/a
B 42%
formaldehyd
50-00-0

formaldehyd

TETRACYCLINE
60-54-8

TETRACYCLINE

4-nitrooxypiperidine
104963-85-1

4-nitrooxypiperidine

amido-N-[4-nitrooxypiperidinomethyl]-tetracycline

amido-N-[4-nitrooxypiperidinomethyl]-tetracycline

Conditions
ConditionsYield
In tetrahydrofuran for 4h; Inert atmosphere; Reflux;36%
In tetrahydrofuran for 4h; Reflux; Inert atmosphere;36%
formaldehyd
50-00-0

formaldehyd

TETRACYCLINE
60-54-8

TETRACYCLINE

4-amino-n-butyric acid
56-12-2

4-amino-n-butyric acid

C27H33N3O10

C27H33N3O10

Conditions
ConditionsYield
With acetic acid In ethanol at 20℃; for 12h; Mannich Aminomethylation;31%
TETRACYCLINE
60-54-8

TETRACYCLINE

A

2,5-dihydroxy-4-(((1S,4R,10S)-6-hydroxy-1-methyl-3,5-dioxo-1,3,4,5-tetrahydro-1,4-methanobenzo[c]oxepin-10-yl)methyl)-3,6-dioxocyclohexa-1,4-dienecarboxamide

2,5-dihydroxy-4-(((1S,4R,10S)-6-hydroxy-1-methyl-3,5-dioxo-1,3,4,5-tetrahydro-1,4-methanobenzo[c]oxepin-10-yl)methyl)-3,6-dioxocyclohexa-1,4-dienecarboxamide

B

2,3,5,6-tetrahydroxy-4-(((1S,4R,10S)-6-hydroxy-1-methyl-3,5-dioxo-1,3,4,5-tetrahydro-1,4-methanobenzo[c]oxepin-10-yl)methyl)benzamide

2,3,5,6-tetrahydroxy-4-(((1S,4R,10S)-6-hydroxy-1-methyl-3,5-dioxo-1,3,4,5-tetrahydro-1,4-methanobenzo[c]oxepin-10-yl)methyl)benzamide

Conditions
ConditionsYield
With mercury(II) diacetate; acetic acid at 50℃; for 48h;A 30%
B 10%
zinc(II) perchlorate hydrate

zinc(II) perchlorate hydrate

TETRACYCLINE
60-54-8

TETRACYCLINE

Zn(C22H24O8N2)2(OClO3)(1+)*ClO4(1-)=[Zn(C22H24O8N2)2(OClO3)]ClO4

Zn(C22H24O8N2)2(OClO3)(1+)*ClO4(1-)=[Zn(C22H24O8N2)2(OClO3)]ClO4

Conditions
ConditionsYield
In further solvent(s) the soln. of salt in ethanol/triethyl orthoformate was heated 40-50°C, added tetracycline, refluxed for 24-48 h, concn. by heating underreduced pressure, cooled to room temp.; filtered, washed with cold EtOH, dried in vac. over anhyd. CaCl2;28%
TETRACYCLINE
60-54-8

TETRACYCLINE

C22H24N2O9

C22H24N2O9

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In methanol for 0.0833333h; Solvent; Inert atmosphere; Cooling with ice;27%
TETRACYCLINE
60-54-8

TETRACYCLINE

2,5-dihydroxy-4-(((1S,4R,10S)-6-hydroxy-1-methyl-3,5-dioxo-1,3,4,5-tetrahydro-1,4-methanobenzo[c]oxepin-10-yl)methyl)-3,6-dioxocyclohexa-1,4-dienecarboxamide

2,5-dihydroxy-4-(((1S,4R,10S)-6-hydroxy-1-methyl-3,5-dioxo-1,3,4,5-tetrahydro-1,4-methanobenzo[c]oxepin-10-yl)methyl)-3,6-dioxocyclohexa-1,4-dienecarboxamide

Conditions
ConditionsYield
In dimethyl sulfoxide at 30℃; for 48h;26%
formaldehyd
50-00-0

formaldehyd

TETRACYCLINE
60-54-8

TETRACYCLINE

glycine
56-40-6

glycine

C25H29N3O10

C25H29N3O10

Conditions
ConditionsYield
With acetic acid In ethanol at 20℃; for 12h; Mannich Aminomethylation;24%
morpholine
110-91-8

morpholine

TETRACYCLINE
60-54-8

TETRACYCLINE

Glyoxilic acid
298-12-4

Glyoxilic acid

(4-dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carbonylamino)-morpholin-4-yl-acetic acid
13729-37-8

(4-dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carbonylamino)-morpholin-4-yl-acetic acid

Conditions
ConditionsYield
In tert-butyl alcohol Heating;
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

TETRACYCLINE
60-54-8

TETRACYCLINE

C31H48N2O8Si3

C31H48N2O8Si3

Conditions
ConditionsYield
With 1,1,1,3,3,3-hexamethyl-disilazane In pyridine at 20℃; for 0.0166667h;
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

TETRACYCLINE
60-54-8

TETRACYCLINE

C37H64N2O8Si5

C37H64N2O8Si5

Conditions
ConditionsYield
With 1,1,1,3,3,3-hexamethyl-disilazane In pyridine at 20℃; for 12h;
TETRACYCLINE
60-54-8

TETRACYCLINE

1-Cyclohex-1-enyl-piperidine; compound with perchloric acid

1-Cyclohex-1-enyl-piperidine; compound with perchloric acid

(4S,4aS,5aS,6S,12aS)-4-Dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid cyclohex-1-enylamide

(4S,4aS,5aS,6S,12aS)-4-Dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid cyclohex-1-enylamide

Conditions
ConditionsYield
(i) DMF, (ii) piperidine; Multistep reaction;
2-amino-1,9-dihydro-6H-purin-6-one
73-40-5

2-amino-1,9-dihydro-6H-purin-6-one

TETRACYCLINE
60-54-8

TETRACYCLINE

guanine*tetracycline
78696-74-9

guanine*tetracycline

Conditions
ConditionsYield
In water at 23℃; formation constant; further solvents;;
L-phenylalanine
63-91-2

L-phenylalanine

TETRACYCLINE
60-54-8

TETRACYCLINE

phenylalanine*tetracycline
78696-79-4

phenylalanine*tetracycline

Conditions
ConditionsYield
In water at 23℃; formation constant; further solvents;;
TETRACYCLINE
60-54-8

TETRACYCLINE

4-epi-anhydrotetracycline
1665-57-2

4-epi-anhydrotetracycline

Conditions
ConditionsYield
With 2-hydroxyethanethiol at 4℃; Irradiation; Title compound not separated from byproducts;
TETRACYCLINE
60-54-8

TETRACYCLINE

L-tyrosine
60-18-4

L-tyrosine

tyrosine*tetracycline
78696-80-7

tyrosine*tetracycline

Conditions
ConditionsYield
In water at 23℃; formation constant; further solvents;;
TETRACYCLINE
60-54-8

TETRACYCLINE

uracil
66-22-8

uracil

uracil*tetracycline
78696-78-3

uracil*tetracycline

Conditions
ConditionsYield
In water at 23℃; formation constant; further solvents;;
TETRACYCLINE
60-54-8

TETRACYCLINE

thymin
65-71-4

thymin

thymine*tetracycline
78696-77-2

thymine*tetracycline

Conditions
ConditionsYield
In water at 23℃; formation constant; further solvents;;
TETRACYCLINE
60-54-8

TETRACYCLINE

hypoxanthine
68-94-0

hypoxanthine

hypoxanthine*tetracycline
78696-76-1

hypoxanthine*tetracycline

Conditions
ConditionsYield
In water at 23℃; formation constant; further solvents;;
Conditions
ConditionsYield
In water at 23℃; formation constant; further solvents;;
TETRACYCLINE
60-54-8

TETRACYCLINE

xanthine
69-89-6

xanthine

xanthine*tetracycline
78696-75-0

xanthine*tetracycline

Conditions
ConditionsYield
In water at 23℃; formation constant; further solvents;;

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