Erlotinib hydrochloride (ERLO) belongs to the tyrosine kinase inhibitor family and is used for the treatment of pancreatic cancers. In the present study, ERLO was entrapped in lipid nanocarriers by means of reverse micellar incorporation. This study aims to optimize the formulation of ERLO-loade...

This study was aimed at developing a nanoparticle strategy to overcome acquired resistance against erlotinib in non-small cell lung cancer (NSCLC). To load erlotinib on biodegradable PLGA nanoparticles, erlotinib-cyclodextrin (Erlo-CD) complex was prepared using β-cyclodextrin sulfobutyl ether,...

Recently, fluorescent carbon dots as optical sensors have drawn tremendous attention due to their attractive optical properties. Herein, we have presented a facile and economical approach to fabricate nitrogen and sulfur co-doped carbon dots (N, S co-doped C-dots) for the temperature and erlotin...

Erlotinib (ERL) is a tyrosine kinase inhibitor which prevents growing of cancer cells. The electrochemical oxidation mechanism of ERL was studied in details using cyclic voltammetry. Cyclic voltammetry, differential pulse and square wave voltammetric techniques were applied for sensitive, fast, ...

Introduction[11C]Erlotinib PET has shown promise to distinguish non-small cell lung cancer (NSCLC) tumors harboring the activating epidermal growth factor receptor (EGFR) mutation delE746-A750 from tumors with wild-type EGFR. To assess the suitability of [11C]erlotinib PET to detect the emergenc...

A selective and sensitive competitive enzyme-linked immunosorbent assay (ELISA) method was developed and validated for the quantification of erlotinib in 50 µL of samples of human serum. Anti-erlotinib serum was obtained by immunizing mice with an antigen conjugated with bovine serum albumin an...

An LC–MS/MS method was developed and validated to quantify the tyrosine kinase inhibitor erlotinib in human scalp hair, as alternative matrix to monitor long-term erlotinib exposure. Hair samples from 10 lung cancer patients were measured and correlated with plasma concentrations. Hair segments...

Recrystallization of two anti-cancer active pharmaceutical ingredients (APIs), erlotinib hydrochloride (erlotinib HCl) and fulvestrant, using supercritical antisolvent (SAS) process was investigated in this study. The most commonly used supercritical carbon dioxide was employed as the antisolven...

This study focuses on improving the manufacturing process for a generic immediate-release tablet containing erlotinib hydrochloride by adding a fines recycling process during roller compaction. Due to the large fraction of small-sized API particles, the starting powder mixture was inconsistently...

The synthesis in 4 steps of new N,N′-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines issued from various symmetric primary diamines as linkers was reported. The key step of our strategy has been the sulphur/nitrogen displacement of (5Z)-5-arylidene-2-ethylsulfanyl-3,5-dihydro-4H-imi...

To make a polymer from ornithine the acryloyl group was added to δ-amino group of the amino acid and N-δ-acryloyl ornithine was polymerized. The presence of α-amino acid groups attached to the polymeric network of the gels enables the complexation of some di- and trivalent metal cations. Copp...

The kinetics of polymerization of the symmetrical non-conjugated divinyl monomer N,N′-methylenebisacrylamide has been studied using CeIV-thiourea redox system as initiator. The rate of polymerization, Rp is proportional to [CeIV]12, [thiourea]12 and [monomer]32. A cyclopolymerization mechanism ...

A temperature-responsive poly(N-isopropylacrylamide-co-N,N′-methylenebisacrylamide) [poly(NIPAAm-co-BIS)] monolith was prepared via a free-radical polymerization technique using an aqueous redox initiator in solution at −12 °C. The effect of the % T (total monomer concentration/100 mL) and % C...

Monodisperse silica/poly(N,N′-methylenebisacrylamide) core–shell composite materials with silica as core and poly(N,N′-methylenebisacrylamide) (PMBAAm) as shell were prepared by a two-stage reaction, in which the silica core with diameter of 500 nm was synthesized in the first stage according...

New nano chelating resin 2-amino pyridine−functionalized polyacrylonitrile (CPN-AP) (≈ 70 nm) was prepared by precipitation polymerization of acrylonitrile with N,N′-methylenebisacrylamide followed by treatment with 2-amino pyridine. The physicochemical properties of the nano chelating resin w...

The early stages of the polymerisation of N,N′-methylenebisacrylamide monomer in dilute aqueous solutions were studied by means of pulse radiolysis technique. The reactivity of the basic products of water radiolysis: OH radicals and hydrated electrons with the monomer were found to be comparabl...

UV photopolymerization was used to prepare films from N-vinyl-2-pyrrolidone (NVP) crosslinked with N,N′-methylenebisacrylamide (MBAA). These samples were crosslinked in the presence of water. Although the initial mixtures of water, NVP and MBAA were optically transparent, the final films were w...

Redox/temperature responsive poly(N-isopropylacrylamide/N-hydroxyethylacrylamide) (P(NIPA/HEAA)) nonionic nanogels (NP-BAC) crosslinked with N,N′-Bis(acryloyl)cystamine (BAC) have been prepared. An analogous nanogel incorporating N,N′-methylenebisacrylamine (BIS), a reduction-insensitive nanog...

The removal of mercury and lead ions from aqueous solutions investigated by ethylenediamine, diethylenetriamine and tetraethylenepentamine functionalized polymeric adsorbent. The adsorbent was prepared by amination of terpolymer synthesized from glycidylmethacrylate, styrene and N,N′-methyleneb...

Crosslinked N-vinyl-2-pyrrolidone (NVP) free-standing films were prepared by UV-induced photopolymerization in the presence of water using N,N′-methylenebisacrylamide (MBAA) as the crosslinker. A series of crosslinked films were prepared at various prepolymerization water contents and NVP/MBAA ...