The six N-(dimethoxybenzyl)-4-bromo-2,5-dimethoxyphenethylamine regioisomers are potential designer compounds related to the common NBOMe drug N-(2-methoxy)benzyl-4-bromo-2,5-dimethoxyphenethylamine (25B-NBOMe). These six compounds represent the incorporation of one additional methoxy-group into...

A usual method for the determination of aldehydes and ketones in different matrices consists of a derivatization with 2,4-dinitrophenylhydrazine (DNPH) followed by HPLC-UV analysis. In the present work, a HPLC-UV gradient elution method has been applied to the analysis of 13 aldehydes and ketone...

A series of iminothiazolines (4a–j) featuring 2,4,5-trichlorophenyl moiety and aroyl/heteroaroyl substituents has been prepared from readily accessible thioureas. In-vitro screening against glucosidase enzymes showed highly specific inhibition of α-glucosidase with a marked dependence of the p...

Four triphenylamine groups-substituted fluorene with rather high glass transition temperature, Tg, of 165 °C, was prepared and employed together with TPD as a composite hole-transporting layer to give a device with very low turn-on voltage and high efficiency. When a hole block layer was fabric...

Two novel p-phenylenediamine-substituted fluorenes have been designed and synthesized. Their applications as hole injection materials in organic electroluminescent devices were investigated. These materials show a high glass transition temperature and a good hole-transporting ability. It has bee...

A novel amorphous hole-transporting carbazole dendrimer, 2,7-bis[3,6-di(carbazol-9-yl)carbazol-9-yl]-9,9-bis-n-hexylfluorene (G2CF), was synthesized by a divergent approach involving bromination and Ullmann coupling reactions. G2CF showed UV–vis absorption bands at 304 and 332 nm in chloroform ...

Herein, a tetracyano-substituted spiro[fluorene-9,9′-xanthene] (SFX) derivative, 2,3′,6′,7-tetracarbonitrile-SFX (TCNSFX) was conveniently synthesized as electron acceptor for combining with tris(4-carbazoyl-9-ylphenyl)amine (TCTA) as electron donor to form exciplex emitter. Subsequently, exc...

Two spiro[fluorene-9,9′-xanthene]-centered (SFX), tetra-carbazole substituted molecules 2,2′,7,7′-tetrakis(N, N-carbazole)-spiro(fluorene-9,9′-xanthene) (SFX-Cr1) and 2,3′,6,′7-tetrakis(N, N-carbazole)-spiro(fluorene-9,9′-xanthene) (SFX-Cr2) were synthesized, and the effect of the positio...

Density Functional Theory (DFT) approach has become one of the most cost effective means to investigate upon the molecular structure and vibrational spectrum and are finding widespread use in the applications related to biological systems. Investigations (experimental and theoretical) on the mol...

The 1:2 complex (1) of dimethylphenyl betaine (DMPB) with two molecules of 2,6-dichloro-4-nitro-phenol (DCNP) was prepared and characterized by X-ray diffraction, B3LYP/6-311++G(d,p) and B3LYP-D3/6-311++G(d,p)calculations, FTIR and NMR spectroscopies. The crystal is monoclinic, space group P21/c...

SummaryTwo N-(2,6-dimethylphenyl)pyridinedicarboximides were synthesized and evaluated for anticonvulsant properties and neurotoxicity. These compounds were mainly active against maximal electroshock (MES) induced seizures in animal models. In rats dosed orally, N-(2,6-dimethylphenyl-2,3-pyridin...

The specific rotation of (S)-4-isopropyl-oxazolidin-2-one is extremely solvent dependent. In chloroform it is dextrorotatory {[α]D26=+15.5(c5.2,CHCl3)}, whereas in ethanol it is levorotatory {[α]D26=-16.1(c5.2,EtOH)}.

The enzymatic hydrolysis of methyl 2-fluoro-2-arylpropionates was performed using lipases from Candida rugosa and Candida cylindracea (OF-360). A careful analysis of the reaction products revealed that racemic 2-hydroxy-2-arylpropionic acid and traces of 2-arylacrylic acid are formed, in additio...

Poly(N-isopropylacrylamide-co-4-vinylpyridine) [poly(NIPAM-co-4-VP)] co-polymer exhibited inverse temperature solubility with a lower critical solution temperature (LCST) in water. Pd nanoparticles were immobilized on these poly(NIPAM-co-4-VP) hydrogels. The heterogeneous Pd catalyst showed high...

A metal free synthesis of S-alkyl thioesters, which does not involve alkylthiol or thiocarboxylic acid as sulfur source is disclosed. The process involves first an acylation at the nitrogen of the readily available N-(2-aminophenyl)-4-methyl-thiazolin-2-thione, second an alkylation at sulfur of ...

Sigma-1 receptor imaging probes for determining the expression levels are desirable for diagnoses of various diseases and companion diagnoses of therapeutic agents targeting the sigma-1 receptor. In this study, we aimed to develop probes with higher affinity for the sigma-1 receptor. For this pu...

A novel and mild method for copper-mediated trifluoromethylation of 5-iodotriazole using (trifluoromethyl)trimethylsilane (Me3SiCF3) as trifluoromethylating reagent with the assistance of Ag2CO3 was developed.

Reported herein is the design, synthesis, and pharmacologic characterization of a class of TRPV1 antagonists constructed on a phenylquinoline platform that evolved from Cinchophen lead. This design composes three sections: a phenylquinoline headgroup attached to an aliphatic carboxamides, which ...

Three complexes of M(dnpi)2 (M = Cu2+, Co2+ and Pb2+; dnpi = 4,5-Diphenyl-2-(4-nitrophenyl)-1H-imidazole) were synthesized and characterized by elemental analysis, IR, UV–Vis, X-ray diffraction and the Z-scan technique. The X-ray diffraction results revealed crystal structures with a rare tetra...

On the basis of the N-protonated structure study of tetraphenylporphyrin, the changes of the geometries and properties of meso-tetrakis(p-carboxylatophenyl)porphyrin and meso-tetrakis(p-nitrophenyl)porphyrin in the protonation process were calculated by using AM1 MO method and symmetry restricti...