An efficient, novel procedure for the synthesis of new imidazole derivatives from α-azido ketones is described. This reaction proceeds via dimerization of aryl glyoxal imino generated from α-azido ketones in the presence of potassium ethylxanthate as a catalyst. A possible mechanism for the en...
Acetaminophen (APAP) hepatotoxity is due to metabolic activation to a toxic reactive metabolite via the hepatic mixed function oxidases. Potassium ethylxanthate (PEX) has been shown to be a potent inhibitor of cytochrome P-450-mediated drug matabolism in experimental animals, both in vivo and in...
Densities of the ternary system 1,4-dioxane + butyl acrylate + ethyl acrylate and its binary butyl acrylate + ethyl acrylate have been measured in the whole composition range, at 298.15 K and atmospheric pressure, using an Anton Paar DMA 5000 oscillating U-tube densimeter. The calculated excess ...
Chitosan was grafted with a novel monomer namely Acryloyl cyanoacetohydrazide (ACAH) which contains carbonyl and cyano groups. The graft copolymerization was conducted in heterogeneous phase using potassium persulfate (K2S2O8) and sodium bisulfite (NaHSO3) as redox initiators. The effect of mono...
Main pathways in reactions of lactim ethers with cyanoacetic acid hydrazide depend on the ring size of the starting lactim ether. Five-membered O-methylbutyrolactim produces pre-dominantly 3-amino-4-(pyrrolidin-2-ylidene)-4,5-dihydropyrazol-5-one, whereas condensation of six-and seven-membered l...
The title compound is used as a precursor in synthesis of differently sized heterocyclic systems bearing quinoline moeity. Investigation of antimicrobial activity of the new products was evaluated using agar well diffusion method against six reference microbial isolates. Most of the new compound...
A voltammetric method has been developed for the determination of N,N'-dinitrosopiperazine (DNPZ) in simulated gastric juice. The method is based on measuring the differential pulse polarographic peak produced in pH 3 Britton Robinson buffer. A well defined, diffusion-controlled cathodic wave wa...
N,N′-dinitrosopiperazine (DNP), with specificity for nasopharyngeal epithelium, is involved in metastasis of nasopharyngeal carcinoma (NPC), although the underlying mechanism of action is unclear.To reveal the pathogenesis of DNP-involved metastasis, we used immunoprecipitation to identify DNP-...
Nasopharyngeal carcinoma (NPC) has a highly metastatic character in the clinic, but the underlying mechanism of action is unclear. N,N′-dinitrosopiperazine (DNP), a carcinogen with organ specificity for the nasopharyngeal epithelium, is involved in metastasis of NPC.Anterior gradient 2 (AGR2) w...
The present study aims to determine the fatty acid profiling of commercially important fresh and boiled Scomberomorus commerson. Fatty acids in fresh and boiled fish were separated and quantitatively determined by gas chromatography–mass spectrophotometer using standard methods. The findings re...
A series of supramolecular salts have been obtained by the self-assembly of 4-fluorobenzylamine and halide ions or metal chloride with 18-crown-6 as the host in the hydrochloric acid medium, i.e. (C 7 H 9 FN) + ⋅X − (X=Cl − , 1; Br − , 2), [(C ...
The conductivity of (cosolvent + water) in the presence of increasing concentration of 1-hexadecylpyridinium bromide was measured at various temperatures. Acetonitrile, dimethylformamide, dimethylsulfoxide, dioxane and ethylene glycol were used as cosolvents. From the conductivity data, the crit...
Micellar behavior of binary combinations of ionic liquid, 1-tetradecyl-3-methylimidazolium bromide, with conventional cationic surfactant 1-hexadecylpyridinium bromide was investigated by means of conductometry to study the effect of cosolvent and water content and temperature. The critical mice...
The critical micelle concentration (CMC) of hexadecylpyridinium bromide (HDPB) is determined conductometrically in binary mixtures of water + cosolvent at various temperatures and at low concentrations of sodium bromide, ranging from 0 to 2.4 × 10−2 M. Dimethylsulfoxide (DMSO) and acetonitrile ...
4-(1,1,3,3-tetramethylbutane)-phenol (4-tert-OP) is one of the most prevalent endocrine disrupting pollutants. Information about bioremediation of 4-tert-OP remains limited, and no study has been reported on the mechanism of 4-tert-OP degradation by yeasts. The yeast Candida rugopelliculosa RRKY...
Groups of Atlantic salmon parr (November, Exp. 1) or pre-smolts (March, Exp. 2) were exposed to estradiol-17β (E2 conc.: nominal 500ngl −1 /actual 8–16ngl −1 ) and two doses of tert-octylphenol (OP: nominal 25μgl −1 /actual 4.5–6.5μgl −1 and OP: nominal 100μ...
Endocrine disrupting chemicals that activate the estrogen receptor are routinely detected in the environment and are a concern for the health of both exposed humans and indigenous wildlife. We exposed the western clawed frog (Xenopus tropicalis) to the weak estrogen octylphenol from Nieuwkoop–F...
Pneumocystic carinii pneumonia, which is a major cause of death among patients suffering from acquired immunodeficiency syndrome, has often been treated successfully with pentamidine isethionate. This study examines pentamidine effects on cellular and secreted proteins from rat alveolar macroph...
Background Leishmania (Viannia) guyanensis is believed to be the principal cause of cutaneous leishmaniasis (CL) in Suriname. This disease is treated with pentamidine isethionate (PI), but treatment failure has increasingly been reported.Aim To evaluate PI for its clinical efficacy, to compare p...
The purpose of this study was to perform physical characterization of pentamidine isethionate (PI) in frozen and freeze‐dried systems and to monitor the phase behavior during all the stages of freeze‐drying. Frozen aqueous PI solutions as well as the final lyophiles were characterized by diffe...
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