The radical polymerization of p-methacryloyloxybenzoic acid (MBA), at 60 °C in DMF followed classical kinetics, whereas that in p-dioxane did not as revealed by the rate being proportional to [MBA]1.50 [AIBN]0.34. This could be explained by the dependency of the efficiency factor ƒ on [MBA] and...
Photolysis of heptamethyl-2-phenyltrisilane and of octamethyl-2,3-diphenyltetrasilane in the presence of dimethyl sulfoxide (DMSO) occurs by two major pathways. The first involves loss of methylphenylsilylene, which reacts with DMSO to yield methylphenylsilanone and dimethyl sulfide. Methylpheny...
A feasible method for treatment of the wastewater from the two-staged neutralization in 2,2′,5,5′-tetrachlorobenzidine (TCB) manufacturing processes, a refractory dye intermediate effluents, based on combined micro-electrochemical oxidation or iron-chipping filtration (ICF) and air-stripping r...
2,2′,5,5′-Tetrachlorobenzidine (TCB), an intermediate in the industrial manufacture of dyes and pigments, is classified as a human carcinogen or a probable putative human carcinogen in USA. During the production of TCB, substantial quantities of industrial effluents are generated. A lab-scale ...
To extend the (strept)avidin-biotin technology for affinity purification of proteins, development of reusable biochips and immobilized enzyme bioreactors, selective immobilization of a protein of interest from a crude sample to a protein array without protein purification and many other possible...
Fluorescence labeling of a cytokine at a specific site is required for observing cytokine-receptor interactions in living cells at the single-molecule level. Here, we demonstrated the C-terminus-specific fluorescence labeling of histidine-tagged thrombopoietin (TPO), a ligand for Mpl, with desth...
The high-affinity binding of biotin to avidin, streptavidin, and related proteins has been exploited for decades. However, a disadvantage of the biotin/biotin-binding protein interaction is that it is essentially irreversible under physiological conditions. Desthiobiotin is a biotin analogue tha...
Desthiobiotin-tagged lentiviral vectors have been metabolically produced by DBL producer cells in a 7,8-diaminopelargonic acid (7-DAPA) dependent manner for envelope independent, single-step affinity purification. 7-DAPA, which has little or no affinity for avidin/streptavidin, was synthesised a...
An easy access to both enantiomers of 3-amino- and 3-(dimethylamino)-4,4-dimethylpyrrolidin-2-one from rac-pantolactam using (R)-α-methylbenzylamine as a chiral auxiliary is described.
Two new series of EP4 antagonists containing a 3-methylaryl-2-carbonyl core have been identified. One series has a 3-substituted-phenyl core, while the other one incorporates a 3-substituted pyridine. Both series led to compounds with potent activity in functional and human whole blood (hWB) ass...
We tested a set of boron containing arylethanolamine derivatives on the human and guinea pig β2 adrenoceptor (β2AR) 3-D structures by docking methodology. The compound with the highest affinity based on docking analysis, (R)-4-(2-(tert-butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)phenyl hydrog...
The formation pathways of two furanoids, 2-acetylfuran and 2,5-dimethyl-4-hydroxy-3[2H]-furanone (DMHF) were studied by GC–MS in the Maillard-type model system based on glucose and selected amino acids. The reaction was performed in 0.01 M phosphate buffer by heating a 1:1 mixture of [13C6] glu...
In the reaction of 2-formylphenylboronic acid with secondary amines different products are formed depending on the structure of the amines. For aliphatic amines the reaction proceeds with the formation of 3-amino-substituted benzoxaboroles or with the formation of complexed boroxins. A crystal s...
In this study we report a new reaction pathway in which the hydroxyl and the aldehyde groups of 5-hydroxymethyl furfural were aminated respectively. Hydroxyl group was aminated via Ritter reaction followed by direct reductive amination of aldehyde group. For the Ritter reaction of 5-hydroxymethy...
Novel tetrakis [(4-(hydroxymethyl)-2,6-dimethoxyphenoxyl)] substituted zinc(II), cobalt(II) and iron(II) phthalocyanines were synthesized by the reaction of (4-(hydroxymethyl)-2,6-dimethoxyphenoxy)phthalonitrile with suitable metal salts in 2-N, N-dimethylaminoethanol. The phthalonitrile ligand ...
Human inosine 5′-monophosphate dehydrogenase (hIMPDH) is a rate-limiting enzyme in the de novo biosynthetic pathway of purine nucleotides, playing crucial roles in cellular proliferation, differentiation, and transformation. Dysregulation of hIMPDH expression and activity have been found in a v...
Mutations in the gene encoding hypoxanthine–guanine phosphoribosyltransferase (HPRT) cause Lesch–Nyhan disease (LND) and its variants (LNV). Due to the technical problems for measuring the HPRT activity in vitro, discordances between the residual HPRT activity and the clinical severity were fo...
SummaryIn this study, we investigated whether orotate phosphoribosyl transferase (OPRT) correlates with the clinicopathological features and effect of 5-fluorouracil (5-FU) in human oral carcinoma. We examined the expression of OPRT mRNA by in situ hybridization in surgical specimens of oral squ...
Orotidine 5′-monophosphate decarboxylase (ODCase) is known as one of the most proficient enzymes. The enzyme catalyzes the last reaction step of the de novo pyrimidine biosynthesis, the conversion from orotidine 5′-monophosphate (OMP) to uridine 5′-monophosphate. The enzyme is found in all th...
The decomposition of 5-phosphoribosyl-α-1-pyrophosphate (PRPP) in the presence of Mg2+ at pH=7.8 yields a combination of products including ribose 5-phosphate, ribose 1-phosphate, 5-phosphoribosyl 1,2 cyclic phosphate, inorganic phosphate, and pyrophosphate. Hydrogen decoupled 31P NMR analysis ...
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