Dysbindin-1 (dystrobrevin binding protein-1, DTNBP1) is now widely accepted as a potential schizophrenia susceptibility gene and accumulating evidence indicates its functions in the neural development. In this study, we tried to identify new binding partners for dysbindin-1 to clarify the novel ...
ObjectiveThe compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a persistent organic pollutant, is harmful to the nervous system, but its effects on the brain are still unclear. This study aimed to investigate the effects of TCDD on astrocytes proliferation and underlying molecular mechanism.
ObjectivePoly(ADP-ribose) polymerase inhibitors (PARPi) are active in cancer cells that have impaired repair of DNA by the homologous recombination (HR) pathway. Strategies that disrupt HR may sensitize HR-proficient tumors to PARP inhibition. As a component of the core cell cycle machinery, cyc...
Accumulating evidences suggest that circular RNAs play vital roles in human cancers. Previously, we found that circHIPK3 suppressed invasion of bladder cancer cells via sponging miR-558 and downregulating heparanase expression. In this study, we discovered that a circular RNA derived from NR3C1 ...
AimsCyclin D1, generally considered to be absent in chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL), has been reported in the proliferation centres (PCs) of recent CLL/SLL cases. Cyclin D1 immunostaining in CLL/SLL may lead to diagnostic confusion. The objective of this study ...
ObjectiveTo evaluate cyclin D1 overexpression in oral squamous cell carcinomas and adjacent non-tumour epithelium as a biomarker of premalignant fields and a risk factor for multiple tumour development.
Pediatric acute myeloid leukemia (AML) is a complex and heterogeneous disease. Several studies have shown the regulatory functions of microRNAs (miRNAs) in pediatric AML progression, and in this study, we aimed to evaluate the biological role of miR-206 in pediatric AML. The results demonstrated...
Cell cycle activation has been associated with varying types of neurological disorders including brain injury. Cyclin D1 is a critical modulator of cell cycle activation and upregulation of Cyclin D1 in neurons contributes to the pathology associated with traumatic brain injury (TBI). Mitochondr...
ObjectiveTo evaluate the association of cyclin D1 overexpression with clinicopathological parameters classically considered of prognostic value in OSCC (T, N, M, clinical stage, degree of differentiation, invasive morphology and, cellular proliferation index).
According to the Earned Dogmatism Hypothesis, social norms entitle experts to be more dogmatic (closed-minded) than non-experts. Consequently, individuals who occupy the expert role are more closed-minded than non-experts. Ottati, Price, Wilson, and Sumaktoyo (2015) originally documented this ef...
The physical and chemical properties, reactivity, synthesis, and applications of 1,3-dioxoles, 1,3-dioxolanes, 1,3-oxathioles, 1,3-oxathiolanes, as well as their S-oxidized and benzo-fused derivatives have been reviewed comprehensively for the period 1995–2006.
A facile strategy for the preparation of A-ring fused pyridosteroids has been accomplished in high yields by the reaction of Vilsmeier reagent (chloromethyleneiminium salt) with steroidal A-ring enamides (2- and 3-ene) under thermal conditions. The structure of 6′-chloro-5α-cholest [3,2-b]pyri...
Publisher SummaryThis chapter discusses the organometallic complexes of pyridines and benzannulated pyridines.The general trends in the coordination modes of the five-membered heterocycles are analyzed in the chapter. Trends in the coordination chemistry of variously substituted pyridines follow...
This chapter contains a review of the recent advances in the synthetic manipulations of the numerous isomers of reduced pyridines, ie. the dihydropyridines, tetrahydropyridines and piperidines. When relevant this chapter highlights the development of asymmetric methods upon these compounds.
Anti-osteoporotic effects of the newly synthesized coumarin–pyridine hybrids were evaluated in primary cultures of rat calvarial osteoblasts in vitro. Compounds 6a, i, j and k were potent in stimulating osteoblast differentiation and mineralization as assessed by the alkaline phosphatase produc...
The pulmonary vasorelaxant properties of two NONOates (diazeniumdiolates) were examined because this novel group of nitric oxide (NO) donors may be useful in pulmonary hypertension. MAHMA NONOate ((Z)-1-{N-Methyl-N-[6-(N-methylammoniohexyl)amino]} diazen-1-ium-1,2-diolate) and spermine NONOate (...
Here we demonstrate a synergistic and tumor selective cytotoxic effect by combined treatment with naphthoxylosides, polyamine synthesis inhibitor, and polyamine based nitric oxide (NO) donor, using in vitro human tumor models. We have earlier reported that heparan sulfate priming naphthoxyloside...
The present study was conducted to know the role of Nitric Oxide (NO) on the acrosome reaction (AR) in Murrah buffalo (Bubalus bubalis) spermatozoa. Ejaculated buffalo spermatozoa were washed, suspended in sp-TALP media containing 6 mg BSA/mL and cell concentration was adjusted to 50 × 106 cell...
In the present study freshly ejaculated Murrah buffalo semen samples of mass motility of +3 or above on a scale of 0–5 were collected and cryopreserved with l-Arginine (1 mM), spermine-NONOate (10 μM) and no additive. Post-thaw sperm motility, viability, membrane integrity and lipid peroxidati...
Nitric oxide (NO) is a known modulator of angiogenesis. The NONOate subfamily of NO donors has long been used in experimental and clinical studies to promote angiogenesis. However, no studies have been conducted yet to compare the angiogenesis potential of these NO donors in respect to their pat...
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