The diastereomeric GSH derivatives γ-L-Glu-L-allo-thioThr-Gly (6) and γ-L-Glu-L-thioThr-Gly (6a) have been synthesized as specific probes of the steric environment near the cysteinyl residue of enzyme bound glutathionyl substrates. Experiments with glyoxalase I indicate that while 6a-methylgly...
Lamotrigine (LTG) is commonly used to control seizure in epilepsy patients and with referenced therapeutic windows in clinical practice. This study is to identify and characterize the function of genetic variants that influence the trough concentrations of LTG in epilepsy patients following mono...
Lamotrigine (6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine), a phenyltriazine anticonvulsant, is a newer anti-epileptic drug. A profile of this drug substance is provided in this chapter and includes physical characteristics of Lamotrigine (e.g. Uv/Vis, IR, NMR and mass spectra). Details reg...
The stability of lamotrigine (LMG) and its principal human metabolite, lamotrigine N2-glucuronide (LMG-N2-G), was studied as a function of pH (4–9). While LMG was stable across the entire pH range, under neutral-basic conditions, LMG-N2-G was converted to three transformation products (TPs) whi...
One of the most persistent pharmaceutical compounds commonly found in treated wastewater is lamotrigine (LTG). It has also been detected in soils and crops irrigated with treated wastewater. Here we focused on the ability of the white-rot edible mushroom Pleurotus ostreatus to remove and transfo...
Anemarrhena asphodeloides is widely used in traditional Chinese medicine, and is known to have anti-diabetic and diuretic effects. In this study, we evaluated the anti-inflammatory effects of anemarsaponin B (ASB), a steroidal saponin isolated from the rhizomes of A. asphodeloides (Liliaceae), i...
The interpretation of the spectra of free atoms and gaseous ions in the 4fN and 5fN periods became less active after critical compilations of energy levels appeared. However, several spectra are still under study and the application of the Racah–Slater and HFR methods to extended sets of config...
ResumenIntroducción y objetivosLa terapia de resincronización cardiaca (TRC) es beneficiosa para pacientes seleccionados con insuficiencia cardiaca (IC), aunque la ausencia de respuesta a la terapia es aún prevalente. Se investiga un conjunto de nuevos biomarcadores asociados a varias vías f...
ResumenIntroducciónLos circuitos de diagnóstico de la hepatitis C son complejos. El diagnóstico de infección activa en la misma muestra simplificaría el proceso estableciendo un acceso rápido al tratamiento. Nuestro objetivo fue estimar el impacto sanitario y económico del diagnóstico de...
The combination of bio-fillers with synthetic polymers has been an exciting route for developing tissue engineering scaffolds, in particular for bone tissue regeneration. In this study, poly(ɛ-caprolactone) (PCL) scaffolds were produced using an additive manufacturing technique and eggshell (ES)...
ES-242-1, a novel bioxanthracene of microbial origin, blocked glutamate-induced neuronal death in a dose-dependent manner at concentrations ranging from 0.01 to 1.0 μM, but not the neuronal death caused by kainic acid or quisqualic acid. ES-242-1 also prevented cell death induced by 2,4-methano...
BackgroundThe management of the pregnancy after delivery of the first fetus during second trimester miscarriage or very early preterm birth has not been well defined.
The propagation and maintenance of gene expression programs are at the foundation of the preservation of cell identity. A large and complex set of epigenetic mechanisms enables the long-term stability and inheritance of transcription states. A key property of authentic epigenetic regulation is b...
The effects of a novel N-methyl-d-aspartate (NMDA) receptor antagonists, ES-242-1 3,3′-dimethyl-3,4,3′,4′-tetrahydro-6,8,6′8′-tetramethoxy-[10,10′-bi-2-oxanthracene]-4,9,9′(1H,1′H)-triol 4-acetate, on NMDA-induced increases of intracellular Ca2+ concentration in cultured hippocampal neur...
Energies of α particles in the decay of heavy Es, Fm and Md isotopes were reevaluated by analyzing previously published and unpublished data. The α-particle spectra were measured in 1970s at the Argonne National Laboratory with a magnetic spectrometer and with silicon detectors using very thin...
The purpose of this study was to determine whether ES-242-1, a novel N-methyl-d-aspartate (NMDA) receptor antagonist of microbial origin, has anti-nociception at the spinal level and to evaluate how its anti-nociceptive effect differs from that of MK-801, a non-competitive NMDA receptor antagoni...
Callus and multiple shoots derived from an SDX-type plant of Scoparia dulcis were found to produce scopadulciol (SDY). The amounts of diterpenoid produced by the multiple shoots were the same as those of the callus and were five times higher than those of the multiple shoots from an SDB-type pla...
The effect of solvent, operating temperature, enzyme concentration and immobilization on activity and enantioselectivity of a Candida rugosa lipase for the kinetic resolution of ±2-(4-chlorophenoxy) propionic acid with 1-butanol in organic solvents was studied. The crude enzyme powder gave more...
Compounds containing amide bond play a pivotal role in various pharmaceutical applications. 2-(2-(2-Ethoxybenzoylamino)-4-chlorophenoxy)-N-(2-ethoxybenzoyl)benzamine 4 is shown to be a potent antiangiogenic agent. In this study, we report the microwave-assisted synthesis, single crystal X-ray st...
The Candida rugosa lipase-catalysed enantioselective hydrolysis of butyl 2-(4-chlorophenoxy)propionate 1 has been carried out in aqueous buffer with ionic liquid as co-solvent. The influence of ionic liquid on the catalytic efficiency and selectivity has been studied, using both hydrophobic and ...
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