An efficient cascade approach to α-hydroxy-β-amino acid derivatives is reported, which goes through a 1,3-dipolar cycloaddition of carbonyl ylides and N-benzoylbenzyl imines and followed by hydrolysis under acidic conditions. This is the first example of using N-benzoylbenzyl imine as dipolaro...
1.1. The recognition of DNA by gene regulatory proteins is often mediated by structural motifs that comprise a protein DNA-binding domain.2.2. Although binding of these proteins to DNA is not itself sufficient to affect transcription it is a necessary prerequisite.3.3. This review summarizes rec...
Background/Aims: Molecular mechanisms underlying transcriptional rat multidrug-resistance protein 2 (Mrp2, Abcc2) gene regulation are mostly unclear. Given the presence of putative binding sites for the Y-box binding protein YB-1 in the regulatory sequence, its trans-regulatory influence was ana...
During oogenesis, Xenopus laevis utilizes homologues of normal transcription or translation factors to sequester a variety of RNA molecules into ribonucleoprotein storage particles. This remarkable adaptive function for a diverse group of regulatory molecules allows the oocyte to stockpile macro...
SummaryWhile point mutations affecting the promoter region of (β-globin gene are widely described, there are no well characterised reports of any point mutations currently found in the promoter of the α2-globin (HBA2) gene. We present clinical and experimental data for three novel HBA2 gene co...
Genomic Southern blot analysis of rat EFIA (gene encoding enhancer factor I subunit A) reveals a complex band pattern when cDNA subfragment probes are used. Screening a rat genomic library with a rat EFIA cDNA probe yields two different processed EFIA pseudogenes, designated rat ΨEFIA#(23) and ...
CCAAT/enhancer-binding protein δ (C/EBPδ) transcription factor is sharply induced at the early stage of the acute phase response. We previously reported that the C/EBPδ gene expression is induced by the acute-phase response factor/signal transducers and activators of transcription 3 (APRF/STA...
The genomic copy multiplicity of the CCAAT transcription complex component enhancer factor I subunit A (EFIA) has been examined. When a mammalian genomic Southern blot was hybridized to a rat EFIA cDNA, a complex pattern consisting of numerous related sequences was found in all the species exami...
β-Lactam antibiotics like cefotaxime are the most commonly used antibacterial agents. Escherichia coli strains 5 A, 10 A, 12 A and 23B isolated from Seagulls feces, are cefotaxime-resistant strains that produces extended-spectrum beta-lactamases. Bacterial resistance to these antibiotics occurs...
In the context of the plethora of proteins harboring iron-sulfur clusters we have already reviewed structure/electrochemistry of metalloproteins expressing single types of iron-sulfur clusters (namely: {Fe(Cys)4}, {[Fe2S2](Cys)4}, {[Fe2S2](Cys)3(X)} (X = Asp, Arg, His), {[Fe2S2](Cys)2(His)2}, {[...
Higher alcohols such as isobutanol possess several physical characteristics that make them attractive as biofuels such as higher energy densities and infrastructure compatibility. Here we have developed a rapid evolutionary strategy for isolating strains of Escherichia coli that effectively prod...
Metabolic regulations were investigated from the viewpoint of gene expressions for Escherichia coli JM109 and pgi knockout E. coli with and without phb genes using RT-PCR. One of the main features of pgi knockout E. coli is the overproduction of NADPH produced in pentose phosphate (PP) pathway. ...
The glutamate transporter GLT-1 from Rattus norvegicus was expressed at high level in BHK cells using the Semliki Forest virus expression system. BHK cells infected with viral particles carrying the GLT-1 gene exhibited 30-fold increased aspartate uptake compared to control cells. The expression...
Glutamate neurotransmission is highly regulated, largely by glutamate transporters. In the spinal cord, the glutamate transporter GLT-1 is primarily responsible for glutamate clearance. Downregulation of GLT-1 can occur in activated astrocytes, and is associated with increased extracellular glut...
The rate of uptake of aspartate into the rat hepatoma cell line H4-II-E-C3 is very much higher than that exhibited by normal rat hepatocytes. Using an RT-PCR-based strategy, a glutamate transporter resembling mouse liver GLT-1A has been cloned from H4-II-E-C3 cells. Northern blotting confirmed t...
Metabolic engineering and construction of recombinant Escherichia coli strains carrying feruloyl-CoA synthetase and enoyl-CoA hydratase genes for the bioconversion of ferulic acid to vanillin offers an alternative way to produce vanillin. Isolation and designing of fcs and ech genes was carried ...
The glutamate transporter GLT-1 from Rattus norvegicus was expressed at high level in baby hamster kidney (BHK-21) cells by the Semliki Forest Virus expression system. We examined the expressed GLT-1 in the plasma membrane and found that the transporter accumulates in detergent-insoluble lipid-p...
GLT-1 is the main glutamate transporter in the brain and undergoes trafficking processes that control its concentration on the cell surface thereby shaping glutamatergic neurotransmission. We have investigated how the traffic of GLT-1 is regulated by transporter activity. We report that internal...
The 1998 evaluation on mass A = 102 (1998De15) has been revised, taking into account all data available before december 2008. Detailed experimental information is presented from the neutron rich nucleus 102Rb to the neutron deficient 102Sn nucleus. No information on excited states of 102Rb is av...
This paper proposes an effective non-dominated moth-flame optimization algorithm (NS-MFO) method for solving multi-objective problems. Most of the multi-objective optimization algorithms use different search techniques inspired by different optimization techniques such as genetic algorithms, dif...
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