A novel, one-pot, phenylboronic acid catalyzed, cyanide promoted synthesis of 2-(2-hydroxyphenyl)benzoxazoles from salicylaldehydes and o-aminophenols is described. The synthesis is characterized by mild conditions, short reaction times, and simple workup of crystalline, high purity products.
A facile one-pot synthesis of 3-(2-hydroxyphenyl)indolin-2-ones has been developed via the TiCl4-mediated Baylis–Hillman (B–H) reaction of N-substituted isatins and cyclohex-2-enone, followed by treatment of the in situ generated B–H alcohols with aq HBr. Baylis–Hillman reaction of aromatic ...
An efficient synthetic method for the preparation of (E)- and (Z)-3(5)-(2-hydroxyphenyl)-4-styrylpyrazoles has been developed. The reaction of (E)- and (Z)-3-styrylchromones with hydrazine hydrate afforded the corresponding (E)- and (Z)-4-styrylpyrazoles, respectively, saved 4′-nitro-derivative...
An efficient transformation of 3-(1-alkynyl)chromone 1 to 2-(2-hydroxyphenyl)-5-phenylfuran-3-carbaldehyde 2 has been accomplished using AgNO3 as catalyst. The ring-chain tautomerism of 2 depends on solvent and substituent.
ABSTRACTUsing the water eliminated mechanism, reactions of 4-pyridinecarboxylic acid hydrazide and salicylaldehyde, benzaldehyde, cinnamaldehyde, and formaldehyde afforded the corresponding N4[(E)-1-(2-hydroxyphenyl) methylidene] (NHPM), N4-[(E)-2-phenylethylidene] (NPI), N4[(E,2E)-3-phenyl-2-pr...
Fluorescence and phosphorescence spectra of physostigmine (eserine) are determined and compared with those reported for the phenyl carbamate pesticides Matacil and Zectran. The conversion of physostigmine to rubreserine is studied in the presence of nucleophilic reagents and inhibitors. Spectral...
Several types of furanomycin analogues were synthesized and investigated with respect to their antibacterial activity. Two different synthetic pathways were developed, based on aldol reactions/ring closing metathesis and an ester enolate Claisen rearrangement. Only the natural product and its de...
A short new route to N-protected l-(+)-furanomycin and two of its isomeric derivatives has been developed, which featured the utility of d-serine as a chiral pool material and ring-closing metathesis as a key ring-forming step.
Background– Interaction between serum uric acid level and diabetic nephropathy is a matter of debate. This study is designed to examine the association between serum uric acid (SUA) level and proteinuria in in type 2 diabetes patients with stages 1 and 2 chronic kidney disease (CKD).
The atmospheric ozonolysis mechanism of (E)-2-formylcinnamaldehyde is investigated at the CCSD(T)//M06-2X/6-311++G(d,p) level of theory. The reaction starts with the formation of primary ozonides (POZs), which decompose to four primary products as phthaldialdehyde+CIs (Criegee intermediates, syn...
A convenient and efficient method for the synthesis of 2-substituted benzothiazoles from simple and readily available 2-amino thiophenols and nitriles is described. The Brønsted acid-catalyzed cyclization reaction was performed under metal and solvent-free conditions.
A key mechanism of Pseudomonas spp. adaptation to environmental stressors is their ability to convert the cis-unsaturated fatty acids of the membrane lipids to their trans-isomers to rigidify the membrane and thereby resist stresses. Although this Cti-catalyzed enzymatic isomerization has been w...
AimsThis randomized controlled trial (RCT) study was carried out to assess effects of omega-3 supplementation alone and in combination with vitamin E on gene expressions of SIRT1, SIRT3, SIRT6, FOXO1, FOXO3 and UCP-2 in patients with coronary artery disease (CAD).
PbCrO4 and Pb2CrO5 have been selectively synthesized via a chemical gas–liquid precipitation process by adjusting the pH value. The structure, size and morphology of the as-synthesized products are characterized by X-ray diffraction and transmission electron microscopy. Differences in UV–Vis s...
Highly uniform single-crystal PbCrO4 nanorods and Pb2CrO5 micro-particles can be selectively synthesized by adjusting the pH value of the parent mixture in the presence of a surfactant of poly(vinyl pyrrolidone). The as-synthesized products are characterized by X-ray diffraction, transmission el...
A new process that could directly prepare α-haloacetal of ketones from various ketones with N-halosuccinimide (NBS/NCS) and ethylene glycol in one step without any other catalysts was reported. The effects of solvents, NBS/NCS and reaction temperature were investigated. Under the optimal condit...
Selective one-pot alkylation or allylation of ketones in the presence of α,β-unsaturated ketones (enones) were accomplished by using our in situ protection methodology. Enones selectively react with a combination of PPh3 and silyl triflates in the presence of ketones to produce phosphonium sil...
A method for stereoselective synthesis of α,α-difluoro-γ-iodo-β,γ-alkenyl ketones via radical difluoroacetylation of iododifluoromethyl ketones with terminal and internal alkynes was reported. This methodology provides a straightforward access to 3,3-disubstitued allylic difluorides.
An efficient catalytic system for hydrogenation of ketones and aldehydes using a Cp*Ir complex [Cp*Ir(2,2′-bpyO)(H2O)] bearing a bipyridine-based functional ligand as catalyst has been developed. A wide variety of secondary and primary alcohols were synthesized by the catalyzed hydrogenation of...
A general and efficient method for the synthesis of 2-oxo-acetamidines via copper-catalyzed oxidative cross-coupling of amines with α-amino ketone compounds was achieved. In this reaction, the C − N bond of α-amino ketone is broken and new C − N and CN bonds are constructed in one single trans...
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