Background and aimBrain death impairs liver function in potential donors and is associated with inflammatory activation. Methylprednisolone treatment after brain death has been shown to reduce inflammatory activity. The aim of the present study was to evaluate the effects of methylprednisolone o...
A novel triazine-type chiral derivatization reagent, i.e., (S)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl) pyrrolidine-2-carboxylate (DMT-(S)-Pro-OSu), was developed for the highly sensitive and selective detection of chiral amines and amino acids by UPLC–MS/MS analysis. The e...
There are two sources of fatty acids in river waters: man-made contamination and naturally occurring. Regarding the latter the determination of free and bound fatty acids present in aquatic systems is important; first because fatty acids are sufficiently diverse in structure that they can be use...
Conformations and configurations were assigned to several N-Me imines and N-alkyl acetaldimines from analyses of their 60-Mc NMR spectra. All aldimines exist exclusively in the syn configuration. Interpretation of the vicinal and long-range (across 4 and 5 and bonds) spin-spin coupling constants...
-The boron trifluoride catalyzed rearrangement of 2,2-di-t-butyloxirane, involving competitive reactions of transient carbenium ions, could be selectively directed towards either 2,2,3,3,4,4- hexamethyltetrahydrofuran or 2-t-butyl-2,3-dimethyl-3-buten-1-ol. Hydride shift to afford 2,2-di-t-butyl...
Publisher SummaryThis chapter discusses the cobalt-catalyzed synthesis of pyridine and its derivatives. Pyridine and its derivatives are technically-important fine chemicals. The applications of cobalt-catalyzed pyridine synthesis are briefly discussed. The cobalt-catalyzed pyridine synthesis is...
Starting from our previously identified novel c-Met kinase inhibitors bearing 1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)-one scaffold, a global structural exploration was conducted to furnish an optimal binding motif for further development, directed by the enzyme inhibitory mechanism. First round...
In dimethylformamide solution, trifluoroethoxylation and methoxylation of 5-chloro-3-trifluoromethylpyridine (2) yield 5-chloro-3-tris(trifluoroethoxyl) methyl pyridine (2a) and a dimethyl ketal of 3-chloronicotinic acid anhydride (2b) with fluorines as leaving groups, respectively. The correspo...
The preparation and application of dihydropyridines continue to attract considerable interest in organic synthesis and medicinal chemistry. The biological activities and synthetic utility of these heterocycles have prompted the development of new routes to their construction. The Hantzsch synthe...
As a continuation of our research and with the aim of obtaining new antimalarial agents, new series of 3-phenylquinoxaline 1,4-di-N-oxide derivatives have been synthesized following the classical Beirut reaction. Antiplasmodial activity was evaluated in vitro against Plasmodium falciparum by the...
A new series of quinoxaline 1,4-di-N-oxides was synthesized and evaluated for antitumor and hypoxic-selective cytotoxic activities. Antitumor activity against liver carcinoma (Hepg2) and brain tumor (U251) human cell lines were evaluated, among the tested compounds, 5b and 9b exhibited potential...
Tuberculosis, an ancient disease undergoing recent control by public hygiene and drug therapy, has experienced a recrudescence throughout the world. New and effective therapies are rapidly needed to combat infections caused by these strains. Some new 2-quinoxalinecarbonitriles have been synthesi...
4-Cyanoquinoline-N-oxides were obtained in the reactions of 2-nitrobenzylcyanide carbanions with acrylonitrile.
A novel and efficient approach to the synthesis of substituted quinoline-1-oxides and the complex compounds SnL2Cl2 (L=2-aminoquinoline-1-oxides) was developed. The reaction has fancy selectivity when 3-(2-nitrophenyl)acrylonitriles were treated with the aid of SnCl2 reagent under the same condi...
BackgroundReproducibility in Science is challenging and may be hard to achieve in alcohol research. Previous general population surveys in Brazil have estimated the prevalence of alcohol dependence to be around 10%. We aim to estimate alcohol use and dependence using different methods and defini...
BackgroundBlackouts are common among young adults and predict alcohol-related harm. However, existing measures do not capture the range of alcohol-induced memory impairment involved in blackout experiences and do not differentiate between fragmentary and en bloc blackouts. This study aimed to de...
ABSTRACTObjectiveEvidence suggests that adolescents are exposed to alcohol marketing in digital media. We aimed to assess recall of Internet alcohol marketing and its association with underage drinking.
Sardinian alcohol-preferring (sP) rats have been selectively bred, over almost 40 years, for high alcohol preference and consumption. sP rats have served as an animal model for more than 120 published studies. With very few exceptions, however, these studies have always employed male sP rats, an...
Alcohol use disorder (AUD) is a chronic relapsing disorder with wide-ranging health consequences. Alcohol targets the central nervous system producing neurodegeneration and subsequent cognitive and behavioral deficits, but the mechanisms behind these effects remain unclear. Recently, evidence ha...
Binary mixtures of water and various alcohols (W/ROH) were characterized in the light of the pure solvent scales, using suitable probe/homomorph couples. Various thermodynamic properties (viz. vapour pressure and enthalpy of mixing), viscosity, and the IR and NMR spectroscopic properties of the ...
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