A new synthetic method is described for the mild and selective reduction of 3-methyl-5-aryl-1,2,4-oxadiazoles to amidines employing iron powder in aqueous medium. Its application is demonstrated in the synthesis of 1, a potent and selective urokinase-type plasminogen activator (uPA) inhibitor.
A series of amidine substituted phenyl-, benzyl-, and phenethylimidazoles based on the known H3 agonist SK&F 91606 (4) has been synthesized and tested as ligands for the histamine H3 receptor. Insertion of a phenyl ring between the imidazole ring and the amidine moiety produces antagonists. The ...
By using 4Na2SO4·2H2O2·NaCl as a reductant, manganese oxide octahedral molecular sieve (OMS-2) with enhanced surface area and mixed valence was prepared successfully. OMS-2 showed excellent catalytic ability towards aerobic oxidative synthesis of 1,3,5-triazines from benzyl alcohols and benzam...
A new method of recovering antimony in hydrochloric acid system by cementation with copper powder was proposed and carried out at laboratory scale. Thermodynamic analysis and cyclic voltammetry test were conducted to study the cementation process. This is a novel antimony removal technology and ...
Very little research has been done into methods for recycling antimony from end of life products. This study investigates separation of antimony from metal oxide varistors (MOVs), where antimony is present between 3 and 5 wt%. In MOVs, antimony is found in spinel (Zn2.33Sb0.67O4, Zn7Sb2O12) and ...
China is facing a shortage of antimony (Sb) resources, and Sb emissions are worsening. In exploring solutions to these issues, this paper attempts to apply substance flow analysis (SFA) to track Sb flow among the lithosphere, anthroposphere, and biosphere in China. The results are as follows: (1...
The promotion of copper electrolyte self-purification with antimonic oxides was studied. It was found that the mixed oxides of Sb(III) and Sb(V) can be used to promote copper electrolyte self-purification. The mixture of Sb2O3·xH2O and Sb2O5·xH2O with Sb(V)/Sb(III) molar ratio 0.05 was used to...
Replacement of one of the methyl groups of the carcinogens 4-dimethylaminoazobenzene (DAB) and 6-dimethylaminophenylazobenzthiazole (6BT) with a cyanoethyl (−CH2CH2CN) substituent dramatically increases their mutagenic potency to Salmonella (strain TA98). The corresponding monomethylamino deriva...
Synthesis of new benzothiazolylazo indole dyes were carried out by diazotization of 2-aminobenzothiazole, 6- and 5,6-disubstituted 2-aminobenzothiazoles using with nitrosyl sulfuric acid and coupling with various 2- and 1,2-disubstituted indole derivatives. The structures of the dyes were charac...
Chemometric descriptors were used to analyze quantitatively the anticonvulsant activity of ninety propanamide derivatives. Molecular geometries of the data set were optimized with B3LYP/6-31G∗∗ quantum mechanical method and chemometric descriptors were calculated from the optimized structure. Li...
Deactivation of Pd/C catalyst often occurs in liquid hydrogenation using industrial materials. For instance, the Pd/C catalyst is deactivated severely in the hydrogenation of N-(3-nitro-4-methoxyphenyl) acetamide. In this study, the chemisorption of sulfur on the surface of deactivated Pd/C was ...
The amide functional group is a fundamental building block of proteins, but is also present in several industrial chemicals such as acetamide and acrylamide. Some acetamide derivatives are known to deplete cytoplasmic heme, and some acrylamide derivatives are known to cause porphyria and may act...
We synthesized a series of N-(6-azulenyl)-N-arylacetamides, and investigated their conformational preferences in solution and in the crystalline state by means of NMR and X-ray analyses. The results indicated that the conformational preferences of these amides are dependent on both the relative ...
BackgroundThe Body Image Concern Inventory (BICI), the Whitely Index (WI), and the Checklist Individual Strength (CIS-20R) are three questionnaires often incorporated in routine outcome monitoring (ROM). Respectively, they assess symptom severity in patients with body dysmorphic disorder, hypoch...
In our previous study, the degree of adsorption of 9 representative antimicrobial agents to Toraymyxin® PMX-F sheets was quantitatively evaluated [1]. As a result, the adsorption rate was 22.1% for Linezolid in the presence of serum.Therefore, we investigated whether two types of antimicrobial a...
The depsidone norstictic acid is a widespread secondary metabolite produced by lichen-forming fungi. Like other lichen substances, most of the norstictic acid is deposited as crystals in the apoplast of lichens, whereas only a small proportion is soluble in water. Since recent studies suggested ...
FT-Raman spectroscopy has been used for the analytical characterization of the Parmotrema tinctorum Del. Ex Nyl. lichen. Lecanoric acid, the major lichen chemical present in the total mass, has been extracted from the lichen, purified and characterized by Raman spectroscopy supported by means of...
Raman spectroscopy using 785 nm excitation was tested as a nondestructive method for determining the presence of the potential biomarker, usnic acid, in experimentally prepared mineral matrices. Investigated samples consisting of usnic acid mixed with powdered hydrothermal minerals, gypsum and c...
The FT-Raman and infrared vibrational spectra of some important lichen compounds from two metabolic pathways are characterised. Key biomolecular marker bands have been suggested for the spectroscopic identification of atranorin, gyrophoric acid, fumarprotocetraric acid rhizocarpic acid, calycin,...
Photophysical and photochemical parameters of the lichen metabolites calycin and rhizocarpic acid were determined. Experiments were carried out in micellar solutions of 3% Brij 35, at pH 2 and 12, and in acetonitrile. Both metabolites absorb in the UV-A and UV-B regions, and emit fluorescence in...
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